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AI Boom
The AI boom, or AI spring, is the ongoing period of rapid Progress in artificial intelligence, progress in the field of artificial intelligence. Prominent examples include AlphaFold, protein folding prediction and Generative artificial intelligence, generative AI, led by laboratories including Google DeepMind and OpenAI. The AI boom is expected to have a profound cultural, philosophical, religious, economic, and social impact, as questions such as AI alignment, ''qualia'', and the development of artificial general intelligence became widely prominent topics of popular discussion. History In 2012, a University of Toronto research team used artificial neural networks and deep learning techniques to lower their error rate below 25% for the first time during the ImageNet challenge for object recognition in computer vision. The event catalyzed the AI boom later in that decade, when many alumni of the ImageNet challenge became leaders in the tech industry. The Generative artificia ...
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Théâtre D'opéra Spatial
''Théâtre D'opéra Spatial'' (French for "Space Opera Theater", ) is an image created by Jason Michael Allen with the generative artificial intelligence platform Midjourney. The image won the 2022 Colorado State Fair's annual fine art competition in the photomanipulation category on September 5, becoming one of the first AI-generated images to win such a prize. Allen said he used at least 624 text prompts and input revisions to get Midjourney to create the image, which he then manipulated with Adobe Photoshop, and enlarged with the Gigapixel AI tool. He disclosed his use of Midjourney when he entered the image in the contest's category of "digital arts/digitally-manipulated photography". The two judges for the category later said they didn't know that Midjourney used artificial intelligence (AI) to generate images, but that they would have awarded Allen the top prize anyway. Some artists accused Allen of cheating. He responded: "I'm not going to apologize for it. I won, an ...
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University Of Toronto
The University of Toronto (UToronto or U of T) is a public research university in Toronto, Ontario, Canada, located on the grounds that surround Queen's Park. It was founded by royal charter in 1827 as King's College, the first institution of higher learning in Upper Canada. Originally controlled by the Church of England, the university assumed its present name in 1850 upon becoming a secular institution. As a collegiate university, it comprises eleven colleges each with substantial autonomy on financial and institutional affairs and significant differences in character and history. The university maintains three campuses, the oldest of which, St. George, is located in downtown Toronto. The other two satellite campuses are located in Scarborough and Mississauga. The University of Toronto offers over 700 undergraduate and 200 graduate programs. In all major rankings, the university consistently ranks in the top ten public universities in the world and as the top university ...
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Text-to-image Model
A text-to-image model is a machine learning model which takes as input a natural language description and produces an image matching that description. Such models began to be developed in the mid-2010s, as a result of advances in deep neural networks. In 2022, the output of state of the art text-to-image models, such as OpenAI's DALL-E 2, Google Brain's Imagen and StabilityAI's Stable Diffusion began to approach the quality of real photographs and human-drawn art. Text-to-image models generally combine a language model, which transforms the input text into a latent representation, and a generative image model, which produces an image conditioned on that representation. The most effective models have generally been trained on massive amounts of image and text data scraped from the web. History Before the rise of deep learning, attempts to build text-to-image models were limited to collages by arranging existing component images, such as from a database of clip art. The inverse t ...
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Large Language Models
A large language model (LLM) is a language model consisting of a neural network with many parameters (typically billions of weights or more), trained on large quantities of unlabelled text using self-supervised learning. LLMs emerged around 2018 and perform well at a wide variety of tasks. This has shifted the focus of natural language processing research away from the previous paradigm of training specialized supervised models for specific tasks. Properties Though the term ''large language model'' has no formal definition, it often refers to deep learning models having a parameter count on the order of billions or more. LLMs are general purpose models which excel at a wide range of tasks, as opposed to being trained for one specific task (such as sentiment analysis, named entity recognition, or mathematical reasoning). The skill with which they accomplish tasks, and the range of tasks at which they are capable, seems to be a function of the amount of resources (data, parameter-siz ...
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Drug Development
Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery. It includes preclinical research on microorganisms and animals, filing for regulatory status, such as via the United States Food and Drug Administration for an investigational new drug to initiate clinical trials on humans, and may include the step of obtaining regulatory approval with a new drug application to market the drug. The entire process – from concept through preclinical testing in the laboratory to clinical trial development, including Phase I–III trials – to approved vaccine or drug typically takes more than a decade. New chemical entity development Broadly, the process of drug development can be divided into preclinical and clinical work. Pre-clinical New chemical entities (NCEs, also known as new molecular entities or NMEs) are compounds that emerge from the process of drug discovery. Th ...
