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Bulbocapnine
Bulbocapnine is an alkaloid found in ''Corydalis'' (notably the European species Corydalis cava, C. cava) and ''Dicentra'', genera of the plant family Fumariaceae which have caused (notably the American species ''Corydalis caseana'') the fatal poisoning of sheep and cattle. It has been shown to act as an acetylcholinesterase inhibitor, and inhibits biosynthesis of dopamine via inhibition of the enzyme tyrosine hydroxylase. Like apomorphine, it is reported to be an inhibitor of amyloid beta protein (Aβ) fiber formation, whose presence is a hallmark of Alzheimer's disease (AD). Bulbocapnine is thus a potential therapeutic under the Biochemistry of Alzheimer's disease, amyloid hypothesis. According to the ''Dorlands Medical Dictionary'', it "inhibits the reflex and motor activities of striated muscle. It has been used in the treatment of muscular tremors and vestibular pathologic nystagmus, nystagmus". A psychiatrist at Tulane University named Robert Galbraith Heath, Robert Heath ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Corydalis Cava
''Corydalis cava'' is a species of flowering plant in the family (biology), family Papaveraceae, native plant, native to moist, shady, woodland habitats throughout most of mainland Europe, although commonest in central and southeast Europe. Its range extends from Spain in the west to Ukraine, Belarus and the Caucasus in the east and as far north as Sweden. It is absent from (though may sometimes be found in a naturalised state in) Iceland, the UK, the Netherlands, Norway, Finland, Russia and Greece. Description ''Corydalis cava'' grows to tall. It is a ephemeral plant, spring ephemeral—foliage that grows in the spring dies down to its tuberous rootstock in summer. It has long-spurred flowers which appear in spring. The flowers may be mauve, purple, red, or white. The seeds contain an elaiosome that attracts ants, which transport the seeds into their ant colony. This seed transportation is called myrmecochory. Toxicity Many of the species in ''Corydalis'' contain alkaloids ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glaucine
Glaucine is an aporphine alkaloid found in several different plant species in the family Papaveraceae such as ''Glaucium flavum'', '' Glaucium oxylobum'' and '' Corydalis yanhusuo'', and in other plants like ''Croton lechleri'' in the family Euphorbiaceae. It has bronchodilator, neuroleptic and antiinflammatory effects, acting as a PDE4 inhibitor and calcium channel blocker, and is used medically as an antitussive in some countries. TLRs plays role in its anti inflammatory effects. Glaucine may produce side effects such as sedation, fatigue, and a hallucinogenic effect characterised by colourful visual images, and has been detected as a novel psychoactive drug. In a 2019 publication,Heng, HL, Chee, CF, Thy, CK, et al. In vitro functional evaluation of isolaureline, dicentrine and glaucine enantiomers at 5‐HT2 and α1 receptors. Chem Biol Drug Des. 2019; 93: 132– 138. https://doi.org/10.1111/cbdd.13390 the isomer (R)-glaucine is reported to be a positive allosteric modula ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Catalepsy
Catalepsy (from Ancient Greek , , "seizing, grasping") is a nervous condition characterized by muscular rigidity and fixity of posture regardless of external stimuli, as well as decreased sensitivity to pain. Signs and symptoms Symptoms include a rigid body, rigid limbs, limbs staying in same position when moved (waxy flexibility), no response, loss of muscle control, and slowing down of bodily functions, such as breathing. Causes Catalepsy is a symptom of certain nervous disorders or conditions such as Parkinson's disease and epilepsy. It is also a characteristic symptom of cocaine withdrawal, as well as one of the features of catatonia. It can be caused by schizophrenia treatment with anti-psychotics, such as haloperidol, and by the anesthetic ketamine. Protein kinase A has been suggested as a mediator of cataleptic behavior. Unsuggested waxy catalepsy, sometimes accompanied by spontaneous anesthesia, is seen as an indicator of hypnotic trance. Suggested or induced r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Corydalis
