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David Gardner-Medwin
David Gardner-Medwin (13 November 193614 June 2014) was a British physician who worked as a paediatric neurologist in Newcastle upon Tyne, serving as the only neurologist for children for a population of 3.5 million. He is credited with introducing multidisciplinary care to the management of boys with Duchenne muscular dystrophy (DMD). When he retired at the age of 60, four consultants were appointed to replace him. In the 1960s, working as a research fellow with neurologist John Walton, he studied the genetics and clinical features of the diseases of muscles, particularly relating to the identification of female carriers of DMD. Parallel to his career in medicine was his interest in natural history and involvement with the Natural History Society of Northumbria, the binding and restoration of books and studies on Thomas Bewick. He finished a study of Bewick's family history and contributed to the Bewick Birthplace Trust's campaign to preserve Bewick's birthplace of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
King's College, Cambridge
King's College is a constituent college of the University of Cambridge. Formally The King's College of Our Lady and Saint Nicholas in Cambridge, the college lies beside the River Cam and faces out onto King's Parade in the centre of the city. King's was founded in 1441 by King Henry VI soon after he had founded its sister institution at Eton College. Initially, King's accepted only students from Eton College. However, the king's plans for King's College were disrupted by the Wars of the Roses and the resultant scarcity of funds, and then his eventual deposition. Little progress was made on the project until 1508, when King Henry VII began to take an interest in the college, probably as a political move to legitimise his new position. The building of the college's chapel, begun in 1446, was finished in 1544 during the reign of Henry VIII. King's College Chapel is regarded as one of the finest examples of late English Gothic architecture. It has the world's largest fan vaul ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edinburgh Academy
The Edinburgh Academy is an Independent school (United Kingdom), independent day school in Edinburgh, Scotland, which was opened in 1824. The original building, on Henderson Row in the city's New Town, Edinburgh, New Town, is now part of the Senior School. The Junior School is located on Arboretum Road to the north of the city's Royal Botanic Garden Edinburgh, Royal Botanic Garden. The Edinburgh Academy was originally a day and boarding school for boys. It ceased boarding and transitioned to co-education in 2008 and is now a fully coeducational day school. The nursery, housed in a 2008 purpose built block on the Junior campus, caters for children from age 2 to 5. The Junior School admits children from age 6 to 10 whilst the Senior School takes pupils from age 10 to 18. Foundation In 1822, the school's founders, Henry Thomas Cockburn, Henry Cockburn and Leonard Horner, agreed that Edinburgh required a new school to promote Classics, classical learning. Edinburgh's Royal High Sch ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Creatinine Kinase
Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme () expressed by various tissues and cell types. CK catalyses the conversion of creatine and uses adenosine triphosphate (ATP) to create phosphocreatine (PCr) and adenosine diphosphate (ADP). This CK enzyme reaction is reversible and thus ATP can be generated from PCr and ADP. In tissues and cells that consume ATP rapidly, especially skeletal muscle, but also brain, photoreceptor cells of the retina, hair cells of the inner ear, spermatozoa and smooth muscle, PCr serves as an energy reservoir for the rapid buffering and regeneration of ATP ''in situ'', as well as for intracellular energy transport by the PCr shuttle or circuit. Thus creatine kinase is an important enzyme in such tissues. Clinically, creatine kinase is assayed in blood tests as a marker of damage of CK-rich tissue such as in myocardial infarction (heart attack), rhabdomyolysis (severe muscle breakdown), muscular ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
X-linked Recessive Inheritance
X-linked recessive inheritance is a mode of inheritance in which a mutation in a gene on the X chromosome causes the phenotype to be always expressed in males (who are necessarily homozygous for the gene mutation because they have one X and one Y chromosome) and in females who are homozygous for the gene mutation, see zygosity. Females with one copy of the mutated gene are carriers. X-linked inheritance means that the gene causing the trait or the disorder is located on the X chromosome. Females have two X chromosomes while males have one X and one Y chromosome. Carrier females who have only one copy of the mutation do not usually express the phenotype, although differences in X-chromosome inactivation (known as skewed X-inactivation) can lead to varying degrees of clinical expression in carrier females, since some cells will express one X allele and some will express the other. The current estimate of sequenced X-linked genes is 499, and the total, including vaguely defined trait ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Muscular Dystrophies
Muscular dystrophies (MD) are a genetically and clinically heterogeneous group of rare neuromuscular diseases that cause progressive weakness and breakdown of skeletal muscles over time. The disorders differ as to which muscles are primarily affected, the degree of weakness, how fast they worsen, and when symptoms begin. Some types are also associated with problems in other organs. Over 30 different disorders are classified as muscular dystrophies. Of those, Duchenne muscular dystrophy (DMD) accounts for approximately 50% of cases and affects males beginning around the age of four. Other relatively common muscular dystrophies include Becker muscular dystrophy, facioscapulohumeral muscular dystrophy, and myotonic dystrophy, whereas limb–girdle muscular dystrophy and congenital muscular dystrophy are themselves groups of several – usually ultrarare – genetic disorders. Muscular dystrophies are caused by mutations in genes, usually those involved in making muscle proteins. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Research Council (United Kingdom)
