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Bufotoxin
Bufotoxins are a family of toxic steroid lactones or substituted Substituted tryptamine, tryptamines of which some may or may not be toxic. They occur in the parotoid glands, skin, and poison of many toads (genus ''Bufo'') and other amphibians, and in some plants and mushrooms. The exact composition varies greatly with the specific source of the toxin. It can contain 5-MeO-DMT, bufagins, bufalin, bufotalin, bufotenin, bufothionine, dehydrobufotenine, epinephrine, norepinephrine, and serotonin. Some authors have also used the term ''bufotoxin'' to describe the conjugate of a bufagin with suberylarginine. The toxic substances found in toads can be divided by chemical structure in two groups: #bufadienolides, which are cardiac glycosides (e.g., bufotalin, bufogenin) #tryptamine-related substances (e.g., bufotenin) Toads known to secrete bufotoxin include the following: *''Colorado River toad, Bufo alvarius'' *''Bufo americanus'' *''Bufo arenarum'' *''Bufo asper'' *''Bufo blombergi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bufo Bufo
The common toad, European toad, or in Anglophone parts of Europe, simply the toad (''Bufo bufo'', from Latin ''bufo'' "toad"), is a frog found throughout most of Europe (with the exception of Ireland, Iceland, and some Mediterranean islands), in the western part of North Asia, and in a small portion of Northwest Africa. It is one of a group of closely related animals that are descended from a common ancestral line of toads and which form a species complex. The toad is an inconspicuous animal as it usually lies hidden during the day. It becomes active at dusk and spends the night hunting for the invertebrates on which it feeds. It moves with a slow, ungainly walk or short jumps, and has greyish-brown skin covered with wart-like lumps. Although toads are usually solitary animals, in the breeding season, large numbers of toads converge on certain breeding ponds, where the males compete to mate with the females. Eggs are laid in gelatinous strings in the water and later hatch out into ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bufotoxin
Bufotoxins are a family of toxic steroid lactones or substituted Substituted tryptamine, tryptamines of which some may or may not be toxic. They occur in the parotoid glands, skin, and poison of many toads (genus ''Bufo'') and other amphibians, and in some plants and mushrooms. The exact composition varies greatly with the specific source of the toxin. It can contain 5-MeO-DMT, bufagins, bufalin, bufotalin, bufotenin, bufothionine, dehydrobufotenine, epinephrine, norepinephrine, and serotonin. Some authors have also used the term ''bufotoxin'' to describe the conjugate of a bufagin with suberylarginine. The toxic substances found in toads can be divided by chemical structure in two groups: #bufadienolides, which are cardiac glycosides (e.g., bufotalin, bufogenin) #tryptamine-related substances (e.g., bufotenin) Toads known to secrete bufotoxin include the following: *''Colorado River toad, Bufo alvarius'' *''Bufo americanus'' *''Bufo arenarum'' *''Bufo asper'' *''Bufo blombergi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bufotalin
Bufotalin is a cardiotoxic bufanolide steroid, cardiac glycoside analogue, secreted by a number of toad species. Bufotalin can be extracted from the skin parotoid glands of several types of toad. Sources ''Rhinella marina'' (Cane toad), ''Rhaebo guttatus'' (Smooth-sided toad), '' Bufo melanostictus'' (Asian toad), and ''Bufo bufo'' (common European toad) are sources of bufotalin. Traditional medicine Bufotalin is part of Ch'an Su, a traditional Chinese medicine used for cancer. It is also known as Venenum Bufonis or senso (Japanese). Toxicity Specifically, in cats the lethal median dose is 0.13 mg/kg."Datasheet: Bufotalin sc-202509" ''Santa Cruz Biotechnology, Inc.''http://datasheets.scbt.com/sc-202509.pdf and in dogs is 0.36 mg/kg (intravenous). Knowing this it is advisable to monitor those functions continuously using an EKG. As there is no antidote against bufotalin all occurring symptoms need to be treated separately or if possible in combination with others. To ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bufo Americanus
