Yagé

AyahuascaPronounced as in the UK and in the US. Also occasionally known in English as ''ayaguasca'' (Spanish-derived), ''aioasca'' (Brazilian Portuguese-derived), or as ''yagé'', pronounced or . Etymologically, all forms but ''yagé'' descend from the compound Quechua word ''ayawaska'', from ''aya'' () and ''waska'' (). For more names for ayahuasca, see § Etymology. is a South American psychoactive decoction prepared from ''Banisteriopsis caapi'' vine and a dimethyltryptamine (DMT)-containing plant, used by Indigenous cultures in the Amazon and Orinoco basins as part of traditional medicine and shamanism. The word ayahuasca, originating from Quechuan languages spoken in the Andes, refers both to the ''B. caapi'' vine and the psychoactive brew made from it, with its name meaning “spirit rope” or “liana of the soul.”

The specific ritual use of ayahuasca was widespread among Indigenous groups by the 19th century, though its precise origin is uncertain. Ayahuasca is traditionally prepared by macerating and boiling ''B. caapi'' with other plants like ''Psychotria viridis'' during a ritualistic, multi-day process. Ayahuasca has been used in diverse South American cultures for spiritual, social, and medicinal purposes, often guided by shamans in ceremonial contexts involving specific dietary and ritual practices, with the Shipibo-Konibo people playing a significant historical and cultural role in its use. It spread widely by the mid-20th century through syncretic religions in Brazil. In the late 20th century, ayahuasca use expanded beyond South America to Europe, North America, and elsewhere, leading to legal cases, non-religious adaptations, and the development of ayahuasca analogs using local or synthetic ingredients.

While DMT is internationally classified as a controlled substance, the plants containing it—including those used to make ayahuasca—are not regulated under international law, leading to varied national policies that range from permitting religious use to imposing bans or decriminalization. The United States patent office controversially granted, challenged, revoked, reinstated, and ultimately allowed to expire a patent on the ayahuasca vine, sparking disputes over intellectual property rights and the cultural and religious significance of traditional Indigenous knowledge.

Ayahuasca produces intense psychological and spiritual experiences with potential therapeutic effects. Ayahuasca’s psychoactive effects primarily result from DMT, rendered orally active by harmala alkaloids in ''B. caapi'', which act as reversible inhibitors of monamine oxidase; ''B. caapi'' and its β-carbolines also exhibit independent contributions to ayahuasca’s effects, acting on serotonin and benzodiazepine receptors. Systematic reviews show ayahuasca has strong antidepressant and anxiolytic effects with generally safe traditional use, though higher doses of ayahuasca or harmala alkaloids may increase risks.

Etymology

''Ayahuasca'' is the hispanicized spelling (i.e., spelled according to Spanish orthography) of a word that originates from the Quechuan languages, which are spoken in the Andean states of Ecuador, Bolivia, Peru, and Colombia. Speakers of Quechuan languages who use modern Quechuan orthography spell it ''ayawaska''. The word refers both to the liana ''Banisteriopsis caapi'', and to the brew prepared from it. In the Quechua languages, ''aya'' means "spirit, soul", or "corpse, dead body", and ''waska'' means "rope" or "woody vine", "liana". The word ''ayahuasca'' has been variously translated as "liana of the soul", "liana of the dead", and "spirit liana". In the cosmovision of its users, the ayahuasca is the vine that allows the spirit to wander detached from the body, entering the spiritual world, otherwise forbidden for the alive.

Common names

Although ayahuasca is the most widely used term in Peru, Bolivia, Ecuador and Brazil, the brew is known by many names throughout northern South America:

* hoasca or oasca in Brazil
* (or , from the Cofán language or iagê in Portuguese). Relatively widespread use in Andean and Amazonian regions throughout the border areas of Colombia, Peru, Ecuador and Brazil. The Cofán people also use the word .
* (or / in Tupi–Guarani language or in proto-Arawak language), used to address both the brew and the ''B. caapi'' itself. Meaning "weed" or "thin leaf", it was the word utilized by Spruce for naming the liana.
* (or /), used by the Colorado people
* (or ), from the Chicham languages
* , (or ) and , from the Yaminawa language
* , from the Shipibo language
* , , , and , from the Kashinawa language
* , and , used by the Tucano people
* (or ) and , from the Arawakan languages
* , from Bora-Muinane languagesSeifart, Frank, & Echeverri, Juan Alvaro (2015)
Proto Bora-Muinane
''LIAMES: Línguas Indígenas Americanas'', 15(2), 279 - 311.
* , used by Ese'Ejja people
* , from Guahibo language
* (or /), used by Tsáchila people
* , from Kamëntšá languageHuber, Randall Q. and Robert B. Reed. 1992.
Vocabulario comparativo: Palabras selectas de lenguas indígenas de Colombia (Comparative vocabulary: Selected words in indigenous languages of Colombia)
'. Bogota, Colombia: Summer Institute of Linguistics.
* ("") or , in Portuguese language, used by União do Vegetal church members
* Daime or Santo Daime, meaning "give me" in Portuguese, the term was coined by Santo Daime's founder Mestre Irineu in the 1940s, from a prayer ''dai-me alegria, dai-me resistência'' ("give me happiness, give me strength"). Daime members also uses the words Luz ("light") or Santa Luz ("holy light")
* Some nomenclature are created by the cultural and symbolic signification of ayahuasca, with names like ''planta professora'' ("plant teacher"), ''professor dos professores'' ("teacher of the teachers"), ''sagrada medicina'' ("holy medicine") or ''la purga'' ("the purge").

