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Jacques Tréfouël
Jacques Tréfouël (9 November 1897, Le Raincy – 11 July 1977, Paris) was a French medicinal chemistry, medical chemist. He collaborated closely with his wife, Thérèse Tréfouël, including on the discovery of sulfanilamide. Biography From 1920 to 1928 he worked as an assistant to Ernest Fourneau in the laboratory of medicinal chemistry at the Pasteur Institute. For the next ten years, he served as laboratory chief at the Institute, during which time, he was involved in the synthesis and development of drugs such as stovarsol, orsanine, and rhodoquine. In 1935, in collaboration with his wife, chemist Thérèse Tréfouël, and pharmacologists Daniel Bovet and Federico Nitti, he conducted research of prontosil, of which, they demonstrated that only a portion of the substance, named sulphanilamide, was active against streptococcus. The group also showed sulphanilamide's effective action against other types of bacteria (meningococcus, pneumococcus, gonococcus, Friedlander's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Le Raincy
Le Raincy () is a prestigious communes of France, commune in the eastern suburbs of Paris, France. It is located from the Kilometre Zero, center of Paris. Le Raincy is a subprefecture of the Seine-Saint-Denis departments of France, department and the seat of the Arrondissement of Le Raincy. Its population is small relative to surrounding communes, just under 15,000. However, its development as an administrative centre, along with the establishment over the years of several schools, gives it more prominence than its population size would suggest. Its character has made it known as ''le Neuilly-sur-Seine, Neuilly de la Seine-Saint-Denis''. History In the 17th and 18th century, Raincy was known primarily as location of the Château du Raincy, now demolished. The commune of Le Raincy was created on 20 May 1869 by detaching a part of the territory of Livry-Gargan and merging it with a part of the territory of Clichy-sous-Bois and a small part of the territory of Gagny. Heraldry ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gonococcus
''Neisseria gonorrhoeae'', also known as ''gonococcus'' (singular) or ''gonococci'' (plural), is a species of Gram-negative diplococci bacteria first isolated by Albert Neisser in 1879. An obligate human pathogen, it primarily colonizes the mucosal lining of the urogenital tract; however, it is also capable of adhering to the mucosa of the nose, pharynx, rectum, and conjunctiva. It causes the sexually transmitted genitourinary infection gonorrhea as well as other forms of gonococcal disease including disseminated gonococcemia, septic arthritis, and gonococcal ophthalmia neonatorum. ''N. gonorrhoeae'' is oxidase positive and a microaerophile that is capable of surviving phagocytosis and growing inside neutrophils. Culturing it requires carbon dioxide supplementation and enriched agar (chocolate agar) with various antibiotics ( Thayer–Martin). It exhibits antigenic variation through genetic recombination of its pili and surface proteins that interact with the immune system. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
French Pharmacologists
French may refer to: * Something of, from, or related to France ** French language, which originated in France ** French people, a nation and ethnic group ** French cuisine, cooking traditions and practices Arts and media * The French (band), a British rock band * "French" (episode), a live-action episode of ''The Super Mario Bros. Super Show!'' * ''Française'' (film), a 2008 film * French Stewart (born 1964), American actor Other uses * French (surname), a surname (including a list of people with the name) * French (tunic), a type of military jacket or tunic * French's, an American brand of mustard condiment * French (catheter scale), a unit of measurement * French Defence, a chess opening * French kiss, a type of kiss See also * France (other) * Franch, a surname * French Revolution (other) * French River (other), several rivers and other places * Frenching (other) * Justice French (other) Justice French may refer to: * C. G. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1977 Deaths
Events January * January 8 – Three bombs explode in Moscow within 37 minutes, killing seven. The bombings are attributed to an Armenia Armenia, officially the Republic of Armenia, is a landlocked country in the Armenian Highlands of West Asia. It is a part of the Caucasus region and is bordered by Turkey to the west, Georgia (country), Georgia to the north and Azerbaijan to ...n separatist group. * January 10 – Mount Nyiragongo erupts in eastern Zaire (now the Democratic Republic of the Congo). * January 17 – 49 marines from the and are killed as a result of a collision in Barcelona harbour, Spain. * January 18 ** Scientists identify a previously unknown Bacteria, bacterium as the cause of the mysterious Legionnaires' disease. ** Australia's worst Granville rail disaster, railway disaster at Granville, a suburb of Sydney, leaves 83 people dead. ** SFR Yugoslavia Prime minister Džemal Bijedić, his wife and 6 others are killed in a plane crash in Bosnia and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1897 Births
Events January * January 2 – The International Alpha Omicron Pi sorority is founded, in New York City. * January 4 – A British force is ambushed by Chief Ologbosere, son-in-law of the ruler. This leads to a punitive expedition against Benin. * January 7 – A cyclone destroys Darwin, Australia. * January 8 – Lady Flora Shaw, future wife of Governor General Lord Lugard, officially proposes the name "Nigeria" in a newspaper contest, to be given to the British Niger Coast Protectorate. * January 22 – In this date's issue of the journal ''Engineering'', the word ''computer'' is first used to refer to a mechanical calculation device. * January 31 – The Czechoslovak Trade Union Association is founded in Prague. February * February 10 – Freedom of religion is proclaimed in Madagascar. * February 16 – The French conquer the island of Raiatea and capture the rebel chief Teraupo'o, ending the Leeward Islands War and brin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arsenic
