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Bufotenin
Bufotenin (5-HO-DMT, bufotenine) is a tryptamine derivative - more specifically, a DMT derivative - related to the neurotransmitter serotonin. It is an alkaloid found in some species of toads (especially the skin), mushrooms and plants. The name bufotenin originates from the toad genus ''Bufo'', which includes several species of psychoactive toads, most notably ''Incilius alvarius'', that secrete bufotoxins from their parotoid glands. Bufotenin is similar in chemical structure to the psychedelics psilocin (4-HO-DMT), 5-MeO-DMT, and DMT, chemicals which also occur in some of the same fungus, plant, and animal species as bufotenin. Nomenclature Bufotenin (bufotenine) is also known by the chemical names 5-hydroxy-''N'',''N''-dimethyltryptamine (5-HO-DMT), ''N'',''N''-dimethyl-5-hydroxytryptamine, dimethyl serotonin, and mappine. History Bufotenin was isolated from toad skin, and named by the Austrian chemist Handovsky at the University of Prague during World War I. The struct ...
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Aphrodisiac
An aphrodisiac is a substance that increases sexual desire, sexual attraction, sexual pleasure, or sexual behavior. Substances range from a variety of plants, spices, foods, and synthetic chemicals. Natural aphrodisiacs like cannabis or cocaine are classified into plant-based and non-plant-based substances. There are non-naturally-occurring aphrodisiacs like MDMA and methamphetamine. Aphrodisiacs can be classified by their type of effects (i.e., psychological or physiological). Aphrodisiacs that contain hallucinogenic properties like Bufotenin have psychological effects on a person that can increase sexual desire and sexual pleasure. Aphrodisiacs that contain smooth muscle relaxing properties like yohimbine have physiological effects on a person that can affect hormone levels and increase blood flow. It is possible that the aphrodisiac effect of a substance is due to the placebo effect. Other substances that impede on areas that aphrodisiacs aim to enhance are classified as an ...
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Psychoactive Toad
The Colorado River toad (''Incilius alvarius''), formerly known as the Sonoran Desert toad, is found in northern Mexico and the southwestern United States. It exudes toxins from glands within its skin that have psychoactive properties. Description The Colorado River toad can grow to about long and is the largest toad in the United States apart from the non-native cane toad (''Rhinella marina''). It has a smooth, leathery skin and is olive green or mottled brown in color. Just behind the large golden eye with horizontal pupil is a bulging kidney-shaped parotoid gland. Below this is a large circular pale green area which is the tympanum or ear drum. By the corner of the mouth there is a white wart and there are white glands on the legs. All these glands produce toxic secretions. Its call is described as, "a weak, low-pitched toot, lasting less than a second." Dogs that have attacked toads have suffered paralysis or even death. Raccoons have learned to pull a toad away from a p ...
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Alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids
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Alkaloids are produced by a large variety of organisms including , , Medicinal plant, plants, an ...
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Psychoactive Toad
The Colorado River toad (''Incilius alvarius''), formerly known as the Sonoran Desert toad, is found in northern Mexico and the southwestern United States. It exudes toxins from glands within its skin that have psychoactive properties. Description The Colorado River toad can grow to about long and is the largest toad in the United States apart from the non-native cane toad (''Rhinella marina''). It has a smooth, leathery skin and is olive green or mottled brown in color. Just behind the large golden eye with horizontal pupil is a bulging kidney-shaped parotoid gland. Below this is a large circular pale green area which is the tympanum or ear drum. By the corner of the mouth there is a white wart and there are white glands on the legs. All these glands produce toxic secretions. Its call is described as, "a weak, low-pitched toot, lasting less than a second." Dogs that have attacked toads have suffered paralysis or even death. Raccoons have learned to pull a toad away from a p ...
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Incilius Alvarius
The Colorado River toad (''Incilius alvarius''), formerly known as the Sonoran Desert toad, is found in northern Mexico and the southwestern United States. It exudes toxins from glands within its skin that have psychoactive properties. Description The Colorado River toad can grow to about long and is the largest toad in the United States apart from the non-native cane toad (''Rhinella marina''). It has a smooth, leathery skin and is olive green or mottled brown in color. Just behind the large golden eye with horizontal pupil is a bulging kidney-shaped parotoid gland. Below this is a large circular pale green area which is the tympanum or ear drum. By the corner of the mouth there is a white wart and there are white glands on the legs. All these glands produce toxic secretions. Its call is described as, "a weak, low-pitched toot, lasting less than a second." Dogs that have attacked toads have suffered paralysis or even death. Raccoons have learned to pull a toad away from a p ...
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Colorado River Toad
The Colorado River toad (''Incilius alvarius''), formerly known as the Sonoran Desert toad, is found in northern Mexico and the southwestern United States. It exudes toxins from glands within its skin that have psychoactive properties. Description The Colorado River toad can grow to about long and is the largest toad in the United States apart from the non-native cane toad (''Rhinella marina''). It has a smooth, leathery skin and is olive green or mottled brown in color. Just behind the large golden eye with horizontal pupil is a bulging kidney-shaped parotoid gland. Below this is a large circular pale green area which is the tympanum or ear drum. By the corner of the mouth there is a white wart and there are white glands on the legs. All these glands produce toxic secretions. Its call is described as, "a weak, low-pitched toot, lasting less than a second." Dogs that have attacked toads have suffered paralysis or even death. Raccoons have learned to pull a toad away from a pon ...
