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Anacardone
Nikethamide is a stimulant which mainly affects the respiratory cycle. Widely known by its former trade name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overdoses, before the advent of endotracheal intubation and positive-pressure lung expansion. It is no longer commonly considered to be of value for such purposes. In alternate terminology, it is known as ''nicotinic acid diethylamide'', which meaningfully emphasizes its laboratory origins, and of which its common name is derived as a blend. Former and current medical use Coramine was used by suspected serial killer John Bodkin Adams when treating patient Gertrude Hullett, whom he was suspected of murdering. However, the toxicity of nikethamide is quite low ( rabbits 650 mg/kg oral, LD50 rats 240 mg/kg subcutaneous). Theodor Morell, Adolf Hitler's personal physician, would inject the German ruler with Coramine when Hitler was unduly sedated with barbiturates ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stimulant
Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and invigorating, or drugs that have Sympathomimetic drug, sympathomimetic effects. Stimulants are widely used throughout the world as prescription medicines as well as without a prescription (either legally or Prohibition (drugs), illicitly) as performance-enhancing substance, performance-enhancing or recreational drug use, recreational drugs. Among narcotics, stimulants produce a noticeable crash or ''Comedown (drugs), comedown'' at the end of their effects. The most frequently prescribed stimulants as of 2013 were lisdexamfetamine (Vyvanse), methylphenidate (Ritalin), and amphetamine (Adderall). It was estimated in 2015 that the percentage of the world population that had used cocaine during a year was 0.4%. For the category "amphetamines and p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
World Anti-Doping Agency
The World Anti-Doping Agency (WADA; french: Agence mondiale antidopage, AMA) is a foundation initiated by the International Olympic Committee based in Canada to promote, coordinate, and monitor the fight against drugs in sports. The agency's key activities include scientific research, education, development of anti-doping capacities, and monitoring of the World Anti-Doping Code, whose provisions are enforced by the UNESCO International Convention Against Doping in Sport. The aims of the Council of Europe Anti-Doping Convention and the United States Anti-Doping Agency are also closely aligned with those of WADA. History The World Anti-Doping Agency is a foundation created through a collective initiative led by the International Olympic Committee (IOC). It was set up on 10 November 1999 in Lausanne, Switzerland, as a result of what was called the "Declaration of Lausanne", to promote, coordinate and monitor the fight against drugs in sports. Since 2002, the organization's head ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nicorandil
Nicorandil is a vasodilatory drug used to treat angina. Angina is chest pain that results from episodes of transient myocardial ischemia. This can be caused by diseases such as atherosclerosis, coronary artery disease and aortic stenosis. Angina commonly arises from vasospasm of the coronary arteries. There are multiple mechanisms causing the increased smooth muscle contraction involved in coronary vasospasm, including increased Rho-kinase activity. Increased levels of Rho-kinase inhibit myosin phosphatase activity, leading to increased calcium sensitivity and hypercontraction. Rho-kinase also decreases nitric oxide synthase activity, which reduces nitric oxide concentrations. Lower levels of nitric oxide are present in spastic coronary arteries. L-type calcium channel expression increases in spastic vascular smooth muscle cells, which could result in excessive calcium influx, and hypercontraction. It was patented in 1976 and approved for medical use in 1983. Side eff ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tokyo
Tokyo (; ja, 東京, , ), officially the Tokyo Metropolis ( ja, 東京都, label=none, ), is the capital and largest city of Japan. Formerly known as Edo, its metropolitan area () is the most populous in the world, with an estimated 37.468 million residents ; the city proper has a population of 13.99 million people. Located at the head of Tokyo Bay, the prefecture forms part of the Kantō region on the central coast of Honshu, Japan's largest island. Tokyo serves as Japan's economic center and is the seat of both the Japanese government and the Emperor of Japan. Originally a fishing village named Edo, the city became politically prominent in 1603, when it became the seat of the Tokugawa shogunate. By the mid-18th century, Edo was one of the most populous cities in the world with a population of over one million people. Following the Meiji Restoration of 1868, the imperial capital in Kyoto was moved to Edo, which was renamed "Tokyo" (). Tokyo was devastate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2020 Summer Olympics
