Alysson Muotri
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Alysson Muotri
Alysson Renato Muotri is a Brazilian researcher from the University of California (UCSD), United States, where he has been working since 2008. He is also the director of the Stem-Cell Program of the UCSD. He's research is about the frontier themes on genetics and neuroscience, like the development of the human nervous system using brain organoids developed from stem cells. He is currently the Brazilian biologist with the largest number of high impact scientific publications. Biography Muotri has a degree in biological sciences from the State University of Campinas (Unicamp) and a PhD in genetic biology from the University of São Paulo (USP). He has experience in genetics, with an emphasis on human and medical genetics, working mainly on the following subjects: DNA repair, viral vectors, cancer, autism, gene therapy and gene modulation. He was one of the first researchers to cultivate embryonic stem cells. From the beginning of his academic life, Muotri was interested in stu ...
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State University Of Campinas
The State University of Campinas ( pt, Universidade Estadual de Campinas), commonly called Unicamp, is a public research university in the state of São Paulo, Brazil. Unicamp is consistently ranked among the top universities in Brazil and Latin America. Established in 1962, Unicamp was designed from scratch as an integrated research center unlike other top Brazilian universities, usually created by the consolidation of previously existing schools and institutes. Its research focus reflects on almost half of its students being graduate students, the largest proportion across all large universities in Brazil, and also in the large number of graduate programs it offers: 153 compared to 70 undergraduate programs. It also offers several non-degree granting open-enrollment courses to around 8,000 students through its extension school. Its main campus occupies located in the district of Barão Geraldo, a suburban area from the downtown center of Campinas, built shortly after the c ...
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Shinya Yamanaka
is a Japanese stem cell researcher and a Nobel Prize laureate. He serves as the director of Center for iPS Cell (induced Pluripotent Stem Cell) Research and Application and a professor at the Institute for Frontier Medical Sciences at Kyoto University; as a senior investigator at the UCSF-affiliated Gladstone Institutes in San Francisco, California; and as a professor of anatomy at University of California, San Francisco (UCSF). Yamanaka is also a past president of the International Society for Stem Cell Research (ISSCR). He received the 2010 BBVA Foundation Frontiers of Knowledge Award in the biomedicine category, the 2011 Wolf Prize in Medicine with Rudolf Jaenisch, and the 2012 Millennium Technology Prize together with Linus Torvalds. In 2012, he and John Gurdon were awarded the Nobel Prize for Physiology or Medicine for the discovery that mature cells can be converted to stem cells. In 2013, he was awarded the $3 million Breakthrough Prize in Life Sciences for his work. ...
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University Of California, San Diego Faculty
A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States, the designation is reserved for colleges that have a graduate school. The word ''university'' is derived from the Latin ''universitas magistrorum et scholarium'', which roughly means "community of teachers and scholars". The first universities were created in Europe by Catholic Church monks. The University of Bologna (''Università di Bologna''), founded in 1088, is the first university in the sense of: *Being a high degree-awarding institute. *Having independence from the ecclesiastic schools, although conducted by both clergy and non-clergy. *Using the word ''universitas'' (which was coined at its foundation). *Issuing secular and non-secular degrees: grammar, rhetoric, logic, theology, canon law, notarial law.Hunt Janin: "The university ...
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Microcephaly
Microcephaly (from New Latin ''microcephalia'', from Ancient Greek μικρός ''mikrós'' "small" and κεφαλή ''kephalé'' "head") is a medical condition involving a smaller-than-normal head. Microcephaly may be present at birth or it may develop in the first few years of life. Since brain growth is correlated with head growth, people with this disorder often have an intellectual disability, poor motor function, poor speech, abnormal facial features, seizures and dwarfism. The disorder is caused by a disruption to the genetic processes that form the brain early in pregnancy, though the cause is not identified in most cases. Many genetic syndromes can result in microcephaly, including chromosomal and single-gene conditions, though almost always in combination with other symptoms. Mutations that result solely in microcephaly (primary microcephaly) exist but are less common. External toxins to the embryo, such as alcohol during pregnancy or vertically transmitted infec ...
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Rett Syndrome
Rett syndrome (RTT) is a genetic disorder that typically becomes apparent after 6–18 months of age and almost exclusively in females. Symptoms include impairments in language and coordination, and repetitive movements. Those affected often have slower growth, difficulty walking, and a smaller head size. Complications of Rett syndrome can include seizures, scoliosis, and sleeping problems. The severity of the condition is variable. Rett syndrome is due to a genetic mutation in the MECP2 gene, on the X chromosome. It almost always occurs as a new mutation, with less than one percent of cases being inherited from a person's parents. It occurs almost exclusively in girls; boys who have a similar mutation typically die shortly after birth. Diagnosis is based on the symptoms and can be confirmed with genetic testing. There is no known cure for Rett syndrome. Treatment is directed at improving symptoms. Anticonvulsants may be used to help with seizures. Special education, ph ...
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Autism Spectrum
The autism spectrum, often referred to as just autism or in the context of a professional diagnosis autism spectrum disorder (ASD) or autism spectrum condition (ASC), is a neurodevelopmental condition (or conditions) characterized by difficulties in social interaction, verbal and nonverbal communication, and the presence of repetitive behavior and restricted interests. Other common signs include unusual responses to sensory stimuli. Autism is generally understood as a ''spectrum disorder'', which means that it can manifest differently in each person: any given autistic individual is likely to show some, but not all, of the characteristics associated with it, and the person may exhibit them to varying degrees. Some autistic people remain nonspeaking over the course of their lifespan, while others have relatively unimpaired spoken language. There is large variation in the level of support people require, and the same person may present differently at varying times. Historically, ...
