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Basal Dendrite
A basal dendrite is a dendrite that emerges from the base of a pyramidal cell that receives information from nearby neurons and passes it to the soma, or cell body. Due to their direct attachment to the cell body itself, basal dendrites are able to deliver strong depolarizing currents and therefore have a strong effect on action potential output in neurons. The physical characteristics of basal dendrites vary based on their location and species that they are found in. For example, the basal dendrites of humans are overall found to be the most intricate and spine-dense, as compared to other species such as Macaques. It is also observed that basal dendrites of the prefrontal cortex are larger and more complex in comparison to the smaller and simpler dendrites that can be seen within the visual cortex. Basal dendrites are capable of vast amounts of analog computing, which is responsible for many of the different nonlinear responses of modulating information in the neocortex. Basal de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dendrite
Dendrites (from Greek δένδρον ''déndron'', "tree"), also dendrons, are branched protoplasmic extensions of a nerve cell that propagate the electrochemical stimulation received from other neural cells to the cell body, or soma, of the neuron from which the dendrites project. Electrical stimulation is transmitted onto dendrites by upstream neurons (usually via their axons) via synapses which are located at various points throughout the dendritic tree. Dendrites play a critical role in integrating these synaptic inputs and in determining the extent to which action potentials are produced by the neuron. Dendritic arborization, also known as dendritic branching, is a multi-step biological process by which neurons form new dendritic trees and branches to create new synapses. The morphology of dendrites such as branch density and grouping patterns are highly correlated to the function of the neuron. Malformation of dendrites is also tightly correlated to impaired nervous syste ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pyramidal Cell
Pyramidal cells, or pyramidal neurons, are a type of multipolar neuron found in areas of the brain including the cerebral cortex, the hippocampus, and the amygdala. Pyramidal neurons are the primary excitation units of the mammalian prefrontal cortex and the corticospinal tract. Pyramidal neurons are also one of two cell types where the characteristic sign, Negri bodies, are found in post-mortem rabies infection. Pyramidal neurons were first discovered and studied by Santiago Ramón y Cajal. Since then, studies on pyramidal neurons have focused on topics ranging from neuroplasticity to cognition. Structure File:GFPneuron.png, Pyramidal neuron visualized by green fluorescent protein (gfp) File:Hippocampal-pyramidal-cell.png, A hippocampal pyramidal cell One of the main structural features of the pyramidal neuron is the conic shaped soma, or cell body, after which the neuron is named. Other key structural features of the pyramidal cell are a single axon, a large apical dendrite, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuroscience Information Framework
The Neuroscience Information Framework is a repository of global neuroscience web resources, including experimental, clinical, and translational neuroscience databases, knowledge bases, atlases, and genetic/ genomic resources and provides many authoritative links throughout the neuroscience portal of Wikipedia. Description The Neuroscience Information Framework (NIF) is an initiative of the NIH Blueprint for Neuroscience Research, which was established in 2004 by the National Institutes of Health. Development of the NIF started in 2008, when the University of California, San Diego School of Medicine obtained an NIH contract to create and maintain "a dynamic inventory of web-based neurosciences data, resources, and tools that scientists and students can access via any computer connected to the Internet". The project is headed by Maryann Martone, co-director of the National Center for Microscopy and Imaging Research (NCMIR), part of the multi-disciplinary Center for Research in Bio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Action Potential
An action potential occurs when the membrane potential of a specific cell location rapidly rises and falls. This depolarization then causes adjacent locations to similarly depolarize. Action potentials occur in several types of animal cells, called excitable cells, which include neurons, muscle cells, and in some plant cells. Certain endocrine cells such as pancreatic beta cells, and certain cells of the anterior pituitary gland are also excitable cells. In neurons, action potentials play a central role in cell-cell communication by providing for—or with regard to saltatory conduction, assisting—the propagation of signals along the neuron's axon toward synaptic boutons situated at the ends of an axon; these signals can then connect with other neurons at synapses, or to motor cells or glands. In other types of cells, their main function is to activate intracellular processes. In muscle cells, for example, an action potential is the first step in the chain of events l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neocortex
The neocortex, also called the neopallium, isocortex, or the six-layered cortex, is a set of layers of the mammalian cerebral cortex involved in higher-order brain functions such as sensory perception, cognition, generation of motor commands, spatial reasoning and language. The neocortex is further subdivided into the true isocortex and the proisocortex. In the human brain, the neocortex is the largest part of the cerebral cortex (the outer layer of the cerebrum). The neocortex makes up the largest part of the cerebral cortex, with the allocortex making up the rest. The neocortex is made up of six layers, labelled from the outermost inwards, I to VI. Etymology The term is from ''cortex'', Latin, " bark" or "rind", combined with ''neo-'', Greek, "new". ''Neopallium'' is a similar hybrid, from Latin ''pallium'', "cloak". ''Isocortex'' and ''allocortex'' are hybrids with Greek ''isos'', "same", and ''allos'', "other". Anatomy The neocortex is the most developed in its organisat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Granule Cell
