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Natural Compound
A natural product is a natural compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life. Natural products can also be prepared by chemical synthesis (both semisynthesis and total synthesis and have played a central role in the development of the field of organic chemistry by providing challenging synthetic targets). The term ''natural product'' has also been extended for commercial purposes to refer to cosmetics, dietary supplements, and foods produced from natural sources without added artificial ingredients. Within the field of organic chemistry, the definition of natural products is usually restricted to organic compounds isolated from natural sources that are produced by the pathways of primary or secondary metabolism. Within the field of medicinal chemistry, the definition is often further restricted to secondary metabolites. Secondary metabolites (or specialized meta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anticancer Drug
Chemotherapy (often abbreviated chemo, sometimes CTX and CTx) is the type of cancer treatment that uses one or more anti-cancer drugs ( chemotherapeutic agents or alkylating agents) in a standard regimen. Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs), or it may aim only to prolong life or to reduce symptoms ( palliative chemotherapy). Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called '' medical oncology''. The term ''chemotherapy'' now means the non-specific use of intracellular poisons to inhibit mitosis (cell division) or to induce DNA damage (so that DNA repair can augment chemotherapy). This meaning excludes the more-selective agents that block extracellular signals (signal transduction). Therapies with specific molecular or genetic targets, which inhibit growth-promoting signals from classic endocrine hormones (primarily est ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytotoxic
Cytotoxicity is the quality of being toxic to cells. Examples of toxic agents are toxic metals, toxic chemicals, microbe neurotoxins, radiation particles and even specific neurotransmitters when the system is out of balance. Also some types of drugs, e.g alcohol, and some venom, e.g. from the puff adder (''Bitis arietans'') or brown recluse spider (''Loxosceles reclusa'') are toxic to cells. Cell physiology Treating cells with the cytotoxic compound can result in a variety of prognoses. The cells may undergo necrosis, in which they lose membrane integrity and die rapidly as a result of cell lysis. The cells can stop actively growing and dividing (a decrease in cell viability), or the cells can activate a genetic program of controlled cell death (apoptosis). Cells undergoing necrosis typically exhibit rapid swelling, lose membrane integrity, shut down metabolism, and release their contents into the environment. Cells that undergo rapid necrosis in vitro do not have sufficient t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alkaloids
Alkaloids are a broad class of naturally occurring organic compounds that contain at least one nitrogen atom. Some synthetic compounds of similar structure may also be termed alkaloids. Alkaloids are produced by a large variety of organisms including bacteria, fungi, plants, and animals. They can be purified from crude extracts of these organisms by acid-base extraction, or solvent extractions followed by silica-gel column chromatography. Alkaloids have a wide range of pharmacological activities including antimalarial (e.g. quinine), antiasthma (e.g. ephedrine), anticancer (e.g. homoharringtonine), cholinomimetic (e.g. galantamine), vasodilatory (e.g. vincamine), antiarrhythmic (e.g. quinidine), analgesic (e.g. morphine), antibacterial (e.g. chelerythrine), and antihyperglycemic activities (e.g. berberine). Many have found use in traditional or modern medicine, or as starting points for drug discovery. Other alkaloids possess psychotropic (e.g. psilocin) and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Albrecht Kossel
Ludwig Karl Martin Leonhard Albrecht Kossel (; 16 September 1853 – 5 July 1927) was a biochemist and pioneer in the study of genetics. He was awarded the Nobel Prize for Physiology or Medicine in 1910 for his work in determining the chemical composition of nucleic acids, the genetic substance of biological cells. Kossel isolated and described the five organic compounds that are present in nucleic acid: adenine, cytosine, guanine, thymine, and uracil. These compounds were later shown to be nucleobases, and are key in the formation of DNA and RNA, the genetic material found in all living cells. Kossel was an important influence on and collaborator with other important researchers in biochemistry, including Henry Drysdale Dakin, Friedrich Miescher, Edwin B. Hart, and his professor and mentor, Felix Hoppe-Seyler. Kossel was editor of the Zeitschrift für Physiologische Chemie (Journal of Physiological Chemistry) from 1895 until his death. Kossel also conducted important ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural Material
* A ″ natural material a substance that comes from plants, animals, or the earth, and has not been made by humans.. Minerals and the metals that can be extracted from them (without further modification) are also considered to belong into this category. Natural materials are used as building materials and clothing. Types include: * Biotic materials ** Wood (rattan, bamboo, bark, etc.) * Plant fiber (coir, ramie, sisal, cotton, flax, hemp, jute, kapok, kenaf, moss, linen, abacá, etc.) * Animal fiber (wool, silk, alpaca, camel, angora, cashmere, mohair, etc.) * Inorganic material ** Stone (flint, granite, limestone, obsidian, sandstone, sand, gems, glass, etc.) ** Native metal (copper, iron, gold, silver, etc.) ** Composites (clay, plasticine, etc.) * Other natural materials. ** Soil See also * Alternative natural materials * Dimension stone * Earth shelter * Earth structure * Green building and wood * Greystone (residential buildings made from limestone) * Hemp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bodily Fluid
Body fluids, bodily fluids, or biofluids, sometimes body liquids, are liquids within the body of an organism. In lean healthy adult men, the total body water is about 60% (60–67%) of the total body weight; it is usually slightly lower in women (52–55%). The exact percentage of fluid relative to body weight is inversely proportional to the percentage of body fat. A lean man, for example, has about 42 (42–47) liters of water in his body. The total body of water is divided into fluid compartments, between the intracellular fluid compartment (also called space, or volume) and the extracellular fluid (ECF) compartment (space, volume) in a two-to-one ratio: 28 (28–32) liters are inside cells and 14 (14–15) liters are outside cells. The ECF compartment is divided into the interstitial fluid volume – the fluid outside both the cells and the blood vessels – and the intravascular volume (also called the vascular volume and blood plasma volume) – the fluid inside t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bioplastic