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Introvertendo
''Introvertendo'' (Portuguese for ''Introvert'') is a Brazilian podcast launched in May 2018. The podcast features a group of autistic people discussing the condition and has become popular among the Brazilian autism community. History In April 2016, a therapeutic group for people diagnosed with Asperger syndrome, an autism spectrum disorder, was created at the Federal University of Goiás, in Goiânia, Brazil Brazil ( pt, Brasil; ), officially the Federative Republic of Brazil (Portuguese: ), is the largest country in both South America and Latin America. At and with over 217 million people, Brazil is the world's fifth-largest country by area .... The group was formed by five people – Luca, Marcos, Michael, Otavio and Tiago – that later became the founders of ''Introvertendo''. The first ''Introvertendo'' episode was released in May 2018. It was the first Brazilian podcast produced by autistic people. In 2019, ''Introvertendo'' hosts started publishing in '' ...
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Autism Rights Movement
The autism spectrum, often referred to as just autism or in the context of a professional diagnosis autism spectrum disorder (ASD) or autism spectrum condition (ASC), is a neurodevelopmental condition (or conditions) characterized by difficulties in social interaction, verbal and nonverbal communication, and the presence of repetitive behavior and restricted interests. Other common signs include unusual responses to sensory stimuli. Autism is generally understood as a ''spectrum disorder'', which means that it can manifest differently in each person: any given autistic individual is likely to show some, but not all, of the characteristics associated with it, and the person may exhibit them to varying degrees. Some autistic people remain nonspeaking over the course of their lifespan, while others have relatively unimpaired spoken language. There is large variation in the level of support people require, and the same person may present differently at varying times. Historically, ...
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International Space Station
The International Space Station (ISS) is the largest modular space station currently in low Earth orbit. It is a multinational collaborative project involving five participating space agencies: NASA (United States), Roscosmos (Russia), JAXA (Japan), ESA (Europe), and CSA (Canada). The ownership and use of the space station is established by intergovernmental treaties and agreements. The station serves as a microgravity and space environment research laboratory in which scientific research is conducted in astrobiology, astronomy, meteorology, physics, and other fields. The ISS is suited for testing the spacecraft systems and equipment required for possible future long-duration missions to the Moon and Mars. The ISS programme evolved from the Space Station ''Freedom'', a 1984 American proposal to construct a permanently crewed Earth-orbiting station, and the contemporaneous Soviet/Russian '' Mir-2'' proposal from 1976 with similar aims. The ISS is the ninth space station to ...
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Sofosbuvir
Sofosbuvir, sold under the brand name Sovaldi among others, is a medication used to treat hepatitis C. It is taken Oral administration, by mouth. Common side effects include fatigue, headache, nausea, and trouble sleeping. Side effects are generally more common in interferon-containing regimens. Sofosbuvir may reactivate hepatitis B in those who have been previously infected. In combination with ledipasvir, daclatasvir or simeprevir, it is not recommended with amiodarone due to the risk of an bradycardia, abnormally slow heartbeat. Sofosbuvir is in the nucleotide analog family of medications and works by blocking the hepatitis C NS5B protein. Sofosbuvir was discovered in 2007 and approved for medical use in the United States in 2013. It is on the WHO Model List of Essential Medicines, World Health Organization's List of Essential Medicines. Medical uses Initial HCV treatment In 2016, the American Association for the Study of Liver Diseases and the Infectious Diseases ...
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Ziraldo
Ziraldo Alves Pinto (born October 24, 1932), usually referred to mononymous person, mononymically as Ziraldo, is a Brazilian author, painter, comic creator, and journalist. His books have sold about ten million copies, have been translated to many foreign languages and adapted to the theater and cinema. His children's books, such as the popular ''O Menino Maluquinho'', have also been the basis of successful films and television series in Brazil. Biography Ziraldo first published his work when he was six years old, a year before he started going to school. This was a drawing printed in the newspaper ''A Folha de Minas'' in 1938. He began working at the newspaper ''Folha de S.Paulo'' in 1954, with a column dedicated to humor. Ziraldo gained national notoriety when he worked at the magazine ''O Cruzeiro'' in 1957 and subsequently at ''Jornal do Brasil'' in 1963. His characters (including Jeremias o Bom, the Supermãe and Mirinho) won readers. In 1960, he launched the first Brazilia ...
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Microcephaly
Microcephaly (from New Latin ''microcephalia'', from Ancient Greek μικρός ''mikrós'' "small" and κεφαλή ''kephalé'' "head") is a medical condition involving a smaller-than-normal head. Microcephaly may be present at birth or it may develop in the first few years of life. Since brain growth is correlated with head growth, people with this disorder often have an intellectual disability, poor motor function, poor speech, abnormal facial features, seizures and dwarfism. The disorder is caused by a disruption to the genetic processes that form the brain early in pregnancy, though the cause is not identified in most cases. Many genetic syndromes can result in microcephaly, including chromosomal and single-gene conditions, though almost always in combination with other symptoms. Mutations that result solely in microcephaly (primary microcephaly) exist but are less common. External toxins to the embryo, such as alcohol during pregnancy or vertically transmitted infec ...
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