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Illumina, Inc.
Illumina, Inc. is an American biotechnology company, headquartered in San Diego, California. Incorporated on April 1, 1998, Illumina develops, manufactures, and markets integrated systems for the analysis of genetic variation and biological function. The company provides a line of products and services that serves the sequencing, genotyping and gene expression, and proteomics markets, and serves more than 155 countries. Illumina's customers include genomic research centers, pharmaceutical companies, academic institutions, clinical research organizations, and biotechnology companies. History Illumina was founded in April 1998 by David Walt, Larry Bock, John Stuelpnagel, Anthony Czarnik, and Mark Chee. While working with CW Group, a venture-capital firm, Bock and Stuelpnagel uncovered what would become Illumina's BeadArray technology at Tufts University and negotiated an exclusive license to that technology. In 1999, Illumina acquired Spyder Instruments (founded by Michal L ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Public Company
A public company is a company whose ownership is organized via shares of share capital, stock which are intended to be freely traded on a stock exchange or in over-the-counter (finance), over-the-counter markets. A public (publicly traded) company can be listed on a stock exchange (listing (finance), listed company), which facilitates the trade of shares, or not (unlisted public company). In some jurisdictions, public companies over a certain size must be listed on an exchange. In most cases, public companies are ''private'' enterprises in the ''private'' sector, and "public" emphasizes their reporting and trading on the public markets. Public companies are formed within the legal systems of particular states and so have associations and formal designations, which are distinct and separate in the polity in which they reside. In the United States, for example, a public company is usually a type of corporation, though a corporation need not be a public company. In the United Kin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Deloitte
Deloitte is a multinational professional services network based in London, United Kingdom. It is the largest professional services network in the world by revenue and number of employees, and is one of the Big Four accounting firms, along with EY, KPMG, and PwC. The Deloitte network is composed of member firms of Deloitte Touche Tohmatsu Limited ( ) a private company limited by guarantee incorporated in England and Wales. The firm was founded by accountant William Welch Deloitte in London, England in 1845 and expanded into the United States in 1890. It merged with Haskins & Sells to form Deloitte Haskins & Sells in 1972 and with Touche Ross in the US to form Deloitte & Touche in 1989. In 1993, the international firm was renamed Deloitte Touche Tohmatsu, later abbreviated to Deloitte. In 2002, Arthur Andersen's practice in the UK as well as several of that firm's practices in Europe and North and South America agreed to merge with Deloitte. Subsequent acquisitions have inc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Madison, Wisconsin
Madison is the List of capitals in the United States, capital city of the U.S. state of Wisconsin. It is the List of municipalities in Wisconsin by population, second-most populous city in the state, with a population of 269,840 at the 2020 United States census, 2020 census. The Madison metropolitan area had 680,796 residents. Centrally located on an isthmus between Lakes Lake Mendota, Mendota and Lake Monona, Monona, the vicinity also encompass Lakes Lake Wingra, Wingra, Lake Kegonsa, Kegonsa and Lake Waubesa, Waubesa. Madison was founded in 1836 and is named after American Founding Fathers of the United States, Founding Father and President James Madison. It is the county seat of Dane County. As the state capital, Madison is home to government chambers including the Wisconsin State Capitol building. It is also home to the University of Wisconsin–Madison, the flagship campus of the University of Wisconsin System. Major companies in the area include American Family Insurance, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Full Genome Sequencing
Whole genome sequencing (WGS), also known as full genome sequencing or just genome sequencing, is the process of determining the entirety of the DNA sequence of an organism's genome at a single time. This entails sequencing all of an organism's chromosomal DNA as well as DNA contained in the mitochondria and, for plants, in the chloroplast. Whole genome sequencing has largely been used as a research tool, but was being introduced to clinics in 2014. In the future of personalized medicine, whole genome sequence data may be an important tool to guide therapeutic intervention. The tool of gene sequencing at SNP level is also used to pinpoint functional variants from association studies and improve the knowledge available to researchers interested in evolutionary biology, and hence may lay the foundation for predicting disease susceptibility and drug response. Whole genome sequencing should not be confused with DNA profiling, which only determines the likelihood that genetic m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Personal Genomics
Personal genomics or consumer genetics is the branch of genomics concerned with the sequencing, analysis and interpretation of the genome of an individual. The genotyping stage employs different techniques, including single-nucleotide polymorphism (SNP) analysis chips (typically 0.02% of the genome), or partial or full genome sequencing. Once the genotypes are known, the individual's variations can be compared with the published literature to determine likelihood of trait expression, ancestry inference and disease risk. Automated high-throughput sequencers have increased the speed and reduced the cost of sequencing, making it possible to offer whole genome sequencing including interpretation to consumers since 2015 for less than $1,000. The emerging market of direct-to-consumer genome sequencing services has brought new questions about both the medical efficacy and the ethical dilemmas associated with widespread knowledge of individual genetic information. In personali ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Manteia Predictive Medicine
