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Blue Fugates
The Fugates, a family living in the hills of Kentucky starting in the 19th century, were commonly known as the "Blue Fugates" or the "Blue People of Kentucky". They are known for being carriers of a genetic trait that led to the blood disorder methemoglobinemia, causing the skin to appear blue. Ancestry Martin Fugate and Elizabeth Smith, ''Science 82'', November, 1982 who had married and settled near Hazard, Kentucky in around 1820, were both carriers of the recessive methemoglobinemia (met-H) gene. As a result, four of their seven children exhibited blue skin, and continued reproduction within the limited local gene pool ensured that many descendants of the Fugates were born with met-H. The disorder can cause heart abnormalities and seizures if the amount of methemoglobin in the blood exceeds 20 percent, but at levels between 10 and 20 percent it can cause blue skin without other symptoms. Most of the Fugates lived long and healthy lives. The "bluest" of the blue Fugates, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kentucky
Kentucky ( , ), officially the Commonwealth of Kentucky, is a state in the Southeastern region of the United States and one of the states of the Upper South. It borders Illinois, Indiana, and Ohio to the north; West Virginia and Virginia to the east; Tennessee to the south; and Missouri to the west. Its northern border is defined by the Ohio River. Its capital is Frankfort, and its two largest cities are Louisville and Lexington. Its population was approximately 4.5 million in 2020. Kentucky was admitted into the Union as the 15th state on June 1, 1792, splitting from Virginia in the process. It is known as the "Bluegrass State", a nickname based on Kentucky bluegrass, a species of green grass found in many of its pastures, which has supported the thoroughbred horse industry in the center of the state. Historically, it was known for excellent farming conditions for this reason and the development of large tobacco plantations akin to those in Virginia and North Carolina i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
JAMA Internal Medicine
''JAMA Internal Medicine'' is a monthly peer-reviewed medical journal published by the American Medical Association. It was established in 1908 as the ''Archives of Internal Medicine'' and obtained its current title in 2013. It covers all aspects of internal medicine, including cardiovascular disease, geriatrics, infectious disease, gastroenterology, endocrinology, allergy, and immunology. The editor in chief is Rita F. Redberg (University of California, San Francisco). According to ''Journal Citation Reports'', the journal's 2021 impact factor is 44.409, ranking it 7th out of 172 journals in the category "Medicine, General & Internal". Naming history Abstracting and indexing The journal is abstracted and indexed in Index Medicus/MEDLINE/PubMed. See also * List of American Medical Association journals A ''list'' is any set of items in a row. List or lists may also refer to: People * List (surname) Organizations * List College, an undergraduate division of the Je ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Family Aggregation
Family aggregation, also known as familial aggregation, is the clustering of certain traits, behaviours, or disorders within a given family. Family aggregation may arise because of genetic or environmental similarities.Butcher, J., S. Mineka, and J. Hooley. Abnormal Psychology. 15. Boston: Pearson, 2010. Print. Schizophrenia The data from the family aggregation studies have been extensively studied to determine the mode of inheritance of schizophrenia. Studies to date have shown that when numerous families are studied, simple modes of inheritance are not statistically supported. The majority of studies analyzing for the mode of inheritance have concluded that a multifactorial threshold mode is most likely. Cardiovascular problems The most consistent and dramatic evidence of family influences on cardiovascular disease (CVD) is family aggregation of physiological factors. In several studies the parent-child and sibling-sibling correlations of blood pressure are approximately .24. G ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Steve Howey (actor)
Steven Michael Robert Howey (born July 12, 1977) is an American film and television actor. He is known for his roles as Van Montgomery on The WB/The CW, CW television series ''Reba (TV series), Reba'', and Kevin Ball on the Showtime (TV network), Showtime series ''Shameless (American TV series), Shameless.'' Howey has also appeared in the films ''Supercross (film), Supercross'', ''DOA: Dead or Alive'', ''Bride Wars'', ''Game Over, Man!'', and ''Something Borrowed (film), Something Borrowed''. Early life and education Howey was born in San Antonio, Texas. He has Scottish people, Scottish ancestry. He graduated from Crescenta Valley High School in La Crescenta-Montrose and attended Northeastern Junior College in Sterling, Colorado, for two years on a basketball scholarship. He later attended his father’s acting workshop where he decided he wanted to become an actor. Career Howey has guest-starred on various TV shows including ''ER (TV series), ER'' (1994) and ''The Drew Carey Sh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Shameless (American TV Series) Characters
A variety of fictional characters appear in the American comedy-drama television series '' Shameless'', created by Paul Abbott. First broadcast on Showtime on January 9, 2011, it is based on the British series of the same name, and features many of its characters. ''Shameless'' is set in Chicago's South Side and tells the story of an alcoholic father, Frank Gallagher, and his six children who take care of each other and create better lives despite Frank's poor influence. Abbott grew up in a family in the United Kingdom much like that portrayed in the UK series. Cast overview Main Recurring Guest * Credited as "Special Guest Star" in the opening title. * Credited only in the episodes he/she appears. * Portrayed by Jane Levy in season 1 and Emma Greenwell in seasons 2 through 6. * Portrayed by twins Brennan Kane and Blake Alexander Johnson during seasons 1 to 2, by twins Brandon and Brenden Sims from season 2 to season 7, and by Christian Isaiah since season 8. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Shameless (American TV Series)
