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Brugia
''Brugia'' is a genus for a group of small roundworms. They are among roundworms that cause the parasitic disease filariasis. Specifically, of the three species known, ''Brugia malayi'' and ''Brugia timori'' cause lymphatic filariasis in humans; and ''Brugia pahangi'' and '' Brugia patei'' infect domestic cats, dogs and other animals. They are transmitted by the bite of mosquitos. Discovery The first species discovered was ''B. malayi''. It was reported by a Dutch parasitologist Steffen Lambert Brug in 1927 from Southeast Asia (Malaya, for which the name was given). It was originally believed to be similar or closely related to another filarial roundworm then named ''Microfilaria bancrofti'' (now ''Wuchereria bancrofti''), described by an English naturalist Thomas Spencer Cobbold in 1877. It was for this reason that Brug gave the original name ''Microfilaria (Filaria) malayi''. Brug was aware of the difference mainly on the basis of their occurrence. He found both the worms in Su ...
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Brugia Malayi
''Brugia malayi'' is a filarial (arthropod-borne) nematode (roundworm), one of the three causative agents of lymphatic filariasis in humans. Lymphatic filariasis, also known as elephantiasis, is a condition characterized by swelling of the lower limbs. The two other filarial causes of lymphatic filariasis are ''Wuchereria bancrofti'' and '' Brugia timori'', which both differ from ''B. malayi'' morphologically, symptomatically, and in geographical extent. ''B. malayi'' is transmitted by '' Mansonia'' mosquitoes and is restricted to South and Southeast Asia. It is one of the tropical diseases targeted for elimination by the year 2020 by the World Health Organization, which has spurred vaccine and drug development, as well as new methods of vector control. Signs and symptoms ''B. malayi'' is one of the causative agents of lymphatic filariasis, a condition marked by infection and swelling of the lymphatic system. The disease is primarily caused by the presence of worms in the lympha ...
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Brugia Patei
''Brugia'' is a genus for a group of small roundworms. They are among roundworms that cause the parasitic disease filariasis. Specifically, of the three species known, ''Brugia malayi'' and ''Brugia timori'' cause lymphatic filariasis in humans; and ''Brugia pahangi'' and '' Brugia patei'' infect domestic cats, dogs and other animals. They are transmitted by the bite of mosquitos. Discovery The first species discovered was ''B. malayi''. It was reported by a Dutch parasitologist Steffen Lambert Brug in 1927 from Southeast Asia (Malaya, for which the name was given). It was originally believed to be similar or closely related to another filarial roundworm then named ''Microfilaria bancrofti'' (now ''Wuchereria bancrofti''), described by an English naturalist Thomas Spencer Cobbold in 1877. It was for this reason that Brug gave the original name ''Microfilaria (Filaria) malayi''. Brug was aware of the difference mainly on the basis of their occurrence. He found both the worms in Su ...
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Brugia Timori
''Brugia timori'' is a filarial (arthropod-borne) nematode (roundworm) which causes the disease "Timor filariasis", or "Timorian filariasis". While this disease was first described in 1965, the identity of ''Brugia timori'' as the causative agent was not known until 1977. In that same year, '' Anopheles barbirostris'' was shown to be its primary vector. There is no known animal reservoir host. Signs and symptoms Like other human filariasis infections, ''Brugia timori'' filariasis causes acute fever and chronic lymphedema. The life cycle of ''Brugia timori'' is very similar to that of ''Wuchereria bancrofti'' and ''Brugia malayi'', leading to nocturnal periodicity of the disease symptoms. Eosinophilia is common during acute stages of infection. So far ''Brugia timori'' has only been found in the Lesser Sunda Islands of Indonesia. It is locally confined to areas inhabited by its mosquito vector, which breeds in rice fields. One study of the prevalence of infection in Mainang v ...
