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A third molar, commonly called wisdom tooth, is one of the three
molars The molars or molar teeth are large, flat teeth at the back of the mouth. They are more developed in mammals. They are used primarily to grind food during chewing. The name ''molar'' derives from Latin, ''molaris dens'', meaning "millstone to ...
per quadrant of the
human dentition The human teeth function to mechanically break down items of food by cutting and crushing them in preparation for swallowing and digesting. As such, they are considered part of the human digestive system. Humans have four types of teeth: inci ...
. It is the most posterior of the three. The age at which wisdom teeth come through ( erupt) is variable, but this generally occurs between late teens and early twenties. Most adults have four wisdom teeth, one in each of the four quadrants, but it is possible to have none, fewer, or more, in which case the extras are called
supernumerary teeth Hyperdontia is the condition of having supernumerary teeth, or teeth that appear in addition to the regular number of teeth (32 in the average adult). They can appear in any area of the dental arch and can affect any dental organ. The opposite ...
. Wisdom teeth may get stuck ( impacted) against other teeth if there is not enough space for them to come through normally. Impacted wisdom teeth are still sometimes removed for orthodontic treatment, believing that they move the other teeth and cause crowding, though this is not held anymore as true. Impacted wisdom teeth may suffer from
tooth decay Tooth decay, also known as cavities or caries, is the breakdown of teeth due to acids produced by bacteria. The cavities may be a number of different colors from yellow to black. Symptoms may include pain and difficulty with eating. Complicatio ...
if oral hygiene becomes more difficult. Wisdom teeth which are partially erupted through the gum may also cause inflammation and infection in the surrounding gum tissues, termed
pericoronitis Pericoronitis is inflammation of the soft tissues surrounding the crown of a partially erupted tooth, including the gingiva (gums) and the dental follicle. The soft tissue covering a partially erupted tooth is known as an ''operculum'', an ar ...
. Some more conservative treatments, such as operculectomies, may be fitting for some cases, yet impacted wisdom teeth are commonly extracted as treatment for these problems, many times before these problems, which might never happen, even occur. Some oppose this prophylactic removal of disease-free impacted wisdom teeth, including among them the
National Institute for Health and Care Excellence The National Institute for Health and Care Excellence (NICE) is an executive non-departmental public body of the Department of Health and Social Care in England that publishes guidelines in four areas: * the use of health technologies withi ...
in the UK.


Structure


Tooth morphology

Morphology of wisdom teeth can be variable. Maxillary (upper) third molars commonly have a triangular crown with a deep central fossa from which multiple irregular fissures originate. Their roots are commonly fused together and can be irregular in shape. Mandibular third molars are the smallest molar teeth in the permanent dentition. The crown usually takes on a rounded rectangular shape that features four or five cusps with an irregular fissure pattern. Roots are greatly reduced in size and can be fused together.


Dental notation

There are several notation systems used in dentistry to identify teeth.  The Palmer/Zsigmondy System.  Under the Palmer/Zsigmondy system, the right and left maxillary wisdom teeth are represented by 8┘ and └8. Whereas, 8┐and ┌8  symbols are used to represent the right and left mandibular wisdom teeth. Another commonly used method of dental notation is the FDI notational system. Under this system, the right and left maxillary third molars are represented by 18 and 28 respectively and the right and left mandibular third molars are numbered as 48 and 38. According to the
Universal Numbering System The Universal Numbering System, sometimes called the "American System", is a dental notation system commonly used in the United States. Most of the rest of the world uses the FDI World Dental Federation notation, accepted as an international sta ...
the right and left upper wisdom teeth are labelled 1 and 16 and the right and left lower wisdom teeth are assigned 17 and 32 respectively.