Other names in the Western world

In the last decades, two new important terminologies emerged. Both are commonly used in the Western world in neoshamanic, recreative or pharmaceutical contexts to address ayahuasca-like substances created without the traditional botanical species, due to it being expensive and/or hard to find in these countries. These concepts are surrounded by some controversies involving ethnobotany, patents, commodification and biopiracy:

* Anahuasca (ayahuasca analogues). A term usually used to refer to the ayahuasca produced with other plant species as sources of DMT (e.g., ''Mimosa hostilis'') or β-carbolines (e.g., ''Peganum harmala'').
* Pharmahuasca (pharmaceutical ayahuasca). This indicates the pills produced from freebase DMT, synthetic harmaline, MAOI medications (such as moclobemide) and other isolated or purified compounds or extracts.

History

Origins

Archaeological evidence of the use of psychoactive plants in northeastern Amazon dates back to 1500–2000 BCE. Anthropomorphic figurines, snuffing trays and pottery vessels, often adorned with mythological figures and sacred animals, offer a glimpse of the pre-Columbian culture regarding use of the sacred plants, their preparation and ritual consumption itar naranjo 86 Although several botanical specimens (like tobacco, coca and ''Anadenanthera spp.'') were identified among these objects, there is no unequivocal evidence of this date referring directly to ayahuasca. ''Banisteriopsis caapi'' use is suggested from a pouch containing carved snuffing trays, bone spatulas and other paraphernalia with traces of harmine and DMT, discovered in a cave in southwestern Bolivia in 2008, and chemical traces of harmine in the hair of two mummies found in northern Chile. Both cases are linked to Tiwanaku people, circa 900 CE. There are several reports of oral and nasal use of ''Anadenanthera spp.'' (rich in bufotenin) ritualistically and therapeutically during labor and infancy, and researchers suggest that addition of ''Banisteriopsis spp.'' to catalyze its psychoactivity emerged later, due to contact between different groups of Amazon and Altiplano.

Despite claims by numerous anthropologists and ethnologists, such as Plutarco Naranjo, regarding the millennial usage of ayahuasca, compelling evidence substantiating its pre-Columbian consumption is yet to be firmly established. As articulated by Dennis McKenna:

"No one can say for certain where the practice may have originated, and about all that can be stated with certainty is that is already spread among numerous indigenous tribes throughout Amazon basin by the time ayahuasca came to the attention of Western ethnographers in the mid-nineteenth century"

The first western references of the ayahuasca beverage dates back to seventeenth century, during the European colonization of the Americas. The earlier report is a letter from Vincente de Valverde to the Holy Office of the Inquisition. Jose Chantre y Herrera still in the seventeenth century, provided the first detailed description of a "devilish potion" cooked from bitter herbs and lianas (called ''ayaguasca'') and its rituals:

" ..In other nations, they set aside an entire night for divination. For this purpose, they select the most capable house in the vicinity because many people are expected to attend the event. The diviner hangs his bed in the middle and places an infernal potion, known as ayahuasca, by his side, which is particularly effective at altering one's senses. They prepare a brew from bitter vines or herbs, which, when boiled sufficiently, must become quite potent. Since it's so strong at altering one's judgment in small quantities, the precaution is not excessive, and it fits into two small pots. The witch doctor drinks a very small amount each time and knows well how many times he can sample the brew without losing his senses to properly conduct the ritual and lead the choir".

Another report produced in 1737 by the missionary Pablo Maroni, describes the use of a psychoactive liana called ayahuasca for divination in the Napo River, Ecuador:

"For divination, they use a beverage, some of white datura flowers, which they also call Campana due to its shape, and others from a vine commonly known as Ayahuasca, both highly effective at numbing the senses and even at taking one's life if taken in excess. They also occasionally use these substances for the treatment of common illnesses, especially headaches. So, the person who wants to divine drinks the chosen substance with certain rituals, and while deprived of their senses from the mouth downwards, to prevent the strength of the plant from harming them, they remain in this state for many hours and sometimes even two or three days until the effects run their course, and the intoxication subsides. After this, they reflect on what their imagination revealed, which occasionally remains with them for delirium. This is what they consider accomplished and propagate as an oracle."

