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Bavarian Nordic
Bavarian Nordic A/S is a fully integrated biotechnology company focused on the development, manufacturing and commercialization of vaccines for infectious diseases and cancer immunotherapies. The company is headquartered in Hellerup, Denmark, with a manufacturing facility in Kvistgård, and an additional site in Hørsholm. The company has a research and development facility in Martinsried, Germany, and offices in Zug, Switzerland, and Morrisville, North Carolina. The company uses viral vectors in its research and development. Technologies MVA-BN MVA-BN is a proprietary technology developed by Bavarian Nordic. It is derived from the Modified vaccinia Ankara virus. MVA-BN is characterized by the inability to replicate in human cells, contrary to other vaccinia-based vaccines, which may replicate in humans, thus potentially causing severe and life-threatening side effects. Developed as the non-replicating smallpox and monkeypox vaccine, MVA-BN is approved in Canada as Imvamune, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aktieselskab
''Aktieselskab'' (; Abbreviation, abbr.: A/S, or a/s, Unicode ; literally meaning: "stock company") is the Denmark, Danish name for a stock-based corporation. An ''aktieselskab'' may be either publicly traded or private. Liability The shareholders of an ''aktieselskab'' are not liable for the debts of the company. This can be used to protect the assets of the company against creditors by forming a group of companies. If an A/S is owned by a holding company (typically another A/S), the profit from the production company can be transferred to the holding company. Since there is no liability for the owners of an A/S, creditors from the production company will not be able to claim the profit in case of bankruptcy. Professional creditors, such as banks, protect themselves from this by demanding that the holding company guarantees the debts of the production company. Formation of an ''aktieselskab'' The formation of an ''aktieselskab'' requires a number of steps, including the followi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kvistgård
Kvistgård is a small town in the southwestern outskirts of Helsingør, Helsingør Municipality, some 40 kilometres north of Copenhagen, Denmark. It is situated in the fork between the Helsingør Motorway to the east, separating it from Espergærde, and Helsingørsvej (part of National route 9) to the west. Kvistgård railway station is a stop on the Litte North railway line between Helsingør and Hillerød. As of 2022, Kvistgård has a population of 1,133. History The first known reference to the village of Nyrup (''Nuthorp'') is in a letter from Pope Alexander III dated 2 November 1178. The village belonged to Esrum Abbey until the Reformation. In 1497 it consisted of 10 farms and in 1681 of six farms and four houses. From 1674 until 1712 the residence of the forester of Kronborg County was in Nyrup. After that he resided at Gurrehus. Before Fredensborg was built, the king also had a hunting lodge at Nyrup. It was located a little north of the village. Nyrup was located at the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Health Canada
Health Canada (HC; french: Santé Canada, SC)Health Canada is the applied title under the Federal Identity Program; the legal title is Department of Health (). is the Structure of the Canadian federal government#Departments, with subsidiary units, department of the Government of Canada responsible for national health policy. The department itself is also responsible for numerous federal health-related agencies, including the Canadian Food Inspection Agency (CFIA) and the Public Health Agency of Canada (PHAC), among others. These organizations help to ensure compliance with federal law in a variety of Healthcare in Canada, healthcare, Agriculture in Canada, agricultural, and Pharmaceutics, pharmaceutical activities. This responsibility also involves extensive collaboration with various other federal- and provincial-level organizations in order to ensure the safety of food, health, and Medication, pharmaceutical products—including the regulation of health research and pharmaceutic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canada
Canada is a country in North America. Its ten provinces and three territories extend from the Atlantic Ocean to the Pacific Ocean and northward into the Arctic Ocean, covering over , making it the world's second-largest country by total area. Its southern and western border with the United States, stretching , is the world's longest binational land border. Canada's capital is Ottawa, and its three largest metropolitan areas are Toronto, Montreal, and Vancouver. Indigenous peoples have continuously inhabited what is now Canada for thousands of years. Beginning in the 16th century, British and French expeditions explored and later settled along the Atlantic coast. As a consequence of various armed conflicts, France ceded nearly all of its colonies in North America in 1763. In 1867, with the union of three British North American colonies through Confederation, Canada was formed as a federal dominion of four provinces. This began an accretion of provinces an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Monkeypox
Monkeypox (also called mpox by the WHO) is an infectious viral disease that can occur in humans and some other animals. Symptoms include fever, swollen lymph nodes, and a rash that forms blisters and then crusts over. The time from exposure to onset of symptoms ranges from five to twenty-one days. The duration of symptoms is typically two to four weeks. There may be mild symptoms, and it may occur without any symptoms being apparent. The classic presentation of fever and muscle pains, followed by swollen glands, with lesions all at the same stage, has not been found to be common to all outbreaks. Cases may be severe, especially in children, pregnant women or people with suppressed immune systems. The disease is caused by the monkeypox virus, a zoonotic virus in the genus ''Orthopoxvirus''. The variola virus, the causative agent of smallpox, is also in this genus. Of the two types in humans, cladeII (formerly West African clade) causes a less severe disease than the Central A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Smallpox
