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Arthur Riggs (geneticist)
Arthur Dale Riggs (August 8, 1939 – March 23, 2022) was an American geneticist who worked with Genentech to express the first artificial gene in bacteria. His work was critical to the modern biotechnology industry because it was the first use of molecular techniques in commercial production of drugs and enabled the large-scale manufacturing of protein drugs, including insulin. He was also a major factor in the origin of epigenetics. Riggs was a professor of biology and, in 2014, founding director of the Diabetes & Metabolism Research Institute of City of Hope National Medical Center. He was the founding dean of City of Hope's graduate school, the Irell & Manella Graduate School of Biological Sciences. He was also director emeritus of the Beckman Research Institute of City of Hope National Medical Center, which he headed from 2000 to 2007. Riggs served on the board of trustees at the Keck Graduate Institute of Applied Life Sciences. In 2006, Riggs was elected to the Nationa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Modesto, California
Modesto () is the county seat and largest city of Stanislaus County, California, United States. With a population of 218,464 at the 2020 census, it is the 19th largest city in the state of California and forms part of the Sacramento-Stockton-Modesto Combined Statistical Area. Modesto is located in the Central Valley, south of Sacramento and north of Fresno. Distances from other places include: north of Merced, California, east of San Francisco, west of Yosemite National Park, and south of Stockton. The city is surrounded by rich farmland. Stanislaus County ranks sixth among California counties in farm production. It is home to Gallo Family Winery, the largest family-owned winery in the United States. Led by milk, almonds, chickens, walnuts, and corn silage, the county grossed nearly $3.1 billion in agricultural production in 2011. The farm-to-table movement plays a central role in Modesto living as in the Central Valley. Modesto has been honored as a Tree Ci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Irell & Manella Graduate School Of Biological Sciences
The Irell & Manella Graduate School of Biological Sciences (formerly the City of Hope Graduate School of Biological Sciences) is a graduate school for biology in the City of Hope National Medical Center in Duarte, California. Program The Irell & Manella Graduate School of Biological Sciences is a doctoral and masters program that trains students to become research scientists with expertise in chemical, molecular, and cellular biology. Graduates of this program are awarded the degree of Doctor of Philosophy (Ph.D.) in Biological Sciences or the degree of Master of Science (M.S.) in Translational Medicine, and as such are equipped to address fundamental questions in the life sciences and biomedicine. Most graduates pursue careers in academia, industry, or government. The school is housed at the Beckman Research Institute of the City of Hope National Medical Center. It is accredited by the Accrediting Commission for Senior Colleges and Universities of the Western Association of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein–DNA Interaction
DNA-binding proteins are proteins that have DNA-binding domains and thus have a specific or general affinity for single- or double-stranded DNA. Sequence-specific DNA-binding proteins generally interact with the major groove of B-DNA, because it exposes more functional groups that identify a base pair. However, there are some known minor groove DNA-binding ligands such as netropsin, distamycin, Hoechst 33258, pentamidine, DAPI and others. Examples DNA-binding proteins include transcription factors which modulate the process of transcription, various polymerases, nucleases which cleave DNA molecules, and histones which are involved in chromosome packaging and transcription in the cell nucleus. DNA-binding proteins can incorporate such domains as the zinc finger, the helix-turn-helix, and the leucine zipper (among many others) that facilitate binding to nucleic acid. There are also more unusual examples such as transcription activator like effectors. Non-specific DNA-protei ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salk Institute
The Salk Institute for Biological Studies is a scientific research institute located in the La Jolla community of San Diego, California, U.S. The independent, non-profit institute was founded in 1960 by Jonas Salk, the developer of the polio vaccine; among the founding consultants were Jacob Bronowski and Francis Crick. Construction of the research facilities began in spring of 1962. The Salk Institute consistently ranks among the top institutions in the US in terms of research output and quality in the life sciences. In 2004, the ''Times Higher Education Supplement'' ranked Salk as the world's top biomedicine research institute, and in 2009 it was ranked number one globally by '' ScienceWatch'' in the neuroscience and behavior areas. The Salk Institute employs 850 researchers in 60 research groups and focuses its research in three areas: molecular biology and genetics; neurosciences; and plant biology. Research topics include aging, cancer, diabetes, birth defects, Alzheimer's dis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Giuseppe Attardi
Giuseppe Attardi (September 14, 1923 – April 5, 2008) was an American molecular biologist of Italian origin, a professor at the California Institute of Technology in Pasadena. He made pioneering studies on the human mitochondrial structure and function.Thomas H. Maugh II, "Giuseppe Attardi, 84; Caltech geneticist linked mitochondrial DNA and aging" – ''Los Angeles Times (April 10, 2008)'' (Retrieved on May 24, 2008) – ''Aarp Bulletin'' (Retrieved on May 24, 2008) He received the |
DNA Replication
In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule. DNA replication occurs in all living organisms acting as the most essential part for biological inheritance. This is essential for cell division during growth and repair of damaged tissues, while it also ensures that each of the new cells receives its own copy of the DNA. The cell possesses the distinctive property of division, which makes replication of DNA essential. DNA is made up of a double helix of two complementary strands. The double helix describes the appearance of a double-stranded DNA which is thus composed of two linear strands that run opposite to each other and twist together to form. During replication, these strands are separated. Each strand of the original DNA molecule then serves as a template for the production of its counterpart, a process referred to as semiconservative replication. As a result of semi-conservative rep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mammal