Latter reports were produced by Juan Magnin in 1740, describing ayahuasca use as a medicinal plant by the Jivaroan peoples (called ''ayahuessa'') and by Franz Xaver Veigl in 1768, that reports about several "dangerous plants", including a bitter liana used for precognition and sorcery. All these reports were written in context of Jesuit missions in South America, specially the Mainas missions, in Latin and sent only to Rome, so their audience wasn't very large and they were promptly lost in the archives. For this reason, ayahuasca didn't receive interest for the entire subsequent century.

Early academic research

In academic discourse, the initial mention of ayahuasca dates back to Manuel Villavicencio's 1858 book, "''Geografía de la República del Ecuador.''" This work vividly delineates the employment and rituals involving ayahuasca by the Jivaro people. Concurrently, Richard Spruce embarked on an Amazonian expedition in 1852 to collect and classify previously unidentified botanical specimens. During this journey, Spruce encountered and documented ''Banisteriopsis caapi'' (at time named ''Banisteria caapi'') and observed an ayahuasca ceremony among the Tucano community situated along the Vaupés River. Subsequently, Spruce uncovered the usage and cultivation of ''B. caapi'' among various indigenous groups dispersed across the Amazon and Orinoco basins, like the Guahibo and Sápara. These multifarious encounters, together with Spruce's personal accounts of subjective ayahuasca experiences, were collated in his work, "Notes of a Botanist On The Amazon and Andes.". By the end of the century, other explorers and anthropologists contributed more extensive documentation concerning ayahuasca, notably the Theodor Koch-Grünberg's documents about Tucano and Arecuna's rituals and ceremonies, Stradelli's first-hand reports of ayahuasca rituals and mythology along the Jurupari and Vaupés and Alfred Simson's first description of admixture of several ingredients in the making of ayahuasca in Putumayo region, published in 1886.

In 1905, Rafael Zerda Bayón named the active extract of ayahuasca as ''telepathine,'' a name latter used by the Colombian chemist Guillermo Fischer Cárdenas when he isolated the substance in 1932. Contemporaneously, Lewin and Gunn were independently studying the properties of the ''banisterine,'' extracted of the ''B. caapi,'' and its effects on animal models. Further clinical trials were being conducted, exploring the effects of banisterine on Parkinson's disease. Later it was found that both ''telepathine'' and ''banisterine'' are the same substance, identical to a chemical already isolated from ''Peganum harmala'' and given the name Harmine.

Shamanism, ''mestizos'' and ''vegetalistas''

Researchers like Peter Gow and Brabec de Mori argue that ayahuasca use indeed developed alongside the Jesuit missions after the 17th century. By examining the ícaros (ayahuasca-related healing chants), they found that the chants are always sung in Quechua (a lingua franca along the Jesuit and Franciscan missions in the region), no matter the linguistic background of the group, with similar language structures between different ícaros that are markedly different from other indigenous songs. Moreover, often the cosmology of ayahuasca often mirrors the Catholicism, with particular similarities in the belief that ayahuasca is thought to be the body of ''ayahuascamama'' that is imbibed as part of the ritual, like wine and bread are taken as being the body and blood of Jesus Christ during Christian Eucharist. Brabec de Mori called this “Christian camouflage” and suggested that rather than being a way for disguising the ayahuasca ritual, it suggests that practice evolved entirely within these contexts.

Indeed, the colonial processes in Western Amazon are intrinsically related with the development of ayahuasca use in the last three centuries, as it promoted a deep reshape in traditional ways of life in the region. Many indigenous groups moved into the Missions, seeking protection from death and slavery promoted by the Bandeiras, inter-tribal violence, starvation and disease (smallpox). This movement resulted in an intense cultural exchange and resulted in the formation of ''mestizos'' (in Spanish) or ''caboclos'' (in Portuguese), a social category formed by people with mixture of European and native ancestry, who were an important part of the economy and culture of the region. According to Peter Gow, the ayahuasca shamanism (the use of ayahuasca by a trained shaman to diagnose and cure illnesses) was developed by these ''mestizos'' in the processes of colonial transformation. The Amazon rubber cycles (1879–1912 and 1945–1945) sped up these transformations, due to slavery, genocide and brutality against indigenous populations and large migratory movements, specially from the Brazilian Northeast Region as a workforce for the rubber plantations. The ''mestizo'' practices became deeply intertwined with the culture of rubber workers, called ''caucheros'' (in Spanish) or ''seringueiros'' (in Portuguese). Ayahuasca use with therapeutic goals is the main result of this Trans-cultural diffusion, with some practitioners pointing the ''caucheros'' as the main responsible for using ayahuasca to cure all sort of ailments of the body, mind and soul, with even some regions using the term ''Yerba de Cauchero'' ("rubber-worker herb"). As a result, the ayahuasca shamans in urban areas and ''mestizo'' settlements, specially in the regions of Iquitos and Pucallpa (in Peru), became the ''vegetalistas,'' folk healers who are said to gain all their knowledge from the plants and the spirits bound to it.

