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Adenovirus Serotype 36
Human adenovirus 36 (HAdV-36) or Ad-36 or Adv36 is one of 52 types of adenoviruses known to infect humans. AD-36, first isolated in 1978 from the feces of a girl suffering from diabetes and enteritis, has long been recognized as a cause of respiratory and eye infections in humans. It was first shown to be associated with obesity in chickens by Dr. Nikhil Dhurandhar. AD-36 infection can induce cellular differentiation of 3T3-L1 preadipocytes and stem cells derived from human adipose tissue. Role in obesity There has been a positive correlation between body fat and the presence of AD-36 antibodies in the blood. Previous research showed that chickens or mice injected with similar types of viruses show a statistically significant weight gain. To date, AD-36 is the only human adenovirus that has been linked with human obesity, present in 30% of obese humans and 11% of nonobese humans. In addition, a study of obese Americans indicates that about 30% of the obese individuals and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adenovirus
Adenoviruses (members of the family ''Adenoviridae'') are medium-sized (90–100 nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double-stranded DNA genome. Their name derives from their initial isolation from human adenoids in 1953. They have a broad range of vertebrate hosts; in humans, more than 50 distinct adenoviral serotypes have been found to cause a wide range of illnesses, from mild respiratory infections in young children (known as the common cold) to life-threatening multi-organ disease in people with a weakened immune system. Virology Classification This family contains the following genera: * '' Atadenovirus'' * '' Aviadenovirus'' * '' Ichtadenovirus'' * '' Mastadenovirus'' (including all human adenoviruses) * '' Siadenovirus'' * '' Testadenovirus'' Diversity In humans, currently there are 88 human adenoviruses (HAdVs) in seven species (Human adenovirus A to G): * A: 12, 18, 31 * B: 3, 7, 11, 14, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Daily Express
The ''Daily Express'' is a national daily United Kingdom middle-market newspaper printed in tabloid format. Published in London, it is the flagship of Express Newspapers, owned by publisher Reach plc. It was first published as a broadsheet in 1900 by Sir Arthur Pearson. Its sister paper, the ''Sunday Express'', was launched in 1918. In June 2022, it had an average daily circulation of 201,608. The paper rose to become the largest circulation newspaper in the world under Lord Beaverbrook, going from 2 million in the 1930s to 4 million in the 1940s. It was acquired by Richard Desmond's company Northern & Shell in 2000. Hugh Whittow was the editor from February 2011 until he retired in March 2018. In February 2018 Trinity Mirror acquired the ''Daily Express'', and other publishing assets of Northern & Shell, in a deal worth £126.7 million. To coincide with the purchase the Trinity Mirror group changed the name of the company to ''Reach''. Hugh Whittow resigned as editor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biology News Net
Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditary information encoded in genes, which can be transmitted to future generations. Another major theme is evolution, which explains the unity and diversity of life. Energy processing is also important to life as it allows organisms to move, grow, and reproduce. Finally, all organisms are able to regulate their own internal environments. Biologists are able to study life at multiple levels of organization, from the molecular biology of a cell to the anatomy and physiology of plants and animals, and evolution of populations.Based on definition from: Hence, there are multiple subdisciplines within biology, each defined by the nature of their research questions and the tools that they use. Like other scientists, biologists use the scientific metho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science Blog
Science is a systematic endeavor that builds and organizes knowledge in the form of testable explanations and predictions about the universe. Science may be as old as the human species, and some of the earliest archeological evidence for scientific reasoning is tens of thousands of years old. The earliest written records in the history of science come from Ancient Egypt and Mesopotamia in around 3000 to 1200 BCE. Their contributions to mathematics, astronomy, and medicine entered and shaped Greek natural philosophy of classical antiquity, whereby formal attempts were made to provide explanations of events in the physical world based on natural causes. After the fall of the Western Roman Empire, knowledge of Greek conceptions of the world deteriorated in Western Europe during the early centuries (400 to 1000 CE) of the Middle Ages, but was preserved in the Muslim world during the Islamic Golden Age and later by the efforts of Byzantine Greek scholars who brought Greek man ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BBC News
BBC News is an operational business division of the British Broadcasting Corporation (BBC) responsible for the gathering and broadcasting of news and current affairs in the UK and around the world. The department is the world's largest broadcast news organisation and generates about 120 hours of radio and television output each day, as well as online news coverage. The service maintains 50 foreign news bureaus with more than 250 correspondents around the world. Deborah Turness has been the CEO of news and current affairs since September 2022. In 2019, it was reported in an Ofcom report that the BBC spent £136m on news during the period April 2018 to March 2019. BBC News' domestic, global and online news divisions are housed within the largest live newsroom in Europe, in Broadcasting House in central London. Parliamentary coverage is produced and broadcast from studios in London. Through BBC English Regions, the BBC also has regional centres across England and national news c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
WebMD
