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Tetramethoxyamphetamine
Tetramethoxyamphetamine (TeMA), or 2,3,4,5-tetramethoxyamphetamine, is a lesser-known psychedelic drug and a substituted amphetamine. Tetramethoxyamphetamine was first synthesized by Alexander Shulgin. In his book '' PiHKAL (Phenethylamines i Have Known And Loved)'', the minimum dosage is listed as 50 mg, and the duration unknown. Tetramethoxyamphetamine produces a threshold, mydriasis, and a headache. Limited data exists about its pharmacological properties, metabolism, and toxicity. See also * Substituted methoxyphenethylamine Methoxyphenethylamines (MPEAs), as well as methoxyamphetamines (MAs) in the case of the amphetamine (α-methylphenethylamine) homologues, are substituted phenethylamines with one or more methoxy groups. In some cases, one or more of the methoxy ... * 2,3,4,5-Tetramethoxyphenethylamine (TeMPEA) * 2,5-Dimethoxy-3,4-methylenedioxyamphetamine (DMMDA) References External links Tetramethoxyamphetamine entry in ''PiHKAL''Tetramethoxyamphetamine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Substituted Methoxyphenethylamine
Methoxyphenethylamines (MPEAs), as well as methoxyamphetamines (MAs) in the case of the amphetamine (α-methylphenethylamine) homologues, are substituted phenethylamines with one or more methoxy groups. In some cases, one or more of the methoxy groups may also be extended to form other alkoxy and related groups such as ethoxy or propoxy. Methoxyphenethylamines may have additional substitutions as well. Many methoxyphenethylamines that have multiple methoxy groups in the 2- through 5-positions of the phenyl ring, for instance mescaline, 2C-B, TMA, DOM, and 25I-NBOMe, are serotonin 5-HT2A receptor agonists and serotonergic psychedelics. Other methoxyphenethylamines, particularly monomethoxyamphetamines like ''para''-methoxyamphetamine (PMA), are monoamine releasing agents of serotonin, norepinephrine, and/or dopamine, with stimulant and/or entactogen-related effects. Compounds closely related to methoxyphenethylamines include methylenedioxyphenethylamines (MDxx) like M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PiHKAL
''PiHKAL: A Chemical Love Story'' is a book by Alexander Shulgin and Ann Shulgin published in 1991. The subject of the work is Psychoactive drug, psychoactive phenethylamine Derivative (chemistry), chemical derivatives, notably those that act as psychedelic drug, psychedelics and/or empathogen-entactogens. The main title, PiHKAL, is an acronym that stands for "Phenethylamines I Have Known and Loved". The book is arranged into two parts, the first part being a fictionalized autobiography of the couple and the second part describing 179 different psychedelic compounds (most of which Shulgin discovered himself), including detailed synthesis instructions, bioassays, dosages, and other commentary. The second part was made freely available by Shulgin on Erowid while the first part is available only in the printed text. While the reactions described are beyond the ability of people with a basic chemistry education, some tend to emphasize techniques that do not require difficult-to-ob ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DOx (psychedelics)
4-Substituted-2,5-dimethoxyamphetamines (DO''x'') is a chemical class of substituted amphetamine derivatives featuring methoxy groups at the 2- and 5- positions of the phenyl ring, and a substituent such as alkyl or halogen at the 4- position of the phenyl ring. They are 4-substituted derivatives of 2,5-dimethoxyamphetamine (2,5-DMA, DOH) and are structurally related to the naturally occurring phenethylamine psychedelic mescaline. The most well-known DOx drugs are DOM, DOI, DOB, DOET, and DOC. DOI is widely used in scientific research. DOM has been used as a recreational drug, while DOET was an experimental pharmaceutical drug. Most compounds of this class are potent and long-lasting psychedelic drugs, and act as selective 5-HT2A, 5-HT2B, and 5-HT2C receptor agonists. A few bulkier derivatives such as DOAM have similarly high affinity for 5-HT2 receptors but have reduced activational efficacy and do not produce psychedelic effects. DOI has been found to have ext ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2,5-Dimethoxy-3,4-methylenedioxyamphetamine
2,5-Dimethoxy-3,4-methylenedioxyamphetamine (DMMDA or DMMDA-1) is a lesser-known psychedelic drug of the substituted amphetamine, amphetamine family related to MMDA (drug), MMDA. It was first chemical synthesis, synthesized by Alexander Shulgin in the 1960s and was described in his 1991 book ''PiHKAL''. Use and effects Shulgin listed the dose (biochemistry), dosage of DMMDA in ''PiHKAL'' as 30 to 75mg and the duration of action, duration as 6 to 8hours. He reported DMMDA as producing LSD-like subjective effects: mental imagery, images, mydriasis, ataxia, and time dilation. DMMDA is not mentioned much in literature outside ''PiHKAL''. Pharmacology The mechanism of action, mechanism behind the subjective effects of DMMDA has not been specifically established. In ''PiHKAL'', Shulgin asserts that the subjective effects of 75mg of DMMDA are equivalent to those of 75 to 100μg of LSD. LSD is a well-known partial agonist of the serotonin 5-HT2A receptor, 5-HT2A receptor. This may su ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