So the ''vegetalist'' movement was a heterogeneous mixture of Western Amazon (''mestizo'' shamanic practices and ''cauchero'' culture) and Andean elements (shaped by other migratory movements, like those originated from Cuzco through Urubamba Valley and from western Ecuador), influenced by Christian aspects derived from the Jesuit missions, as reflected by the mythology, rituals and moral codes related to ''vegetalista'' ayahuasca use.

Ayahuasca religions

Although ''mestizo'', ''vegetalista'' and indigenous ayahuasca use was part of a longer tradition, these several configurations of ''mestizo vegetalismo'' were not isolated phenomena. In the end of the nineteenth century, several messianic/millennialist cults sparkled across semi-urban areas across the entire Amazon region, merging different elements of indigenous and ''mestizo'' folk culture with Catholicism, Spiritism and Protestantism. In this context, the use of ayahuasca will take form of urban, organized non-indigenous religions in outskirts of main cities of northwest of Brazil, (along the basins of Madeira, Juruá and Purus River) within the ''cauchero/seringueiro'' cultural complex, resignifying and adapting both the ''vegetalista'' and ''mestizo'' shamanism to new urban formations, unifying essential elements to building a cosmology for the new emerging cult/faith, merging with elements of folk Catholicism, African-Brazilian religions and Kardecist spiritism. These new cults arise from charismatic leaderships, often messianic and prophetic, who came from rural areas after migration movements, sometimes called ''ayahuasqueiros'', in semi-urban communities across the borders of Brazil, Bolívia and Peru (a region that will later form the state of Acre). This new configuration of these belief systems is referred by Goulart as ''tradição religiosa ayahuasqueira urbana amazônica'' ("urban-amazonian ''ayahuasqueiro'' religious tradition") or ''campo ayahuasqueiro brasileiro'' ("brazilian ''ayahuasqueiro'' field") by Labate, emerging as three main structured religions, the Santo Daime and Barquinha, in Rio Branco and the União do Vegetal (UDV) in Porto Velho, three denominations that, notwithstanding shared characteristics besides ayahuasca utilization, have several particularities regarding its practices, conceptions and processes building social legitimacy and relationships with Brazilian government, media, science and other society stances. Since the latter half of twentieth century, the ayahuasca religious expanded to other parts of Brazil and several countries in the world, notably in the West.

Modern use

Beat writer William S. Burroughs read a paper by Richard Evans Schultes on the subject and while traveling through South America in the early 1950s sought out ayahuasca in the hopes that it could relieve or cure opiate addiction (see '' The Yage Letters''). Ayahuasca became more widely known when the McKenna brothers published their experience in the Amazon in ''True Hallucinations''. Dennis McKenna later studied pharmacology, botany, and chemistry of ayahuasca and oo-koo-he, which became the subject of his master's thesis.

Richard Evans Schultes allowed Claudio Naranjo to make a special journey by canoe up the Amazon River to study ayahuasca with the South American Indigenous peoples. He brought back samples of the beverage and published the first scientific description of the effects of its active alkaloids.

In recent years, the brew has been popularized by Wade Davis (''One River),'' English novelist Martin Goodman in ''I Was Carlos Castaneda'', Chilean novelist Isabel Allende, writer Kira Salak, author Jeremy Narby (''The Cosmic Serpent''), author Jay Griffiths (''Wild: An Elemental Journey''), American novelist Steven Peck, radio personality Robin Quivers,, writer Paul Theroux ('' Figures in a Landscape: People and Places''), and NFL quarterback Aaron Rodgers.

Preparation

Sections of ''Banisteriopsis caapi'' vine are macerated and boiled alone or with leaves from any of a number of other plants, including ''Psychotria viridis'' (''chacruna''), '' Diplopterys cabrerana'' (also known as ''chaliponga'' and ''chacropanga''), and ''Mimosa tenuiflora'', among other ingredients which can vary greatly from one shaman to the next. The resulting brew may contain the powerful psychedelic drug dimethyltryptamine and monoamine oxidase inhibiting harmala alkaloids, which are necessary to make the DMT orally active by allowing it (DMT) to be processed by the liver. The traditional making of ayahuasca follows a ritual process that requires the user to pick the lower Chacruna leaf at sunrise, then say a prayer. The vine must be "cleaned meticulously with wooden spoons" and pounded "with wooden mallets until it's fibre."

Brews can also be made with plants that do not contain DMT, ''Psychotria viridis'' being replaced by plants such as ''Justicia pectoralis'', ''Brugmansia'', or sacred tobacco, also known as ''mapacho'' (''Nicotiana rustica''), or sometimes left out with no replacement. This brew varies radically from one batch to the next, both in potency and psychoactive effect, based mainly on the skill of the shaman or brewer, as well as other admixtures sometimes added and the intent of the ceremony. Natural variations in plant alkaloid content and profiles also affect the final concentration of alkaloids in the brew, and the physical act of cooking may also serve to modify the alkaloid profile of harmala alkaloids.