Smallpox was an infectious disease caused by variola virus (often called smallpox virus) which belongs to the genus Orthopoxvirus. The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980, making it the only human disease to be eradicated. The initial symptoms of the disease included fever and vomiting. This was followed by formation of ulcers in the mouth and a skin rash. Over a number of days, the skin rash turned into the characteristic fluid-filled blisters with a dent in the center. The bumps then scabbed over and fell off, leaving scars. The disease was spread between people or via contaminated objects. Prevention was achieved mainly through the smallpox vaccine. Once the disease had developed, certain antiviral medication may have helped. The risk of death was about 30%, with higher rates among babies. Often, those who survived had extensive scarring of their ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vaccinia
''Vaccinia virus'' (VACV or VV) is a large, complex, enveloped virus belonging to the poxvirus family. It has a linear, double-stranded DNA genome approximately 190 kbp in length, which encodes approximately 250 genes. The dimensions of the virion are roughly 360 × 270 × 250 nm, with a mass of approximately 5–10 fg. The vaccinia virus is the source of the modern smallpox vaccine, which the World Health Organisation used to eradicate smallpox in a global vaccination campaign in 1958–1977. Although ''smallpox'' no longer exists in the wild, ''vaccinia'' virus is still studied widely by scientists as a tool for gene therapy and genetic engineering. Smallpox had been an endemic human disease that had a 30% fatality rate. In 1796, the British doctor Edward Jenner proved that an infection with the relatively mild cowpox virus would also confer immunity to the deadly smallpox. Jenner referred to cowpox as ''variolae vaccinae'' (smallpox of the cow). However, the origins ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Expert Review Of Vaccines
''Expert Review of Vaccines'' is a monthly peer-reviewed medical journal covering all aspects impacting the clinical effectiveness of vaccines. According to the ''Journal Citation Reports'', the journal has a 2015 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as i ... of 4.222, making it the highest-impact journal dedicated specifically to vaccines. References External links * {{Official website, https://www.tandfonline.com/toc/ierv20/current Vaccinology journals English-language journals Expert Review journals Monthly journals Academic journals established in 2002 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Modified Vaccinia Ankara
Modified vaccinia Ankara (MVA) is an attenuated (weakened) strain of the vaccinia virus. It is being used as a vaccine (called MVA-BN, brand names: Imvanex in the EU, Imvamune in Canada, and Jynneos in the US) against smallpox and monkeypox, having fewer side effects than the traditional smallpox vaccine. This third-generation smallpox vaccine has the advantage that it cannot reproduce complete virions in human cells, "the block of the MVA life cycle occurs at the step of virion assembly resulting in assembly of immature virus particles that are not released from the infected cell." By inserting antigen genes into its genome, modified vaccinia Ankara virus is also used as an experimental viral vector for vaccines against non-poxvirus diseases. Development as a poxvirus vaccine The traditional smallpox vaccine, which was used in the smallpox eradication campaign 1958–1977, consists of a live vaccinia virus which can replicate in humans but usually does not cause disease. It ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Viral Vector
Viral vectors are tools commonly used by molecular biologists to deliver genetic material into cells. This process can be performed inside a living organism (''in vivo'') or in cell culture (''in vitro''). Viruses have evolved specialized molecular mechanisms to efficiently transport their genomes inside the cells they infect. Delivery of genes or other genetic material by a vector is termed transduction and the infected cells are described as transduced. Molecular biologists first harnessed this machinery in the 1970s. Paul Berg used a modified SV40 virus containing DNA from the bacteriophage λ to infect monkey kidney cells maintained in culture. In addition to their use in molecular biology research, viral vectors are used for gene therapy and the development of vaccines. Key properties of a viral vector VIRAL VECTORS are tailored to their specific applications but generally share a few key properties. *''Safety'': Although viral vectors are occasionally created from pathog ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Morrisville, North Carolina
Morrisville is a town located primarily in Wake County, North Carolina, United States (a small portion extends into neighboring Durham County). The population was 18,576 at the 2010 census. The U.S. Census Bureau estimated the town's population to be 28,846 as of July 1, 2019. Morrisville is part of the Research Triangle metropolitan region. The regional name originated after the 1959 creation of the Research Triangle Park, located midway between the cities of Raleigh and Durham. The Research Triangle region encompasses the U.S. Census Bureau's Combined Statistical Area (CSA) of Raleigh-Durham-Cary. The estimated population of the Raleigh-Durham-Cary CSA was 1,565,223 as of July 1, 2006, with the Raleigh-Cary Metropolitan Statistical Area (MSA) portion estimated at 994,551 residents. The operational headquarter of an American -Chinese multinational technology company Lenovo is located in the municipal limits. History The area was originally named in 1852 after Jeremiah Morris ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Switzerland
). Swiss law does not designate a ''capital'' as such, but the federal parliament and government are installed in Bern, while other federal institutions, such as the federal courts, are in other cities (Bellinzona, Lausanne, Luzern, Neuchâtel, St. Gallen a.o.). , coordinates = , largest_city = Zürich , official_languages = , englishmotto = "One for all, all for one" , religion_year = 2020 , religion_ref = , religion = , demonym = , german: Schweizer/Schweizerin, french: Suisse/Suissesse, it, svizzero/svizzera or , rm, Svizzer/Svizra , government_type = Federalism, Federal assembly-independent Directorial system, directorial republic with elements of a direct democracy , leader_title1 = Federal Council (Switzerland), Federal Council , leader_name1 = , leader_title2 = , leader_name2 = Walter Thurnherr , legislature = Fe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
