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Anhalidine
Anhalidine is a naturally occurring tetrahydroisoquinoline based alkaloid which can be isolated from ''Lophophora williamsii The peyote (; ''Lophophora williamsii'' ) is a small, spineless cactus which contains psychoactive alkaloids, particularly mescaline. ''Peyote'' is a Spanish word derived from the Nahuatl (), meaning "caterpillar cocoon", from a root , "to ...''; it has also been detected other cactii and several species of '' Acacia''. It is part of a family of compounds that are structurally related to mescaline. See also * Pellotine References Lophophora Isoquinoline alkaloids Norsalsolinol ethers {{alkaloid-stub ...
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Pellotine
Pellotine is an alkaloid found in ''Lophophora'' species. Pellotine is slightly narcotic, and has been used by Native Americans as a constituent of peyote for sacramental purposes. Psychological and physiological effects 8-10 mg of isolated pellotine is known to cause convulsions in frogs. When injected subcutaneously to humans, participants have reported drowsiness and a desire not to exert any physical or mental effort with one study reporting it to have hypnotic effects. It is also reported to lower blood pressure and heart rate. Ancient use Native inhabitants of north-eastern Mexico around 810–1070 CE (according to carbon dating) are thought to have used a number of "mescal beans" containing pellotine, among other alkaloids and mescaline. While it is known that these pellotine-containing beans were ornamental, it is unclear whether they were used for their psychoactive effects. See also * Anhalamine * Anhalidine Anhalidine is a naturally occurring tetrahydroisoqu ...
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Tetrahydroisoquinoline
Tetrahydroisoquinoline (TIQ or THIQ) is an organic compound with the chemical formula C9H11N. Classified as a secondary amine, it is derived from isoquinoline by hydrogenation. It is a colorless viscous liquid that is miscible with most organic solvents. The tetrahydroisoquinoline skeleton is encountered in a number of bioactive compounds and drugs. Reactions As a secondary amine, tetrahydroisoquinoline has weakly basic properties and forms salts with strong acids. It can be dehydrogenated to give isoquinoline and hydrogenated to decahydroisoquinoline. Like other secondary amines, tetrahydroisoquinoline can be oxidized to the corresponding nitrone using hydrogen peroxide, catalyzed by selenium dioxide. Toxicology Tetrahydroisoquinoline derivatives may be formed in the body as metabolites of some drugs, and this was once thought to be involved in the development of alcoholism. This theory has now been discredited and is no longer generally accepted by the scientific community, ...
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Alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids
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Alkaloids are produced by a large variety of organisms including , , Medicinal plant, plants, an ...
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Lophophora Williamsii
The peyote (; ''Lophophora williamsii'' ) is a small, spineless cactus which contains psychoactive alkaloids, particularly mescaline. ''Peyote'' is a Spanish word derived from the Nahuatl (), meaning "caterpillar cocoon", from a root , "to glisten". p. 246. See peyotl in Wiktionary. Peyote is native to Mexico and southwestern Texas. It is found primarily in the Sierra Madre Occidental, the Chihuahuan Desert and in the states of Nayarit, Coahuila, Nuevo León, Tamaulipas, and San Luis Potosí among scrub. It flowers from March to May, and sometimes as late as September. The flowers are pink, with thigmotactic anthers (like ''Opuntia''). Known for its psychoactive properties when ingested, peyote has at least 5,500 years of entheogenic and medicinal use by indigenous North Americans. Description The various species of the genus ''Lophophora'' grow low to the ground and they often form groups with numerous, crowded shoots. The blue-green, yellow-green or sometimes reddish-g ...
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Cactii
A cactus (, or less commonly, cactus) is a member of the plant family Cactaceae, a family comprising about 127 genera with some 1750 known species of the order Caryophyllales. The word ''cactus'' derives, through Latin, from the Ancient Greek word (''káktos''), a name originally used by Theophrastus for a spiny plant whose identity is now not certain. Cacti occur in a wide range of shapes and sizes. Although some species live in quite humid environments, most cacti live in habitats subject to at least some drought. Many live in extremely dry environments, even being found in the Atacama Desert, one of the driest places on Earth. Because of this, cacti show many adaptations to conserve water. For example, almost all cacti are succulents, meaning they have thickened, fleshy parts adapted to store water. Unlike many other succulents, the stem is the only part of most cacti where this vital process takes place. Most species of cacti have lost true leaves, retaining only spines, ...
