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Lathyrism
Lathyrism is a condition caused by eating certain legumes of the genus ''Lathyrus''. There are three types of lathyrism: '' neurolathyrism'', '' osteolathyrism'', and '' angiolathyrism'', all of which are incurable, differing in their symptoms and in the body tissues affected. Neurolathyrism is the type associated with the consumption of legumes in the genus ''Lathyrus'' that contain the toxin ODAP. ODAP ingestion results in motorneuron death. The result is paralysis and muscle atrophy of the lower limbs. Osteolathyrism, a different type of lathyrism, affects the connective tissues, not the motorneurons. Osteolathyrism results from the ingestion of '' Lathyrus odoratus'' seeds (sweet peas), and is often referred to as odoratism. It is caused by a different toxin, beta-aminopropionitrile, which affects the linking of the subunits of collagen, a major structural protein found in connective tissue. A third type of lathyrism is angiolathyrism, which is similar to osteolathyrism i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurolathyrism
Neurolathyrism, is a neurological disease of humans, caused by eating certain legumes of the genus ''Lathyrus''. This disease is mainly associated with the consumption of '' Lathyrus sativus'' (also known as ''grass pea'', ''chickling pea'', ''kesari dal'', or ''almorta'') and to a lesser degree with ''Lathyrus cicera'', '' Lathyrus ochrus'' and ''Lathyrus clymenum'' containing the toxin ODAP. This is not to be confused with osteolathyrism, a different type of lathyrism that affects the connective tissues. Osteolathyrism results from the ingestion of '' Lathyrus odoratus'' seeds (''sweet peas'') and is often referred to as odoratism. It is caused by a different toxin ( beta-aminopropionitrile) which affects the linking of collagen, a protein of connective tissues. Another type of lathyrism is angiolathyrism which is similar to osteolathyrism in its effects on connective tissue. However, the blood vessels are affected as opposed to bone. Signs and symptoms The consumption of la ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurolathyrism
Neurolathyrism, is a neurological disease of humans, caused by eating certain legumes of the genus ''Lathyrus''. This disease is mainly associated with the consumption of '' Lathyrus sativus'' (also known as ''grass pea'', ''chickling pea'', ''kesari dal'', or ''almorta'') and to a lesser degree with ''Lathyrus cicera'', '' Lathyrus ochrus'' and ''Lathyrus clymenum'' containing the toxin ODAP. This is not to be confused with osteolathyrism, a different type of lathyrism that affects the connective tissues. Osteolathyrism results from the ingestion of '' Lathyrus odoratus'' seeds (''sweet peas'') and is often referred to as odoratism. It is caused by a different toxin ( beta-aminopropionitrile) which affects the linking of collagen, a protein of connective tissues. Another type of lathyrism is angiolathyrism which is similar to osteolathyrism in its effects on connective tissue. However, the blood vessels are affected as opposed to bone. Signs and symptoms The consumption of la ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Osteolathyrism
Osteolathyrism, sometimes referred to as odoratism, is a form of the disease Lathyrism. The disease results from the ingestion of '' Lathyrus odoratus'' seeds (sweet peas). The toxin found in the sweet peas is ( beta-aminopropionitrile), which affects the linking of collagen, a protein of connective tissues. The condition results in damage to bone and mesenchymal connective tissues. Osteolathyrism occurs in people in combination with neurolathyrism and angiolathyrism in areas where famine demands reliance on a crop with known detrimental effects. It occurs in cattle and horses with diets overreliant upon the grass pea. Prominent symptoms include skeletal deformities and bone pain. Signs and symptoms *Bone pain *Skeletal deformity *Fatigue *Malnourishment Cause Aside from ''L. odoratus'', other members of the genus are also known to cause the disease, including '' L. sylvestris'', '' L. cicera'', and '' L. clymenum''. ''L. odoratus'' grows well under famine conditions, often ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Osteolathyrism
Osteolathyrism, sometimes referred to as odoratism, is a form of the disease Lathyrism. The disease results from the ingestion of '' Lathyrus odoratus'' seeds (sweet peas). The toxin found in the sweet peas is ( beta-aminopropionitrile), which affects the linking of collagen, a protein of connective tissues. The condition results in damage to bone and mesenchymal connective tissues. Osteolathyrism occurs in people in combination with neurolathyrism and angiolathyrism in areas where famine demands reliance on a crop with known detrimental effects. It occurs in cattle and horses with diets overreliant upon the grass pea. Prominent symptoms include skeletal deformities and bone pain. Signs and symptoms *Bone pain *Skeletal deformity *Fatigue *Malnourishment Cause Aside from ''L. odoratus'', other members of the genus are also known to cause the disease, including '' L. sylvestris'', '' L. cicera'', and '' L. clymenum''. ''L. odoratus'' grows well under famine conditions, often ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Beta-aminopropionitrile
Aminopropionitrile, also known as β-aminopropionitrile (BAPN), is an organic compound with both amine and nitrile functional groups. It is a colourless liquid. The compound occurs naturally and is of interest in the biomedical community. Biochemical and medical occurrence BAPN is the toxic constituent of peas from Lathyrus plants, e.g., lathyrus odoratus. Lathyrism, a disease known for centuries, encompasses 2 distinct entities: a disorder of the nervous system (neurolathyrism) leading to limb paralysis, and a disorder of connective tissue, causing either bone deformity (osteolathyrism) or aortic aneurisms (angiolathyrim). BAPN causes osteolathyrism and angiolathyrism when ingested in large quantities." It can cause osteolathyrism, neurolathyrism, and/or angiolathyrism. It is an antirheumatic agent in veterinary medicine. It has attracted interest as an anticancer agent. Production Aminopropionitrile is prepared by the reaction of ammonia with acrylonitrile.Karsten Eller, E ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxalyldiaminopropionic Acid