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Brugia Pahangi
''Brugia pahangi'' is a parasitic roundworm belonging to the genus ''Brugia''. It is a filarial nematode The nematodes ( or grc-gre, Νηματώδη; la, Nematoda) or roundworms constitute the phylum Nematoda (also called Nemathelminthes), with plant-Parasitism, parasitic nematodes also known as eelworms. They are a diverse animal phylum inhab ... known to infect the lymph vessels of domestic cats and wild animals, causing a disease filariasis. Geographic location ''Brugia pahangi'' have been found in cats in Malaysia, Thailand, and Indonesia. A large population of cats, more specifically stray cats, are infected with the parasite. When the nematode was first being studied, a report by Mak et al. (1980) reported that 11% of cats sampled in the Peninsular Malaysia were infected. In Thailand, 25% of the blood samples take from 83 cats residing in Buddhist temples carried the worm (Palmieri et al., 1985). Morphology The size is approximately 280 μm long by 5–6  ...
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Lymphatic Filariasis
Lymphatic filariasis is a human disease caused by parasitic worms known as filarial worms. Usually acquired in childhood, it is a leading cause of permanent disability worldwide. While most cases have no symptoms, some people develop a syndrome called elephantiasis, which is marked by severe swelling in the arms, legs, breasts, or genitals. The skin may become thicker as well, and the condition may become painful. Affected people are often unable to work and are often shunned or rejected by others because of their disfigurement and disability. It is the first of the mosquito-borne diseases to be have been identified. The worms are spread by the bites of infected mosquitoes. Three types of worms are known to cause the disease: ''Wuchereria bancrofti'', ''Brugia malayi'', and ''Brugia timori'', with ''Wuchereria bancrofti'' being the most common. These worms damage the lymphatic system. The disease is diagnosed by microscopic examination of blood collected during the night. The ...
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Filariasis
Filariasis is a parasitic disease caused by an infection with roundworms of the Filarioidea type. These are spread by blood-feeding insects such as black flies and mosquitoes. They belong to the group of diseases called helminthiases. These parasites exist in the wild in subtropical parts of southern Asia, Africa, the South Pacific, and parts of South America. One does not acquire them in temperate areas like Europe or the United States. Eight known filarial worms have humans as a definitive host. These are divided into three groups according to the part of the body they affect: * Lymphatic filariasis is caused by the worms ''Wuchereria bancrofti'', ''Brugia malayi'', and ''Brugia timori''. These worms occupy the lymphatic system, including the lymph nodes; in chronic cases, these worms lead to the syndrome of ''elephantiasis''. * Subcutaneous filariasis is caused by ''Loa loa'' (the eye worm), ''Mansonella streptocerca'', and ''Onchocerca volvulus''. These worms occupy the la ...
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Wuchereria Bancrofti
''Wuchereria bancrofti'' is a filarial (arthropod-borne) nematode (roundworm) that is the major cause of lymphatic filariasis. It is one of the three parasitic worms, together with ''Brugia malayi'' and '' B. timori'', that infect the lymphatic system to cause lymphatic filariasis. These filarial worms are spread by a variety of mosquito vector species. ''W. bancrofti'' is the most prevalent of the three and affects over 120 million people, primarily in Central Africa and the Nile delta, South and Central America, the tropical regions of Asia including southern China, and the Pacific islands. If left untreated, the infection can develop into lymphatic filariasis. In rare conditions, it also causes tropical pulmonary eosinophilia. No vaccine is commercially available, but high rates of cure have been achieved with various antifilarial regimens and lymphatic filariasis is the target of the World Health Organization Global Program to Eliminate Lymphatic Filariasis with the aim to erad ...
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Giemsa Stain
Giemsa stain (), named after German chemist and bacteriologist Gustav Giemsa, is a nucleic acid stain used in cytogenetics and for the histopathological diagnosis of malaria and other parasites. Uses It is specific for the phosphate groups of DNA and attaches itself to regions of DNA where there are high amounts of adenine-thymine bonding. Giemsa stain is used in Giemsa banding, commonly called G-banding, to stain chromosomes and often used to create a Karyotype, karyogram (chromosome map). It can identify chromosomal aberrations such as chromosomal translocation, translocations and chromosomal inversion, rearrangements. It stains the trophozoite ''Trichomonas vaginalis'', which presents with greenish discharge and motile cells on wet prep. Giemsa stain is also a Differential staining, differential stain, such as when it is combined with Wright's stain, Wright stain to form Wright-Giemsa stain. It can be used to study the adherence of pathogenic bacteria to human cells. It dif ...
