WY-46824 is a
norepinephrine-dopamine reuptake inhibitor related to
venlafaxine that was disclosed by Paige Mahaney, ''et al.'' of
Wyeth in 2008. The compound actually appears in an article a year earlier in 2007 but is not the main focus of the work.
It has
NET binding of 46 nM,
DAT = 58 nM and
SERT = 18795 nM. The racemic compound was resolved into its constituent enantiomers, and the (S) enantiomer is the more active one. The N-desmethyl derivative shows similar activity.
References
{{Stimulants
Cyclohexanols
Norepinephrine–dopamine reuptake inhibitors
Chloroarenes
Phenethylamines
Piperazines
Tertiary alcohols