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Street Drug
Recreational drug use indicates the use of one or more psychoactive drugs to induce an altered state of consciousness either for pleasure or for some other casual purpose or pastime by modifying the perceptions and emotions of the user. When a psychoactive drug enters the user's body, it induces an intoxicating effect. Generally, recreational drugs are divided into three categories: depressants (drugs that induce a feeling of relaxation and calmness); stimulants (drugs that induce a sense of energy and alertness); and hallucinogens (drugs that induce perceptual distortions such as hallucination). In popular practice, recreational drug use generally is a tolerated social behaviour, rather than perceived as the medical condition of self-medication. However, heavy use of some drugs is socially stigmatized. Many people also use prescribed and controlled depressants such as opioids, as well as opiates and benzodiazepines. Common recreational drugs include caffeine, commonly found ...
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DMT (drug)
''N'',''N''-Dimethyltryptamine (DMT or ''N'',''N''-DMT, SPL026) is a substituted tryptamine that occurs in many plants and animals, including human beings, and which is both a derivative and a structural analog of tryptamine. It is used as a psychedelic drug and prepared by various cultures for ritual purposes as an entheogen. DMT has a rapid onset, intense effects, and a relatively short duration of action. For those reasons, DMT was known as the "business trip" during the 1960s in the United States, as a user could access the full depth of a psychedelic experience in considerably less time than with other substances such as LSD or psilocybin mushrooms. DMT can be inhaled, ingested, or injected and its effects depend on the dose, as well as the mode of administration. When inhaled or injected, the effects last a short period of time: about five to 15 minutes. Effects can last three hours or more when orally ingested along with a monoamine oxidase inhibitor (MAOI), such as th ...
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Bufotoxin
Bufotoxins are a family of toxic steroid lactones or substituted Substituted tryptamine, tryptamines of which some may or may not be toxic. They occur in the parotoid glands, skin, and poison of many toads (genus ''Bufo'') and other amphibians, and in some plants and mushrooms. The exact composition varies greatly with the specific source of the toxin. It can contain 5-MeO-DMT, bufagins, bufalin, bufotalin, bufotenin, bufothionine, dehydrobufotenine, epinephrine, norepinephrine, and serotonin. Some authors have also used the term ''bufotoxin'' to describe the conjugate of a bufagin with suberylarginine. The toxic substances found in toads can be divided by chemical structure in two groups: #bufadienolides, which are cardiac glycosides (e.g., bufotalin, bufogenin) #tryptamine-related substances (e.g., bufotenin) Toads known to secrete bufotoxin include the following: *''Colorado River toad, Bufo alvarius'' *''Bufo americanus'' *''Bufo arenarum'' *''Bufo asper'' *''Bufo blombergi ...
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Dimethyltryptamine
''N'',''N''-Dimethyltryptamine (DMT or ''N'',''N''-DMT, SPL026) is a substituted tryptamine that occurs in many plants and animals, including human beings, and which is both a derivative and a structural analog of tryptamine. It is used as a psychedelic drug and prepared by various cultures for ritual purposes as an entheogen. DMT has a rapid onset, intense effects, and a relatively short duration of action. For those reasons, DMT was known as the "business trip" during the 1960s in the United States, as a user could access the full depth of a psychedelic experience in considerably less time than with other substances such as LSD or psilocybin mushrooms. DMT can be inhaled, ingested, or injected and its effects depend on the dose, as well as the mode of administration. When inhaled or injected, the effects last a short period of time: about five to 15 minutes. Effects can last three hours or more when orally ingested along with a monoamine oxidase inhibitor (MAOI), such as ...
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World War I
World War I (28 July 1914 11 November 1918), often abbreviated as WWI, was one of the deadliest global conflicts in history. Belligerents included much of Europe, the Russian Empire, the United States, and the Ottoman Empire, with fighting occurring throughout Europe, the Middle East, Africa, the Pacific, and parts of Asia. An estimated 9 million soldiers were killed in combat, plus another 23 million wounded, while 5 million civilians died as a result of military action, hunger, and disease. Millions more died in genocides within the Ottoman Empire and in the 1918 influenza pandemic, which was exacerbated by the movement of combatants during the war. Prior to 1914, the European great powers were divided between the Triple Entente (comprising France, Russia, and Britain) and the Triple Alliance (containing Germany, Austria-Hungary, and Italy). Tensions in the Balkans came to a head on 28 June 1914, following the assassination of Archduke Franz Ferdin ...
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Heinrich Wieland
Heinrich Otto Wieland (; 4 June 1877 – 5 August 1957) was a German chemist. He won the 1927 Nobel Prize in Chemistry for his research into the bile acids. Career In 1901 Wieland received his doctorate at the University of Munich while studying under Johannes Thiele. In 1904 he completed his habilitation, then continued to teach at the university and starting in 1907 was a consultant for Boehringer Ingelheim. In 1914 he became associate professor for special topics in organic chemistry, and director of the Organic Division of the State Laboratory in Munich. From 1917 to 1918 Wieland worked in the service of the (KWI) Kaiser Wilhelm Institute for Physical Chemistry and Electrochemistry in Dahlem then led by Fritz Haber as an alternative to regular military service. There he was involved in weapons research for instance finding new synthetic routes for mustard gas. He is also credited with the first synthesis of Adamsite. From 1913 to 1921, he was Professor at the Technical Un ...
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