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Delta-3-Tetrahydrocannabinol
Delta-3-Tetrahydrocannabinol (Delta-3-THC, Δ3-THC, Δ6a(10a)-THC, EA-1477) is a synthetic isomer of tetrahydrocannabinol, developed during the original research in the 1940s to develop synthetic routes to the natural products Δ8-THC and Δ9-THC found in the cannabis plant. While the normal ''trans'' configuration of THC is in this case flattened by the double bond, it still has two enantiomers as the 9-methyl group can exist in an (R) or (S) conformation. The (S) enantiomer has similar effects to Δ9-THC though with several times lower potency, while the (R) enantiomer is many times less active or inactive, depending on the assay used. See also * 7,8-Dihydrocannabinol * Cannabitriol * Delta-4-Tetrahydrocannabinol * Delta-7-Tetrahydrocannabinol * Delta-10-Tetrahydrocannabinol * Hexahydrocannabinol * JWH-138 * Parahexyl Parahexyl (Synhexyl, n-hexyl-Δ3-THC, (C6)-Δ6a(10a)-THC) is a synthetic homologue of THC which was invented in 1941 during attempts to elucidate the stru ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Delta-4-Tetrahydrocannabinol
Delta-4-Tetrahydrocannabinol (Delta-4-THC, Δ4-THC, Δ6a(7)-THC) is a synthetic isomer of tetrahydrocannabinol, developed in the 1970s during research to develop improved synthetic routes to the natural forms Δ8-THC and Δ9-THC. Only the (9R, 10aR) enantiomer has been synthesised, though other isomers are possible. See also * 7,8-Dihydrocannabinol * Delta-3-Tetrahydrocannabinol * Delta-7-Tetrahydrocannabinol * Delta-10-Tetrahydrocannabinol * Hexahydrocannabinol Hexahydrocannabinol (HHC) is a hydrogenated derivative of tetrahydrocannabinol. It is a naturally occurring phytocannabinoid that has rarely been identified as a trace component in ''Cannabis sativa'', but can also be produced synthetically by hy ... References Benzochromenes Cannabinoids {{cannabinoid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Delta-8-Tetrahydrocannabinol
Delta-8-tetrahydrocannabinol (delta-8-THC, Δ8-THC) is a psychoactive cannabinoid found in the Cannabis plant. It is an isomer of Tetrahydrocannabinol, delta-9-tetrahydrocannabinol (delta-9-THC, Δ9-THC), the compound commonly known as THC. ∆8-THC is under preliminary research for its biological properties. Effects ∆8-THC is moderately less Potency (pharmacology), potent than Δ9-THC. This essentially means that it has properties similar to those of ∆9-THC, although to a lesser degree per milligram of material consumed. Delta-8-THC and delta-9-THC both contain a double bond in their molecular structure, but the location is different. Delta-8-THC has the bond in the eighth carbon while delta-9 contains it in the 9th carbon. Although ∆8-THC functions similarly to Δ9-THC in many ways, it appears to be only two-thirds as psychoactive. This may be because it binds differently to CB1, the cannabinoid receptor that regulates much of THC’s mind-altering effect. ∆8-THC ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Delta-7-Tetrahydrocannabinol
Delta-7-Tetrahydrocannabinol (alternatively numbered as Delta-5-Tetrahydrocannabinol, Δ5-THC, Δ7-THC) is a synthetic isomer of tetrahydrocannabinol. The (6aR,9S,10aR)-Δ7-THC epimer is only slightly less potent than Δ9-THC itself, while the (9R) enantiomer is much less potent. See also * 7,8-Dihydrocannabinol * Delta-3-Tetrahydrocannabinol * Delta-4-Tetrahydrocannabinol * Delta-8-Tetrahydrocannabinol * Delta-10-Tetrahydrocannabinol * Hexahydrocannabinol References Benzochromenes Cannabinoids {{pharm-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Delta-10-Tetrahydrocannabinol