The actual preparation of the brew takes several hours, often taking place over the course of more than one day. After adding the plant material, each separately at this stage, to a large pot of water, it is boiled until the water is reduced by half in volume. The individual brews are then added together and brewed until reduced significantly. This combined brew is what is taken by participants in ayahuasca ceremonies.

Traditional use

The uses of ayahuasca in traditional societies in South America vary greatly. Some cultures do use it for shamanic purposes, but in other cases, it is consumed socially among friends, in order to learn more about the natural environment, and even in order to visit friends and family who are far away.

Nonetheless, people who work with ayahuasca in non-traditional contexts often align themselves with the philosophies and cosmologies associated with ayahuasca shamanism, as practiced among Indigenous peoples like the Urarina of the Peruvian Amazon. Dietary taboos are often associated with the use of ayahuasca, although these seem to be specific to the culture around Iquitos, Peru, a major center of ayahuasca tourism. Ayahuasca retreats or ''healing centers'' can also be found in the Sacred Valley of Peru, in areas such as Cusco and Urubamba, where similar dietary preparations can be observed. These retreats often employ members of the Shipibo-Konibo tribe, an indigenous community native to the Peruvian Amazon.

In the rainforest, these taboos tend towards the purification of one's self—abstaining from spicy and heavily seasoned foods, excess fat, salt, caffeine, acidic foods (such as citrus) and sex before, after, or during a ceremony. A diet low in foods containing tyramine has been recommended, as the speculative interaction of tyramine and MAOIs could lead to a hypertensive crisis; however, evidence indicates that harmala alkaloids act only on MAO-A, in a reversible way similar to moclobemide (an antidepressant that does not require dietary restrictions). Dietary restrictions are not used by the highly urban Brazilian ayahuasca church União do Vegetal, suggesting the risk is much lower than perceived and probably non-existent.

The ritual use of ayahuasca by the Achuar people is featured in the Bruce Parry 2008 documentary series ''Amazon'', in which Parry forces himself to participate in the rite.

Ceremony and the role of shamans

Shamans, curanderos and experienced users of ayahuasca advise against consuming ayahuasca when not in the presence of one or several well-trained shamans.

In some areas, there are purported ''brujos'' (Spanish for "witches") who masquerade as real shamans and who entice tourists to drink ayahuasca in their presence. Shamans believe one of the purposes for this is to steal one's energy and/or power, of which they believe every person has a limited stockpile.

The shamans lead the ceremonial consumption of the ayahuasca beverage, in a rite that typically takes place over the entire night. During the ceremony, the effect of the drink lasts for hours. Prior to the ceremony, participants are instructed to abstain from spicy foods, red meat and sex. The ceremony is usually accompanied with purging which include vomiting and diarrhea, which is believed to release built-up emotions and negative energy.

Shipibo-Konibo and their relation to Ayahuasca

It is believed that the Shipibo-Konibo are among the earliest practitioners of Ayahuasca ceremonies, with their connection to the brew and ceremonies surrounding it dating back centuries, perhaps a millennium.

Some members of the Shipibo community have taken to the media to express their views on Ayahuasca entering the mainstream, with some calling it "the commercialization of ayahuasca." Some of them have even expressed their worry regarding the increased popularity, saying "the contemporary 'ayahuasca ceremony' may be understood as a substitute for former cosmogonical rituals that are nowadays not performed anymore."

Icaros

The Shipibo have their own language, called Shipibo, a Panoan language spoken by approximately 26,000 people in Peru and Brazil. This language is commonly sung by the shaman in the form of a chant, called an Icaro, during the Ayahuasca ritual as a way to establish a "balance of energy" during the ritual to help protect and guide the user during their experience.

Traditional brew

Traditional ayahuasca brews are usually made with ''Banisteriopsis caapi'' as an MAOI, while dimethyltryptamine sources and other admixtures vary from region to region. There are several varieties of caapi, often known as different "colors", with varying effects, potencies, and uses.

