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Psychoactive Toad
The Colorado River toad (''Incilius alvarius''), formerly known as the Sonoran Desert toad, is found in northern Mexico and the southwestern United States. It exudes toxins from glands within its skin that have psychoactive properties. Description The Colorado River toad can grow to about long and is the largest toad in the United States apart from the non-native cane toad (''Rhinella marina''). It has a smooth, leathery skin and is olive green or mottled brown in color. Just behind the large golden eye with horizontal pupil is a bulging kidney-shaped parotoid gland. Below this is a large circular pale green area which is the tympanum or ear drum. By the corner of the mouth there is a white wart and there are white glands on the legs. All these glands produce toxic secretions. Its call is described as, "a weak, low-pitched toot, lasting less than a second." Dogs that have attacked toads have suffered paralysis or even death. Raccoons have learned to pull a toad away from a p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Charles Frédéric Girard
Charles Frédéric Girard (8 March 1822 – 29 January 1895) was a French biologist specializing in ichthyology and herpetology. Born in Mulhouse, France, he studied at the College of Neuchâtel, Switzerland, as a student of Louis Agassiz. In 1847, he accompanied Agassiz as his assistant to Harvard University. Three years later, Spencer Fullerton Baird called him to the Smithsonian Institution to work on its growing collection of North American reptiles, amphibians and fishes. He worked at the museum for the next ten years and published numerous papers, many in collaboration with Baird. In 1854, he was naturalized as a U.S. citizen. Besides his work at the Smithsonian, he managed to earn an M.D. from Georgetown University in Washington, D.C. in 1856. In 1859 he returned to France and was awarded the Cuvier Prize by the Institute of France for his work on the North American reptiles and fishes two years later. When the American Civil War broke out, he joined the Confederate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canal
Canals or artificial waterways are waterways or engineered channels built for drainage management (e.g. flood control and irrigation) or for conveyancing water transport vehicles (e.g. water taxi). They carry free, calm surface flow under atmospheric pressure, and can be thought of as artificial rivers. In most cases, a canal has a series of dams and locks that create reservoirs of low speed current flow. These reservoirs are referred to as ''slack water levels'', often just called ''levels''. A canal can be called a ''navigation canal'' when it parallels a natural river and shares part of the latter's discharges and drainage basin, and leverages its resources by building dams and locks to increase and lengthen its stretches of slack water levels while staying in its valley. A canal can cut across a drainage divide atop a ridge, generally requiring an external water source above the highest elevation. The best-known example of such a canal is the Panama Canal. Many ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
5-HT1A Receptor
The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor, or 5-HT receptor, that binds serotonin, also known as 5-HT, a neurotransmitter. 5-HT1A is expressed in the brain, spleen, and neonatal kidney. It is a G protein-coupled receptor (GPCR), coupled to the Gi protein, and its activation in the brain mediates hyperpolarisation and reduction of firing rate of the postsynaptic neuron. In humans, the serotonin 1A receptor is encoded by the HTR1A gene. Distribution The 5-HT1A receptor is the most widespread of all the 5-HT receptors. In the central nervous system, 5-HT1A receptors exist in the cerebral cortex, hippocampus, septum, amygdala, and raphe nucleus in high densities, while low amounts also exist in the basal ganglia and thalamus. The 5-HT1A receptors in the raphe nucleus are largely somatodendritic autoreceptors, whereas those in other areas such as the hippocampus are postsynaptic receptors. Function Neuromodulation 5-HT1A recepto ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
5-HT2 Receptor
