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Michael Rosbash
Michael Morris Rosbash (born March 7, 1944) is an American geneticist and chronobiologist. Rosbash is a professor and researcher at Brandeis University and investigator at the Howard Hughes Medical Institute. Rosbash's research group cloned the ''Drosophila'' period gene in 1984 and proposed the Transcription Translation Negative Feedback Loop for circadian clocks in 1990. In 1998, they discovered the cycle gene, clock gene, and cryptochrome photoreceptor in ''Drosophila'' through the use of forward genetics, by first identifying the phenotype of a mutant and then determining the genetics behind the mutation. Rosbash was elected to the National Academy of Sciences in 2003. Along with Michael W. Young and Jeffrey C. Hall, he was awarded the 2017 Nobel Prize in Physiology or Medicine "for their discoveries of molecular mechanisms controlling the circadian rhythm". Life Michael Rosbash was born in Kansas City, Missouri. His parents, Hilde and Alfred Rosbash, were Jewish ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kansas City, Missouri
Kansas City, Missouri, abbreviated KC or KCMO, is the largest city in the U.S. state of Missouri by List of cities in Missouri, population and area. The city lies within Jackson County, Missouri, Jackson, Clay County, Missouri, Clay, and Platte County, Missouri, Platte counties, with a small portion lying within Cass County, Missouri, Cass County. It is the central city of the Kansas City metropolitan area, which straddles the Missouri–Kansas state line and has a population of 2,392,035. As of the 2020 United States census, 2020 census, the city had a population of 508,090, making it the sixth-most populous city in the Midwestern United States, Midwest and List of United States cities by population, 38th-most populous city in the United States. Kansas City was founded in the 1830s as a port on the Missouri River at its confluence with the Kansas River from the west. On June 1, 1850, the town of Kansas was incorporated; shortly after came the establishment of the Kansas Terr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Circadian Clock
A circadian clock, or circadian oscillator, also known as one’s internal alarm clock is a biochemical oscillator that cycles with a stable phase and is synchronized with solar time. Such a clock's ''in vivo'' period is necessarily almost exactly 24 hours (the earth's current solar day). In most living organisms, internally synchronized circadian clocks make it possible for the organism to anticipate daily environmental changes corresponding with the day–night cycle and adjust its biology and behavior accordingly. The term circadian derives from the Latin ''circa'' (about) ''dies'' (a day), since when taken away from external cues (such as environmental light), they do not run to exactly 24 hours. Clocks in humans in a lab in constant low light, for example, will average about 24.2 hours per day, rather than 24 hours exactly. The normal body clock oscillates with an endogenous period of exactly 24 hours, it entrains, when it receives sufficient daily corrective signals from ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hazzan
A ''hazzan'' (; , lit. Hazan) or ''chazzan'' (, plural ; ; ) is a Jewish musician or precentor trained in the vocal arts who leads the congregation in songful prayer. In English, this prayer leader is often referred to as a cantor, a term also used in Christianity. The person who leads the congregation in a public prayer is called the '' sh'liaḥ'' (Hebrew for ' emissary of the congregation'). Any person is called a ''sh'liach tzibbur'' while they are leading a prayer. However, the term ''hazzan'' more commonly refers to someone who has special training in leading prayers, or who is appointed to lead prayers on a regular basis in a particular synagogue. Qualifications Jewish law restricts the role of ''sh'liah tzibbur'' to adult Jews; in Orthodox Judaism, it is restricted to males. In theory, any layperson can be a ; many synagogue-attending Jews will serve in this role from time to time, especially on weekdays or during a Yahrzeit. Proficiency in Hebrew pronunciation i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Times Of Israel
''The Times of Israel'' (ToI) is an Israeli multi-language online newspaper that was launched in 2012 and has since become the largest English-language Jewish and Israeli news source by audience size. It was co-founded by Israeli journalist David Horovitz, who is also the founding editor, and American billionaire investor Seth Klarman.Forbes: The World's Billionaires: Seth Klarman . April 2014. Based in , it "documents developments in Israel, the Middle East and around the Jewish world." Along with its original English site, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nazi Germany
Nazi Germany, officially known as the German Reich and later the Greater German Reich, was the German Reich, German state between 1933 and 1945, when Adolf Hitler and the Nazi Party controlled the country, transforming it into a Totalitarianism, totalitarian dictatorship. The Third Reich, meaning "Third Realm" or "Third Empire", referred to the Nazi claim that Nazi Germany was the successor to the earlier Holy Roman Empire (800–1806) and German Empire (1871–1918). The Third Reich, which the Nazis referred to as the Thousand-Year Reich, ended in May 1945, after 12 years, when the Allies of World War II, Allies defeated Germany and entered the capital, Berlin, End of World War II in Europe, ending World War II in Europe. After Hitler was appointed Chancellor of Germany in 1933, the Nazi Party began to eliminate political opposition and consolidate power. A 1934 German referendum confirmed Hitler as sole ''Führer'' (leader). Power was centralised in Hitler's person, an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jewish
Jews (, , ), or the Jewish people, are an ethnoreligious group and nation, originating from the Israelites of History of ancient Israel and Judah, ancient Israel and Judah. They also traditionally adhere to Judaism. Jewish ethnicity, religion, and community are highly interrelated, as Judaism is their ethnic religion, though it is not practiced by all ethnic Jews. Despite this, religious Jews regard Gerim, converts to Judaism as members of the Jewish nation, pursuant to the Conversion to Judaism, long-standing conversion process. The Israelites emerged from the pre-existing Canaanite peoples to establish Kingdom of Israel (Samaria), Israel and Kingdom of Judah, Judah in the Southern Levant during the Iron Age.John Day (Old Testament scholar), John Day (2005), ''In Search of Pre-Exilic Israel'', Bloomsbury Publishing, pp. 47.5 [48] 'In this sense, the emergence of ancient Israel is viewed not as the cause of the demise of Canaanite culture but as its upshot'. Originally, J ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Washington Post