Manteia Predictive Medicine S.A. (initially incorporated under the name "GenInEx S.A.") was a start-up company created in November 2000 as a spin-off of Serono, a Swiss-based biotechnology company, now part of Merck-Serono, by private founders. Its aim was to provide preventive and curative treatment guidelines for common and complex diseases. These guidelines were envisaged as composed of two parts: * a "personal genome card" containing the entire genome sequence of the person holding the card * an Internet link to a treatment database to be referenced by doctors The company was basing its strategy on the development of so-called "DNA colony sequencing" technology (now commercialized by Illumina), its proprietary massive parallel sequencing technology whose development had been initiated in late 1996 at Glaxo-Welcome's Geneva Biomedical Research Institute (GBRI), by Pascal Mayer and Laurent Farinelli. This work has been protected by several patents and patents applications, public ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hayward, California
Hayward is a city located in Alameda County, California, United States, in the East Bay subregion of the San Francisco Bay Area. With a population of 162,954 as of 2020, Hayward is the sixth largest city in the Bay Area, and the third largest in Alameda County. Hayward was ranked as the 36th most populous List of municipalities in California, municipality in California. It is included in the San Francisco Bay Area Combined Statistical Area, San Francisco–Oakland–San Jose Metropolitan Statistical Area by the US Census. It is located primarily between Castro Valley, California, Castro Valley, San Leandro, California, San Leandro and Union City, California, Union City, and lies at the eastern terminus of the San Mateo-Hayward Bridge, San Mateo–Hayward Bridge. The city was devastated early in its history by the 1868 Hayward earthquake. From the early 20th century until the beginning of the 1980s, Hayward's economy was dominated by its now defunct food canning and salt production ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
David Klenerman
Sir David Klenerman (born 1959) is a British biophysical chemist and a professor of biophysical chemistry at the Department of Chemistry at the University of Cambridge and a Fellow of Christ's College, Cambridge. He is best known for his contribution in the field of next-generation sequencing of DNA (that subsequently resulted in Solexa, a high-speed DNA sequencing company that he co-founded), nanopipette-based scanning ion-conductance microscopy, and super-resolution microscopy. Early life and education Klenerman is the son of two South African-born Jews. He was educated at the University of Cambridge where he was an undergraduate student of Christ's College, Cambridge and received his BA degree in 1982. He earned his PhD degree in chemistry in 1986 as a postgraduate student of Churchill College, Cambridge and was supervised by Ian William Murison Smith. Career and research After his doctorate, Klenerman went to Stanford University as a Fulbright scholar to work on high ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Shankar Balasubramanian
Sir Shankar Balasubramanian (born 30 September 1966) is an Indian-born British chemist and Herchel Smith Professor of Medicinal Chemistry in the Department of Chemistry at the University of Cambridge, ccessed 4 April 2013 Senior Group Leader at the Cancer Research UK Cambridge Institute and Fellow of Trinity College, Cambridge. He is recognised for his contributions in the field of nucleic acids. He is scientific founder of Solexa and biomodal (formally Cambridge Epigenetix). Education Born in Madras (now Chennai) India in 1966, Shankar Balasubramanian moved to the UK with his parents in 1967. He grew up in a rural area just outside Runcorn, Cheshire, and attended Daresbury Primary School, then Appleton Hall High School (which has since amalgamated to form Bridgewater High School). He went on to study the Natural Sciences Tripos at Fitzwilliam College, Cambridge, where he did his undergraduate degree from 1985 to 1988 and continued with a PhD for research on the reaction mech ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Analysis
Proteomics is the large-scale study of proteins. Proteins are vital macromolecules of all living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replication of DNA. In addition, other kinds of proteins include antibodies that protect an organism from infection, and hormones that send important signals throughout the body. The proteome is the entire set of proteins produced or modified by an organism or system. Proteomics enables the identification of ever-increasing numbers of proteins. This varies with time and distinct requirements, or stresses, that a cell or organism undergoes. Proteomics is an interdisciplinary domain that has benefited greatly from the genetic information of various genome projects, including the Human Genome Project. It covers the exploration of proteomes from the overall level of protein composition, structure, and activity, and is an important component of function ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Single Nucleotide Polymorphism
In genetics and bioinformatics, a single-nucleotide polymorphism (SNP ; plural SNPs ) is a germline substitution of a single nucleotide at a specific position in the genome. Although certain definitions require the substitution to be present in a sufficiently large fraction of the population (e.g. 1% or more), many publications do not apply such a frequency threshold. For example, a G nucleotide present at a specific location in a reference genome may be replaced by an A in a minority of individuals. The two possible nucleotide variations of this SNP – G or A – are called alleles. SNPs can help explain differences in susceptibility to a wide range of diseases across a population. For example, a common SNP in the CFH gene is associated with increased risk of age-related macular degeneration. Differences in the severity of an illness or response to treatments may also be manifestations of genetic variations caused by SNPs. For example, two common SNPs in the ''A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fortune (magazine)
''Fortune'' (stylized in all caps) is an American global business magazine headquartered in New York City. It is published by Fortune Media Group Holdings, a global business media company. The publication was founded by Henry Luce in 1929. The magazine competes with ''Forbes'' and '' Bloomberg Businessweek'' in the national business magazine category and distinguishes itself with long, in-depth feature articles. The magazine regularly publishes ranked lists including ranking companies by revenue such as in the ''Fortune'' 500 that it has published annually since 1955, and in the ''Fortune'' Global 500. The magazine is also known for its annual ''Fortune Investor's Guide''. History ''Fortune'' was founded by ''Time'' magazine co-founder Henry Luce in 1929, who declared it as "the Ideal Super-Class Magazine", a "distinguished and de luxe" publication "vividly portraying, interpreting and recording the Industrial Civilization". Briton Hadden, Luce's business partner, was no ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