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Acacia
''Acacia'', commonly known as the wattles or acacias, is a large genus of shrubs and trees in the subfamily Mimosoideae of the pea family Fabaceae. Initially, it comprised a group of plant species native to Africa and Australasia. The genus name is New Latin, borrowed from the Greek (), a term used by Dioscorides for a preparation extracted from the leaves and fruit pods of ''Vachellia nilotica'', the original type of the genus. In his ''Pinax'' (1623), Gaspard Bauhin mentioned the Greek from Dioscorides as the origin of the Latin name. In the early 2000s it had become evident that the genus as it stood was not monophyletic and that several divergent lineages needed to be placed in separate genera. It turned out that one lineage comprising over 900 species mainly native to Australia, New Guinea, and Indonesia was not closely related to the much smaller group of African lineage that contained ''A. nilotica''—the type species. This meant that the Australasian lineage (by ...
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Mescaline
Mescaline or mescalin (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic protoalkaloid of the substituted phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin. Biological sources It occurs naturally in several species of cacti. It is also found in small amounts in certain members of the bean family, Fabaceae, including ''Acacia berlandieri''. However those claims concerning ''Acacia'' species have been challenged and have been unsupported in any additional analysis. History and use Peyote has been used for at least 5,700 years by Indigenous peoples of the Americas in Mexico. Europeans noted use of peyote in Native American religious ceremonies upon early contact, notably by the Huichols in Mexico. Other mescaline-containing cacti such as the San Pedro have a long history of use in South America, from Peru to Ecuador. While religious and ceremonial peyote use was widespread in the Aztec empire and northern M ...
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Lophophora
''Lophophora'' () is a genus of spineless, button-like cacti. Its area range covers southern through northeastern and north-central Mexico to Querétaro in central Mexico. The species are extremely slow growing, sometimes taking up to thirty years to reach flowering age (at the size of about a golf ball, excluding the root) in the wild. Cultivated specimens grow considerably faster, usually taking between three and ten years to reach from seedling to mature flowering adult. The slow rate of reproduction and over-harvesting by collectors render the species under threat in the wild. Taxonomy ''Lophophora'' means "crest-bearing", referring to the tufts of trichomes that adorn each tubercle. ''Lophophora'' has been reported to have two species, '' L. diffusa'' and '' L. williamsii''. Another three species have been proposed: ''L. fricii'', ''L. koehresii'', and ''L. alberto-vojtechii''. Recent DNA sequencing studies (Butterworth et al. 2002) have shown that ''L. diffusa'' and ''L. w ...
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Isoquinoline Alkaloids
Isoquinoline alkaloids are natural products of the group of alkaloids, which are chemically derived from isoquinoline. They form the largest group among the alkaloids. Isoquinoline alkaloids can be further classified based on their different chemical basic structures. The most common structural types are the benzylisoquinolines and the aporphines.Bettina Ruff: ''Chemische und biochemische Methoden zur stereoselektiven Synthese von komplexen Naturstoffen.'' Verlag Logos, Berlin 2012, , S. 8. () According to current knowledge, a total of about 2500 isoquinoline alkaloids are known nowadays, which are mainly formed by plants.Jennifer M. Finefield, David H. Sherman, Martin Kreitman, Robert M. Williams: ''Enantiomere Naturstoffe: Vorkommen und Biogenese.'' In: ''Angewandte Chemie.'' Wiley-VCH, Weinheim 2012, doi:10.1002/ange.201107204, S. 4905–4915. Known examples Morphin - Morphine.svg, Morphine Codein - Codeine.svg, Codeine Papaverin - Papaverine.svg, Papaverine Berbe ...
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