The 5-HT2 receptors are a subfamily of 5-HT receptors that bind the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). The 5-HT2 subfamily consists of three G protein-coupled receptors (GPCRs) which are coupled to Gq/G11 and mediate excitatory neurotransmission Neurotransmission (Latin: ''transmissio'' "passage, crossing" from ''transmittere'' "send, let through") is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron), ..., including 5-HT2A, 5-HT2B, and 5-HT2C. For more information, please see the respective main articles of the individual subtypes: * 5-HT2A receptor * 5-HT2B receptor * 5-HT2C receptor See also * 5-HT1 receptor * 5-HT3 receptor * 5-HT4 receptor * 5-HT5 receptor * 5-HT6 receptor * 5-HT7 receptor * 5-HT2 antagonists References {{Serotonergics Serotonin receptors ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Substituted Tryptamine
Substituted tryptamines, or serotonin analogues, are organic compounds which may be thought of as being derived from tryptamine itself. The molecular structures of all tryptamines contain an indole ring, joined to an amino group, amino (NH2) group via an ethyl (−CH2–CH2−) side chain, sidechain. In substituted tryptamines, the indole ring, sidechain, and/or amino group are modified by substituting another group for one of the hydrogen (H) atoms. Well-known tryptamines include serotonin, an important neurotransmitter, and melatonin, a hormone involved in regulating the sleep-wake cycle. Tryptamine alkaloids are found in fungi, plants and animals; and sometimes used by humans for the neurological or psychotropic effects of the substance. Prominent examples of tryptamine alkaloids include psilocybin (from "psilocybin mushrooms") and dimethyltryptamine, DMT. In South America, dimethyltryptamine is obtained from numerous plant sources, like chacruna, and it is often used in ayahuas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bufo
''Bufo'' is a genus of true toads in the amphibian family Bufonidae. As traditionally defined, it was a wastebasket genus containing a large number of toads from much of the world, but following taxonomic reviews most of these have been moved to other genera, leaving only seventeen extant (living) species from Europe, northern Africa and Asia in this genus, including the well-known common toad (''B. bufo''). Some of the genera that contain species formerly placed in ''Bufo'' are ''Anaxyrus'' (many North American species), ''Bufotes'' (European green toad and relatives), ''Duttaphrynus'' (many Asian species, including the Asian common toad introduced elsewhere), ''Epidalea'' (natterjack toad) and ''Rhinella'' (many Latin American species, including the cane toad introduced elsewhere). Description True toads have in common stocky figures and short legs, which make them relatively poor jumpers. Their dry skin is thick and "warty". Behind their eyes, ''Bufo'' species have wart-li ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bufotenin
Bufotenin (5-HO-DMT, bufotenine) is a tryptamine derivative - more specifically, a DMT derivative - related to the neurotransmitter serotonin. It is an alkaloid found in some species of toads (especially the skin), mushrooms and plants. The name bufotenin originates from the toad genus ''Bufo'', which includes several species of psychoactive toads, most notably ''Incilius alvarius'', that secrete bufotoxins from their parotoid glands. Bufotenin is similar in chemical structure to the psychedelics psilocin (4-HO-DMT), 5-MeO-DMT, and DMT, chemicals which also occur in some of the same fungus, plant, and animal species as bufotenin. Nomenclature Bufotenin (bufotenine) is also known by the chemical names 5-hydroxy-''N'',''N''-dimethyltryptamine (5-HO-DMT), ''N'',''N''-dimethyl-5-hydroxytryptamine, dimethyl serotonin, and mappine. History Bufotenin was isolated from toad skin, and named by the Austrian chemist Handovsky at the University of Prague during World War I. The struct ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
5-MeO-DMT
5-MeO-DMT (5-methoxy-''N'',''N''-dimethyltryptamine) or O-methyl-bufotenin is a psychedelic of the tryptamine class. It is found in a wide variety of plant species, and also is secreted by the glands of at least one toad species, the Colorado River toad. Like its close relatives DMT and bufotenin (5-HO-DMT), it has been used as an entheogen in South America. Slang terms include Five-methoxy, The power, and Toad venom. Chemistry 5-MeO-DMT was first synthesized in 1936, and in 1959 it was isolated as one of the psychoactive ingredients of '' Anadenanthera peregrina'' seeds used in preparing Yopo snuff. It was once believed to be a major component of the psychoactive effects of the snuff, although this has recently been shown to be unlikely, due to the limited or sometimes even non-existent quantity contained within the seeds, which instead achieve their psychoactivity from the ''O''-demethylated metabolite of 5-MeO-DMT, bufotenin. It is metabolized mainly by CYP2D6. Effects D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maricopa County, Arizona