WebMD is an American corporation known primarily as an online publisher of news and information pertaining to human health and well-being. The site includes information pertaining to drugs. It is one of the top healthcare websites. It was founded in 1998 by internet entrepreneur Jeff Arnold. In early 1999, it was part of a three way merger with Sapient Health Network (SHN) and Direct Medical Knowledge (DMK). SHN began in Portland, Oregon, in 1996 by Jim Kean, Bill Kelly, and Kris Nybakken, who worked together at a CD-ROM publishing firm, Creative Multimedia. Later in 1999, WebMD merged with Healtheon, founded by Netscape Communications founder James H. Clark. Traffic During March 2020, WebMD's network of websites reached more unique visitors each month than any other leading private or government healthcare website, making it the leading health publisher in the United States. In the fourth quarter of 2016, WebMD recorded an average of 179.5 million unique users per month, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fat Virus
The term "infectobesity" refers to the hypothesis that obesity in humans can be caused by pathogenic organisms, and the emerging field of medical research that studies the relationship between pathogens and weight gain. The term was coined in 2001 by Dr. Nikhil V. Dhurandhar, at the Pennington Biomedical Research Center. Bacteria The study of the effect of infectious agents on metabolism is still in its early stages. Gut flora has been shown to differ between lean and obese humans. There is an indication that gut flora in obese and lean individuals can affect the metabolic potential. This apparent alteration of the metabolic potential is believed to confer a greater capacity to harvest energy contributing to obesity. Whether these differences are the direct cause or the result of obesity has yet to be determined unequivocally. A possible mechanistic explanation linking gut flora to obesity involves short chain fatty acids. Humans are unable to digest complex polysaccharides and re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LiveScience
Live Science is a science news website run by Future via Purch, which it purchased from Imaginova in 2009. Stories and editorial commentary are typically syndicated to major news outlets, such as Yahoo!, MSNBC, AOL, and Fox News.{{fact, date=March 2020 Live Science was originally launched in 2004, but was subsequently shut down and re-launched in 2007. Live Science covers scientific breakthroughs, research ventures and odd facts from around the world in an online newsmagazine format. Purch consumer brands (including Live Science) were acquired by Future in 2018.{{Cite web , url=https://www.futureplc.com/brand/live-science/ , title=Live Science , work=Future plc Future plc is an international multimedia company established in the United Kingdom in 1985. The company has over 220 brands that span magazines, newsletters, websites, and events in fields such as video games, technology, films, music, photogr ... , access-date=18 December 2018 References {{reflist External links ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibodies
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the pathogen, called an antigen. Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision. Using this binding mechanism, an antibody can ''tag'' a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. In contrast, the remainder of the antibody is relatively constant. It only occurs in a few vari ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human
Humans (''Homo sapiens'') are the most abundant and widespread species of primate, characterized by bipedalism and exceptional cognitive skills due to a large and complex brain. This has enabled the development of advanced tools, culture, and language. Humans are highly social and tend to live in complex social structures composed of many cooperating and competing groups, from families and kinship networks to political states. Social interactions between humans have established a wide variety of values, social norms, and rituals, which bolster human society. Its intelligence and its desire to understand and influence the environment and to explain and manipulate phenomena have motivated humanity's development of science, philosophy, mythology, religion, and other fields of study. Although some scientists equate the term ''humans'' with all members of the genus ''Homo'', in common usage, it generally refers to ''Homo sapiens'', the only extant member. Anatomically moder ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adipose Tissue
Adipose tissue, body fat, or simply fat is a loose connective tissue composed mostly of adipocytes. In addition to adipocytes, adipose tissue contains the stromal vascular fraction (SVF) of cells including preadipocytes, fibroblasts, vascular endothelial cells and a variety of immune cells such as adipose tissue macrophages. Adipose tissue is derived from preadipocytes. Its main role is to store energy in the form of lipids, although it also cushions and insulates the body. Far from being hormonally inert, adipose tissue has, in recent years, been recognized as a major endocrine organ, as it produces hormones such as leptin, estrogen, resistin, and cytokines (especially TNFα). In obesity, adipose tissue is also implicated in the chronic release of pro-inflammatory markers known as adipokines, which are responsible for the development of metabolic syndrome, a constellation of diseases including, but not limited to, type 2 diabetes, cardiovascular disease and atherosclerosis. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stem Cell
In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can differentiate into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type of cell in a cell lineage. They are found in both embryonic and adult organisms, but they have slightly different properties in each. They are usually distinguished from progenitor cells, which cannot divide indefinitely, and precursor or blast cells, which are usually committed to differentiating into one cell type. In mammals, roughly 50–150 cells make up the inner cell mass during the blastocyst stage of embryonic development, around days 5–14. These have stem-cell capability. ''In vivo'', they eventually differentiate into all of the body's cell types (making them pluripotent). This process starts with the differentiation into the three germ layers – the ectoderm, mesoderm and endoderm – at the gastrulation stage. However ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