Mammals () are a group of vertebrate animals constituting the class Mammalia (), characterized by the presence of mammary glands which in females produce milk for feeding (nursing) their young, a neocortex (a region of the brain), fur or hair, and three middle ear bones. These characteristics distinguish them from reptiles (including birds) from which they diverged in the Carboniferous, over 300 million years ago. Around 6,400 extant species of mammals have been described divided into 29 orders. The largest orders, in terms of number of species, are the rodents, bats, and Eulipotyphla (hedgehogs, moles, shrews, and others). The next three are the Primates (including humans, apes, monkeys, and others), the Artiodactyla ( cetaceans and even-toed ungulates), and the Carnivora (cats, dogs, seals, and others). In terms of cladistics, which reflects evolutionary history, mammals are the only living members of the Synapsida (synapsids); this clade, together with Saur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemistry
Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions: their composition, structure, properties, behavior and the changes they undergo during a Chemical reaction, reaction with other Chemical substance, substances. Chemistry also addresses the nature of chemical bonds in chemical compounds. In the scope of its subject, chemistry occupies an intermediate position between physics and biology. It is sometimes called the central science because it provides a foundation for understanding both Basic research, basic and Applied science, applied scientific disciplines at a fundamental level. For example, chemistry explains aspects of plant growth (botany), the formation of igneous rocks (geology), how atmospheric ozone is formed and how environmental pollutants are degraded (ecology), the properties ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trailer Park
A trailer park,caravan park, mobile home park, mobile home community or manufactured home community is a temporary or permanent area for mobile homes and travel trailers. Advantages include low cost compared to other housing, and quick and easy moving to a new area (for example, when taking a job in a distant place while keeping the same home). Trailer parks, especially in American culture, are stereotypically viewed as lower income housing for occupants living at or below the poverty line who have low social status. Despite the advances in trailer home technology, the trailer park image survives as evoked by a statement from Presidential adviser James Carville who, in the course of one of the Bill Clinton White House political scandals, suggested "Drag $100 bills through trailer parks, there's no telling what you'll find," in reference to Paula Jones. Tornadoes and hurricanes often inflict serious damage on trailer parks, usually because the structures are not secured to the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
San Bernardino High School
San Bernardino High School (SBHS) is an American public high school and city located at 1850 North E Street within San Bernardino, California and a member of the San Bernardino City Unified School District. SBHS was granted charter as a city in 1963, under the name Cardinal City after the school's mascot, the Cardinal. SBHS is the oldest high school in the City of San Bernardino. History San Bernardino High School was officially established when residents of the San Bernardino, California approved a $60,000 bond for construction of a high school in 1891. Construction of a three story-building at the southwest corner of Eighth and E Streets was completed in 1892 and received state accreditation in 1893 as San Bernardino Polytechnic High School. In 1915, after enrollment had exceeded 400 students, a new campus was built consisting of five main buildings. In 1963, California Governor Edmund G. Brown granted the SBHS a city charter under the name Cardinal City. Academics San Bernard ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
San Bernardino, California
San Bernardino (; Spanish for "Saint Bernardino") is a city and county seat of San Bernardino County, California, United States. Located in the Inland Empire region of Southern California, the city had a population of 222,101 in the 2020 census, making it the 18th-largest city in California. San Bernardino is the economic, cultural, and political hub of the San Bernardino Valley and the Inland Empire. The governments of El Salvador, Guatemala, and Mexico have established the metropolitan area’s only consulates in the downtown area of the city. Additionally, San Bernardino serves as an anchor city to the 3rd largest metropolitan area in California (after Los Angeles and San Francisco) and the 13th largest metropolitan area in the United States; the San Bernardino-Riverside MSA. Furthermore, the city’s University District serves as a college town, as home to California State University, San Bernardino. San Bernardino was named in 1810, when Spanish priest Francisco Du ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Great Depression
The Great Depression (19291939) was an economic shock that impacted most countries across the world. It was a period of economic depression that became evident after a major fall in stock prices in the United States. The economic contagion began around September and led to the Wall Street stock market crash of October 24 (Black Thursday). It was the longest, deepest, and most widespread depression of the 20th century. Between 1929 and 1932, worldwide gross domestic product (GDP) fell by an estimated 15%. By comparison, worldwide GDP fell by less than 1% from 2008 to 2009 during the Great Recession. Some economies started to recover by the mid-1930s. However, in many countries, the negative effects of the Great Depression lasted until the beginning of World War II. Devastating effects were seen in both rich and poor countries with falling personal income, prices, tax revenues, and profits. International trade fell by more than 50%, unemployment in the U.S. rose to 23% and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
