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Effective Population Size
The effective population size (''N''''e'') is the size of an idealised population that would experience the same rate of genetic drift as the real population. Idealised populations are those following simple one- locus models that comply with assumptions of the neutral theory of molecular evolution. The effective population size is normally smaller than the census population size ''N'', partly because chance events prevent some individuals from breeding, and partly due to background selection and genetic hitchhiking. The same real population could have a different effective population size for different properties of interest, such as genetic drift (or more precisely, the speed of coalescence) over one generation vs. over many generations. Within a species, areas of the genome that have more genes and/or less genetic recombination tend to have lower effective population sizes, because of the effects of selection at linked sites. In a population with selection at many loci an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Idealised Population
In population genetics an idealised population is one that can be described using a number of simplifying assumptions. Models of idealised populations are either used to make a general point, or they are fit to data on real populations for which the assumptions may not hold true. For example, coalescent theory is used to fit data to models of idealised populations. The most common idealized population in population genetics is described in the Wright-Fisher model after Sewall Wright and Ronald Fisher (1922, 1930) and (1931). Wright-Fisher populations have constant size, and their members can mate and reproduce with any other member. Another example is a Moran model, which has overlapping generations, rather than the non-overlapping generations of the Fisher-Wright model. The complexities of real populations can cause their behavior to match an idealised population with an effective population size that is very different from the census population size of the real population. For ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science (journal)
''Science'' is the peer review, peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals. It was first published in 1880, is currently circulated weekly and has a subscriber base of around 130,000. Because institutional subscriptions and online access serve a larger audience, its estimated readership is over 400,000 people. ''Science'' is based in Washington, D.C., United States, with a second office in Cambridge, UK. Contents The major focus of the journal is publishing important original scientific research and research reviews, but ''Science'' also publishes science-related news, opinions on science policy and other matters of interest to scientists and others who are concerned with the wide implications of science and technology. Unlike most scientific journals, which focus on a specific field, ''Science'' and its rival ''Nature (journal), Nature'' cover the full range of List of academ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
F-statistics
In population genetics, ''F''-statistics (also known as fixation indices) describe the statistically expected level of heterozygosity in a population; more specifically the expected degree of (usually) a reduction in heterozygosity when compared to Hardy–Weinberg expectation. ''F''-statistics can also be thought of as a measure of the correlation between genes drawn at different levels of a (hierarchically) subdivided population. This correlation is influenced by several evolution Evolution is the change in the heritable Phenotypic trait, characteristics of biological populations over successive generations. It occurs when evolutionary processes such as natural selection and genetic drift act on genetic variation, re ...ary processes, such as genetic drift, founder effect, population bottleneck, bottleneck, genetic hitchhiking, meiotic drive, mutation, gene flow, inbreeding, natural selection, or the Wahlund effect, but it was originally designed to measure the amount ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inbreeding
Inbreeding is the production of offspring from the mating or breeding of individuals or organisms that are closely genetic distance, related genetically. By analogy, the term is used in human reproduction, but more commonly refers to the genetic disorders and other consequences that may arise from expression of wikt:deleterious, deleterious dominance (genetics), recessive traits resulting from incestuous sexual relationships and consanguinity. Animals avoid inbreeding only rarely. Inbreeding results in homozygous, homozygosity which can increase the chances of offspring being affected by recessive phenotypic trait, traits. In extreme cases, this usually leads to at least temporarily decreased Fitness (biology), biological fitness of a population (called inbreeding depression), which is its ability to survive and reproduce. An individual who inherits such deleterious traits is colloquially referred to as ''inbred''. The avoidance of expression of such deleterious recessive allel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Allele Frequency
Allele frequency, or gene frequency, is the relative frequency of an allele (variant of a gene) at a particular locus in a population, expressed as a fraction or percentage. Specifically, it is the fraction of all chromosomes in the population that carry that allele over the total population or sample size. Microevolution is the change in allele frequencies that occurs over time within a population. Given the following: # A particular locus on a chromosome and a given allele at that locus # A population of ''N'' individuals with ploidy ''n'', i.e. an individual carries ''n'' copies of each chromosome in their somatic cells (e.g. two chromosomes in the cells of diploid species) # The allele exists in ''i'' chromosomes in the population then the allele frequency is the fraction of all the occurrences ''i'' of that allele and the total number of chromosome copies across the population, ''i''/(''nN''). The allele frequency is distinct from the genotype frequency, although they a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ronald Fisher