The American toad (''Anaxyrus americanus'') is a common species of toad found throughout Canada and the eastern United States. It is divided into three subspecies: the eastern American toad (''A. a. americanus''), the dwarf American toad (''A. a. charlesmithi'') and the rare Hudson Bay toad (''A. a. copei''). Recent taxonomic treatments place this species in the genus ''Anaxyrus'' instead of ''Bufo''. Tadpoles The eggs of the American toad are laid in two strings and can hatch in 2–14 days. When hatched the tadpoles are recognizable by their skinny tails in relation to the size of their black bodies. They may advance to adulthood in 50–65 days. When metamorphosis is completed, the "toadlets" may stay in the water for a short period of time before they become mostly land based. Often entire groups of tadpoles reach the ''toadlet'' stage at once and a mass migration to higher ground takes place usually to shaded areas of mid range and upland forests bordering the marshes from ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bufothionine
Bufothionine is a sulfur-containing compound which is present in the bufotoxins secreted by the parotoid gland of certain toads of the genera ''Bufo'' and '' Chaunus''. This specific compound can be found in the skin of certain species of toad such as the Asiatic Toad, '' Chaunus arunco'', '' Chaunus crucifer'', '' Chaunus spinulosus'', and '' Chaunus arenarum''. Research In ancient times, cinobufacini, which is extracted from the skin and the parotid venom glands of toad of the bufo genus was used to treat symptoms like swelling and pain. In the present time, cinobufacinin injections are used to achieve satisfactory effect on Hepatocellular carcinoma (HCC) in China. Bufothionine is a major active component of cinobufacini. Bufothionine has been shown to suppress growth of cancerous liver cells ''in vitro'' . In vivo, bufothionine has also been showing relieved symptoms and anti inflammatory activities in tumor bearing mice. Experiments were conducted in which cultured cancer cel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bufotenin
Bufotenin (5-HO-DMT, bufotenine) is a tryptamine derivative - more specifically, a DMT derivative - related to the neurotransmitter serotonin. It is an alkaloid found in some species of toads (especially the skin), mushrooms and plants. The name bufotenin originates from the toad genus ''Bufo'', which includes several species of psychoactive toads, most notably ''Incilius alvarius'', that secrete bufotoxins from their parotoid glands. Bufotenin is similar in chemical structure to the psychedelics psilocin (4-HO-DMT), 5-MeO-DMT, and DMT, chemicals which also occur in some of the same fungus, plant, and animal species as bufotenin. Nomenclature Bufotenin (bufotenine) is also known by the chemical names 5-hydroxy-''N'',''N''-dimethyltryptamine (5-HO-DMT), ''N'',''N''-dimethyl-5-hydroxytryptamine, dimethyl serotonin, and mappine. History Bufotenin was isolated from toad skin, and named by the Austrian chemist Handovsky at the University of Prague during World War I. The struct ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bufagin
Bufagin is a toxic steroid C24H34O5 obtained from toad's milk, the poisonous secretion of a skin gland on the back of the neck of a large toad (''Rhinella marina'', synonym ''Bufo marinus'', the cane toad). The toad produces this secretion when it is injured, scared or provoked. Bufagin resembles chemical substances from digitalis in physiological activity and chemical structure. ''Bufagin'' also refers to any of several similar substances found as components of the mixture bufotoxin in secretions of other toads, as well as plants and mushrooms. Chemistry Bufagin and bufagins are bufadienolide derivatives. This means they are steroids with a pyran- (delta-)lactone ring attached to ring D (the five-membered one). The difference to digitalis compounds is that the latter have a furan- (gamma-)lactone ring that has one carbon atom and one double bond less. Effects of bufagins Some bufagins have effects similar to poisoning by digitalis, having effects on the cardiac muscle, causin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parotoid Gland
The parotoid gland (alternatively, paratoid gland) is an external skin gland on the back, neck, and shoulder of toads and some frogs and salamanders. It can secrete a number of milky alkaloid substances (depending on the species) known collectively as bufotoxins, which act as neurotoxins to deter predation. These cutaneous glands are called parotoid as they are somewhat similarly positioned to mammalian parotid gland, although the latter have a different function, excreting saliva within the mouth rather than externally excreted defensive chemicals. A study of the parotoid glands of the Colorado River toad in 1976 found that the parotoid glands were "composed of numerous lobules", each of which is a separate unit with a lumen surrounded by a double cell layer. The cell layers have interlocking microvilli. The study found that the outer cell layer resembled smooth muscle cells, with some organelles hypothesised to "function in some aspects of venom synthesis, active cellular trans ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bufo