Variation

Agenesis In medicine, agenesis () refers to the failure of an organ to develop during embryonic growth and development due to the absence of primordial tissue. Many forms of agenesis are referred to by individual names, depending on the organ affected: * A ...
of wisdom teeth differs by population, ranging from practically zero in
Aboriginal Tasmanians The Aboriginal Tasmanians ( Palawa kani: ''Palawa'' or ''Pakana'') are the Aboriginal people of the Australian island of Tasmania, located south of the mainland. For much of the 20th century, the Tasmanian Aboriginal people were widely, an ...
to nearly 100% in
indigenous Mexicans Indigenous peoples of Mexico ( es, gente indígena de México, pueblos indígenas de México), Native Mexicans ( es, nativos mexicanos) or Mexican Native Americans ( es, pueblos originarios de México, lit=Original peoples of Mexico), are those ...
(se
research paper
with world map showing prevalence). The difference is related to the
PAX9 Paired box gene 9, also known as PAX9, is a protein which in humans is encoded by the ''PAX9'' gene. It is also found in other mammals. Expression and function This gene is a member of the Pax genes, paired box (PAX) family of transcription f ...
, and
MSX1 Homeobox protein MSX-1, is a protein that in humans is encoded by the ''MSX1'' gene. MSX1 transcripts are not only found in thyrotrope-derived TSH cells, but also in the TtT97 thyrotropic tumor, which is a well differentiated hyperplastic tissue ...
gene (and perhaps other genes).


Age of eruption

There is significant variation between the reported age of eruption of wisdom teeth between different populations. For example, wisdom teeth tend to erupt earlier in people with African heritage compared to Asian and European heritage. Generally wisdom teeth erupt most commonly between age 17 and 21. Eruption may start as early as age 13 in some groups and typically occurs before the age of 25. If they have not erupted by age 25, oral surgeons generally consider that the tooth will not erupt spontaneously. Root development can continue for up to three years after eruption occurs.


Function

Anthropologists believe wisdom teeth, or the third set of molars, were the evolutionary answer to human ancestors' early diet of coarse, rough food – like leaves, roots, nuts and meats. After the advent of agriculture over 10,000 years ago, soft human diets became more common, including carbohydrate and high energy foods. Such diets typically result in jaws growing with less forward growth than those of paleolithic humans and not enough room for the wisdom teeth.


Clinical significance

Wisdom teeth (often notated clinically as M3 for third molar) have long been identified as a source of problems and continue to be the most commonly impacted teeth in the human mouth. Impaction of the wisdom teeth results in a risk of periodontal disease and
dental cavities Dental may refer to: * Dental consonant, in phonetics * Dental Records, an independent UK record label * Dentistry, oral medicine * Teeth See also * * Dental care (disambiguation) * Dentist (disambiguation) * Tooth (disambiguation) A tooth (pl ...
. Less than 2% of adults age 65 years or older maintain the teeth without cavities or periodontal disease and 13% maintain unimpacted wisdom teeth without cavities or periodontal disease. Impacted wisdom teeth lead to pathology in 12% of cases. Impacted wisdom teeth are classified by the direction and depth of impaction, the amount of available space for tooth eruption and the amount soft tissue or bone that covers them. The classification structure allows clinicians to estimate the probabilities of impaction, infections and complications associated with wisdom teeth removal. Wisdom teeth are also classified by the presence of symptoms and disease. Treatment of an erupted wisdom tooth is the same as any other tooth in the mouth. If impacted and having a pathology, such as
caries Tooth decay, also known as cavities or caries, is the breakdown of teeth due to acids produced by bacteria. The cavities may be a number of different colors from yellow to black. Symptoms may include pain and difficulty with eating. Complicatio ...
or pericoronitis, treatment can be
dental restoration Dental restoration, dental fillings, or simply fillings are treatments used to restore the function, integrity, and morphology of missing tooth structure resulting from caries or external trauma as well as to the replacement of such structure sup ...
, salt water rinses, local treatment to the infected tissue overlying the impaction, oral
antibiotic An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of ...
s, operculectomy, or if those failed, extraction or
coronectomy When extracting lower wisdom teeth, coronectomy is a treatment option involving removing the Crown_(tooth), crown of the lower wisdom tooth, whilst keeping the roots in place in healthy patients. This option is given to patients as an alternative t ...
.


