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Metabolomic Databases
Metabolomics is the scientific study of chemical processes involving metabolites, the small molecule substrates, intermediates, and products of cell metabolism. Specifically, metabolomics is the "systematic study of the unique chemical fingerprints that specific cellular processes leave behind", the study of their small-molecule metabolite profiles. The metabolome represents the complete set of metabolites in a biological cell, tissue, organ, or organism, which are the end products of cellular processes. Messenger RNA (mRNA), gene expression data, and proteomics, proteomic analyses reveal the set of gene products being produced in the cell, data that represents one aspect of cellular function. Conversely, metabolic profiling can give an instantaneous snapshot of the physiology of that cell, and thus, metabolomics provides a direct "functional readout of the physiological state" of an organism. There are indeed quantifiable correlations between the metabolome and the other cellular ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Central Dogma Of Biology Showing The Flow Of Information From DNA To The Phenotype
''The'' is a grammatical Article (grammar), article in English language, English, denoting nouns that are already or about to be mentioned, under discussion, implied or otherwise presumed familiar to listeners, readers, or speakers. It is the definite article in English. ''The'' is the Most common words in English, most frequently used word in the English language; studies and analyses of texts have found it to account for seven percent of all printed English-language words. It is derived from gendered articles in Old English which combined in Middle English and now has a single form used with nouns of any gender. The word can be used with both singular and plural nouns, and with a noun that starts with any letter. This is different from many other languages, which have different forms of the definite article for different genders or numbers. Pronunciation In most dialects, "the" is pronounced as (with the voiced dental fricative followed by a schwa) when followed by a con ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Linus Pauling
Linus Carl Pauling ( ; February 28, 1901August 19, 1994) was an American chemist and peace activist. He published more than 1,200 papers and books, of which about 850 dealt with scientific topics. ''New Scientist'' called him one of the 20 greatest scientists of all time. For his scientific work, Pauling was awarded the Nobel Prize in Chemistry in 1954. For his peace activism, he was awarded the Nobel Peace Prize in 1962. He is one of five people to have Nobel Prize#Multiple laureates, won more than one Nobel Prize. Of these, he is the only person to have been awarded two unshared Nobel Prizes, and one of two people to be awarded Nobel Prizes in different fields, the other being Marie Curie. Pauling was one of the founders of the fields of quantum chemistry and molecular biology. His contributions to the theory of the chemical bond include the concept of orbital hybridisation and the first accurate scale of electronegativity, electronegativities of the elements. Pauling also wo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cerebrospinal Fluid
Cerebrospinal fluid (CSF) is a clear, colorless Extracellular fluid#Transcellular fluid, transcellular body fluid found within the meninges, meningeal tissue that surrounds the vertebrate brain and spinal cord, and in the ventricular system, ventricles of the brain. CSF is mostly produced by specialized Ependyma, ependymal cells in the choroid plexuses of the ventricles of the brain, and absorbed in the arachnoid granulations. It is also produced by ependymal cells in the lining of the ventricles. In humans, there is about 125 mL of CSF at any one time, and about 500 mL is generated every day. CSF acts as a shock absorber, cushion or buffer, providing basic mechanical and immune system, immunological protection to the brain inside the Human skull, skull. CSF also serves a vital function in the cerebral autoregulation of cerebral blood flow. CSF occupies the subarachnoid space (between the arachnoid mater and the pia mater) and the ventricular system around and inside t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benjamin Cravatt III
Benjamin Franklin Cravatt III is a professor in the Department of Chemistry at The Scripps Research Institute in La Jolla, California. Considered a co-inventor of activity-based proteomics and a substantial contributor to research on the endocannabinoid system, he is a prominent figure in the field of chemical biology. Cravatt was elected to the National Academy of Sciences in 2014, and the American Academy of Arts and Sciences in 2016. He is Gilula Chair of Chemical Biology, a Cope Scholar, and a Searle Scholar. Early life and education His father was a dentist and his mother a dental hygienist, both of whom instilled in Cravatt an interest in biology as a child. Ben Cravatt is left handed. Cravatt entered Stanford University in 1988, graduating in 1992 with a BS in the Biological Sciences and a BA in History. He then received a PhD in Macromolecular and Cellular Structure and Chemistry from The Scripps Research Institute in 1996, where he worked under the joint supe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scripps Research
Scripps Research is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences. Headquartered in San Diego, California, the institute has over 170 laboratories employing 2,100 scientists, technicians, graduate students, and administrative and other staff. The institute holds over 1,100 patents, has produced 11 FDA-approved therapeutics, and has generated over 50 spin-off companies. The Scripps Research graduate program is ranked 9th nationally in the biological sciences, 6th for organic chemistry, and 6th for biochemistry. In 2022, their Jupiter, Florida, campus became a part of the University of Florida. Jupiter-based graduate students remain part of the Scripps Research graduate program. History Scripps Research began with the Scripps Metabolic Clinic, founded near the current site in the La Jolla area of San Diego in 1924 by philanthropist Ellen Browning Scripps, who was inspired by the discovery of insulin. In 1946, t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Richard Lerner