''Shameless'' is an American comedy drama television series developed by John Wells that aired on Showtime from January 9, 2011, to April 11, 2021. It is an adaptation of Paul Abbott's British series of the same name and features an ensemble cast led by William H. Macy and Emmy Rossum. The show is set on the South Side of Chicago, Illinois. With the premiere of the ninth season on September 9, 2018, ''Shameless'' became the longest-running original scripted series in Showtime's history. In January 2019, the series was renewed for a tenth season, which premiered on November 10, 2019. In January 2020, the series was renewed for its eleventh and final season, which was scheduled to premiere in mid-2020, but was delayed due to the COVID-19 pandemic; it instead premiered on December 6, 2020. On December 14, 2020, Showtime announced that they were airing a clip show series during Season 11, ''Shameless: Hall of Shame,'' containing new scenes juxtaposed with clips from the show to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Great Depression
The Great Depression (19291939) was an economic shock that impacted most countries across the world. It was a period of economic depression that became evident after a major fall in stock prices in the United States. The economic contagion began around September and led to the Wall Street stock market crash of October 24 (Black Thursday). It was the longest, deepest, and most widespread depression of the 20th century. Between 1929 and 1932, worldwide gross domestic product (GDP) fell by an estimated 15%. By comparison, worldwide GDP fell by less than 1% from 2008 to 2009 during the Great Recession. Some economies started to recover by the mid-1930s. However, in many countries, the negative effects of the Great Depression lasted until the beginning of World War II. Devastating effects were seen in both rich and poor countries with falling personal income, prices, tax revenues, and profits. International trade fell by more than 50%, unemployment in the U.S. rose to 23% and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kim Michele Richardson
Kim Michele Richardson is an American writer. As a child Richardson was placed in a rural Kentucky orphanage, Saint Thomas-Saint Vincent Orphan Asylum. In 2004, she and her sisters, along with 40 other plaintiffs who had lived in the institution run by the Sisters of Charity order and the Roman Catholic Church The Catholic Church, also known as the Roman Catholic Church, is the largest Christian church, with 1.3 billion baptized Catholics worldwide . It is among the world's oldest and largest international institutions, and has played a ... sued for damages suffered through alleged years of abuse by their caretakers between the 1930s to the 1970s. Richardson recounted her experiences at the orphanage during the 1960s and 1970s in her memoir ''The Unbreakable Child''. Bibliography Fiction * ''The Book Woman's Daughter'' (Sourcebooks Landmark, 2022); * '' The Book Woman of Troublesome Creek'' (Sourcebooks Landmark, 2019); * ''The Sisters of Glass Ferry'' (K ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Book Woman Of Troublesome Creek
''The Book Woman of Troublesome Creek'' is a 2019 novel by Kim Michele Richardson. The story is a fictionalized account of real subjects in the history of eastern Kentucky. Cussy Mary is a "Book Woman" — one of the Packhorse Librarians who delivered books to remote areas of the Appalachian Mountains during the Great Depression, from 1935 to 1943, as part of President Franklin D. Roosevelt's Works Progress Administration (WPA) program. Cussy Mary is also a "Blue" — the last of a line of blue-skinned people, whose skin appears the unusual shade due to a rare genetic disorder. As a Book Woman, Cussy Mary is highly regarded, but as a Blue, she is feared and reviled, and experiences racism, discrimination and violence. Plot summary In 1936 eastern Kentucky, 19-year-old Cussy Mary Carter works for the New Deal–funded Pack Horse Library Project, delivering reading material to the remote hill people of the Appalachian Mountains. Cussy Mary, sometimes known as Bluet, lives with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methylene Blue
Methylthioninium chloride, commonly called methylene blue, is a salt used as a dye and as a medication. Methylene blue is a thiazine dye. As a medication, it is mainly used to treat methemoglobinemia by converting the ferric iron in hemoglobin to ferrous iron. Specifically, it is used to treat methemoglobin levels that are greater than 30% or in which there are symptoms despite oxygen therapy. It has previously been used for treating cyanide poisoning and urinary tract infections, but this use is no longer recommended. Methylene blue is typically given by injection into a vein. Common side effects include headache, vomiting, confusion, shortness of breath, and high blood pressure. Other side effects include serotonin syndrome, red blood cell breakdown, and allergic reactions. Use often turns the urine, sweat, and stool blue to green in color. While use during pregnancy may harm the baby, not using it in methemoglobinemia is likely more dangerous. Methylene blue was first pr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Introduction To Genetics
Genetics is the study of genes and tries to explain what they are and how they work. Genes are how living organisms inherit features or traits from their ancestors; for example, children usually look like their parents because they have inherited their parents' genes. Genetics tries to identify which traits are inherited and to explain how these traits are passed from generation to generation. Some traits are part of an organism's physical appearance, such as a person's eye color, height or weight. Other sorts of traits are not easily seen and include blood types or resistance to diseases. Some traits are inherited through our genes, so tall and thin people tend to have tall and thin children. Other traits come from interactions between our genes and the environment, so a child might inherit the tendency to be tall, but if they are poorly nourished, they will still be short. The way our genes and environment interact to produce a trait can be complicated. For example, the ch ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytochrome B5 Reductase
Cytochrome-''b''5 reductase is a NADH-dependent enzyme that converts ferricytochrome from a Fe3+ form to a Fe2+ form. It contains flavin adenine dinucleotide, FAD and catalyzes the reaction: In its b5-reducing capacity, this enzyme is involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, and drug metabolism. This enzyme can also reduce methemoglobin to normal hemoglobin, gaining it the inaccurate synonym methemoglobin reductase. Isoforms expressed in erythrocytes (CYB5R1, CYB5R3) perform this function ''in vivo''. Ferricyanide is another substrate ''in vitro''. The following four human genes encode cytochrome-''b''5 reductases: * CYB5R1 * CYB5R2 * CYB5R3 * CYB5R4 * CYB5RL See also * Cytochrome b5 * Diaphorase * Methemoglobinemia * Reductase * Leghemoglobin reductase References External links * {{Portal bar, Biology, border=no EC 1.6.2 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
