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POLE1
DNA polymerase epsilon catalytic subunit is an enzyme that in humans is encoded by the ''POLE'' gene. It is the central catalytic subunit of DNA polymerase epsilon. Clinical significance POLE, along with POLD1, has recently been associated with multiple adenoma. Interactions POLE has been shown to Protein-protein interaction, interact with RAD17. References Further reading * * * * * * * * * * * * * * * * {{gene-12-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
POLD1
The gene polymerase delta 1 (''POLD1'') encodes the large, POLD1/p125, catalytic subunit of the DNA polymerase delta (PolĪ“) complex. The PolĪ“ enzyme is responsible for synthesizing the lagging strand of DNA, and has also been implicated in some activities at the leading strand (Figure 1). The POLD1/p125 subunit encodes both DNA polymerizing and exonuclease domains, which provide the protein an important second function in proofreading to ensure replication accuracy during DNA synthesis, and in a number of types of replication-linked DNA repair following DNA damage. Germline mutations impairing activity of POLD1 have been implicated in several types of hereditary cancer, in some sporadic cancers, and in a developmental syndrome of premature aging, Mandibular hypoplasia, Deafness, and Progeroid features and Lipodystrophy (MDPL/ MDP syndrome). Studies of POLD1 emphasize the importance of maintaining genomic stability to limit tumorigenesis. It is currently unclear whether the en ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
