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Jrk
''dClock (clk)'' is a gene located on the 3L chromosome of ''Drosophila melanogaster''. Gene mapping, Mapping and Molecular cloning, cloning of the gene indicates that it is the ''Drosophila'' Homology (biology), homolog of the mouse gene CLOCK (''mClock''). The Jrk mutation disrupts the Transcription (biology), transcription cycling of ''Period (gene), per'' and ''Timeless (gene), tim'' and manifests dominant effects. Discovery Discovered at Brandeis University in 1998, cloning the mutant ''Jrk'' led to the identification of the Drosophila melanogaster, drosophila Homology (biology), homolog of the mammalian CLOCK, Clock gene in DNA. ''Jrk'' mutation ''Jrk'' is a mutation of a gene (not to be confused with JRKL ) discovered by Michael Rosbash and his colleagues in 1998. A common misconception is that the ''Jrk'' mutant gene is the ''Drosophila'' homolog of CLOCK (''mClock''), which disrupts cycling transcription of the ''Period (gene), per'' and ''Timeless (gene), tim'' genes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Michael Rosbash
Michael Morris Rosbash (born March 7, 1944) is an American geneticist and chronobiologist. Rosbash is a professor and researcher at Brandeis University and investigator at the Howard Hughes Medical Institute. Rosbash's research group cloned the ''Drosophila'' period gene in 1984 and proposed the Transcription Translation Negative Feedback Loop for circadian clocks in 1990. In 1998, they discovered the cycle gene, clock gene, and cryptochrome photoreceptor in ''Drosophila'' through the use of forward genetics, by first identifying the phenotype of a mutant and then determining the genetics behind the mutation. Rosbash was elected to the National Academy of Sciences in 2003. Along with Michael W. Young and Jeffrey C. Hall, he was awarded the 2017 Nobel Prize in Physiology or Medicine "for their discoveries of molecular mechanisms controlling the circadian rhythm". Life Michael Rosbash was born in Kansas City, Missouri. His parents, Hilde and Alfred Rosbash, were Jewish ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |