Sahachiro Hata
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was a prominent Japanese
bacteriologist A bacteriologist is a microbiologist, or similarly trained professional, in bacteriology -- a subdivision of microbiology that studies bacteria, typically Pathogenic bacteria, pathogenic ones. Bacteriologists are interested in studying and learnin ...
who researched the
bubonic plague Bubonic plague is one of three types of plague caused by the plague bacterium (''Yersinia pestis''). One to seven days after exposure to the bacteria, flu-like symptoms develop. These symptoms include fever, headaches, and vomiting, as well a ...
under
Kitasato Shibasaburō Baron was a Japanese physician and bacteriologist. He is remembered as the co-discoverer of the infectious agent of bubonic plague in Hong Kong during an outbreak in 1894, almost simultaneously with Alexandre Yersin. Kitasato was nominated ...
and assisted in developing the
Arsphenamine Arsphenamine, also known as Salvarsan or compound 606, is a drug that was introduced at the beginning of the 1910s as the first effective treatment for syphilis, relapsing fever, and African trypanosomiasis. This organoarsenic compound was the f ...
drug in 1909 in the laboratory of
Paul Ehrlich Paul Ehrlich (; 14 March 1854 – 20 August 1915) was a Nobel Prize-winning German physician and scientist who worked in the fields of hematology, immunology, and antimicrobial chemotherapy. Among his foremost achievements were finding a cure ...
. Hata received three unsuccessful nominations for the
Nobel Prize The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfr ...
, one from Swiss surgeon
Emil Kocher Emil Theodor Kocher (25 August 1841 – 27 July 1917) was a Swiss physician and medical researcher who received the 1909 Nobel Prize in Physiology or Medicine for his work in the physiology, pathology and surgery of the thyroid. Among his many a ...
for
Chemistry Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions ...
in 1911 and two by Japanese colleagues Hayazo Ito and G Osawa for
Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute, Nobel Assembly at the Karolinska Institutet, Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Pr ...
in 1912 and 1913, respectively.


Early life

Hata was born in Tsumo Village,
Shimane prefecture is a prefecture of Japan located in the Chūgoku region of Honshu. Shimane Prefecture is the second-least populous prefecture of Japan at 665,205 (February 1, 2021) and has a geographic area of 6,708.26 km2. Shimane Prefecture borders Yamaguc ...
(now part of Masuda City) as the eighth son of the Yamane family. At the age of 14, he was adopted by the Hata family, whose male members were doctors from generation to generation. Hata completed his medical education in
Okayama is the capital city of Okayama Prefecture in the Chūgoku region of Japan. The city was founded on June 1, 1889. , the city has an estimated population of 720,841 and a population density of 910 persons per km2. The total area is . The city is ...
at the Third Higher School of Medicine (now
Okayama University is a national university in Japan. The main campus is located in Tsushima-Naka, Okayama, Okayama Prefecture. The school was founded in 1870 and it was established as a university in 1949. History Okayama University was originally founded as t ...
School of Medicine). In 1897, he became an assistant at Okayama Prefectural Hospital where he learned internal medicine from Zenjiro Inoue and
biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...
from Torasaburo Araki.


Plague Research

Sahachiro Hata researched
bubonic plague Bubonic plague is one of three types of plague caused by the plague bacterium (''Yersinia pestis''). One to seven days after exposure to the bacteria, flu-like symptoms develop. These symptoms include fever, headaches, and vomiting, as well a ...
with Japanese bacteriologist and physician,
Kitasato Shibasaburō Baron was a Japanese physician and bacteriologist. He is remembered as the co-discoverer of the infectious agent of bubonic plague in Hong Kong during an outbreak in 1894, almost simultaneously with Alexandre Yersin. Kitasato was nominated ...
, who co-discovered the infectious agent, a bacterium called ''
Yersinia pestis ''Yersinia pestis'' (''Y. pestis''; formerly '' Pasteurella pestis'') is a gram-negative, non-motile, coccobacillus bacterium without spores that is related to both ''Yersinia pseudotuberculosis'' and ''Yersinia enterocolitica''. It is a facult ...
.'' Hata worked as an assistant for Kitasato and conducted research into the prevention of plague and other epidemic diseases. Hata helped formulate the "Communicable Disease Prevention Law," which was enacted in 1897 as the first legal framework for disease control in Japan. Among other things the law mandated reporting of certain disease to a public health agency in service of their control.