Oxalyldiaminopropionic acid (ODAP) is a structural analogue of the neurotransmitter glutamate found in the grass pea ''Lathyrus sativus''. It is the neurotoxin responsible for the motor neuron degeneration syndrome lathyrism. Sources ODAP is found in the seeds of the legume ''L. sativus'', a grass pea plant, in the range of .5% w/w. ''L. sativus'' can be found in areas of Southern, Central, and Eastern Europe, the Mediterranean Basin, Iraq and Afghanistan as well as areas of Asia and Africa.Heuzé V., Tran G., Hassoun P., Lessire M., Lebas F., 2016. Grass pea (Lathyrus sativus). Feedipedia, a programme by INRA, CIRAD, AFZ and FAO. https://www.feedipedia.org/node/285 Last updated on April 19, 2016, 15:36 History In some regions, including the Indian subcontinent, Bangladesh, Ethiopia and Nepal, the grass pea has become a staple food item. The plant has a high tolerance of environmental conditions which results in it being the only available food source in times of famine or drought ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Angiolathyrism
Angiolathyrism is a form of Lathyrism disease. It is mainly caused the consumption of '' Lathyrus sativus'' (also known as ''grass pea'') and to a lesser degree by ''Lathyrus cicera'', '' Lathyrus ochrus'' and ''Lathyrus clymenum'' at ''Prince Leopold Institute of Tropical Medicine'' online database containing the . The main chemical responsible is β- |
Lathyrus Sativus
''Lathyrus sativus'', also known as grass pea, cicerchia, blue sweet pea, chickling pea, chickling vetch, Indian pea, white pea and white vetch,'' Kew Gardens'''Lathyrus sativus'' (grass pea) is a legume (family Fabaceae) commonly grown for human consumption and livestock feed in Asia and East Africa. It is a particularly important crop in areas that are prone to drought and famine, and is thought of as an 'insurance crop' as it produces reliable yields when all other crops fail. The Serra de'Conti Cicerchia is included in the Ark of Taste. The seeds contain a neurotoxin that causes lathyrism, a neurodegenerative disease, if eaten as a primary protein source for a prolonged period. Cultivation ''Lathyrus sativus'' grows best where the average temperature is 10–25 °C and average rainfall is per year. Like other legumes, it improves the nitrogen content of soil. The crop can survive drought or floods, but grows best in moist soils. It tolerates a range of soil types from ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Angiolathyrism
Angiolathyrism is a form of Lathyrism disease. It is mainly caused the consumption of '' Lathyrus sativus'' (also known as ''grass pea'') and to a lesser degree by ''Lathyrus cicera'', '' Lathyrus ochrus'' and ''Lathyrus clymenum'' at ''Prince Leopold Institute of Tropical Medicine'' online database containing the . The main chemical responsible is β- |
Lysyl Oxidase
Lysyl oxidase (LOX), also known as protein-lysine 6-oxidase, is an enzyme that, in humans, is encoded by the ''LOX'' gene. It catalyzes the conversion of lysine molecules into highly reactive aldehydes that form cross-links in extracellular matrix proteins. Its inhibition can cause osteolathyrism, but, at the same time, its upregulation by tumor cells may promote metastasis of the existing tumor, causing it to become malignant and cancerous. Structure In the yeast strain ''Pichia pastoris'', lysyl oxidase constitutes a homodimeric structure. Each monomer consists of an active site that includes a Cu(II) atom coordinated with three histidine residues as well as 2,4,5-trihydroxyphenalanine quinone (TPQ), a crucial cofactor. In humans, the LOX gene is located on chromosome 5 q23.3-31.2. The DNA sequence encodes a polypeptide of 417 amino acids, the first 21 residues of which constitute a signal peptide, with a weight of approximately 32 kDa. The carboxyterminus contains ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lathyrus Odoratus
The sweet pea, ''Lathyrus odoratus'', is a flowering plant in the genus ''Lathyrus'' in the family Fabaceae (legumes), native to Sicily, southern Italy and the Aegean Islands. It is an annual climbing plant, growing to a height of , where suitable support is available. The leaves are pinnate with two leaflets and a terminal tendril, which twines around supporting plants and structures, helping the sweet pea to climb. In the wild plant the flowers are purple, broad; they are larger and highly variable in color in the many cultivars. Flowers are usually strongly scented. The annual species, ''L. odoratus'', may be confused with the everlasting pea, '' L. latifolius'', a perennial. Horticultural development Scottish nurseryman Henry Eckford (1823–1905) cross-bred and developed the sweet pea, turning it from a rather insignificant if sweetly scented flower into a floral sensation of the 19th century. His initial success and recognition came while serving as head gardener for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lathyrus
''Lathyrus'' is a genus of flowering plants in the legume family Fabaceae, and contains approximately 160 species. Commonly known as peavines or vetchlings, they are native to temperate areas, with a breakdown of 52 species in Europe, 30 species in North America, 78 in Asia, 24 in tropical East Africa, and 24 in temperate South America. There are annual and perennial species which may be climbing or bushy. This genus has numerous sections, including ''Orobus'', which was once a separate genus. Uses Many species are cultivated as garden plants. The genus includes the garden sweet pea (''Lathyrus odoratus'') and the perennial everlasting pea (''Lathyrus latifolius''). Flowers on these cultivated species may be rose, red, maroon, pink, white, yellow, purple or blue, and some are bicolored. They are also grown for their fragrance. Cultivated species are susceptible to fungal infections including downy and powdery mildew. Other species are grown for food, including the Ind ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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