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Stuart Kauffman
Stuart Alan Kauffman (born September 28, 1939) is an American medical doctor, theoretical biology, theoretical biologist, and complex systems researcher who studies the origin of life on Earth. He was a professor at the University of Chicago, University of Pennsylvania, and University of Calgary. He is currently emeritus professor of biochemistry at the University of Pennsylvania and affiliate faculty at the Institute for Systems Biology. He has a number of awards including a MacArthur Fellowship and a American Society for Cybernetics#Wiener and McCulloch awards, Wiener Medal. He is best known for arguing that the complexity of biological systems and organisms might result as much from self-organization and far-from-equilibrium dynamics as from Darwinian natural selection, as discussed in his book ''Origins of Order'' (1993). In 1967 and 1969 he used random Boolean networks to investigate generic self-organizing properties of gene regulatory networks, proposing that cell types ar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sacramento
Sacramento ( or ; ; ) is the capital city of the U.S. state of California and the seat of Sacramento County. Located at the confluence of the Sacramento and American Rivers in Northern California's Sacramento Valley, Sacramento's 2020 population of 524,943 makes it the fourth-most populous city in Northern California, the sixth-most populous in the state, the ninth-most populous state capital, and the 35th most populous city in the United States. Sacramento is the seat of the California Legislature and the governor of California. Sacramento is also the cultural and economic core of the Greater Sacramento area, which at the 2020 census had a population of 2,680,831, the fourth-largest metropolitan area in California. Before the arrival of the Spanish, the area was inhabited by the Nisenan, Maidu, and other indigenous peoples of California. In 1808, Spanish cavalryman Gabriel Moraga surveyed and named the ''Río del Santísimo Sacramento'' (Sacramento River), a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Institute For Systems Biology
Institute for Systems Biology (ISB) is a non-profit research institution located in Seattle, Washington, United States. ISB concentrates on systems biology, the study of relationships and interactions between various parts of biological systems, and advocates an interdisciplinary approach to biological research. Goals Systems biology is the study of biological systems in a holistic manner by integrating data at all levels of the biological information hierarchy, from global down to the individual organism, and below down to the molecular level. The vision of ISB is to integrate these concepts using a cross-disciplinary approach combining the efforts of biologists, chemists, computer scientists, engineers, mathematicians, physicists, and physicians. On its website, ISB has defined four areas of focus: * P4 Medicine – This acronym refers to predictive, preventive, personalized and participatory medicine, which focuses on wellness rather than mere treatment of disease. * Global ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Model (abstract)
The term conceptual model refers to any model that is formed after a wikt:concept#Noun, conceptualization or generalization process. Conceptual models are often abstractions of things in the real world, whether physical or social. Semantics, Semantic studies are relevant to various stages of process of concept formation, concept formation. Semantics is fundamentally a study of concepts, the meaning that thinking beings give to various elements of their experience. Overview Concept models and conceptual models The value of a conceptual model is usually directly proportional to how well it corresponds to a past, present, future, actual or potential state of affairs. A concept model (a model of a concept) is quite different because in order to be a good model it need not have this real world correspondence. In artificial intelligence, conceptual models and conceptual graphs are used for building expert systems and knowledge-based systems; here the analysts are concerned to repres ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Complex Systems
A complex system is a system composed of many components that may interact with one another. Examples of complex systems are Earth's global climate, organisms, the human brain, infrastructure such as power grid, transportation or communication systems, complex software and electronic systems, social and economic organizations (like cities), an ecosystem, a living cell, and, ultimately, for some authors, the entire universe. The behavior of a complex system is intrinsically difficult to model due to the dependencies, competitions, relationships, and other types of interactions between their parts or between a given system and its environment. Systems that are " complex" have distinct properties that arise from these relationships, such as nonlinearity, emergence, spontaneous order, adaptation, and feedback loops, among others. Because such systems appear in a wide variety of fields, the commonalities among them have become the topic of their independent area of research. In ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Santa Fe Institute
The Santa Fe Institute (SFI) is an independent, nonprofit theoretical research institute located in Santa Fe, New Mexico, United States and dedicated to the multidisciplinary study of the fundamental principles of complex adaptive systems, including physical, computational, biological, and social systems. The institute is ranked 24th among the world's "Top Science and Technology Think Tanks" and 24th among the world's "Best Transdisciplinary Research Think Tanks" according to the 2020 edition of the ''Global Go To Think Tank Index Reports'', published annually by the University of Pennsylvania. The institute consists of a small number of resident faculty and postdoctoral researchers, a large group of external faculty whose primary appointments are at other institutions, and a number of visiting scholars. The institute is advised by a group of eminent scholars, including several Nobel Prize-winning scientists. Although theoretical scientific research is the institute's primary ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biophysics
Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations. Biophysical research shares significant overlap with biochemistry, molecular biology, physical chemistry, physiology, nanotechnology, bioengineering, computational biology, biomechanics, developmental biology and systems biology. The term ''biophysics'' was originally introduced by Karl Pearson in 1892. Roland Glaser. Biophysics: An Introduction'. Springer; 23 April 2012. . The term ''biophysics'' is also regularly used in academia to indicate the study of the physical quantities (e.g. electric current, temperature, stress, entropy) in biological systems. Other biological sciences also perform research on the biophysical properties of living organisms including molecular biology, cell biology, chemical biology, and bioche ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biochemistry
Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, and metabolism. Over the last decades of the 20th century, biochemistry has become successful at explaining living processes through these three disciplines. Almost all List of life sciences, areas of the life sciences are being uncovered and developed through biochemical methodology and research.#Voet, Voet (2005), p. 3. Biochemistry focuses on understanding the chemical basis that allows biomolecule, biological molecules to give rise to the processes that occur within living Cell (biology), cells and between cells,#Karp, Karp (2009), p. 2. in turn relating greatly to the understanding of tissue (biology), tissues and organ (anatomy), organs as well as organism structure and function.#Miller, Miller (2012). p. 62. Biochemistry is closely ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Developmental Genetics
Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of regeneration, asexual reproduction, metamorphosis, and the growth and differentiation of stem cells in the adult organism. Perspectives The main processes involved in the embryonic development of animals are: tissue patterning (via regional specification and patterned cell differentiation); tissue growth; and tissue morphogenesis. * Regional specification refers to the processes that create the spatial patterns in a ball or sheet of initially similar cells. This generally involves the action of cytoplasmic determinants, located within parts of the fertilized egg, and of inductive signals emitted from signaling centers in the embryo. The early stages of regional specification do not generate functional differentiated cells, but cell populations committed to developing to a specific region or part of the organism. These are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marshall Scholar
The Marshall Scholarship is a postgraduate scholarship for "intellectually distinguished young Americans ndtheir country's future leaders" to study at any university in the United Kingdom. It is considered among the most prestigious scholarships for U.S. citizens, and along with the Fulbright Scholarship, it is the only broadly available scholarship available to Americans to study at any university in the United Kingdom. Created by the Parliament of the United Kingdom in 1953 as a living gift to the United States in recognition of the generosity of Secretary of State George C. Marshall and the Marshall Plan in the wake of World War II, the goal of the scholarship was to strengthen the Special Relationship between the two countries for "the good of mankind in this turbulent world." The scholarships are awarded by the Marshall Aid Commemoration Commission and are largely funded by the British government. The program was also the first major co-educational British graduate scho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peptides
Peptides are short chains of amino acids linked by peptide bonds. A polypeptide is a longer, continuous, unbranched peptide chain. Polypeptides that have a molecular mass of 10,000 Dalton (unit), Da or more are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides. Peptides fall under the broad chemical classes of biopolymer, biological polymers and oligomers, alongside nucleic acids, oligosaccharides, polysaccharides, and others. Proteins consist of one or more polypeptides arranged in a biologically functional way, often bound to ligand (biochemistry), ligands such as coenzymes and cofactor (biochemistry), cofactors, to another protein or other macromolecule such as DNA or RNA, or to complex macromolecular assemblies. Amino acids that have been incorporated into peptides are termed Residue (chemistry)#Biochemistry, residues. A water molecule is released during formation of each amide bond.. Al ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polymers
A polymer () is a substance or material that consists of very large molecules, or macromolecules, that are constituted by many repeating subunits derived from one or more species of monomers. Due to their broad spectrum of properties, both synthetic and natural polymers play essential and ubiquitous roles in everyday life. Polymers range from familiar synthetic plastics such as polystyrene to natural biopolymers such as DNA and proteins that are fundamental to biological structure and function. Polymers, both natural and synthetic, are created via polymerization of many small molecules, known as monomers. Their consequently large molecular mass, relative to small molecule compounds, produces unique physical properties including toughness, high elasticity, viscoelasticity, and a tendency to form amorphous and semicrystalline structures rather than crystals. Polymers are studied in the fields of polymer science (which includes polymer chemistry and polymer p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autocatalytic Set
An autocatalytic set is a collection of entities, each of which can be created catalytically by other entities within the set, such that as a whole, the set is able to catalyze its own production. In this way the set ''as a whole'' is said to be autocatalytic. Autocatalytic sets were originally and most concretely defined in terms of molecular entities, but have more recently been metaphorically extended to the study of systems in sociology, ecology, and economics. Autocatalytic sets also have the ability to replicate themselves if they are split apart into two physically separated spaces. Computer models illustrate that split autocatalytic sets will reproduce all of the reactions of the original set in each half, much like cellular mitosis. In effect, using the principles of autocatalysis, a small metabolism can replicate itself with very little high level organization. This property is why autocatalysis is a contender as the foundational mechanism for complex evolution. Pri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