Delta-10-Tetrahydrocannabinol (Delta-10-THC, Δ10-THC, alternatively numbered as Δ2-THC) is an isomer of tetrahydrocannabinol, discovered in the 1980s. Two enantiomers have been reported in the literature, with the 9-methyl group in either the (R) or (S) conformation; of these, the (R) enantiomer appears to be the more active isomer, with about 30 to 40 percent the potency of delta-9-THC. Δ10-THC has rarely been reported as a trace component of natural cannabis, though it is thought to be a degradation product similar to cannabinol rather than being produced by the plant directly. However, it is found more commonly as an impurity in synthetic delta-8-THC produced from cannabidiol and can also be synthesized directly from delta-9-THC. See also * 7,8-Dihydrocannabinol * 9-OH-HHC * Delta-3-Tetrahydrocannabinol * Delta-4-Tetrahydrocannabinol * Delta-7-Tetrahydrocannabinol * Delta-6-Cannabidiol * Hexahydrocannabinol * THC-O-acetate THC acetate ester (THC-O-acetate, THC aceta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
JWH-138
JWH-138 (THC-Octyl, Δ8-THC-C8) is a synthetic cannabinoid first synthesised by John W. Huffman, with a Ki of 8.5nM at the CB1 cannabinoid receptor. Isomers The Δ3/Δ6a(10a) isomer was synthesised in 1941, but was found to be slightly less active than Δ3-THC itself. The alternate isomer Δ9-THC-C8 has also been synthesised, but has not been identified as a natural product. See also * Cannabicyclohexanol * Parahexyl * Tetrahydrocannabihexol Tetrahydrocannabihexol (Δ9-THCH, Δ9-Parahexyl, n-Hexyl-Δ9-THC) is a phytocannabinoid, the hexyl homologue of tetrahydrocannabinol (THC) which was first isolated from ''Cannabis'' plant material in 2020 along with the corresponding hexyl homol ... * THCP References {{cannabinoid-stub Xanthenes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parahexyl
Parahexyl (Synhexyl, n-hexyl-Δ3-THC, (C6)-Δ6a(10a)-THC) is a synthetic homologue of THC which was invented in 1941 during attempts to elucidate the structure of Δ9-THC, one of the active components of cannabis. Parahexyl is similar in both structure and activity to THC, differing only in the position of one double bond and the lengthening of the chain by one CH2 group to . Parahexyl produces effects typical of other cannabinoid receptor agonists in animals. It has a somewhat higher oral bioavailability than THC itself but is otherwise very similar. Presumably, it acts as a CB1 agonist in the same way as THC, but as there has been no research published using parahexyl since the discovery of the CB1 receptor, this has not been definitively confirmed. Parahexyl was occasionally used as an anxiolytic in the mid-20th century, the dosage ranging from 5 mg to 90 mg. Parahexyl was made illegal under UN convention in 1982 on the basis of its structural similarity and simi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tetrahydrocannabinol
Tetrahydrocannabinol (THC) is the principal psychoactive constituent of cannabis and one of at least 113 total cannabinoids identified on the plant. Although the chemical formula for THC (C21H30O2) describes multiple isomers, the term ''THC'' usually refers to the Delta-9-THC isomer with chemical name (−)-''trans''-Δ9-tetrahydrocannabinol. THC is a lipid found in cannabis and, like most pharmacologically active secondary metabolites of plants, it is assumed to be involved in the plant's evolutionary adaptation, putatively against insect predation, ultraviolet light, and environmental stress. THC was first discovered and isolated by Israeli chemist Raphael Mechoulam in Israel in 1964. It was found that, when smoked, THC is absorbed into the bloodstream and travels to the brain, attaching itself to endocannabinoid receptors located in the cerebral cortex, cerebellum, and basal ganglia. These are the parts of the brain responsible for thinking, memory, pleasure, coordination a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural Product
A natural product is a natural compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life. Natural products can also be prepared by chemical synthesis (both semisynthesis and total synthesis) and have played a central role in the development of the field of organic chemistry by providing challenging synthetic targets. The term natural product has also been extended for commercial purposes to refer to cosmetics, dietary supplements, and foods produced from natural sources without added artificial ingredients. Within the field of organic chemistry, the definition of natural products is usually restricted to organic compounds isolated from natural sources that are produced by the pathways of primary or secondary metabolism. Within the field of medicinal chemistry, the definition is often further restricted to secondary metabolites. Secondary metabolites (or specialized metabolites ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cannabis