Common pathologies associated with wisdom teeth

Odontogenic infection An odontogenic infection is an infection that originates within a tooth or in the closely surrounding tissues. The term is derived from '' odonto-'' (Ancient Greek: , – 'tooth') and '' -genic'' (Ancient Greek: , ; – 'birth'). The most common ...
s are a dental complication originating inside the tooth or in close proximity to the surrounding tissues. There are different types of odontogenic infections which may affect impacted wisdom teeth such as
periodontitis Periodontal disease, also known as gum disease, is a set of inflammatory conditions affecting the tissues surrounding the teeth. In its early stage, called gingivitis, the gums become swollen and red and may bleed. It is considered the main cau ...
,
pulpitis Pulpitis is inflammation of dental pulp tissue. The pulp contains the blood vessels, the nerves, and connective tissue inside a tooth and provides the tooth’s blood and nutrients. Pulpitis is mainly caused by bacterial infection which itself is ...
, dental abscess and
pericoronitis Pericoronitis is inflammation of the soft tissues surrounding the crown of a partially erupted tooth, including the gingiva (gums) and the dental follicle. The soft tissue covering a partially erupted tooth is known as an ''operculum'', an ar ...
. Pericoronitis is a common pathology of impacted third molar. It is an acute localized infection of the tissue surrounding the impacted wisdom teeth. Clinically the tissue appears to be red, tender to touch and edematous. The common symptoms the patient’s report are pain ‘that ranges from dull to throbbing to intense’ and often radiates to mouth, ear or floor of the mouth. Moreover, swelling of the cheek,
halitosis Bad breath, also known as halitosis, is a symptom in which a noticeably unpleasant breath odour is present. It can result in anxiety among those affected. It is also associated with depression and symptoms of obsessive compulsive disorder. ...
and trismuscan occur.


Odontogenic cysts

Odontogenic cysts are a less common pathology of the impacted wisdom tooth. They are described as ‘cavities filled with liquid, semiliquid or gaseous content with odontogenic epithelial lining and connective tissue on the outside’. However, studies have found cysts to be prevalent in a small percentage of impacted wisdom teeth that are extracted. The most common types associated with impacted third molars are
radicular cyst Radicular pain, or radiculitis, is pain "radiated" along the dermatome (sensory distribution) of a nerve due to inflammation or other irritation of the nerve root ( radiculopathy) at its connection to the spinal column. A common form of radic ...
s,
dentigerous cyst Dentigerous cyst, also known as follicular cyst is an epithelial-lined developmental cyst formed by accumulation of fluid between the reduced enamel epithelium and crown of an unerupted tooth. It is formed when there is an alteration in the reduc ...
s and odontogenic keratocysts.


Oral hygiene care

Practice and maintenance of good oral hygiene can help prevent and control some wisdom tooth pathologies. In addition to twice daily toothbrushing,
interdental cleaning Interdental cleaning or interproximal cleaning is part of oral hygiene where the aim is to clean the areas in between the teeth, otherwise known as the proximal surfaces of teeth. This is to remove the dental plaque in areas a toothbrush cannot rea ...
is recommended to ensure plaque build doesn’t occur in interdental areas. There are various products available for this – dental floss and interdental brushes being the most common.


Removal of impacted wisdom teeth

Removal of asymptomatic
impacted wisdom teeth Impacted wisdom teeth is a condition where the third molars (wisdom teeth) are prevented from erupting into the mouth. This can be caused by a physical barrier, such as other teeth, or when the tooth is angled away from a vertical position. Com ...
with the absence of disease and no evidence of local infection as a prophylactic method has been disputed within the dental community for a long time. There is insufficient, reliable scientific evidence for dental health professionals and policy makers to determine if asymptomatic disease-free impacted wisdom teeth should be removed. Therefore, the decision will depend on a combination of clinical expertise and patient preference. If the tooth is retained, regular check-ups to identify any problems that may occur is recommended. Considering the lack of quality evidence at present, more long-term studies need to be undertaken to obtain a reliable scientific conclusion.


Mandibular third molar surgery recovery

Platelet-rich fibrin (PRF) is a postoperative method used to heal the alveolar socket following the removal of the mandibular third molar. PRF is a second generation result of the isolation of platelets, white blood cells, stem cells and growth factors from blood samples. Studies have shown that when used there are improvements in pain sensations, swelling and a decreased risk of developing dry socket. This method was shown to only reduce symptoms and is not completely preventive. To date there is no clear correlation between the use of PRF after a mandibular third molar removal surgery and the recovery of jaw spasms, bone restoration and soft tissue healing. Further studies with larger study samples are needed to validate current theories.