Finding the 'Magic Bullet' for Syphilis

In 1909, Sahachiro Hata went to work in
Paul Ehrlich Paul Ehrlich (; 14 March 1854 – 20 August 1915) was a Nobel Prize-winning German physician and scientist who worked in the fields of hematology, immunology, and antimicrobial chemotherapy. Among his foremost achievements were finding a cure ...
's laboratory, the National Institute for Experimental Therapeutics, in
Frankfurt, Germany Frankfurt, officially Frankfurt am Main (; Hessian: , "Frank ford on the Main"), is the most populous city in the German state of Hesse. Its 791,000 inhabitants as of 2022 make it the fifth-most populous city in Germany. Located on its na ...
to help Ehrlich in his quest to develop a treatment for syphilis called the 'magic bullet.' The causative agent of syphilis was discovered to be the
spirochete A spirochaete () or spirochete is a member of the phylum Spirochaetota (), (synonym Spirochaetes) which contains distinctive diderm (double-membrane) gram-negative bacteria, most of which have long, helically coiled (corkscrew-shaped or s ...
''
Treponema pallidum ''Treponema pallidum'', formerly known as ''Spirochaeta pallida'', is a spirochaete bacterium with various subspecies that cause the diseases syphilis, bejel (also known as endemic syphilis), and yaws. It is transmitted only among humans. It is ...
'' by
Fritz Schaudinn Fritz Richard Schaudinn (19 September 1871 – 22 June 1906) was a German zoologist. Born in Röseningken, East Prussia, he co-discovered, with Erich Hoffmann in 1905, the causative agent of syphilis, ''Spirochaeta pallida'' (also known as ''Trep ...
and
Erich Hoffmann Erich Hoffmann (25 April 1868 – 8 May 1959) was a German dermatologist who was a native of Witzmitz, Pomerania. He studied medicine at the Berlin Military Academy, and was later a professor at the Universities of Halle and Bonn. Hoffmann ...
in 1905. Syphilis was initially treated by topical-application or ingestion of
mercury Mercury commonly refers to: * Mercury (planet), the nearest planet to the Sun * Mercury (element), a metallic chemical element with the symbol Hg * Mercury (mythology), a Roman god Mercury or The Mercury may also refer to: Companies * Merc ...
, which was very toxic. However, arsenical compounds had proven to be effective against
trypanosomes Trypanosomatida is a group of kinetoplastid excavates distinguished by having only a single flagellum. The name is derived from the Greek ''trypano'' (borer) and ''soma'' (body) because of the corkscrew-like motion of some trypanosomatid species. ...
, which are similar to spirochetes, so Ehrlich directed Hata to screen all of the known synthetic arsenic derivatives for antisyphilitic properties. When Hata injected compound 606,
arsphenamine Arsphenamine, also known as Salvarsan or compound 606, is a drug that was introduced at the beginning of the 1910s as the first effective treatment for syphilis, relapsing fever, and African trypanosomiasis. This organoarsenic compound was the f ...
, into rabbits infected with syphilis, he found it to be effective against syphilis ''
in vivo Studies that are ''in vivo'' (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and ...
.'' It was called compound 606 because it was the 606th compound that Ehrlich and Hata tested. Arsphenamine was first thought to be ineffective when it was tested by Ehrlich's former assistants, so their inadequate methods were blamed for the delay of this important discovery. At the Congress for Internal Medicine at
Wiesbaden Wiesbaden () is a city in central western Germany and the capital of the state of Hesse. , it had 290,955 inhabitants, plus approximately 21,000 United States citizens (mostly associated with the United States Army). The Wiesbaden urban area ...
in April 1910, Ehrlich and Hata shared their successful clinical results, which showed that arsphenamine treated syphilis in humans. The drug was marketed under the name
Salvarsan Arsphenamine, also known as Salvarsan or compound 606, is a drug that was introduced at the beginning of the 1910s as the first effective treatment for syphilis, relapsing fever, and African trypanosomiasis. This organoarsenic compound was the fi ...
and gained international acclaim as the "arsenic that saves" and as the first man-made
antibiotic An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of ...
. In the wake of their discovery, some sections of European society condemned Hata's and Ehrlich's 'magic bullet' because they believed that syphilis was a divine punishment for sin and immoral acts, and thus the infected did not deserve to be cured. Before Salvarsan, drugs were not made to target specific diseases, like in the case of mercury treatments. Therefore, Hata's and Ehrlich's work represents a turning point for experimental and therapeutic pharmacology and paved the way for the development of antibiotics decades later. Salvarsan was established as the standard treatment for syphilis until it was replaced by the antibiotic
penicillin Penicillins (P, PCN or PEN) are a group of β-lactam antibiotics originally obtained from ''Penicillium'' moulds, principally '' P. chrysogenum'' and '' P. rubens''. Most penicillins in clinical use are synthesised by P. chrysogenum using ...
after
World War II World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposin ...
, which has fewer adverse side effects. Hata returned to Japan and became the leading bacteriologist of his generation and continued his work testing arsphenamine against syphilis. Hata became a director at the Kitasato Institute, and he also lectured at
Keio University , mottoeng = The pen is mightier than the sword , type = Private research coeducational higher education institution , established = 1858 , founder = Yukichi Fukuzawa , endowmen ...
. In 1927, he was elected a member of the
Academy of Sciences Leopoldina The German National Academy of Sciences Leopoldina (german: Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften), short Leopoldina, is the national academy of Germany, and is located in Halle (Saale). Founded ...
.


References

* Low, Morris. ''Building a Modern Japan: Science, Technology, and Medicine in the Meiji Era and Beyond''.
Palgrave Macmillan Palgrave Macmillan is a British academic and trade publishing company headquartered in the London Borough of Camden. Its programme includes textbooks, journals, monographs, professional and reference works in print and online. It maintains off ...
(2005). * Porter, Roy. ''Blood and Guts: A Short History of Medicine''. W. W. Norton & Company; Reprint edition (June 2004). * Waller, John. ''The Discovery of the Germ: Twenty Years That Transformed the Way We Think About Disease'' ("Revolutions in Science" series).
Columbia University Press Columbia University Press is a university press based in New York City, and affiliated with Columbia University. It is currently directed by Jennifer Crewe (2014–present) and publishes titles in the humanities and sciences, including the fiel ...
(2003),


External links


Hata Sahachiro Memorial Museum, Shimane
(Japanese site) {{DEFAULTSORT:Hata, Sahachiro 1873 births 1938 deaths Japanese bacteriologists Japanese microbiologists People from Shimane Prefecture People of Meiji-period Japan Okayama University alumni