Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an

atrial natriuretic peptide receptor An atrial natriuretic peptide receptor is a receptor for atrial natriuretic peptide. Mechanism NPRA and NPRB are linked to guanylyl cyclases, while NPRC is G-protein-linked and is a "clearance receptor" that acts to internalise and destroy the ...

. In humans it is encoded by the ''NPR1''

gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

Function

NPR1 is a membrane-bound

guanylate cyclase Guanylate cyclase (EC 4.6.1.2, also known as guanyl cyclase, guanylyl cyclase, or GC; systematic name GTP diphosphate-lyase (cyclizing; 3′,5′-cyclic-GMP-forming)) is a lyase enzyme that converts guanosine triphosphate (GTP) to cyclic guanos ...

that serves as the receptor for both atrial and brain natriuretic peptides ( ANP and BNP, respectively). It is localized in the kidneyBioGPS > NPR1
Retrieved Nov 2010 where it results in

natriuresis Natriuresis is the process of sodium excretion in the urine through the action of the kidneys. It is promoted by ventricular and atrial natriuretic peptides as well as calcitonin, and inhibited by chemicals such as aldosterone. Natriuresis lowers t ...

upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and

adipocytes Adipocytes, also known as lipocytes and fat cells, are the cells that primarily compose adipose tissue, specialized in storing energy as fat. Adipocytes are derived from mesenchymal stem cells which give rise to adipocytes through adipogenesis. I ...

References

External links

* EC 4.6.1 {{membrane-protein-stub

Function

See also

References

Further reading

External links