The , officially the and also known as , was an international multi-sport event held from 23 July to 8 August 2021 in Tokyo, Japan, with some preliminary events that began on 21 July. Tokyo was selected as the host city during the 125th IOC Session in Buenos Aires, Argentina, on 7 September 2013. The Games were originally scheduled to take place from 24 July to 9 August 2020, but due to the global COVID-19 pandemic, on 24 March 2020, the event was postponed to 2021, the first such instance in the history of the Olympic Games (previous games had been cancelled but not rescheduled). However, the event retained the ''Tokyo 2020'' branding for marketing purpose.Multiple sources: * * * It was largely held behind closed doors with no public spectators permitted due to the declaration of a state of emergency in the Greater Tokyo Area in response to the pandemic, the first and so far only Olympic Games to be held without official spectators. The Games were the mos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kariem Hussein
Kariem Hussein (born 4 January 1989) is a Swiss athlete who specialises in the 400 metres hurdles. His first major success was the gold medal at the 2014 European Championships in Zürich. His personal best in the event is 48.45, set at a meeting in Zug in 2015 and again at Weltklasse Zürich in 2017. It is also technically his fastest flat 400m because he has not attempted the distance since 2009 when his PR was 48.58. Hussein was born in Münsterlingen. His father, a former international volleyball player, is Egyptian and his mother is Swiss. Doping On 23 July 2021 he was banned by the Swiss Anti-Doping Agency from competing for 9 months, after a banned substance (nikethamide) was confirmed in the probes taken from him. This decision meant Hussein missed the 2020 Summer Olympics in Tokyo. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Germany
Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated between the Baltic and North seas to the north, and the Alps to the south; it covers an area of , with a population of almost 84 million within its 16 constituent states. Germany borders Denmark to the north, Poland and the Czech Republic to the east, Austria and Switzerland to the south, and France, Luxembourg, Belgium, and the Netherlands to the west. The nation's capital and most populous city is Berlin and its financial centre is Frankfurt; the largest urban area is the Ruhr. Various Germanic tribes have inhabited the northern parts of modern Germany since classical antiquity. A region named Germania was documented before AD 100. In 962, the Kingdom of Germany formed the bulk of the Holy Roman Empire. During the 16th ce ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kart
Kart racing or karting is a road racing variant of motorsport with open-wheel, four-wheeled vehicles known as go-karts or shifter karts. They are usually raced on scaled-down circuits, although some professional kart races are also held on full-size motorsport circuits. Karting is commonly perceived as the stepping stone to the higher ranks of motorsports, with most of Formula One champions including Sebastian Vettel, Nico Rosberg, Ayrton Senna, Max Verstappen, Lewis Hamilton, Michael Schumacher, Kimi Räikkönen, and Fernando Alonso having begun their careers in karting. Karts vary widely in speed and some (known as superkarts) can reach speeds exceeding , while recreational go-karts intended for the general public may be limited to lower speeds. History American Art Ingels is generally accepted to be the father of karting. A veteran hot rodder and a race car builder at Kurtis Kraft, he built the first kart in Southern California in 1956. Early karting events were held i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tennis (magazine)
''Tennis'' is a U.S. print sports magazine devoted to the sport of tennis. It is published eight months per year, and operates a website, Tennis.com. History The magazine was established in May 1965, published out of Chicago with a regional focus. Asher Birnbaum of Skokie, IL was the founder, editor and publisher. The tennis boom of the 1970s resulted in a rapid expansion of the magazine, both in scope and circulation. In addition to top tennis stars, celebrities like Johnny Carson and Farrah Fawcett appeared on the cover. It was owned by Golf Digest / Tennis Magazine and sold to the New York Times Company. Miller Publishing bought the magazine in 1997 from The New York Times Company. It brought on two retired champions as part owners and contributors: first Chris Evert in 2000 then Pete Sampras in 2003. In the early 2010s the circulation was 600,000 subscriptions, the majority of which were purchased by the United States Tennis Association (USTA) for its members. In 2014, pub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BBC News
BBC News is an operational business division of the British Broadcasting Corporation (BBC) responsible for the gathering and broadcasting of news and current affairs in the UK and around the world. The department is the world's largest broadcast news organisation and generates about 120 hours of radio and television output each day, as well as online news coverage. The service maintains 50 foreign news bureaus with more than 250 correspondents around the world. Deborah Turness has been the CEO of news and current affairs since September 2022. In 2019, it was reported in an Ofcom report that the BBC spent £136m on news during the period April 2018 to March 2019. BBC News' domestic, global and online news divisions are housed within the largest live newsroom in Europe, in Broadcasting House in central London. Parliamentary coverage is produced and broadcast from studios in London. Through BBC English Regions, the BBC also has regional centres across England and national news c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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