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Coronavirus 5′ UTR
Coronavirus genomes are Positive-sense single-stranded RNA virus, positive-sense single-stranded RNA molecules with an untranslated region (UTR) at the Directionality (molecular biology), 5′ end which is called the Five prime untranslated region, 5′ UTR. The 5′ UTR is responsible for important biological functions, such as viral Viral replication, replication, Transcription (biology), transcription and packaging. The 5′ UTR has a conserved RNA Nucleic acid secondary structure, secondary structure but different Coronavirus genera (alphacoronavirus, Alpha-, betacoronavirus, Beta-, gammacoronavirus, Gamma-, and Deltacoronavirus (genus), Deltacoronaviruses) have different structural features described below. Alphacoronavirus 5′ UTR The first 150 to 200 nucleotides within the 5′ UTR of Alphacoronaviruses are highly structured and shown to be Conserved sequence, conserved on the structural level. The 5′ UTRs are predicted to contain three conserved stem-loops: * SL1 is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coronavirus
Coronaviruses are a group of related RNA viruses that cause diseases in mammals and birds. In humans and birds, they cause respiratory tract infections that can range from mild to lethal. Mild illnesses in humans include some cases of the common cold (which is also caused by other viruses, predominantly rhinoviruses), while more lethal varieties can cause SARS, MERS and COVID-19. In cows and pigs they cause diarrhea, while in mice they cause hepatitis and encephalomyelitis. Coronaviruses constitute the subfamily ''Orthocoronavirinae'', in the family ''Coronaviridae'', order ''Nidovirales'' and realm ''Riboviria''. They are enveloped viruses with a Positive-strand RNA virus, positive-sense single-stranded RNA genome and a nucleocapsid of helical symmetry. The genome size of coronaviruses ranges from approximately 26 to 32 kilobases, one of the largest among RNA viruses. They have characteristic club-shaped Spike protein, spikes that project from their surface, which in electron ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