DMT admixtures:
* ''Psychotria viridis'' (Chacruna) Rätsch, Christian (2005), pp. 704-708. The Encyclopedia of Psychoactive Plants: Ethnopharmacology and Its Applications. Rochester, Vermont: Park Street Press, 1998. – leaves
* ''Psychotria carthagenensis'' (Amyruca) – leaves
* '' Diplopterys cabrerana'' (Chaliponga, Chagropanga, ''Banisteriopsis rusbyana'') – leaves
* ''Mimosa tenuiflora'' (''M. hostilis'') - root bark

Other common admixtures:
* ''Justicia pectoralis''
* ''Brugmansia sp.'' (Toé)
* Opuntia ''sp''.
* Epiphyllum ''sp.''
* Cyperus ''sp.''
* ''Nicotiana rustica'' (Mapacho, variety of tobacco)
* ''Ilex guayusa'', a relative of yerba mate
* '' Lygodium venustum'', (Tchai del monte)
* ''Phrygilanthus eugenioides'' and Clusia ''sp'' (both called Miya)
* '' Lomariopsis japurensis'' (Shoka)

Common admixtures with their associated ceremonial values and spirits:

* Ayahuma bark: Cannon Ball tree. Provides protection and is used in healing susto (soul loss from spiritual fright or trauma).
*Capirona bark: Provides cleansing, balance and protection. It is noted for its smooth bark, white flowers, and hard wood.
*Chullachaki caspi bark (''Byrsonima christianeae''): Provides cleansing to the physical body. Used to transcend physical body ailments.
*Lopuna blanca bark: Provides protection.
*Punga amarilla bark: Yellow Punga. Provides protection. Used to pull or draw out negative spirits or energies.
* Remo caspi bark: Oar Tree. Used to move dense or dark energies.
*Wyra (huaira) caspi bark (''Cedrelinga catanaeformis): Mermaid Spirit. Provides major heart chakra opening, healing of emotions and relationships.

Non-traditional use

In the late 20th century, the practice of ayahuasca drinking began spreading to Europe, North America and elsewhere. The first ayahuasca churches, affiliated with the Brazilian Santo Daime, were established in the Netherlands. A legal case was filed against two of the Church's leaders, Hans Bogers (one of the original founders of the Dutch Santo Daime community) and Geraldine Fijneman (the head of the Amsterdam Santo Daime community). Bogers and Fijneman were charged with distributing a controlled substance (DMT); however, the prosecution was unable to prove that the use of ayahuasca by members of the Santo Daime constituted a sufficient threat to public health and order such that it warranted denying their rights to religious freedom under ECHR Article 9. The 2001 verdict of the Amsterdam district court is an important precedent. Since then groups that are not affiliated to the Santo Daime have used ayahuasca, and a number of different "styles" have been developed, including non-religious approaches.

Ayahuasca analogs

In modern Europe and North America, ayahuasca analogs are often prepared using non-traditional plants which contain the same alkaloids. For example, seeds of the Syrian rue plant can be used as a substitute for the ayahuasca vine, and the DMT-rich ''Mimosa hostilis'' is used in place of '' chacruna''. Australia has several indigenous plants which are popular among modern '' ayahuasqueros'' there, such as various DMT-rich species of ''Acacia''.

The name "ayahuasca" specifically refers to a botanical decoction that contains ''Banisteriopsis caapi''.

Brews similar to ayahuasca may be prepared using several plants not traditionally used in South America:

DMT admixtures:
* ''Acacia maidenii'' (Maiden's wattle) – bark *not all plants are "active strains", meaning some plants will have very little DMT and others larger amounts
* ''Acacia phlebophylla'', and other Acacias, most commonly employed in Australia – bark
* ''Anadenanthera peregrina'', ''A. colubrina, A. excelsa, A. macrocarpa''
* ''Desmanthus illinoensis'' (Illinois bundleflower) – root bark is mixed with a native source of beta-Carbolines (e.g., passion flower in North America) to produce a hallucinogenic drink called prairiehuasca.

MAOI admixtures:
* Harmal (''Peganum harmala'', Syrian rue) – seeds
* Passion flower
* synthetic MAOIs, especially RIMAs (due to the dangers presented by irreversible MAOIs)

Effects

Adverse effects

In the short term, ingesting Ayahuasca can cause nausea, vomiting and diarrhea. These three effects, known as purging, are traditionally recognized to be a part of the spiritual experience of ayahuasca. Physiologically, vomiting is a result of increased serotonin circulating in the gut, which directly stimulates the vagus nerve. Other short-term side effects include increased blood pressure and tachycardia. Additionally, increased secretion of hormones like prolactin, cortisone, and growth hormone has been correlated with ayahuasca consumption. Rarer side effects include dyspnea, seizures and serotonin syndrome. Ayahuasca is suspected of triggering psychosis in people with a predisposition to the condition, and there is a lack of safety information for Ayahuasca's possible effects on pregnancy and breastfeeding.

Psychological effects

People who have consumed ayahuasca report having mystical experiences and spiritual revelations regarding their purpose on earth, the true nature of the universe, and deep insight into how to be the best person they possibly can. Many people also report therapeutic effects, especially around depression and personal traumas.

This is viewed by many as a spiritual awakening and what is often described as a near-death experience or rebirth. It is often reported that individuals feel they gain access to higher spiritual dimensions and make contact with various spiritual or extra-dimensional beings who can act as guides or healers.