Maricopa County is in the south-central part of the U.S. state of Arizona. As of the 2020 census, the population was 4,420,568, making it the state's most populous county, and the fourth-most populous in the United States. It contains about 62% of Arizona's population, making Arizona one of the most centralized states in the nation. The county seat is Phoenix, the state capital and fifth-most populous city in the United States. Maricopa County is the central county of the Phoenix-Mesa- Chandler, AZ Metropolitan Statistical Area. The Office of Management and Budget renamed the metropolitan area in September 2018. Previously, it was the Phoenix-Mesa-Glendale metropolitan area, and in 2000, that was changed to Phoenix-Mesa-Scottsdale. Maricopa County was named after the Maricopa Native Americans. Five Native American Reservations are located in the county. The largest are the Salt River Pima-Maricopa Indian Community (east of Scottsdale) and the Gila River Indian Community (so ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Woodhouse's Toad
Woodhouse's toad (''Anaxyrus woodhousii'') is a medium-sized () true toad native to the United States and Mexico. There are three recognized subspecies. ''A. woodhousii'' tends to hybridize with '' Anaxyrus americanus'' where their ranges overlap. Taxonomy Woodhouse's toad was first described in 1854 by the French herpetologist Charles Frédéric Girard. He gave it the name ''Bufo woodhousii'' in honor of the American physician and naturalist Samuel Washington Woodhouse. The large genus ''Bufo'' was split by Frost ''et al.'' in 2006, with the North American species being included in the genus ''Anaxyrus'' and this toad becoming ''A. woodhousii''. There are three recognised subspecies: *Rocky Mountain toad – '' Anaxyrus woodhousii woodhousii'' ( Girard, 1854) *East Texas toad – ''Anaxyrus woodhousii velatus'' (Bragg and Sanders, 1951)Bragg, A. N., and O. Sanders. 1951. A new subspecies of the ''Bufo woodhousii'' group of toads (Salientia: Bufonidae). Wasmann Journal of Biol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Red-spotted Toad
The red-spotted toad (''Anaxyrus punctatus'', formerly ''Bufo punctatus'') is a toad in the family Bufonidae found in the southwestern United States and northwestern Mexico. Description It is a small toad species growing to in length. It has a flattened head and body, and a light grey, olive or reddish brown dorsum with reddish or orange skin glands. It has a whitish or buff venter with or without faint dark spotting, and round parotoid glands. The snout is pointed. The juvenile toad looks similar to the adult, but has more prominent ventral spotting and the undersides of its feet are yellow. The male red-spotted toad has a dusky throat and develops nuptial pads during the breeding season. It may hybridize with the western toad (''Anaxyrus boreas'') in some locations, possibly with other toad species too. It is docile and easily handled with little or no skin gland secretions. Distribution and habitat This toad is native to the southwestern United States and northwestern Mexi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Great Plains Toad
The Great Plains toad, ''Anaxyrus cognatus'', is a relatively large species of true toad native to central North America. Distribution The amphibian is native throughout the Canadian Prairies (northern Great Plains) in southern Alberta, Manitoba, and Saskatchewan; and into northern Mexico in the Sonoran Desert and Mexican Plateau. Description The Great Plains toad is grey, brown, and green in color, with darker colored blotching. It can grow to anywhere between in length. Its primary diet is various species of cutworms. It prefers grassland habitat with loose soil that is easy to burrow in. Breeding occurs throughout the spring and summer months, most often immediately after heavy rainfall. In dry areas it may only emerge from its burrow for a few weeks when conditions are right, and usually at night, but in areas with permanent water bodies and abundant rain it may be active all day.Grismer, L. L. (2002). ''Amphibians and Reptiles of Baja California''. Los Angeles: University o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