''Corydalis'' (from Greek ''korydalís'' " crested lark") is a genus of about 470 species of annual and perennial herbaceous plants in the family Papaveraceae, native to the temperate Northern Hemisphere and the high mountains of tropical eastern Africa. They are most diverse in China and the Himalayas, with at least 357 species in China. Ecology ''Corydalis'' species are used as food plants by the larvae of some Lepidoptera species (butterflies), especially the clouded Apollo. Toxicity ''Corydalis cava'' and some other tuberous species contain the alkaloid bulbocapnine, which is occasionally used in medicine but scientific evidence is lacking in the correct dosages and side effects. Many of the species in ''Corydalis'' contain other toxins and alkaloids like canadine, which blocks calcium. The species ''C. caseana'' is poisonous to livestock. Taxonomy Current species There are about 470 species, including: * '' Corydalis ambigua'' * ''Corydalis aurea'' * ''Corydalis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Corydalis Caseana
''Corydalis'' (from Greek ''korydalís'' "crested lark") is a genus of about 470 species of annual and perennial herbaceous plants in the family Papaveraceae, native to the temperate Northern Hemisphere and the high mountains of tropical eastern Africa. They are most diverse in China and the Himalayas, with at least 357 species in China. Ecology ''Corydalis'' species are used as food plants by the larvae of some Lepidoptera species (butterflies), especially the clouded Apollo. Toxicity ''Corydalis cava'' and some other tuberous species contain the alkaloid bulbocapnine, which is occasionally used in medicine but scientific evidence is lacking in the correct dosages and side effects. Many of the species in ''Corydalis'' contain other toxins and alkaloids like canadine, which blocks calcium. The species ''C. caseana'' is poisonous to livestock. Taxonomy Current species There are about 470 species, including: * '' Corydalis ambigua'' * '' Corydalis aurea'' * ''Corydalis bu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Robert Galbraith Heath
Robert Galbraith Heath (May 9, 1915 – September 21, 1999) was an American psychiatrist. He followed the theory of biological psychiatry that organic defects were the sole source of mental illness, and that consequently mental problems were treatable by physical means. He published 425 papers and three books. One of his first papers is dated 1946. He was profiled as a "famous American psychiatrist" in 1983 by ''Psychiatric Annals''. Heath founded the Department of Psychiatry and Neurology at Tulane University, New Orleans, in 1949 and remained its chairman until 1980. He performed many experiments there involving electrical stimulation of the brain via surgically implanted electrodes. He placed deep brain stimulation (DBS) electrodes into the brains of more than 54 patients. Indeed, he has been cited as the first, or one of the first, researcher(s) to have placed electrodes deep into the brains of living human patients. It has been suggested that this work was financed in part b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Racemic
In chemistry, a racemic mixture, or racemate (), is one that has equal amounts of left- and right-handed enantiomers of a chiral molecule or salt. Racemic mixtures are rare in nature, but many compounds are produced industrially as racemates. History The first known racemic mixture was racemic acid, which Louis Pasteur found to be a mixture of the two enantiomeric isomers of tartaric acid. He manually separated the crystals of a mixture by hand, starting from an aqueous solution of the sodium ammonium salt of racemate tartaric acid. Pasteur benefited from the fact that ammonium tartrate salt that gives enantiomeric crystals with distinct crystal forms (at 77 °F). Reasoning from the macroscopic scale down to the molecular, he reckoned that the molecules had to have non-superimposable mirror images. A sample with only a single enantiomer is an ''enantiomerically pure'' or ''enantiopure'' compound. Etymology From racemic acid found in grapes; from Latin ''racemus'', me ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stupor
Stupor is the lack of critical mental function and a level of consciousness, in which an affected person is almost entirely unresponsive and responds only to intense stimuli such as pain. The word derives from the Latin '' stupor'' ("numbness, insensibility"). Signs and symptoms Stupor is characterised by impaired reaction to external stimuli. Those in a stuporous state are rigid, mute and only appear to be conscious, as the eyes are open and follow surrounding objects. If not stimulated externally, a patient with stupor will appear to be in a sleepy state most of the time. In some extreme cases of severe depressive disorders the patient can become motionless, lose their appetite and become mute. Short periods of restricted responsivity can be achieved by intense stimulation (e.g. pain, bright light, loud noise, shock). Causes Stupor is associated with infectious diseases, complicated toxic states (e.g. heavy metals), severe hypothermia, mental illnesses (e.g. schizophrenia, maj ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Central Intelligence Agency