The experiences that people have while under the influence of ayahuasca are also culturally influenced. Westerners typically describe experiences with psychological terms like "ego death" and understand the hallucinations as repressed memories or metaphors of mental states. However, at least in Iquitos, Peru (a center of ayahuasca ceremonies), those from the area describe the experiences more in terms of the actions in the body and understand the visions as reflections of their environment, sometimes including the person who they believe caused their illness, as well as interactions with spirits.

Most psychological effects can be accredited to the influx of serotonin caused by the psychoactive combination of DMT with ''beta-''carbolines. Serotonin stimulates a group of G-protein coupled receptors known as 5-HT receptors. Specifically, stimulation of the 5-HT2A receptor type is correlated with hallucinogenic effects.

Potential therapeutic effects

There are potential antidepressant and anxiolytic effects of ayahuasca.

Ayahuasca has also been studied for the treatment of addictions and shown to be effective, with lower Addiction Severity Index scores seen in users of ayahuasca compared to controls. Ayahuasca users have also been seen to consume less alcohol.

Pharmacology

DMT

N,N-Dimethyltryptamine (DMT) is a naturally occurring, serotonergic hallucinogen found in plants and mammals, classified as a DEA Schedule I substance with no accepted medical use, and under investigation for clinical applications.

Ayahuasca’s psychoactive effects stem mainly from DMT, made orally active by MAOIs in the ''B. caapi'' vine, and its activation of serotonin receptors, particularly 5-HT2A, with additional contributions from harmine and harmaline.

Harmala alkaloids

While many studies focus on DMT and serotonin agonists, recent research and traditional use highlight the central role of the ''B. caapi'' vine and its β-carbolines in ayahuasca, noting their potential psychotropic effects through serotonin and benzodiazepine receptor interactions.

Harmala alkaloids like harmaline and harmine are believed to cause hallucinations, vomiting, confusion, and ataxia through central nervous system stimulation and 5-HT receptor binding, similar to DMT.

Harmine

Harmine is a naturally occurring harmala alkaloid with monoamine oxidase-inhibiting under preliminary research for potential anti-HIV properties. It is found in various plants such as ''Peganum harmala'' and ''B. caapi'', historically studied for Parkinson’s disease and currently in early-phase clinical trials.

Harmine is the primary β-carboline alkaloid in ayahuasca and has been studied for potential therapeutic effects including modulation of astrocytic function, anti-inflammatory properties, influence on neural progenitor proliferation, and possible roles in addiction and depression treatment through mechanisms involving glutamate regulation and BDNF signaling.

Harmaline

Harmaline is a beta-carboline alkaloid derived from the harman skeleton, found in various organisms including ''Peganum'' seeds, and acts as a oneirogen.

Harmaline, a harmala alkaloid, has been reported to exhibit a range of pharmacological effects, including hypothermic, vasorelaxant, antimicrobial, antitumoral, antiplatelet, antileishmanial, and antiplasmodial activities, as well as anxiolytic, antidepressant, and hallucinogenic properties at certain doses.

Tetrahydroharmine

Tetrahydroharmine is a harmala alkaloid found in organisms such as ''Daphnia pulex'' and ''Euglena gracilis''.

Tetrahydroharmine, a component of ayahuasca with weak SSRI properties, has been associated with increased serotonin uptake sites and variable psychoactive effects, with preferences for higher tetrahydroharmine content reported in some ayahuasca-using churches, potentially due to differences in plant composition and preparation methods.

Effect of polymorphisms

Individual polymorphisms of the cytochrome P450-2D6 enzyme, and more over the isolated indocine metabolite from the inhabitation of CPY134a, with a varied rate of gustation due to physiological factors affect the ability of individuals to metabolize harmine.

Interactions

Society and culture

Legal status

Internationally, DMT is a Schedule I drug under the Convention on Psychotropic Substances. The Commentary on the Convention on Psychotropic Substances notes, however, that the plants containing it are not subject to international control:

A fax from the Secretary of the International Narcotics Control Board (INCB) to the Netherlands Ministry of Public Health sent in 2001 goes on to state that "Consequently, preparations (e.g. decoctions) made of these plants, including ayahuasca, are not under international control and, therefore, not subject to any of the articles of the 1971 Convention."

Despite the INCB's 2001 affirmation that ayahuasca is not subject to drug control by international convention, in its 2010 Annual Report the Board recommended that governments consider controlling (i.e. criminalizing) ayahuasca at the national level. This recommendation by the INCB has been criticized as an attempt by the Board to overstep its legitimate mandate and as establishing a reason for governments to violate the human rights (i.e., religious freedom) of ceremonial ayahuasca drinkers.

