Andrew Bruce Holmes
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Andrew Bruce Holmes
Andrew Bruce Holmes (born 5 September 1943) is an Australian and British senior research chemist and professor at the Bio21 Institute, Melbourne, Australia, and the past President of the Australian Academy of Science. His research interests lie in the synthesis of biologically-active natural products (spanning therapeutic materials to new biotechnological probes) and optoelectronic polymers (with applications to electroluminescent flexible displays and organic solar cells). Education Holmes' undergraduate studies and masters' research were conducted at the University of Melbourne in Australia. Travelling to the UK on a Shell Overseas Science Scholarship, he performed his PhD work at University College London under the supervision of Franz Sondheimer. Career and research As a postdoctoral researcher, Holmes worked on the total synthesis of Vitamin B12 with Albert Eschenmoser. In 1972 he was appointed as a demonstrator to the University of Cambridge where he stayed for 32 ...
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Melbourne
Melbourne ( ; Boonwurrung/Woiwurrung: ''Narrm'' or ''Naarm'') is the capital and most populous city of the Australian state of Victoria, and the second-most populous city in both Australia and Oceania. Its name generally refers to a metropolitan area known as Greater Melbourne, comprising an urban agglomeration of 31 local municipalities, although the name is also used specifically for the local municipality of City of Melbourne based around its central business area. The metropolis occupies much of the northern and eastern coastlines of Port Phillip Bay and spreads into the Mornington Peninsula, part of West Gippsland, as well as the hinterlands towards the Yarra Valley, the Dandenong and Macedon Ranges. It has a population over 5 million (19% of the population of Australia, as per 2021 census), mostly residing to the east side of the city centre, and its inhabitants are commonly referred to as "Melburnians". The area of Melbourne has been home to Aboriginal ...
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Hasselt University
Hasselt University (Dutch: ''Universiteit Hasselt or UHasselt'') is a public research university with campuses in Hasselt and Diepenbeek, Belgium. It has more than 6,700 students and 1,660 academic, administrative and technical staff (2022). The university was officially established in 1971 as the Limburg Universitair Centrum (LUC) and changed its name to Hasselt University in 2005. UHasselt is ranked 53rd out of 539 in the 2022 ''Times Higher Education'' ranking of universities younger than 50 years. In the European Commission's ''U-Multirank 2022'', UHasselt scores a top ten overall result, with fifteen excellent indicators. Hasselt University has an extensive regional, national and global network of more than 500 partners, fostering collaboration in education, research and innovation. As of October 2020, Rector of Hasselt University is Prof. Bernard Vanheusden. Vice-Rector for Education is Prof. Wanda Guedens, Vice-Rector for Research Prof. Ken Haenen. History Establishme ...
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Polymer Chemistry
Polymer chemistry is a sub-discipline of chemistry that focuses on the structures of chemicals, chemical synthesis, and chemical and physical properties of polymers and macromolecules. The principles and methods used within polymer chemistry are also applicable through a wide range of other chemistry sub-disciplines like organic chemistry, analytical chemistry, and physical chemistry. Many materials have polymeric structures, from fully inorganic metals and ceramics to DNA and other biological molecules. However, polymer chemistry is typically related to synthetic and organic compositions. Synthetic polymers are ubiquitous in commercial materials and products in everyday use, such as plastics, and rubbers, and are major components of composite materials. Polymer chemistry can also be included in the broader fields of polymer science or even nanotechnology, both of which can be described as encompassing polymer physics and polymer engineering.Hans-Heinrich Moretto, Manfred Sch ...
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Organic Chemistry
Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J.; Greeves, N. and Warren, S. (2012) ''Organic Chemistry''. Oxford University Press. pp. 1–15. . Study of structure determines their structural formula. Study of properties includes physical and chemical properties, and evaluation of chemical reactivity to understand their behavior. The study of organic reactions includes the chemical synthesis of natural products, drugs, and polymers, and study of individual organic molecules in the laboratory and via theoretical ( in silico) study. The range of chemicals studied in organic chemistry includes hydrocarbons (compounds containing only carbon and hydrogen) as well as compounds based on carbon, but also containing other elements, especially oxygen, nitrogen, sulfur, phosphorus (included in ...
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Scientific Demonstration
A scientific demonstration is a procedure carried out for the purposes of demonstrating scientific principles, rather than for hypothesis testing or knowledge gathering (although they may originally have been carried out for these purposes). Most scientific demonstrations are simple laboratory demonstrations intended to demonstrate physical principles, often in a surprising or entertaining way. They are carried out in schools and universities, and sometimes in public demonstrations in popular science lectures and TV programs aimed at the general public. Many scientific demonstrations are chosen for their combination of educational merit and entertainment value, which is often provided by dramatic phenomena such as explosions. Public scientific demonstrations were a common occurrence in the Age of Enlightenment, and have long been a feature of the British Royal Institution Christmas Lectures, which date back to 1825. In the television era, scientific demonstrations have featured i ...