Sir Ronald Aylmer Fisher (17 February 1890 – 29 July 1962) was a British polymath who was active as a mathematician, statistician, biologist, geneticist, and academic. For his work in statistics, he has been described as "a genius who almost single-handedly created the foundations for modern statistical science" and "the single most important figure in 20th century statistics". In genetics, Fisher was the one to most comprehensively combine the ideas of Gregor Mendel and Charles Darwin, as his work used mathematics to combine Mendelian genetics and natural selection; this contributed to the revival of Darwinism in the early 20th-century revision of the theory of evolution known as the Modern synthesis (20th century), modern synthesis. For his contributions to biology, Richard Dawkins declared Fisher to be the greatest of Darwin's successors. He is also considered one of the founding fathers of Neo-Darwinism. According to statistician Jeffrey T. Leek, Fisher is the most in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Selection Coefficient
Selection coefficient, usually denoted by the letter ''s'', is a measure used in population genetics to quantify the relative fitness of a genotype compared to other genotypes. Selection coefficients are central to the quantitative description of evolution, since fitness differences determine the change in genotype frequencies attributable to selection Selection may refer to: Science * Selection (biology), also called natural selection, selection in evolution ** Sex selection, in genetics ** Mate selection, in mating ** Sexual selection in humans, in human sexuality ** Human mating strat .... The selection coefficient is typically calculated using fitness values. The fitness (W) of a genotype is a measure of its reproductive success, often expressed as a fraction of the maximum reproductive success in the population. The formula to calculate the selection coefficient s for a genotype is: s = 1 - W, where W is the relative fitness of the genotype, ranging between 0 and 1. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eskimo
''Eskimo'' () is a controversial Endonym and exonym, exonym that refers to two closely related Indigenous peoples: Inuit (including the Alaska Native Iñupiat, the Canadian Inuit, and the Greenlandic Inuit) and the Yupik peoples, Yupik (or Siberian Yupik, Yuit) of eastern Siberia and Alaska. A related third group, Aleuts, who inhabit the Aleutian Islands, are generally excluded from the definition of ''Eskimo''. The three groups share a relatively recent common ancestor, and speak related languages belonging to the family of Eskaleut languages. These circumpolar peoples have traditionally inhabited the Arctic and subarctic regions from eastern Siberia (Russia) to Alaska (United States), Northern Canada, Nunavik, Nunatsiavut, and Greenland. Some Inuit, Yupik, Aleut, and other individuals consider the term ''Eskimo'', which is of a disputed etymology, to be pejorative or even offensive. ''Eskimo'' continues to be used within a historical, linguistic, archaeological, and cultural ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lineage (genetic)
A genetic lineage includes all descendants of a given genetic sequence, typically following a new mutation. It is not the same as an allele because it excludes cases where different mutations give rise to the same allele, and includes descendants that differ from the ancestor by one or more mutations. The genetic sequence can be of different sizes, e.g. a single gene or a haplotype containing multiple adjacent genes along a chromosome. Given recombination, each gene can have a separate genetic lineages, even as the population shares a single organismal lineage. In asexual microbes or somatic cells, cell lineages exactly match genetic lineages, and can be traced. Incomplete lineage sorting Incomplete lineage sorting describes when the phylogenetic tree for a gene does not match that of the species. For example, while most human gene lineages coalesce first with chimpanzee lineages, and then with gorilla lineages, other configurations also occur. Lineage selection Lineage s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pearson Correlation Coefficient
In statistics, the Pearson correlation coefficient (PCC) is a correlation coefficient that measures linear correlation between two sets of data. It is the ratio between the covariance of two variables and the product of their standard deviations; thus, it is essentially a normalized measurement of the covariance, such that the result always has a value between −1 and 1. As with covariance itself, the measure can only reflect a linear correlation of variables, and ignores many other types of relationships or correlations. As a simple example, one would expect the age and height of a sample of children from a school to have a Pearson correlation coefficient significantly greater than 0, but less than 1 (as 1 would represent an unrealistically perfect correlation). Naming and history It was developed by Karl Pearson from a related idea introduced by Francis Galton in the 1880s, and for which the mathematical formula was derived and published by Auguste Bravais in 1844. The nami ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromosome
A chromosome is a package of DNA containing part or all of the genetic material of an organism. In most chromosomes, the very long thin DNA fibers are coated with nucleosome-forming packaging proteins; in eukaryotic cells, the most important of these proteins are the histones. Aided by chaperone proteins, the histones bind to and condense the DNA molecule to maintain its integrity. These eukaryotic chromosomes display a complex three-dimensional structure that has a significant role in transcriptional regulation. Normally, chromosomes are visible under a light microscope only during the metaphase of cell division, where all chromosomes are aligned in the center of the cell in their condensed form. Before this stage occurs, each chromosome is duplicated ( S phase), and the two copies are joined by a centromere—resulting in either an X-shaped structure if the centromere is located equatorially, or a two-armed structure if the centromere is located distally; the jo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetic Linkage
Genetic linkage is the tendency of Nucleic acid sequence, DNA sequences that are close together on a chromosome to be inherited together during the meiosis phase of sexual reproduction. Two Genetic marker, genetic markers that are physically near to each other are unlikely to be separated onto different Chromatid, chromatids during chromosomal crossover, and are therefore said to be more ''linked'' than markers that are far apart. In other words, the nearer two Gene, genes are on a chromosome, the lower the chance of Genetic recombination, recombination between them, and the more likely they are to be inherited together. Markers on different chromosomes are perfectly ''unlinked'', although the penetrance of potentially deleterious alleles may be influenced by the presence of other alleles, and these other alleles may be located on other chromosomes than that on which a particular potentially deleterious allele is located. Genetic linkage is the most prominent exception to Gregor M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