''Cannabis'' () is a genus of flowering plants in the family Cannabaceae. The number of species within the genus is disputed. Three species may be recognized: ''Cannabis sativa'', '' C. indica'', and '' C. ruderalis''. Alternatively, ''C. ruderalis'' may be included within ''C. sativa'', all three may be treated as subspecies of ''C. sativa'', or ''C. sativa'' may be accepted as a single undivided species. The genus is widely accepted as being indigenous to and originating from Asia. The plant is also known as hemp, although this term is often used to refer only to varieties of ''Cannabis'' cultivated for non-drug use. Cannabis has long been used for hemp fibre, hemp seeds and their oils, hemp leaves for use as vegetables and as juice, medicinal purposes, and as a recreational drug. Industrial hemp products are made from cannabis plants selected to produce an abundance of fibre. Various cannabis strains have been bred, often selectively to pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
7,8-Dihydrocannabinol
7,8-Dihydrocannabinol (7,8-DHC) is a trace component of cannabis. Despite its structural similarity to active cannabinoids such as tetrahydrocannabinol and cannabinol, its pharmacology has not been studied. See also * 8,9-Dihydrocannabidiol * Delta-3-THC * Delta-4-THC * Delta-7-THC * Delta-8-THC * Delta-10-THC * Hexahydrocannabinol Hexahydrocannabinol (HHC) is a hydrogenated derivative of tetrahydrocannabinol. It is a naturally occurring phytocannabinoid that has rarely been identified as a trace component in ''Cannabis sativa'', but can also be produced synthetically by hy ... References Cannabinoids Benzochromenes {{cannabinoid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cannabitriol
Cannabitriol ((+)-CBT, (''S'',''S'')-9,10-Dihydroxy-Δ6a(10a)-THC) is a phytocannabinoid first isolated in 1966, an oxidation product of tetrahydrocannabinol which has been identified both as a trace component of cannabis and as a metabolite in cannabis users. Its pharmacology has been little studied, though it has been found to act as an antiestrogen and aromatase inhibitor. See also * 8,11-Dihydroxy-THC * 9-OH-HHC * Cannabicitran (also sometimes called CBT) * Delta-3-THC Delta-3-Tetrahydrocannabinol (Delta-3-THC, Δ3-THC, Δ6a(10a)-THC, EA-1477) is a synthetic isomer of tetrahydrocannabinol, developed during the original research in the 1940s to develop synthetic routes to the natural products Δ8-THC and Δ9-TH ... References External linksCBD Oil & Capsules Cannabinoids Benzochromenes Phenols {{cannabinoid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hexahydrocannabinol
Hexahydrocannabinol (HHC) is a hydrogenated derivative of tetrahydrocannabinol. It is a naturally occurring phytocannabinoid that has rarely been identified as a trace component in ''Cannabis sativa'', but can also be produced synthetically by hydrogenation of cannabis extracts. HHC was first synthesized in 1947 by Roger Adams using natural THC found in ''Cannabis sativa''. Several research groups have successfully synthesized (+)-HHC and (-)-HHC using citronellal and olivetol, as well as other related compounds. While similar compounds have previously been identified in cannabis, hexahydrocannabinol itself has rarely been isolated from the plant. The de Las Heras group in 2020 took lipid extract from ''Cannabis sativa'' seeds and discovered 43 cannabinoids in the crude extract; one of them being hexahydrocannabinol. It has two diastereomers at the methyl (9) position. HHC is typically made from Δ8-THC, or Δ9-THC. There are no double bonds in the cyclohexyl ring like D8/D9 hav ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