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Vitamin B12 Total Synthesis
The total synthesis of the complex biomolecule vitamin B12 was accomplished in two different approaches by the collaborating research groups of Robert Burns Woodward at Harvard and Albert Eschenmoser at ETH in 1972. The accomplishment required the effort of no less than 91 postdoctoral researchers (Harvard: 77, ETH: 14), and 12 Ph.D. students (at ETH) from 19 different nations over a period of almost 12 years. The synthesis project induced and involved a major change of paradigm in the field of natural product synthesis. The molecule Vitamin B12, C63H88CoN14O14P, is the most complex of all known vitamins. Its chemical structure had been determined by x-ray crystal structure analysis in 1956 by the research group of Dorothy Hodgkin (Oxford University) in collaboration with Kenneth N. Trueblood at UCLA and John G. White at Princeton University. Core of the molecule is the corrin structure, a nitrogenous tetradentate ligand system. This is biogenetically related to porphyrins a ...
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Postdoctoral Researcher
A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to pursue additional research, training, or teaching in order to have better skills to pursue a career in academia, research, or any other field. Postdocs often, but not always, have a temporary academic appointment, sometimes in preparation for an academic faculty position. They continue their studies or carry out research and further increase expertise in a specialist subject, including integrating a team and acquiring novel skills and research methods. Postdoctoral research is often considered essential while advancing the scholarly mission of the host institution; it is expected to produce relevant publications in peer-reviewed academic journals or conferences. In some countries, postdoctoral research may lead to further formal qualificati ...
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Organic Solar Cells
An organic solar cell (OSC) or plastic solar cell is a type of photovoltaic that uses organic electronics, a branch of electronics that deals with conductive organic polymers or small organic molecules, for light absorption and charge transport to produce electricity from sunlight by the photovoltaic effect. Most organic photovoltaic cells are polymer solar cells. The molecules used in organic solar cells are solution-processable at high throughput and are cheap, resulting in low production costs to fabricate a large volume. Combined with the flexibility of organic molecules, organic solar cells are potentially cost-effective for photovoltaic applications. Molecular engineering (''e.g.,'' changing the length and functional group of polymers) can change the band gap, allowing for electronic tunability. The Attenuation coefficient, optical absorption coefficient of organic molecules is high, so a large amount of light can be absorbed with a small amount of materials, usually on the ...
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Rollable Display
A flexible display or rollable display is an electronic visual display which is flexible in nature, as opposed to the traditional flat screen displays used in most electronic devices. In recent years there has been a growing interest from numerous consumer electronics manufacturers to apply this display technology in e-readers, mobile phones and other consumer electronics. Such screens can be rolled up like a scroll without the image or text being distorted. Technologies involved in building a rollable display include electronic ink, Gyricon, Organic LCD, and OLED. Electronic paper displays which can be rolled up have been developed by E Ink. At CES 2006, Philips showed a rollable display prototype, with a screen capable of retaining an image for several months without electricity. In 2007, Philips launched a 5-inch, 320 x 240-pixel rollable display based on E Ink’s electrophoretic technology. Some flexible organic light-emitting diode displays have been demons ...
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Electroluminescent
Electroluminescence (EL) is an optical and electrical phenomenon, in which a material emits light in response to the passage of an electric current or to a strong electric field. This is distinct from black body light emission resulting from heat (incandescence), a chemical reaction (chemiluminescence), sound (sonoluminescence), or other mechanical action (mechanoluminescence). Mechanism Electroluminescence is the result of radiative recombination of electrons & holes in a material, usually a semiconductor. The excited electrons release their energy as photons - light. Prior to recombination, electrons and holes may be separated either by doping the material to form a p-n junction (in semiconductor electroluminescent devices such as light-emitting diodes) or through excitation by impact of high-energy electrons accelerated by a strong electric field (as with the phosphors in electroluminescent displays). It has been recently shown that as a solar cell improves its light-to- ...
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OLED
An organic light-emitting diode (OLED or organic LED), also known as organic electroluminescent (organic EL) diode, is a light-emitting diode (LED) in which the emissive electroluminescent layer is a film of organic compound that emits light in response to an electric current. This organic layer is situated between two electrodes; typically, at least one of these electrodes is transparent. OLEDs are used to create digital displays in devices such as television screens, computer monitors, and portable systems such as smartphones and handheld game consoles. A major area of research is the development of white OLED devices for use in solid-state lighting applications. There are two main families of OLED: those based on small molecules and those employing polymers. Adding mobile ions to an OLED creates a light-emitting electrochemical cell (LEC) which has a slightly different mode of operation. An OLED display can be driven with a passive-matrix (PMOLED) or active-matrix (AMOLED) ...
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Natural Products
A natural product is a natural Chemical compound, compound or chemical substance, substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life. Natural products can also be prepared by chemical synthesis (both semisynthesis and total synthesis) and have played a central role in the development of the field of organic chemistry by providing challenging synthetic targets. The term natural product has also been extended for commercial purposes to refer to cosmetics, dietary supplements, and foods produced from natural sources without added artificial ingredients. Within the field of organic chemistry, the definition of natural products is usually restricted to organic compounds isolated from natural sources that are produced by the pathways of primary metabolite, primary or secondary metabolite, secondary metabolism. Within the field of medicinal chemistry, the definition is often further restric ...
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