The Central Intelligence Agency (CIA ), known informally as the Agency and historically as the Company, is a civilian foreign intelligence service of the federal government of the United States, officially tasked with gathering, processing, and analyzing national security information from around the world, primarily through the use of human intelligence (HUMINT) and performing covert actions. As a principal member of the United States Intelligence Community (IC), the CIA reports to the Director of National Intelligence and is primarily focused on providing intelligence for the President and Cabinet of the United States. President Harry S. Truman had created the Central Intelligence Group under the direction of a Director of Central Intelligence by presidential directive on January 22, 1946, and this group was transformed into the Central Intelligence Agency by implementation of the National Security Act of 1947. Unlike the Federal Bureau of Investigation (FBI), which ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Project MKUltra
Project MKUltra (or MK-Ultra) was an illegal human experimentation program designed and undertaken by the U.S. Central Intelligence Agency (CIA), intended to develop procedures and identify drugs that could be used in interrogations to weaken individuals and force confessions through brainwashing and psychological torture. It began in 1953 and was halted in 1973. MKUltra used numerous methods to manipulate its subjects' mental states and brain functions, such as the covert administration of high doses of psychoactive drugs (especially LSD) and other chemicals, electroshocks,National Public Radio (NPR), 9 Sept. 2019"The CIA's Secret Quest For Mind Control: Torture, LSD And A 'Poisoner In Chief'"(On-air interview with journalist Stephen Kinzer) hypnosis, sensory deprivation, isolation, and verbal and sexual abuse, in addition to other forms of torture. MKUltra was preceded by two drug-related experiments, Project Bluebird and Project Artichoke. It was organized through th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Naked Lunch
''Naked Lunch'' (sometimes ''The Naked Lunch'') is a 1959 novel by American writer William S. Burroughs. The book is structured as a series of loosely connected vignettes, intended by Burroughs to be read in any order. The reader follows the narration of junkie William Lee, who takes on various aliases, from the U.S. to Mexico, eventually to Tangier and the dreamlike Interzone. The vignettes (which Burroughs called "routines") are drawn from Burroughs' own experiences in these places and his addiction to drugs: heroin, morphine and, while in Tangier, majoun (a strong hashish confection), as well as a German opioid with the brand name Eukodol (oxycodone), of which he wrote frequently. The novel was included in ''Times "100 Best English-language Novels from 1923 to 2005". In 1991, David Cronenberg directed a film of the same name based on the novel and other Burroughs writings. Title origin The book was originally published with the title ''The Naked Lunch'' in Paris in July 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Waxy Flexibility
Waxy flexibility is a psychomotor symptom of catatonia as associated with schizophrenia, bipolar disorder, or other mental disorders which leads to a decreased response to stimuli and a tendency to remain in an immobile posture. Attempts to reposition the patient are met by "slight, even resistance", and after being repositioned, the patient will typically remain in the new position. Waxy flexibility rarely occurs in cases of delirium. The presence of waxy flexibility along with at least two other catatonic symptoms such as stupor or negativism are enough to warrant a diagnosis of catatonia. If one were to move the arm of someone with waxy flexibility, the patient would keep that arm where it had been positioned until moved again, as if positioning malleable wax. Further alteration of an individual's posture is similar to bending a candle. Although waxy flexibility has historically been linked to schizophrenia, there are also other disorders which it may be associated with, such ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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