''The Washington Post'', locally known as ''The'' ''Post'' and, informally, ''WaPo'' or ''WP'', is an American daily newspaper published in Washington, D.C., the national capital. It is the most widely circulated newspaper in the Washington metropolitan area and has a national audience. As of 2023, the ''Post'' had 130,000 print subscribers and 2.5 million digital subscribers, both of which were the List of newspapers in the United States, third-largest among U.S. newspapers after ''The New York Times'' and ''The Wall Street Journal''. The ''Post'' was founded in 1877. In its early years, it went through several owners and struggled both financially and editorially. In 1933, financier Eugene Meyer (financier), Eugene Meyer purchased it out of bankruptcy and revived its health and reputation; this work was continued by his successors Katharine Graham, Katharine and Phil Graham, Meyer's daughter and son-in-law, respectively, who bought out several rival publications. The ''Post ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jeffrey C
Jeffrey may refer to: * Jeffrey (name) Jeffrey is a common English language, English given name, and a variant form of the name Geoffrey (given name), Geoffrey (itself from a Middle French variant of Godfrey (name), Godfrey, Gottfried). It has been argued that the common derivation of ..., including a list of people with the name * Jeffrey's, Newfoundland and Labrador, Canada * Jeffrey City, Wyoming, United States * Jeffrey Street, Sydney, Australia * Jeffreys Bay, Western Cape, South Africa Art and entertainment * ''Jeffrey'' (play), a 1992 off-Broadway play by Paul Rudnick * ''Jeffrey'' (1995 film), a 1995 film by Paul Rudnick, based on Rudnick's play of the same name * ''Jeffrey'' (2016 film), a 2016 Dominican Republic documentary film * Jeffrey's sketch, a sketch on American TV show ''Saturday Night Live'' *'' Nurse Jeffrey'', a spin-off miniseries from the American medical drama series ''House, MD'' People with the surname * Alexander Jeffrey (1806–1874), Scottish s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Michael W
Michael may refer to: People * Michael (given name), a given name * Michael (surname), including a list of people with the surname Michael Given name * Michael (bishop elect), English 13th-century Bishop of Hereford elect * Michael (Khoroshy) (1885–1977), cleric of the Ukrainian Orthodox Church of Canada * Michael Donnellan (fashion designer), Michael Donnellan (1915–1985), Irish-born London fashion designer, often referred to simply as "Michael" * Michael (footballer, born 1982), Brazilian footballer * Michael (footballer, born 1983), Brazilian footballer * Michael (footballer, born 1993), Brazilian footballer * Michael (footballer, born February 1996), Brazilian footballer * Michael (footballer, born March 1996), Brazilian footballer * Michael (footballer, born 1999), Brazilian footballer Rulers Byzantine emperors *Michael I Rangabe (d. 844), married the daughter of Emperor Nikephoros I *Michael II (770–829), called "the Stammerer" and "the Amorian" *Michael III ( ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Academy Of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the National Academy of Medicine (NAM). As a national academy, new members of the organization are elected annually by current members, based on their distinguished and continuing achievements in original research. Election to the National Academy is one of the highest honors in the scientific field in the United States. Member of the National Academy of Sciences, Members of the National Academy of Sciences serve ''pro bono'' as "advisers to the nation" on science, engineering, and medicine. The group holds a congressional charter under Title 36 of the United States Code. Congress legislated and President Abraham Lincoln signed an Act of Congress (1863) establishing the National Academy of Sciences as an independent, trusted nongovernmen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Forward Genetics
Forward genetics is a molecular genetics approach of determining the genetic basis responsible for a phenotype. Forward genetics provides an unbiased approach because it relies heavily on identifying the genes or genetic factors that cause a particular phenotype or trait of interest. This was initially done by using naturally occurring mutations or inducing mutants with radiation, chemicals, or insertional mutagenesis (e.g. transposable elements). Subsequent breeding takes place, mutant individuals are isolated, and then the gene is gene mapping, mapped. Forward genetics can be thought of as a counter to reverse genetics, which determines the function of a gene by analyzing the phenotypic effects of altered DNA sequences. Mutant phenotypes are often observed long before having any idea which gene is responsible, which can lead to genes being named after their mutant phenotype (e.g. Drosophila ''rosy'' gene which is named after the eye colour in mutants). Techniques used in Forward ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Photoreception
A photoreceptor cell is a specialized type of neuroepithelial cell found in the retina that is capable of visual phototransduction. The great biological importance of photoreceptors is that they convert light (visible electromagnetic radiation) into signals that can stimulate biological processes. To be more specific, photoreceptor proteins in the cell absorb photons, triggering a change in the cell's membrane potential. There are currently three known types of photoreceptor cells in mammalian eyes: rods, cones, and intrinsically photosensitive retinal ganglion cells. The two classic photoreceptor cells are rods and cones, each contributing information used by the visual system to form an image of the environment, sight. Rods primarily mediate scotopic vision (dim conditions) whereas cones primarily mediate photopic vision (bright conditions), but the processes in each that supports phototransduction is similar. The intrinsically photosensitive retinal ganglion cells were dis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
