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Archaic Human Admixture With Modern Humans
There is evidence for interbreeding between archaic and modern humans during the Middle Paleolithic and early Upper Paleolithic. The interbreeding happened in several independent events that included Neanderthals and Denisovans, as well as several unidentified hominins. In Eurasia, interbreeding between Neanderthals and Denisovans with modern humans took place several times. The introgression events into modern humans are estimated to have happened about 47,000–65,000 years ago with Neanderthals and about 44,000–54,000 years ago with Denisovans. Neanderthal-derived DNA has been found in the genomes of most or possibly all contemporary populations, varying noticeably by region. It accounts for 1–4% of modern genomes for people outside Sub-Saharan Africa, although estimates vary, and either none or possibly up to 0.3% — according to recent research — for those in Africa. It is highest in East Asians, intermediate in Europeans, and lower in Southeast Asians. According ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Homo Sapiens Lineage
''Homo'' () is the genus that emerged in the (otherwise extinct) genus ''Australopithecus'' that encompasses the extant species ''Homo sapiens'' (modern humans), plus several extinct species classified as either ancestral to or closely related to modern humans (depending on the species), most notably ''Homo erectus'' and ''Homo neanderthalensis''. The genus emerged with the appearance of ''Homo habilis'' just over 2 million years ago. ''Homo'', together with the genus ''Paranthropus'', is probably sister to ''Australopithecus africanus'', which itself had previously split from the lineage of '' Pan'', the chimpanzees. ''Homo erectus'' appeared about 2 million years ago and, in several early migrations, spread throughout Africa (where it is dubbed ''Homo ergaster'') and Eurasia. It was likely that the first human species lived in a hunter-gatherer society and was able to control fire. An adaptive and successful species, ''Homo erectus'' persisted for more than a million years ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genome Sequencing
Whole genome sequencing (WGS), also known as full genome sequencing, complete genome sequencing, or entire genome sequencing, is the process of determining the entirety, or nearly the entirety, of the DNA sequence of an organism's genome at a single time. This entails sequencing all of an organism's chromosomal DNA as well as DNA contained in the mitochondria and, for plants, in the chloroplast. Whole genome sequencing has largely been used as a research tool, but was being introduced to clinics in 2014. In the future of personalized medicine, whole genome sequence data may be an important tool to guide therapeutic intervention. The tool of gene sequencing at SNP level is also used to pinpoint functional variants from association studies and improve the knowledge available to researchers interested in evolutionary biology, and hence may lay the foundation for predicting disease susceptibility and drug response. Whole genome sequencing should not be confused with DNA profiling ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Morocco
Morocco (),, ) officially the Kingdom of Morocco, is the westernmost country in the Maghreb region of North Africa. It overlooks the Mediterranean Sea to the north and the Atlantic Ocean to the west, and has land borders with Algeria to Algeria–Morocco border, the east, and the disputed territory of Western Sahara to Morocco–Western Sahara border, the south. Mauritania lies to the south of Western Sahara. Morocco also claims the Spain, Spanish Enclave and exclave, exclaves of Ceuta, Melilla and Peñón de Vélez de la Gomera, and several small Plazas de soberanía, Spanish-controlled islands off its coast. It spans an area of or , with a population of roughly 37 million. Its official and predominant religion is Islam, and the official languages are Arabic and Berber languages, Berber; the Moroccan Arabic, Moroccan dialect of Arabic and French language, French are also widely spoken. Culture of Morocco, Moroccan identity and culture is a mix of Arab culture, Arab, Berbe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Berbers
, image = File:Berber_flag.svg , caption = The Berber ethnic flag , population = 36 million , region1 = Morocco , pop1 = 14 million to 18 million , region2 = Algeria , pop2 = 9 million to ~13 million , region3 = Mauritania , pop3 = 2.9 million , region4 = Niger , pop4 = 2.6 million, Niger: 11% of 23.6 million , region5 = France , pop5 = 2 million , region6 = Mali , pop6 = 850,000 , region7 = Libya , pop7 = 600,000 , region8 = Belgium , pop8 = 500,000 (including descendants) , region9 = Netherlands , pop9 = 467,455 (including descendants) , region10 = Burkina Faso , pop10 = 406,271, Burkina Faso: 1.9% of 21.4 million , region11 = Egypt , pop11 = 23,000 or 1,826,580 , region12 = Tunisia , pop12 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Western Eurasians
The Genetic history of Europe deals with the formation, ethnogenesis, and other DNA-specific information about populations indigenous, or living in Europe. The most significant recent dispersal of modern humans from Africa gave rise to an undifferentiated " non-African" lineage by some 70–50 ka (70-50,000 years ago). By about 50–40 ka a West Eurasian lineage had emerged, as had a separate East Eurasian lineage. Both East and West Eurasians acquired Neanderthal admixture in Europe and Asia. European early modern humans (EEMH) lineages between 40 and 26 ka (Aurignacian) were still part of a large Western Eurasian "meta-population", related to Central and Western Asian populations. Divergence into genetically distinct sub-populations within Western Eurasia is a result of increased selection pressure and founder effects during the Last Glacial Maximum (LGM, Gravettian). By the end of the LGM, after 20 ka, A Western European lineage, dubbed West European Hunter-Gatherer (WHG ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
East Asians
East Asian people (East Asians) are the people from East Asia, which consists of China, Taiwan, Japan, Mongolia, North Korea, and South Korea. The total population of all countries within this region is estimated to be 1.677 billion and 21% of the world's population in 2020. However, large East Asian diasporas, such as the Chinese, Japanese, Korean, and Mongolian diasporas, as well as diasporas of other East Asian ethnic groups, mean that the 1.677 billion does not necessarily represent an accurate figure for the numbers of East Asian people worldwide. The major ethnic groups that form the core of East Asia are the Chinese, Koreans, and Japanese. Other ethnic groups of East Asia include the Ainu, Bai, Manchus, Mongols and other Mongolic peoples, Nivkh, Qiang, Ryukyuans, Tibetans, and Yakuts. Culture The major East Asian language families are the Sinitic, Japonic, and Koreanic families. Other language families include the Tibeto-Burman, Ainu languages, Mongolic, Tungusic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Purifying Selection
