Lavoltidine (
INN,
USAN,
BAN
Ban, or BAN, may refer to:
Law
* Ban (law), a decree that prohibits something, sometimes a form of censorship, being denied from entering or using the place/item
** Imperial ban (''Reichsacht''), a form of outlawry in the medieval Holy Roman ...
; previously known as loxtidine, code name AH-23,844) is a highly
potent and
selective H2 receptor antagonist
An antagonist is a character in a story who is presented as the chief foe of the protagonist.
Etymology
The English word antagonist comes from the Greek ἀνταγωνιστής – ''antagonistēs'', "opponent, competitor, villain, enemy, ri ...
which was under development by Glaxo Wellcome (now
GlaxoSmithKline
GSK plc, formerly GlaxoSmithKline plc, is a British multinational pharmaceutical and biotechnology company with global headquarters in London, England. Established in 2000 by a merger of Glaxo Wellcome and SmithKline Beecham. GSK is the tent ...
)
as a treatment for
gastroesophageal reflux disease
Gastroesophageal reflux disease (GERD) or gastro-oesophageal reflux disease (GORD) is one of the upper gastrointestinal chronic diseases where stomach content persistently and regularly flows up into the esophagus, resulting in symptoms and/ ...
but was discontinued due to the discovery that it produced
gastric carcinoid tumors in rodents.
See also
*
H2 receptor antagonist
*
Sufotidine (analogous sequence in which
sulfone replaces the
hydroxyl
In chemistry, a hydroxy or hydroxyl group is a functional group with the chemical formula and composed of one oxygen atom covalently bonded to one hydrogen atom. In organic chemistry, alcohols and carboxylic acids contain one or more hydrox ...
group)
References
{{Histaminergics
Abandoned drugs
Primary alcohols
Amines
H2 receptor antagonists
1-Piperidinyl compounds
Triazoles
Phenol ethers