DNA polymerase epsilon catalytic subunit is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that in humans is encoded by the ''POLE''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
It is the central catalytic subunit of
DNA polymerase epsilon
DNA polymerase epsilon is a member of the DNA polymerase family of enzymes found in eukaryotes. It is composed of the following four subunits: POLE (central catalytic unit), POLE2 (subunit 2), POLE3 (subunit 3), and POLE4 (subunit 4). Recent evi ...
.
Clinical significance
POLE, along with
POLD1
The gene polymerase delta 1 (''POLD1'') encodes the large, POLD1/p125, catalytic subunit of the DNA polymerase delta (PolĪ“) complex. The PolĪ“ enzyme is responsible for synthesizing the lagging strand of DNA, and has also been implicated in some ...
, has recently been associated with multiple adenoma.
Interactions
POLE has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
RAD17
Cell cycle checkpoint protein RAD17 is a protein that in humans is encoded by the ''RAD17'' gene.
Function
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene ...
.
References
Further reading
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