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Parasitic Disease
A parasitic disease, also known as parasitosis, is an infectious disease caused by parasites. Parasites are organisms which derive sustenance from its host while causing it harm. The study of parasites and parasitic diseases is known as parasitology. Medical parasitology is concerned with three major groups of parasites: parasitic protozoa, helminths, and parasitic arthropods. Parasitic diseases are thus considered those diseases that are caused by pathogens belonging taxonomically to either the animal kingdom, or the protozoan kingdom. Terminology Although organisms such as bacteria function as parasites, the usage of the term "parasitic disease" is usually more restricted. The three main types of organisms causing these conditions are protozoa (causing protozoan infection), helminths (helminthiasis), and ectoparasites. Protozoa and helminths are usually endoparasites (usually living inside the body of the host), while ectoparasites usually live on the surface of the host. Protozoa ...
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Thomas Spencer Cobbold
Thomas Spencer Cobbold FRS (26 May 182810 March 1886) was an English biologist. Life He was born at Ipswich, the third son of Rev. Richard Cobbold, author of the ''History of Margaret Catchpole''. After graduating in medicine at the University of Edinburgh in 1851, he was appointed lecturer on botany at St Mary's Hospital, London in 1857, and also on zoology and comparative anatomy at Middlesex Hospital in 1861. He was elected a Fellow of the Royal Society in June, 1864. From 1868 he acted as Swiney Lecturer on geology at the British Museum until 1873, when he became professor of botany at the Royal Veterinary College, afterwards filling a chair of helminthology which was specially created for him at that institution. He was president of the Quekett Microscopical Club The Quekett Microscopical Club is a learned society for the promotion of microscopy. Its members come from all over the world, and include both amateur and professional microscopists. It is a registered cha ...
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Loa Loa
''Loa loa'' is a filarial (arthropod-borne) nematode (roundworm) that causes ''Loa loa'' filariasis. ''Loa loa'' actually means "worm worm", but is commonly known as the "eye worm", as it localizes to the conjunctiva of the eye. ''Loa loa'' is commonly found in Africa.Schmidt, Gerald et al. "Foundations of Parasitology". 7th ed. McGraw Hill, New York, NY, 2005. It mainly inhabits rain forests in West Africa and has native origins in Ethiopia. The disease caused by ''Loa loa'' is called loiasis and is one of the neglected tropical diseases. ''L. loa'' is one of three parasitic filarial nematodes that cause subcutaneous filariasis in humans. The other two are ''Mansonella streptocerca and Onchocerca volvulus'' (causes river blindness). Maturing larvae and adults of the "eye worm" occupy the subcutaneous layer of the skin – the fat layer – of humans, causing disease. The ''L. loa'' adult worm which travels under the skin can survive up to 10–15 years, causing inflammati ...
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Mansonia (fly)
''Mansonia'' mosquitoes are big, black or brown mosquitoes with sparkling on their wings and legs. They breed in ponds and lakes containing certain aquatic plants, especially the floating type like ''Pistia stratiotes'' and water hyacinth. The eggs are laid in star-shaped clusters on the undersurface of leaves of these plants. The larvae and pupae are found attached to the rootlets of these plants by their siphon tubes. They obtain their air supply from these rootlets. When about to become adult, these pupae come to the surface of water and the fully formed adults emerge and escape. The control of ''Mansonia'' mosquitoes is easy by removal or destruction of the aquatic host plants by herbicides. A study published in 2013 determined that the species '' Mansonia dyari'' Belkin, Heinemann, and Page should be considered a potential vector of Rift Valley fever virus and would need to be controlled if the virus were introduced into an area where it occurs.Turell, Michael J.; Britch, Se ...
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