In natural selection, negative selection or purifying selection is the selective removal of alleles that are deleterious. This can result in stabilising selection through the purging of deleterious genetic polymorphisms that arise through random mutations. Purging of deleterious alleles can be achieved on the population genetics level, with as little as a single point mutation being the unit of selection. In such a case, carriers of the harmful point mutation have fewer offspring each generation, reducing the frequency of the mutation in the gene pool. In the case of strong negative selection on a locus, the purging of deleterious variants will result in the occasional removal of linked variation, producing a decrease in the level of variation surrounding the locus under selection. The incidental purging of non-deleterious alleles due to such spatial proximity to deleterious alleles is called background selection. This effect increases with lower mutation rate but decreases wit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Johannes Krause
Johannes Krause (born July 17, 1980 in Leinefelde) is a German biochemist with a research focus on historical infectious diseases and human evolution. Since 2010, he has been professor of archaeology and paleogenetics at the University of Tübingen. In 2014, Krause was named a founding co-director of the new Max Planck Institute for the Science of Human History in Jena. Career From 2000 to 2005, Krause studied biochemistry in Leipzig and at the University College Cork in Ireland. In 2005 he obtained his diploma with the publication ''The mitochondrial genome of the woolly mammoth'' at the Max Planck Institute for Evolutionary Anthropology, followed by a doctoral dissertation in 2008 under Svante Pääbo entitled ''From genes to genomes: Applications for multiplex PCR in Ancient DNA Research'' regarding genetic investigations into Neanderthals and cave bears.Michael Bolus: Laudatio: Dr. Johannes Krause, Preisträger des zwölften Tübinger Förderpreises für Ältere Urgeschichte u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Introgression
Introgression, also known as introgressive hybridization, in genetics is the transfer of genetic material from one species into the gene pool of another by the repeated backcrossing of an interspecific hybrid with one of its parent species. Introgression is a long-term process, even when artificial; it may take many hybrid generations before significant backcrossing occurs. This process is distinct from most forms of gene flow in that it occurs between two populations of different species, rather than two populations of the same species. Introgression also differs from simple hybridization. Simple hybridization results in a relatively even mixture; gene and allele frequencies in the first generation will be a uniform mix of two parental species, such as that observed in mules. Introgression, on the other hand, results in a complex, highly variable mixture of genes, and may only involve a minimal percentage of the donor genome. Definition Introgression or introgressive hybridi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The New York Times
''The New York Times'' (''the Times'', ''NYT'', or the Gray Lady) is a daily newspaper based in New York City with a worldwide readership reported in 2020 to comprise a declining 840,000 paid print subscribers, and a growing 6 million paid digital subscribers. It also is a producer of popular podcasts such as '' The Daily''. Founded in 1851 by Henry Jarvis Raymond and George Jones, it was initially published by Raymond, Jones & Company. The ''Times'' has won 132 Pulitzer Prizes, the most of any newspaper, and has long been regarded as a national " newspaper of record". For print it is ranked 18th in the world by circulation and 3rd in the U.S. The paper is owned by the New York Times Company, which is publicly traded. It has been governed by the Sulzberger family since 1896, through a dual-class share structure after its shares became publicly traded. A. G. Sulzberger, the paper's publisher and the company's chairman, is the fifth generation of the family to head the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
David Reich (geneticist)
David Emil Reich (born July 14, 1974) is an American geneticist known for his research into the population genetics of ancient humans, including their migrations and the mixing of populations, discovered by analysis of genome-wide patterns of mutations. He is professor in the department of genetics at the Harvard Medical School, and an associate of the Broad Institute. Reich was highlighted as one of Nature's 10 for his contributions to science in 2015. He received the Dan David Prize in 2017, the NAS Award in Molecular Biology, the Wiley Prize, and the Darwin–Wallace Medal in 2019. In 2021 he was awarded the Massry Prize. Early life Reich grew up as part of a Jewish family in Washington, D.C. His parents are novelist Tova Reich (sister of Rabbi Avi Weiss) and Walter Reich, a professor at George Washington University, who served as the first director of the United States Holocaust Memorial Museum. David Reich started out as a sociology major as an undergraduate at Harvard Coll ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1000 Genomes Project
The 1000 Genomes Project (abbreviated as 1KGP), launched in January 2008, was an international research effort to establish by far the most detailed catalogue of human genetic variation. Scientists planned to sequence the genomes of at least one thousand anonymous participants from a number of different ethnic groups within the following three years, using newly developed technologies which were faster and less expensive. In 2010, the project finished its pilot phase, which was described in detail in a publication in the journal ''Nature''. In 2012, the sequencing of 1092 genomes was announced in a ''Nature'' publication. In 2015, two papers in ''Nature'' reported results and the completion of the project and opportunities for future research. Many rare variations, restricted to closely related groups, were identified, and eight structural-variation classes were analyzed. The project unites multidisciplinary research teams from institutes around the world, including China, Ita ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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