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Δ4-Tibolone
δ4-Tibolone (developmental code name ORG-OM-38), also known as 7α-methylnorethisterone or as 7α-methyl-17α-ethynyl-19-nortestosterone, is a synthetic androgen and progestin which was never marketed. The compound is a major active metabolite of tibolone, which itself is a prodrug of δ4-tibolone along with 3α-hydroxytibolone and 3β-hydroxytibolone (which, in contrast to δ4-tibolone, are estrogens). Tibolone and δ4-tibolone are thought to be responsible for the androgenic and progestogenic activity of tibolone, while 3α-hydroxytibolone and 3β-hydroxytibolone are thought to be responsible for its estrogenic Estrogen (also spelled oestrogen in British English; see spelling differences) is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. There are three maj ... activity. See also * List of androgens/anabolic steroids * List of progestogens References Abandoned d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tibolone
Tibolone, sold under the brand name Livial among others, is a medication which is used in menopausal hormone therapy and in the treatment of postmenopausal osteoporosis and endometriosis. The medication is available alone and is not formulated or used in combination with other medications. It is taken oral administration, by mouth. Side effects of tibolone include acne and hirsutism, increased hair growth among others. Tibolone is a synthetic compound, synthetic steroid with weak estrogen (medication), estrogenic, progestogen (medication), progestogenic, and androgenic activity, and hence is an agonist of the estrogen receptor, estrogen, progesterone receptor, progesterone, and androgen receptors. It is a prodrug of several metabolites. The estrogenic effects of tibolone may show tissue selectivity in their distribution. Tibolone was developed in the 1960s and was introduced for medical use in 1988. It is marketed widely throughout the world. The medication is not available in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