Richard Alan Lerner (August 26, 1938 – December 2, 2021) was an American research chemist. He was best known for his work on catalytic antibodies and combinatorial antibody libraries. Lerner served as President of The Scripps Research Institute (TSRI) from 1987 until January 1, 2012, and was a member of its Skaggs Institute for Chemical Biology, in La Jolla, California. Biography Lerner grew up on the South Side of Chicago and excelled at chemistry and wrestling as a schoolboy.Sydney Freedberg. Scientist Tycoon. ''St. Petersburg Times'', June 17, 2007 He attended Hirsch High School. After attending Northwestern University as an undergraduate, Lerner obtained an MD from Stanford Medical School in 1964, then undertook postdoctoral training at Scripps Clinic and Research Foundation, an early incarnation of the institute he would eventually lead. In the 1970s Lerner carried out research at the Wistar Institute in Philadelphia then returned to La Jolla to the now renamed R ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gary Siuzdak
Gary Siuzdak is an American chemist best known for his work in the field of metabolomics, activity metabolomics (a termed coined in 2019), and mass spectrometry. His lab discovered indole-3-propionic acid as a gut bacteria derived metabolite in 2009. He is currently the Professor and Director of The Center for Metabolomics and Mass Spectrometry at Scripps Research in La Jolla, California. Siuzdak has also made contributions to virus analysis, viral structural dynamics, as well as developing mass spectrometry imaging technology using nanostructured surfaces. The Siuzdak lab is also responsible for creating the research tools eXtensible Computational Mass Spectrometry (XCMS Online, XCMS), METLIN, METLIN Neutral Loss and Q-MRM. As of January 2021, the XCMS Online, XCMS/METLIN platform has over 50,000 registered users. Siuzdak studied chemistry (B.S.) and applied mathematics (B.A.) at Rhode Island College. He then went to Dartmouth College for his graduate work where he built his firs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mass Spectrometry
Mass spectrometry (MS) is an analytical technique that is used to measure the mass-to-charge ratio of ions. The results are presented as a ''mass spectrum'', a plot of intensity as a function of the mass-to-charge ratio. Mass spectrometry is used in many different fields and is applied to pure samples as well as complex mixtures. A mass spectrum is a type of plot of the ion signal as a function of the mass-to-charge ratio. These spectra are used to determine the elemental or isotopic signature of a sample, the masses of particles and of molecules, and to elucidate the chemical identity or structure of molecules and other chemical compounds. In a typical MS procedure, a sample, which may be solid, liquid, or gaseous, is ionization, ionized, for example by bombarding it with a Electron ionization, beam of electrons. This may cause some of the sample's molecules to break up into positively charged fragments or simply become positively charged without fragmenting. These ions (fragmen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Imperial College London
Imperial College London, also known as Imperial, is a Public university, public research university in London, England. Its history began with Prince Albert of Saxe-Coburg and Gotha, Prince Albert, husband of Queen Victoria, who envisioned a Albertopolis, cultural district in South Kensington that included museums, colleges, and the Royal Albert Hall. In 1907, these colleges – the Royal College of Science, the Royal School of Mines, and the City and Guilds of London Institute – merged to form the Imperial College of Science and Technology. In 1988, Imperial merged with St Mary's Hospital, London, St Mary's Hospital Medical School and then with Charing Cross and Westminster Medical School to form the Imperial College School of Medicine. The Imperial Business School was established in 2003 and officially opened by Elizabeth II, Queen Elizabeth II. Formerly a constituent college of the University of London, Imperial became an independent university in 2007. Imperial is o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Birkbeck College, University Of London
Birkbeck, University of London (formally Birkbeck College, University of London), is a public research university located in London, England, and a member institution of the University of London. Established in 1823 as the London Mechanics' Institute by its founder Joseph Clinton Robertson and its supporters George Birkbeck, Jeremy Bentham, J. C. Hobhouse and Henry Brougham, Birkbeck is one of the few universities to specialise in evening higher education in the United Kingdom. Birkbeck's main building is in Bloomsbury, in the London Borough of Camden in Central London. Birkbeck offers more than 200 undergraduate and postgraduate programmes. Birkbeck's academic activities are organised into five constituent faculties, which are subdivided into nineteen departments. The university is a member of academic organisations such as the Association of Commonwealth Universities and the European University Association. The university is also a member of the Screen Studies Group, L ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jeremy K
Jeremy may refer to: * Jeremy (given name), an English male given name * Jérémy, a French given name * ''Jeremy'' (film), a 1973 film * "Jeremy" (song), a 1992 song by Pearl Jam * Jeremy (snail), a left-coiled garden snail that died in 2017 * ''Jeremy'', a 1919 novel by Hugh Walpole See also * * * Jeremiah (other) * Jeremie (other) * Jerome (other) Jerome (c.347–420) was a priest, confessor, theologian and historian from Dalmatia. Jerome may also refer to: People Given name * Jerome (given name), a masculine name of Greek origin, with a list of people so named * Saint Jerome (disambigu ... * Jeromy (other) {{disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Magic Angle Spinning
In solid-state NMR spectroscopy, magic-angle spinning (MAS) is a technique routinely used to produce better resolution NMR spectra. MAS NMR consists in spinning the sample (usually at a frequency of 1 to 130 kHz) at the magic angle θm (ca. 54.74°, where cos2θm=1/3) with respect to the direction of the magnetic field. Three main interactions responsible in solid state NMR ( dipolar, chemical shift anisotropy, quadrupolar) often lead to very broad and featureless NMR lines. However, these three interactions in solids are orientation-dependent and can be averaged to some extent by MAS: * The nuclear dipolar interaction has a 3\cos^2\theta - 1 dependence, where \theta is the angle between the internuclear axis and the main magnetic field. As a result, the dipolar interaction vanish at the magic angle θm and the interaction contributing to the line broadening is removed. Even though all internuclear vectors cannot be all set to the magic angle, rotating the sample around ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