''Bufo'' is a genus of true toads in the amphibian family Bufonidae. As traditionally defined, it was a wastebasket genus containing a large number of toads from much of the world, but following taxonomic reviews most of these have been moved to other genera, leaving only seventeen extant (living) species from Europe, northern Africa and Asia in this genus, including the well-known common toad (''B. bufo''). Some of the genera that contain species formerly placed in ''Bufo'' are ''Anaxyrus'' (many North American species), ''Bufotes'' (European green toad and relatives), ''Duttaphrynus'' (many Asian species, including the Asian common toad introduced elsewhere), ''Epidalea'' (natterjack toad) and ''Rhinella'' (many Latin American species, including the cane toad introduced elsewhere). Description True toads have in common stocky figures and short legs, which make them relatively poor jumpers. Their dry skin is thick and "warty". Behind their eyes, ''Bufo'' species have wart-li ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bufo Asper
The Asian giant toad (''Phrynoidis asper''), sometimes referred to as the river toad, is a species of true toad native to Mainland Southeast Asia and the Greater Sundas. It is a medium-large toad, but it is easily confused with its larger relative, the giant river toad (''P. juxtasper''). Description ''Phrynoidis asper'' is generally a dark grey, green, black or brown in color, and is heavily covered in tubercles. Females can reach up to in snout–to–vent Vent or vents may refer to: Science and technology Biology *Vent, the cloaca region of an animal *Vent DNA polymerase, a thermostable DNA polymerase Geology *Hydrothermal vent, a fissure in a planet's surface from which geothermally heated water ... length and males up to . They can be commonly found near stream and rivers. Photos File:Giant Asian Toad (Phrynoidis aspera) (8688768164).jpg File:River Toad Phrynoidis aspera (7920853968).jpg File:River Toad (Phrynoidis aspera) (6731222373).jpg References *Frogs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cardiac Glycoside
Cardiac glycosides are a class of organic compounds that increase the output force of the heart and decrease its rate of contractions by inhibiting the cellular sodium-potassium ATPase pump. Their beneficial medical uses are as treatments for congestive heart failure and cardiac arrhythmias; however, their relative toxicity prevents them from being widely used. Most commonly found as secondary metabolites in several plants such as foxglove plants, these compounds nevertheless have a diverse range of biochemical effects regarding cardiac cell function and have also been suggested for use in cancer treatment. Classification General structure The general structure of a cardiac glycoside consists of a steroid molecule attached to a sugar (glycoside) and an R group. The steroid nucleus consists of four fused rings to which other functional groups such as methyl, hydroxyl, and aldehyde groups can be attached to influence the overall molecule's biological activity. Cardiac glycosi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bufo Arenarum
''Rhinella arenarum'' is a species of toad in the family Bufonidae that is found in southern Brazil and Uruguay; can also occur in Paraguay. It is also found in Argentina from the Chubut Province northward, Bolivia , image_flag = Bandera de Bolivia (Estado).svg , flag_alt = Horizontal tricolor (red, yellow, and green from top to bottom) with the coat of arms of Bolivia in the center , flag_alt2 = 7 × 7 square p ... east of the Andes. ''Rhinella arenarum'' inhabits small ponds or bogs with stagnant water, in dry, temperate habitats, mostly in open areas. It is locally common. While it is collected for educational and scientific uses and also suffers from road kills, it in general is not threatened. Fossils representing this species are known with certainty from the late Pliocene up to the Holocene of central Argentina. References arenarum Amphibians described in 1867 Amphibians of Brazil Amphibians of Bolivia Amphibians ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
