Ascaris lumbricoides

''Ascaris lumbricoides'' is a large parasitic worm that causes ascariasis in humans. A roundworm of genus ''Ascaris'', it is the most common parasitic worm in humans. An estimated one-sixth of the human population is at some point infected by a roundworm such as ''A. lumbricoides''; people living in tropical and subtropical countries are at greater risk of infection.

It has been proposed that ''Ascaris lumbricoides'' and ''Ascaris suum'' (pig roundworm) are the same species.

Lifecycle

''Ascaris lumbricoides'', a roundworm, infects humans via the fecal-oral route. Eggs released by adult females are shed in feces. Unfertilized eggs are often observed in fecal samples but never become infective. Fertilized eggs embryonate and become infectious after 18 days to several weeks in soil, depending on the environmental conditions (optimum: moist, warm, shaded soil).Parasites - Ascariasis. (14 February 2018). Retrieved from https://www.cdc.gov/parasites/ascariasis/biology.html

Infection occurs when a human swallows water or food contaminated with embryonated eggs. In the duodenum, a single rhabditiform larva hatches from each of the ingested eggs. The larvae then penetrate the mucosa and submucosa and enter the venules or lymphatic vessels. From there, the larvae then pass through the heart to enter the pulmonary circulation. The larvae then break through the walls of the pulmonary capillaries to enter the alveoli.Murray, Patrick R.; Rosenthal, Ken S.; Pfaller, Michael A. ''Medical Microbiology'', Fifth Edition. United States: Elsevier Mosby, 2005 The juvenile worms then migrate from the alveoli, through the bronchioles and bronchi, and into the trachea. An acute inflammatory reaction can occur if some of the worms get lost during this migration process and accumulate in other organs of the body.

Once in the trachea, the worms are coughed up into the pharynx and then swallowed again, after which they pass through the stomach and into the small intestine, where they mature into adult worms. The adult worms begin producing fertilized eggs within 60–65 days of being swallowed; females produce as many as 200,000 eggs per day for 12–18 months. These fertilized eggs become infectious after two weeks in soil; they can persist in soil for 10 years or more.

It might seem odd that the worms end up in the same place where they began. One hypothesis to account for this behavior is that the migration mimics an intermediate host, which would be required for juveniles of an ancestral form to develop to the third stage. Another possibility is that tissue migration enables faster growth and larger size, which increases reproductive capacity.

The eggs have a lipid layer which makes them resistant to the effects of acids and alkalis, as well as other chemicals. This resilience helps to explain why this nematode is such a ubiquitous parasite.

Morphology

''Ascaris lumbricoides'' is characterized by its great size. Males are in diameter and long. The male's posterior end is curved ventrally and has a bluntly pointed tail. Females are wide and long. The vulva is located in the anterior end and accounts for about one-third of its body length. Uteri may contain up to 27 million eggs at a time, with 200,000 being laid per day. Fertilized eggs are oval to round in shape and are long and wide with a thick outer shell. Unfertilized eggs measure long and wide.Roberts, Larry S.; Janovy, John Jr. ''Foundations of Parasitology'', Eighth Edition. United States: McGraw-Hill, 2009

Epidemiology

An estimated 1 billion people are infected with ''A. lumbricoides'' worldwide. While infection occurs throughout most of the world, ''A. lumbricoides'' infection is most common in sub-Saharan Africa, the Americas, China, and east Asia. Although the prevalence is low in the United States, the infection still exists in southeastern part of the United States due to its temperature and humid climate.

''Ascaris lumbricoides'' eggs are extremely resistant to strong chemicals, desiccation, and low temperatures. The eggs can remain viable in the soil for several months or even years. Eggs of ''A. lumbricoides'' have been identified in archeological coprolites in the Americas, Europe, Africa, the Middle East, and New Zealand, the oldest ones being more than 24,000 years old.

Infections

Infections with these parasites are more common where sanitation is poor, and raw human feces are used as fertilizer.

Symptoms

Often, no symptoms are presented with a minor ''A. lumbricoides'' infection, the inevitable consequence being the e.g. once a year passage of such clearly visible worm(s) on close inspection. In the case of bad infections symptoms commonly include bloody sputum, cough, fever, abdominal discomfort, intestinal ulcer(s), as well as a less commonly missed passing of the quite long worms. Ascariasis is the most common cause of Löffler's syndrome worldwide. Accompanying pathological symptoms include pulmonary infiltration, eosinophilia (symptoms of the overabundance of eosinophils in the blood such as asthma and allergic reactions), and a diagnostic symptom is, aside from standard microscopy of stools, radiographic opacities. One study has observed increases in fertility in infected women, in a similar vein to good diet and exercise, but with all of the pathological negatives and discomforts the disease carries with it, varying from host to host and again with diet.

Prevention

Preventing any fecal-borne disease requires educated hygienic habits/culture and effective fecal treatment systems. This is particularly important with ''A. lumbricoides'' because its eggs are one of the most difficult pathogens to kill (second only to prions), and the eggs commonly survive 1–3 years. ''A. lumbricoides'' lives in the intestine where it lays eggs. Infection occurs when the eggs, too small to be seen by the unaided eye, are eaten. The eggs may get onto vegetables when improperly processed human feces of infected people are used as fertilizer for food crops. Infection may occur when food is handled without removing or killing the eggs on the hands, clothes, hair, raw vegetables/fruit, or cooked food that is (re)infected by handlers, containers, etc. Bleach does not readily kill ''A. lumbricoides'' eggs, but it will remove their sticky film, to allow the eggs to be rinsed away. ''A. lumbricoides'' eggs can be reduced by hot composting methods, but to completely kill them may require rubbing alcohol, iodine, specialized chemicals, cooking heat, or "unusually" hot composting (for example, over for 24 hours).

Acetic acid, found in vinegar, will effectively kill ''A. lumbricoides'' eggs on vegetable surfaces in 30 minutes at 5% solution strength.

History

Giant intestinal roundworms have been known since antiquity. In 1758 Linnaeus named them ''Ascaris lumbricoides''. For many centuries, they were thought to arise by spontaneous generation. In 1855, ''Ascaris'' eggs were found in human faeces by Henry Ransom in England then this was described in the literature two years later by Casimir-Joseph Davaine in France. Attempts to infect animals by feeding them eggs were unsuccessful. In 1886, Salvatore Calandruccio in Italy successfully infected a boy to whom he had given 150 eggs. Battista Grassi published this information without giving any acknowledgement to Calandruccio. Development was thought to occur directly within the bowel lumen but in Francis Stewart in Hong Kong in 1916 fed eggs to rats, then later mice, and found infective larvae in the faeces and in the lungs but no mature worms. In 1918, Sadao Yoshida ingested larvae recovered from the trachea of a guinea pig, then found eggs in his own stools 76 days later. In 1922, Shimesu Koino ingested 2,000 ''Ascaris lumbricoides'' eggs, found larvae in his sputum a few days later, then after 50 days took an anthelmintic and recovered 667 immature ''Ascaris lumbricoides'', thus confirming the life cycle.

References

External links

''Ascaris lumbricoides'' Video - DAVE Project

''Ascaris lumbricoides'' Poll - Research

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Ascaridida
Parasitic nematodes of humans
Nematodes described in 1758
Taxa named by Carl Linnaeus