Arsenic is a chemical element; it has Symbol (chemistry), symbol As and atomic number 33. It is a metalloid and one of the pnictogens, and therefore shares many properties with its group 15 neighbors phosphorus and antimony. Arsenic is notoriously toxic. It occurs naturally in many minerals, usually in combination with sulfur and metals, but also as a pure elemental crystal. It has various Allotropes of arsenic, allotropes, but only the grey form, which has a metallic appearance, is important to industry. The primary use of arsenic is in alloys of lead (for example, in car batteries and ammunition). Arsenic is also a common n-type dopant in semiconductor electronic devices, and a component of the III–V compound semiconductor gallium arsenide. Arsenic and its compounds, especially the trioxide, are used in the production of pesticides, treated wood products, herbicides, and insecticides. These applications are declining with the increasing recognition of the persistent tox ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pentavalents
In chemistry, the valence (US spelling) or valency (British spelling) of an atom is a measure of its combining capacity with other atoms when it forms chemical compounds or molecules. Valence is generally understood to be the number of chemical bonds that each atom of a given chemical element typically forms. Double bonds are considered to be two bonds, triple bonds to be three, quadruple bonds to be four, quintuple bonds to be five and sextuple bonds to be six. In most compounds, the valence of hydrogen is 1, of oxygen is 2, of nitrogen is 3, and of carbon is 4. Valence is not to be confused with the related concepts of the coordination number, the oxidation state, or the number of valence electrons for a given atom. Description The valence is the combining capacity of an atom of a given element, determined by the number of hydrogen atoms that it combines with. In methane, carbon has a valence of 4; in ammonia, nitrogen has a valence of 3; in water, oxygen has a valence of 2; ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sulfamide
Sulfamide (IUPAC name: sulfuric diamide) is a compound with the chemical formula and structure . Sulfamide is produced by the reaction of sulfuryl chloride with ammonia. Sulfamide was first prepared in 1838 by the French chemist Henri Victor Regnault. Sulfamide functional group In organic chemistry, the term ''sulfamide'' may also refer to the functional group which consists of at least one organic group attached to a nitrogen atom of sulfamide. Symmetric sulfamides can be prepared directly from amines, sulfur dioxide gas and an oxidant: : In this example, the reactants are aniline, triethylamine (, Et = ethyl group), and iodine. Sulfur dioxide is believed to be activated through a series of intermediates: , and . The sulfamide functional group is an increasingly common structural feature used in medicinal chemistry. See also * Sulfamic acid * Sulfonamide In organic chemistry, the sulfonamide functional group (also spelled sulphonamide) is an organosulfur group with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Malaria
Malaria is a Mosquito-borne disease, mosquito-borne infectious disease that affects vertebrates and ''Anopheles'' mosquitoes. Human malaria causes Signs and symptoms, symptoms that typically include fever, Fatigue (medical), fatigue, vomiting, and headaches. In severe cases, it can cause jaundice, Epileptic seizure, seizures, coma, or death. Symptoms usually begin 10 to 15 days after being bitten by an infected ''Anopheles'' mosquito. If not properly treated, people may have recurrences of the disease months later. In those who have recently survived an infection, reinfection usually causes milder symptoms. This partial Immunity (medical), resistance disappears over months to years if the person has no continuing exposure to malaria. The mosquitoes themselves are harmed by malaria, causing reduced lifespans in those infected by it. Malaria is caused by protozoa, single-celled microorganisms of the genus ''Plasmodium''. It is spread exclusively through bites of infected female ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Académie Des Sciences
The French Academy of Sciences (, ) is a learned society, founded in 1666 by Louis XIV at the suggestion of Jean-Baptiste Colbert, to encourage and protect the spirit of French Scientific method, scientific research. It was at the forefront of scientific developments in Europe in the 17th and 18th centuries, and is one of the earliest Academy of Sciences, Academies of Sciences. Currently headed by Patrick Flandrin (President of the academy), it is one of the five Academies of the . __TOC__ History The Academy of Sciences traces its origin to Colbert's plan to create a general academy. He chose a small group of scholars who met on 22 December 1666 in the King's library, near the present-day Bibliothèque nationale de France, Bibliothèque Nationale, and thereafter held twice-weekly working meetings there in the two rooms assigned to the group. The first 30 years of the academy's existence were relatively informal, since no statutes had as yet been laid down for the ins ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Académie De Médecine
An academy (Attic Greek: Ἀκαδήμεια; Koine Greek Ἀκαδημία) is an institution of tertiary education. The name traces back to Plato's school of philosophy, founded approximately 386 BC at Akademia, a sanctuary of Athena, the goddess of wisdom and skill, north of Athens, Greece. The Royal Spanish Academy defines academy as scientific, literary or artistic society established with public authority and as a teaching establishment, public or private, of a professional, artistic, technical or simply practical nature. Etymology The word comes from the ''Academy'' in ancient Greece, which derives from the Athenian hero, '' Akademos''. Outside the city walls of Athens, the gymnasium was made famous by Plato as a center of learning. The sacred space, dedicated to the goddess of wisdom, Athena, had formerly been an olive grove, hence the expression "the groves of Academe". In these gardens, the philosopher Plato conversed with followers. Plato developed his session ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