Bioplastics are plastic materials produced from renewable biomass sources. Timeline of plastic development, Historically, bioplastics made from natural materials like shellac or Celluloid, cellulose had been the first plastics. Since the end of the 19th century they have been increasingly superseded by fossil-fuel plastics derived from petroleum or natural gas (''fossilized'' biomass is not considered to be Renewable resource, renewable in reasonable short time). Today, in the context of bioeconomy and circular economy, bioplastics are gaining interest again. Conventional petro-based polymers are increasingly blended with bioplastics to manufacture "bio-attributed" or "mass-balanced" plastic products - so the difference between bio- and other plastics might be difficult to define. Bioplastics can be produced by: * processing directly from Biopolymer, natural biopolymers including polysaccharides (e.g., corn starch or rice starch, cellulose, chitosan, and alginate) and proteins ( ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bio-based Material
A bio-based material is a material intentionally made, either wholly or partially, from substances derived from living (or once-living) organisms, such as plants, animals, enzymes, and microorganisms, including bacteria, fungi and yeast. Due to their main characteristics of being renewable and to their ability to store carbon over their growth, recent years assisted to their upsurge as a valid alternative compared to more traditional materials in view of climate mitigation. In European context, more specifically, European Union, which has set 2050 as a target date to reach climate neutrality, is trying to implement, among other measures, the production and utilization of bio-based materials in many diverse sectors. Indeed, several European regulations, such as the European Industrial Strategy, the EU Biotechnology and Biomanufacturing Initiative and the Circular Action Plan, emphasize bio-materials. These regulations aim to support innovation, investment, and market adoption of b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biotic Material
Biotic material or biological derived material is any material that originates from living organisms. Most such materials contain carbon and are capable of decay. The earliest form of life on Earth arose at least 3.5 billion years ago.Schopf, J.W., Kudryavtsev, A.B., Czaja, A.D., and Tripathi, A.B. (2007). "Evidence of some Archean life: Stromatolites and microfossils." ''Precambrian Research''. 158:141–155.Schopf, J.W. (2006). "Fossil evidence of Archaean life." ''Philos. Trans. R. Soc. Lond. B. Biol. Sci.'' 29;361(1470) 869–885. Earlier physical evidences of life include graphite, a biogenic substance, in 3.7 billion-year-old metasedimentary rocks discovered in southwestern Greenland, as well as, "remains of biotic life" found in 4.1 billion-year-old rocks in Western Australia. Early edition, published online before print. Earth's biodiversity has expanded continually except when interrupted by mass extinctions. Although scholars estimate that over 99 percent of all spec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Extinction
Extinction is the termination of an organism by the death of its Endling, last member. A taxon may become Functional extinction, functionally extinct before the death of its last member if it loses the capacity to Reproduction, reproduce and recover. As a species' potential Range (biology), range may be very large, determining this moment is difficult, and is usually done retrospectively. This difficulty leads to phenomena such as Lazarus taxon, Lazarus taxa, where a species presumed extinct abruptly "reappears" (typically in the Fossil, fossil record) after a period of apparent absence. Over five billion species are estimated to have died out. It is estimated that there are currently around 8.7 million species of eukaryotes globally, possibly many times more if microorganisms are included. Notable extinct animal species include Dinosaur, non-avian dinosaurs, Machairodontinae, saber-toothed cats, and mammoths. Through evolution, species arise through the process of specia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Profit (economics)
In economics, profit is the difference between revenue that an economic entity has received from its outputs and total costs of its inputs, also known as surplus value. It is equal to total revenue minus total cost, including both Explicit cost, explicit and implicit cost, implicit costs. It is different from accounting profit, which only relates to the explicit costs that appear on a firm's financial statements. An accountant measures the firm's accounting profit as the firm's total revenue minus only the firm's explicit costs. An Economists, economist includes all costs, both explicit and implicit costs, when analyzing a firm. Therefore, economic profit is smaller than accounting profit. ''Normal profit'' is often viewed in conjunction with economic profit. Normal profits in business refer to a situation where a company generates revenue that is equal to the total costs incurred in its operation, thus allowing it to remain operational in a competitive industry. It is the mi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Development
Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery. It includes preclinical research on microorganisms and animals, filing for regulatory status, such as via the United States Food and Drug Administration for an investigational new drug to initiate clinical trials on humans, and may include the step of obtaining regulatory approval with a new drug application to market the drug. The entire process—from concept through preclinical testing in the laboratory to clinical trial development, including Phase I–III trials—to approved vaccine or drug typically takes more than a decade. New chemical entity development Broadly, the process of drug development can be divided into preclinical and clinical work. Pre-clinical New chemical entities (NCEs, also known as new molecular entities or NMEs) are compounds that emerge from the process of drug discovery. These h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
