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2,6-Dichloropyridine
2,6-Dichloropyridine is a chloropyridine with the formula C5H3Cl2N. A white solid, it is one of six isomers of dichloropyridine. It serves as a precursor to the antibiotic enoxacin, as well as the drug and anpirtoline and the antifungal liranaftate. Synthesis 2,6-Dichoropyridine is produced by reaction of pyridine with chlorine. 2-Chloropyridine is an intermediate. Toxicity The is 115 mg/kg (oral, mice). References Chloropyridines {{organic-compound-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chloropyridine
Chloropyridines are a group of aryl chlorides consisting of a pyridine ring with chlorine atoms as substituents. This may refer to: * 2-Chloropyridine *3-Chloropyridine * 4-Chloropyridine * 2,6-Dichloropyridine Production Direct halogenation of pyridine with chlorine gas above 270 °C gives a mixture of 2-chloropyridine and 2,6-dichloropyridine. 2- and 4-chloropyridine are prepared from the corresponding pyridinols using phosphoryl chloride: : Uses Chloropyridines are important intermediates to pharmaceuticals and agrochemicals. A major use of 2-chloropyridine is the production of production of the fungicide pyrithione. Reaction of 4-chloropyridine with thioglycolic acid gives pyridylmercaptoacetic acid, a step in the production of cephalosporin The cephalosporins (sg. ) are a class of β-lactam antibiotics originally derived from the fungus ''Acremonium'', which was previously known as ''Cephalosporium''. Together with cephamycins, they constitute a subgroup of β-l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dichloropyridine
Dichloropyridines are organic compounds with the formula , consisting of a pyridine ring substituted with two chlorides. Six isomers are known. They are white or colorless, most are solids at room temperature. {, class="wikitable" , + Isomers of Dichloropyridine , - ! Name !! Registry number !! melting point (°C) , - , 2,3-Dichloropyridine , , 2402-77-9 , , 203–204 , - , 2,4-Dichloropyridine , , 26452-80-2 , , -1 , - , 2,5-Dichloropyridine , , 16110-09-1 , , 193–194 , - , 2,6-Dichloropyridine 2,6-Dichloropyridine is a chloropyridine with the formula C5H3Cl2N. A white solid, it is one of six isomers of dichloropyridine. It serves as a precursor to the antibiotic enoxacin, as well as the drug and anpirtoline and the antifungal liranaftat ... , , 2402-78-0 , , 211–212 , - , 3,4-Dichloropyridine , , 55934-00-4 , , 22–24 , - , 3,5-Dichloropyridine , , 2457-47-8 , , 178–179 References Chloropyridines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enoxacin
EnoxacinEnoxacin is sold under the following trade names: Almitil, Bactidan, Bactidron, Comprecin, Enoksetin, Enoxen, Enroxil, Enoxin, Enoxor, Flumark, Penetrex, Gyramid, Vinone. is an oral broad-spectrum fluoroquinolone antibacterial agent used in the treatment of urinary tract infections and gonorrhea. Insomnia is a common adverse effect. It is no longer available in the United States. It has been shown recently that it may have cancer inhibiting effect. Mechanism of action Quinolones and fluoroquinolones are bactericidal drugs, eradicating bacteria by interfering with DNA replication. Like other fluoroquinolones, enoxacin functions by inhibiting bacterial DNA gyrase and topoisomerase IV. The inhibition of these enzymes prevents bacterial DNA replication, transcription, repair and recombination. Recently, it was shown that Enoxacin inhibits the expression of the microRNA mir-34-5p, leading to an increase in the lifespan of the nematode C. elegans. Enoxacin is active aga ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anpirtoline
Anpirtoline (chemical formula C10H13ClN2S) is a synthetic chemical compound used as a 5-HT1B receptor agonist as well as a 5-HT3 receptor antagonist, causing a decrease in serotonin synthesis and a reduction in aggressive behavior. Anpirtoline hydrochloride appears as a white solid and is soluble in water. Being synthetic, the compound can be purchased from suppliers. Properties Physical Anpirtoline hydrochloride appears as a white solid at room temperature and is soluble in water and DMSO. Its has a density of 1.27 g/cm3 and a molar mass of 265.20. Structurally, the most notable parts of anpirtoline hydrochloride are two six-membered rings bonded via a sulfur atom. Chemical The melting point of anpirtoline hydrochloride is 126-128 °C. The flash point of the compound is 174 °C. Many of Anpirtoline hydrochloride's chemical properties remain unknown or untested. Uses Currently, anpirtoline is primarily used for research purposes due to its receptor agonist and re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Liranaftate
Liranaftate (trade name Zefnart) is a topical antifungal drug. It is used as a 2% cream used to treat tinea pedis (athlete's foot), tinea corporis (ringworm), and tinea cruris (jock itch). It was approved for use in Japan in August 2000. Liranaftate works by inhibiting the fungal enzyme squalene epoxidase that is necessary for the fungus to synthesize sterol Sterol is an organic compound with formula , whose molecule is derived from that of gonane by replacement of a hydrogen atom in position 3 by a hydroxyl group. It is therefore an alcohol of gonane. More generally, any compounds that contain the go ...s which are essential for cell membrane integrity. References Thiocarbamates Antifungals Tetralins Pyridines Methoxy compounds {{antiinfective-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