Under American federal law, DMT is a Schedule I drug that is illegal to possess or consume; however, certain religious groups have been legally permitted to consume ayahuasca. A court case allowing the União do Vegetal to import and use the tea for religious purposes in the United States, '' Gonzales v. O Centro Espírita Beneficente União do Vegetal'', was heard by the U.S. Supreme Court on November 1, 2005; the decision, released February 21, 2006, allows the UDV to use the tea in its ceremonies pursuant to the Religious Freedom Restoration Act. In a similar case in Ashland, Oregon-based Santo Daime church sued for their right to import and consume ayahuasca tea. In March 2009, U.S. District Court Judge Panner ruled in favor of the Santo Daime, acknowledging its protection from prosecution under the Religious Freedom Restoration Act.

In 2017 the Santo Daime Church Céu do Montréal in Canada received religious exemption to use ayahuasca as a sacrament in their rituals.

Religious use in Brazil was legalized after two official inquiries into the tea in the mid-1980s, which concluded that ayahuasca is not a recreational drug and has valid spiritual uses.

In France, Santo Daime won a court case allowing them to use the tea in early 2005; however, they were not allowed an exception for religious purposes, but rather for the simple reason that they did not perform chemical extractions to end up with pure DMT and harmala and the plants used were not scheduled. Four months after the court victory, the common ingredients of ayahuasca as well as harmala were declared ''stupéfiants'', or narcotic schedule I substances, making the tea and its ingredients illegal to use or possess.

In June 2019, Oakland, California, decriminalized natural entheogens. The City Council passed the resolution in a unanimous vote, ending the investigation and imposition of criminal penalties for use and possession of entheogens derived from plants or fungi. The resolution states: "Practices with Entheogenic Plants have long existed and have been considered to be sacred to human cultures and human interrelationships with nature for thousands of years, and continue to be enhanced and improved to this day by religious and spiritual leaders, practicing professionals, mentors, and healers throughout the world, many of whom have been forced underground."
In January 2020, Santa Cruz, California, and in September 2020, Ann Arbor, Michigan, decriminalized natural entheogens.

Intellectual property issues

Ayahuasca has stirred debate regarding intellectual property protection of traditional knowledge. In 1986 the US Patent and Trademarks Office (PTO) allowed the granting of a patent on the ayahuasca vine ''B. caapi''. It allowed this patent based on the assumption that ayahuasca's properties had not been previously described in writing. Several public interest groups, including the Coordinating Body of Indigenous Organizations of the Amazon Basin (COICA) and the Coalition for Amazonian Peoples and Their Environment (Amazon Coalition) objected. In 1999 they brought a legal challenge to this patent which had granted a private US citizen "ownership" of the knowledge of a plant that is well-known and sacred to many Indigenous peoples of the Amazon, and used by them in religious and healing ceremonies.

Later that year the PTO issued a decision rejecting the patent, on the basis that the petitioners' arguments that the plant was not "distinctive or novel" were valid; however, the decision did not acknowledge the argument that the plant's religious or cultural values prohibited a patent. In 2001, after an appeal by the patent holder, the US Patent Office reinstated the patent, albeit to only a specific plant and its asexually reproduced offspring. The law at the time did not allow a third party such as COICA to participate in that part of the reexamination process. The patent, held by US entrepreneur Loren Miller, expired in 2003.

Research

A 2016 systematic literature review found that ayahuasca and its alkaloids show promising anxiolytic and antidepressant effects in both animal and human studies, suggesting the potential for new treatments with fewer side effects. A 2024 systematic review and meta-analysis found that ayahuasca shows strong antidepressant effects ( Hedges’ g = -1.34).

A separate 2024 systematic thematic review found that traditional ayahuasca use is generally safe, though higher doses of ayahuasca or higher doses of isolated harmala alkaloids like harmaline may pose risks.

Ayahuasca has been reported to restore the blunted salivary cortisol awakening response in people with treatment-resistant depression 48hours after the experience, although circulating cortisol levels remained blunted.

See also

* Changa
* Icaro
* Kambo (drug)
* Ibogaine
* Yachay
* Dimethyltryptamine/harmine

Notes

References

Further reading

* Burroughs, William S. and Allen Ginsberg. '' The Yage Letters''. San Francisco: City Lights, 1963.
* Langdon, E. Jean Matteson & Gerhard Baer, eds. ''Portals of Power: Shamanism in South America''. Albuquerque: University of New Mexico Press, 1992.
* Shannon, Benny. ''The Antipodes of the Mind: Charting the Phenomenology of the Ayahuasca Experience''. Oxford: Oxford University Press, 2002.
* Taussig, Michael. ''Shamanism, Colonialism, and the Wild Man: A Study in Terror and Healing''. Chicago: University of Chicago Press, 1986.
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External links

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Ayahuasca - PsychonautWiki

Ayahuasca - Erowid

What is Ayahuasca? - Tripsitter

The Ayahuasca Experience: A Pilgrimage to the Spirit - Double Blind Magazine

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5-HT2A agonists

Biopiracy
Entheogens
Herbal and fungal hallucinogens
Indigenous culture of the Amazon
Mixed drinks
Monoamine oxidase inhibitors
Polysubstance drinks
Serotonin receptor agonists