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Protein Folding
Protein folding is the physical process by which a protein chain is translated to its native three-dimensional structure, typically a "folded" conformation by which the protein becomes biologically functional. Via an expeditious and reproducible process, a polypeptide folds into its characteristic three-dimensional structure from a random coil. Each protein exists first as an unfolded polypeptide or random coil after being translated from a sequence of mRNA to a linear chain of amino acids. At this stage the polypeptide lacks any stable (long-lasting) three-dimensional structure (the left hand side of the first figure). As the polypeptide chain is being synthesized by a ribosome, the linear chain begins to fold into its three-dimensional structure. Folding of many proteins begins even during translation of the polypeptide chain. Amino acids interact with each other to produce a well-defined three-dimensional structure, the folded protein (the right hand side of the figure), ...
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Stanford University
Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is considered among the most prestigious universities in the world. Stanford was founded in 1885 by Leland and Jane Stanford in memory of their only child, Leland Stanford Jr., who had died of typhoid fever at age 15 the previous year. Leland Stanford was a U.S. senator and former governor of California who made his fortune as a railroad tycoon. The school admitted its first students on October 1, 1891, as a coeducational and non-denominational institution. Stanford University struggled financially after the death of Leland Stanford in 1893 and again after much of the campus was damaged by the 1906 San Francisco earthquake. Following World War II, provost of Stanford Frederick Terman inspired and supported faculty and graduates' entrepreneu ...
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Transformer (machine Learning Model)
A transformer is a deep learning model that adopts the mechanism of self-attention, differentially weighting the significance of each part of the input data. It is used primarily in the fields of natural language processing (NLP) and computer vision (CV). Like recurrent neural networks (RNNs), transformers are designed to process sequential input data, such as natural language, with applications towards tasks such as translation and text summarization. However, unlike RNNs, transformers process the entire input all at once. The attention mechanism provides context for any position in the input sequence. For example, if the input data is a natural language sentence, the transformer does not have to process one word at a time. This allows for more parallelization than RNNs and therefore reduces training times. Transformers were introduced in 2017 by a team at Google Brain and are increasingly the model of choice for NLP problems, replacing RNN models such as long short-term memor ...
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Diffusion Model
In machine learning, diffusion models, also known as diffusion probabilistic models, are a class of latent variable models. They are Markov chains trained using variational inference. The goal of diffusion models is to learn the latent structure of a dataset by modeling the way in which data points diffuse through the latent space. In computer vision, this means that a neural network is trained to denoise images blurred with Gaussian noise by learning to reverse the diffusion process. Three examples of generic diffusion modeling frameworks used in computer vision are denoising diffusion probabilistic models, noise conditioned score networks, and stochastic differential equations. Diffusion models were introduced in 2015 with a motivation from non-equilibrium thermodynamics. Diffusion models can be applied to a variety of tasks, including image denoising, inpainting, super-resolution, and image generation. For example, an image generation model would start with a random noise ima ...
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Generative Adversarial Network
A generative adversarial network (GAN) is a class of machine learning frameworks designed by Ian Goodfellow and his colleagues in June 2014. Two neural networks contest with each other in the form of a zero-sum game, where one agent's gain is another agent's loss. Given a training set, this technique learns to generate new data with the same statistics as the training set. For example, a GAN trained on photographs can generate new photographs that look at least superficially authentic to human observers, having many realistic characteristics. Though originally proposed as a form of generative model for unsupervised learning, GANs have also proved useful for semi-supervised learning, fully supervised learning, and reinforcement learning. The core idea of a GAN is based on the "indirect" training through the discriminator, another neural network that can tell how "realistic" the input seems, which itself is also being updated dynamically. This means that the generator is not trai ...
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Graphical Processing Unit
A graphics processing unit (GPU) is a specialized electronic circuit designed to manipulate and alter memory to accelerate the creation of images in a frame buffer intended for output to a display device. GPUs are used in embedded systems, mobile phones, personal computers, workstations, and game consoles. Modern GPUs are efficient at manipulating computer graphics and image processing. Their parallel structure makes them more efficient than general-purpose central processing units (CPUs) for algorithms that process large blocks of data in parallel. In a personal computer, a GPU can be present on a video card or embedded on the motherboard. In some CPUs, they are embedded on the CPU die. In the 1970s, the term "GPU" originally stood for ''graphics processor unit'' and described a programmable processing unit independently working from the CPU and responsible for graphics manipulation and output. Later, in 1994, Sony used the term (now standing for ''graphics processing unit'') i ...
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Computer Vision
Computer vision is an interdisciplinary scientific field that deals with how computers can gain high-level understanding from digital images or videos. From the perspective of engineering, it seeks to understand and automate tasks that the human visual system can do. Computer vision tasks include methods for acquiring, processing, analyzing and understanding digital images, and extraction of high-dimensional data from the real world in order to produce numerical or symbolic information, e.g. in the forms of decisions. Understanding in this context means the transformation of visual images (the input of the retina) into descriptions of the world that make sense to thought processes and can elicit appropriate action. This image understanding can be seen as the disentangling of symbolic information from image data using models constructed with the aid of geometry, physics, statistics, and learning theory. The scientific discipline of computer vision is concerned with the theory ...
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