The Medical Research Council (MRC) is responsible for co-coordinating and funding medical research in the United Kingdom. It is part of United Kingdom Research and Innovation (UKRI), which came into operation 1 April 2018, and brings together the UK's seven research councils, Innovate UK and Research England. UK Research and Innovation is answerable to, although politically independent from, the Department for Business, Energy and Industrial Strategy. The MRC focuses on high-impact research and has provided the financial support and scientific expertise behind a number of medical breakthroughs, including the development of penicillin and the discovery of the structure of DNA. Research funded by the MRC has produced 32 Nobel Prize winners to date. History The MRC was founded as the Medical Research Committee and Advisory Council in 1913, with its prime role being the distribution of medical research funds under the terms of the National Insurance Act 1911. This was a consequen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Aldren Turner
John is a common English name and surname: * John (given name) * John (surname) John may also refer to: New Testament Works * Gospel of John, a title often shortened to John * First Epistle of John, often shortened to 1 John * Second Epistle of John, often shortened to 2 John * Third Epistle of John, often shortened to 3 John People * John the Baptist (died c. AD 30), regarded as a prophet and the forerunner of Jesus Christ * John the Apostle (lived c. AD 30), one of the twelve apostles of Jesus * John the Evangelist, assigned author of the Fourth Gospel, once identified with the Apostle * John of Patmos, also known as John the Divine or John the Revelator, the author of the Book of Revelation, once identified with the Apostle * John the Presbyter, a figure either identified with or distinguished from the Apostle, the Evangelist and John of Patmos Other people with the given name Religious figures * John, father of Andrew the Apostle and Saint Peter * Pop ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pathology
Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatment, the term is often used in a narrower fashion to refer to processes and tests that fall within the contemporary medical field of "general pathology", an area which includes a number of distinct but inter-related medical specialties that diagnose disease, mostly through analysis of tissue, cell, and body fluid samples. Idiomatically, "a pathology" may also refer to the predicted or actual progression of particular diseases (as in the statement "the many different forms of cancer have diverse pathologies", in which case a more proper choice of word would be " pathophysiologies"), and the affix ''pathy'' is sometimes used to indicate a state of disease in cases of both physical ailment (as in cardiomy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Internship (medicine)
A medical intern is a physician in training who has completed medical school and has a medical degree but does not yet have a license to practice medicine unsupervised. Medical education generally ends with a period of practical training similar to internship, but the way the overall program of academic and practical medical training is structured differs depending upon the country, as does the terminology used (see medical education and medical school for further details). Australia In Australia, medical graduates must complete one year in an accredited hospital post before they receive full registration. This year of conditional registration is called the intern year. An internship is not necessarily completed in a hospital at the same state as the graduate's medical school. Brazil In Brazil, medical school consists of six years or twelve semesters. The final two years (or one and a half years, depending on the University in question) are the internship. During this time, st ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
X-linked Recessive
X-linked recessive inheritance is a mode of inheritance in which a mutation in a gene on the X chromosome causes the phenotype to be always expressed in males (who are necessarily homozygous for the gene mutation because they have one X and one Y chromosome) and in females who are homozygous for the gene mutation, see zygosity. Females with one copy of the mutated gene are carriers. X-linked inheritance means that the gene causing the trait or the disorder is located on the X chromosome. Females have two X chromosomes while males have one X and one Y chromosome. Carrier females who have only one copy of the mutation do not usually express the phenotype, although differences in X-chromosome inactivation (known as skewed X-inactivation) can lead to varying degrees of clinical expression in carrier females, since some cells will express one X allele and some will express the other. The current estimate of sequenced X-linked genes is 499, and the total, including vaguely defined trait ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drawing Of Boy With Duchenne Muscular Dystrophy
Drawing is a visual art that uses an instrument to mark paper or another two-dimensional surface. The instruments used to make a drawing are pencils, crayons, pens with inks, brushes with paints, or combinations of these, and in more modern times, computer styluses with graphics tablets or gamepads in VR drawing software. A drawing instrument releases a small amount of material onto a surface, leaving a visible mark. The most common support for drawing is paper, although other materials, such as cardboard, vellum, wood, plastic, leather, canvas, and board, have been used. Temporary drawings may be made on a blackboard or whiteboard. Drawing has been a popular and fundamental means of public expression throughout human history. It is one of the simplest and most efficient means of communicating ideas. The wide availability of drawing instruments makes drawing one of the most common artistic activities. In addition to its more artistic forms, drawing is frequently used in c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
A History Of British Birds
''A History of British Birds'' is a natural history book by Thomas Bewick, published in two volumes. Volume 1, ''Land Birds'', appeared in 1797. Volume 2, ''Water Birds'', appeared in 1804. A supplement was published in 1821. The text in ''Land Birds'' was written by Ralph Beilby, while Bewick took over the text for the second volume. The book is admired mainly for the beauty and clarity of Bewick's wood-engravings, which are widely considered his finest work, and among the finest in that medium. ''British Birds'' has been compared to works of poetry and literature. It plays a recurring role in Charlotte Brontë's novel ''Jane Eyre''. William Wordsworth praised Bewick in the first lines of his poem "The Two Thieves": "Oh now that the genius of Bewick were mine, And the skill which he learned on the banks of the Tyne." The book was effectively the first "field guide" for non-specialists. Bewick provides an accurate illustration of each species, from life if possible, or from ski ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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