A granule is a large particle or grain. It can refer to: * Granule (cell biology), any of several submicroscopic structures, some with explicable origins, others noted only as cell type-specific features of unknown function ** Azurophilic granule, a structure characteristic of the azurophil eukaryotic cell type ** Chromaffin granule, a structure characteristic of the chromophil eukaryotic cell type. * Astrophysics and geology: ** Granule (solar physics), a visible structure in the photosphere of the Sun arising from activity in the Sun's convective zone ** Martian spherules, spherical granules of material found on the surface of the planet Mars ** Granule (geology), a specified particle size of 2–4 millimetres (-1 to -2 on the φ scale) * Granule, in pharmaceutical terms, small particles gathered into a larger, permanent aggregate in which the original particles can still be identified * Granule (Oracle DBMS), a unit of contiguously allocated virtual memory * Granular synthesis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apical Dendrite
An apical dendrite is a dendrite that emerges from the apex of a pyramidal cell. Apical dendrites are one of two primary categories of dendrites, and they distinguish the pyramidal cells from spiny stellate cells in the cortices. Pyramidal cells are found in the prefrontal cortex, the hippocampus, the entorhinal cortex, the olfactory cortex, and other areas. Dendrite arbors formed by apical dendrites are the means by which synaptic inputs into a cell are integrated.Cline HT. Dendritic arbor development and synaptogenesis. ''Current Opinion in Neurobiology'' 2001; 11: 118–126 The apical dendrites in these regions contribute significantly to memory, learning, and sensory associations by modulating the excitatory and inhibitory signals received by the pyramidal cells. Background Two types of dendrites present on pyramidal cells are apical and basal dendrites. Apical dendrites are the most distal along the ascending trunk, and reside in layer 1. These distal apical dendrites r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hippocampus Proper
The hippocampus proper refers to the actual structure of the hippocampus which is made up of three regions or subfields. The subfields CA1, CA2, and CA3 use the initials of cornu Ammonis, an earlier name of the hippocampus. Structure There are four hippocampal subfields, regions in the hippocampus proper which form a neural circuit called the trisynaptic circuit. CA1 CA1 is the first region in the hippocampal circuit, from which a major output pathway goes to layer V of the entorhinal cortex. Another significant output is to the subiculum. CA2 CA2 is a small region located between CA1 and CA3. It receives some input from layer II of the entorhinal cortex via the perforant path. Its pyramidal cells are more like those in CA3 than those in CA1. It is often ignored due to its small size. CA3 CA3 receives input from the mossy fibers of the granule cells in the dentate gyrus, and also from cells in the entorhinal cortex via the perforant path. The mossy fiber pathway ends in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TAOK2
Serine/threonine-protein kinase TAO2 is an enzyme that in humans is encoded by the ''TAOK2'' gene. Interactions TAOK2 has been shown to interact with MAP2K6 and MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the ''MAP2K3'' gene. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This k .... References Further reading * * * * * * * * * * * * * * * {{cite journal , vauthors = Scharrenberg R, Richter M, Johanns O, Meka DP, Rücker T, Murtaza N, Lindenmaier Z, Ellegood J, Naumann A, Zhao B, Schwanke B, Sedlacik J, Fiehler J, Hanganu-Opatz IL, Lerch JP, Singh KK, de Anda FC , display-authors = 6 , title = TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model , journal = Molecular Psychiatry , volume = , issue = , date = September 2022 , pmid = 36123424 , pmc = , doi = 10.1038/s413 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NPR1
Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the ''NPR1'' gene. Function NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides ( ANP and BNP, respectively). It is localized in the kidneyBioGPS > NPR1Retrieved Nov 2010 where it results in natriuresis upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and adipocytes. See also * Atrial natriuretic peptide receptor An atrial natriuretic peptide receptor is a receptor for atrial natriuretic peptide. Mechanism NPRA and NPRB are linked to guanylyl cyclases, while NPRC is G-protein-linked and is a "clearance receptor" that acts to internalise and destroy the ... References Further reading * * * * External links * EC 4.6.1 {{membrane-protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SEMA3A
Semaphorin-3A is a protein that in humans is encoded by the ''SEMA3A'' gene. Function The ''SEMA3A'' gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted Semaphorin-3A protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Semaphorin-3A is secreted by neurons and surrounding tissue to guide migrating cells and axons in the developing nervous system. Axon pathfinding is the process by which neurons follow very precise paths, sends out axons, and react to specific chemical environments to reach the correct endpoint. The guidance is critical for the precise formation of neurons and the surrounding vasculature. Guidance cues, such as Sema3A, induce the collapse and paralysis of neuronal grow ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cerebrum
The cerebrum, telencephalon or endbrain is the largest part of the brain containing the cerebral cortex (of the two cerebral hemispheres), as well as several subcortical structures, including the hippocampus, basal ganglia, and olfactory bulb. In the human brain, the cerebrum is the uppermost region of the central nervous system. The cerebrum prenatal development, develops prenatally from the forebrain (prosencephalon). In mammals, the Dorsum (biology), dorsal telencephalon, or Pallium (neuroanatomy), pallium, develops into the cerebral cortex, and the ventral telencephalon, or Pallium (neuroanatomy), subpallium, becomes the basal ganglia. The cerebrum is also divided into approximately symmetric Lateralization of brain function, left and right cerebral hemispheres. With the assistance of the cerebellum, the cerebrum controls all voluntary actions in the human body. Structure The cerebrum is the largest part of the brain. Depending upon the position of the animal it lies eithe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