Prognosis

About a third of symptomatic unerupted wisdom teeth have been shown to partially erupt and be non-functional or non-hygienic. Studies have also shown that 30% to 60% of people with a previously asymptomatic impacted wisdom teeth will have an extraction of at least one of them in 4 to 12 years from diagnosis.


Risk factors of inferior alveolar nerve damage

Temporary and permanent
inferior alveolar nerve The inferior alveolar nerve (IAN) (also the inferior dental nerve) is a branch of the mandibular nerve, which is itself the third branch of the trigeminal nerve. The inferior alveolar nerves supply sensation to the lower teeth. Structure The in ...
(IAN) damage is a known complication of the surgical removal of impacted lower third molars, happening in 1 in 85 and 1 in 300 extractions, respectively. Studies have shown that certain risk factors may increase the likelihood of IAN damage. Proximity of the impacted third molar root to the
mandibular canal In human anatomy, the mandibular canal is a canal within the mandible that contains the inferior alveolar nerve, inferior alveolar artery, and inferior alveolar vein. It runs obliquely downward and forward in the ramus, and then horizontally f ...
, which can be seen in radiographs, has been shown to be a high-risk factor for IAN damage. Alongside this, the depth of impaction of the tooth, surgical technique and surgeons experience are all contributing risk factors for IAN damage during this procedure. Careful case-by-case consideration is crucial to avoid this risk.


Lower anterior teeth crowding

Lower anterior teeth crowding has been a common discussion among the orthodontic community for decades. In the 1970s it was thought that unerupted wisdom teeth produced a forward directed force which would cause crowding of the anterior segment. Recent research has shown that there is no agreed opinion and that the cause is due to a variety of factors. This includes dental factors such as tooth crown size and primary tooth loss. Skeletal factors which include growth of the maxilla and mandible and the presence of
malocclusions In orthodontics, a malocclusion is a misalignment or incorrect relation between the teeth of the upper and lower dental arches when they approach each other as the jaws close. The English-language term dates from 1864; Edward Angle (1855-1930) ...
. General factors, including the age and gender of the patient. Overall, recent research has suggested that wisdom teeth alone do not cause crowding of teeth.


History

Although formally known as third molars, the common name is wisdom teeth because they appear so late – much later than the other teeth, at an age where people are presumably "wiser" than as a child, when the other teeth erupt. The term probably came as a translation of the
Latin Latin (, or , ) is a classical language belonging to the Italic branch of the Indo-European languages. Latin was originally a dialect spoken in the lower Tiber area (then known as Latium) around present-day Rome, but through the power of the ...
''dens sapientiae''. Their eruption has been known to cause dental issues for millennia; it was noted at least as far back as
Aristotle Aristotle (; grc-gre, Ἀριστοτέλης ''Aristotélēs'', ; 384–322 BC) was a Greek philosopher and polymath during the Classical period in Ancient Greece. Taught by Plato, he was the founder of the Peripatetic school of phil ...
: The oldest known impacted wisdom tooth belonged to a European woman who lived between 13,000 and 11,000
BCE Common Era (CE) and Before the Common Era (BCE) are year notations for the Gregorian calendar (and its predecessor, the Julian calendar), the world's most widely used calendar era. Common Era and Before the Common Era are alternatives to the or ...
, in the Magdalenian period. Nonetheless, molar impaction was relatively rare prior to the modern era. With the
Industrial Revolution The Industrial Revolution was the transition to new manufacturing processes in Great Britain, continental Europe, and the United States, that occurred during the period from around 1760 to about 1820–1840. This transition included going f ...
, the affliction became ten times more common, owing to the new prevalence of soft, processed, and sugary foods.


See also


References


External links


National Institute of Clinical Health and Excellence Guideline to Wisdom teeth removal

Wisdom tooth extraction
WebMD article {{DEFAULTSORT:Wisdom Tooth Types of teeth Vestigial organs Human mouth anatomy Acute pain Supernumerary body parts