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Sahachiro Hata
was a prominent Japanese bacteriologist who researched the bubonic plague under Kitasato Shibasaburō and assisted in developing the Arsphenamine drug in 1909 in the laboratory of Paul Ehrlich. Hata received three unsuccessful nominations for the Nobel Prize, one from Swiss surgeon Emil Kocher for Chemistry in 1911 and two by Japanese colleagues Hayazo Ito and G Osawa for Physiology or Medicine in 1912 and 1913, respectively. Early life Hata was born in Tsumo Village, Shimane prefecture (now part of Masuda City) as the eighth son of the Yamane family. At the age of 14, he was adopted by the Hata family, whose male members were doctors from generation to generation. Hata completed his medical education in Okayama at the Third Higher School of Medicine (now Okayama University School of Medicine). In 1897, he became an assistant at Okayama Prefectural Hospital where he learned internal medicine from Zenjiro Inoue and biochemistry from Torasaburo Araki. Plague Research Sahachiro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Masuda, Shimane
is a city located in Shimane Prefecture, Japan. The city was founded on August 1, 1952. As of December 2021, the city has a population of 44,976. As of December 2019, the city has a population of 46,209. As of March 2017, the city has a population of 46,892 and a population density of 64 persons per km². The total area is 733.16 km². At the end of September 2010, the city had a population of 51,118. At the end of August 2009, the city had a population of 51,599. At the end of September 2008, the city had a population of 52,022. On November 1, 2004, the towns of Mito and Hikimi (both from Mino District) were merged into Masuda. Therefore, Mino District was dissolved as a result of this merger. Iwami Airport is located in Masuda. Geography Climate Masuda has a humid subtropical climate (Köppen climate classification ''Cfa'') with very warm summers and cool winters. Precipitation is abundant throughout the year. The average annual temperature in Masuda is . The avera ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Okayama
is the capital city of Okayama Prefecture in the Chūgoku region of Japan. The city was founded on June 1, 1889. , the city has an estimated population of 720,841 and a population density of 910 persons per km2. The total area is . The city is the site of Kōraku-en, known as one of the top three traditional gardens in Japan, and Okayama Castle, which is ranked among the best 100 Japanese castles. The city is famous as the setting of the Japanese fable "Momotarō". Okayama joined the UNESCO Global Network of Learning Cities in 2016. History Sengoku period to Teisho period Before the Muromachi period, Okayama was one corner of a farm region and included a small castle built by the Kanemitsu. In the Sengoku period, Ukita Naoie attacked Okayama and attacked the castle for the transportation resources and extensive farmland in the region. Naoie remodeled the castle, built the old Sanyo road to the central part of the castle town, and called in craftsmen both from inside and outs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arsphenamine
Arsphenamine, also known as Salvarsan or compound 606, is a drug that was introduced at the beginning of the 1910s as the first effective treatment for syphilis, relapsing fever, and African trypanosomiasis. This organoarsenic compound was the first modern antimicrobial agent. History Arsphenamine was first synthesized in 1907 in Paul Ehrlich's lab by Alfred Bertheim. The antisyphilitic activity of this compound was discovered by Sahachiro Hata in 1909, during a survey of hundreds of newly synthesized organic arsenical compounds. Ehrlich had theorized that by screening many compounds, a drug could be discovered that would have anti-microbial activity but not kill the human patient. Ehrlich's team began their search for such a " magic bullet" among chemical derivatives of the dangerously toxic drug atoxyl. This project was the first organized team effort to optimize the biological activity of a lead compound through systematic chemical modifications, the basis for nearly all mod ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trypanosomatida
Trypanosomatida is a group of kinetoplastid excavates distinguished by having only a single flagellum. The name is derived from the Greek ''trypano'' (borer) and ''soma'' (body) because of the corkscrew-like motion of some trypanosomatid species. All members are exclusively parasitic, found primarily in insects. A few genera have life-cycles involving a secondary host, which may be a vertebrate, invertebrate or plant. These include several species that cause major diseases in humans. Some trypanosomatida are intracellular parasites, with the important exception of Trypanosoma brucei. Medical importance The three major human diseases caused by trypanosomatids are; African trypanosomiasis (sleeping sickness, caused by ''Trypanosoma brucei'' and transmitted by tsetse flies), South American trypanosomiasis (Chagas disease, caused by '' T. cruzi'' and transmitted by triatomine bugs), and leishmaniasis (a set of trypanosomal diseases caused by various species of ''Leishmania'' trans ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mercury (element)
Mercury is a chemical element with the symbol Hg and atomic number 80. It is also known as quicksilver and was formerly named hydrargyrum ( ) from the Greek words, ''hydor'' (water) and ''argyros'' (silver). A heavy, silvery d-block A block of the periodic table is a set of elements unified by the atomic orbitals their valence electrons or vacancies lie in. The term appears to have been first used by Charles Janet. Each block is named after its characteristic orbital: s-blo ... element, mercury is the only metallic element that is known to be liquid at standard temperature and pressure; the only other element that is liquid under these conditions is the halogen bromine, though metals such as caesium, gallium, and rubidium melt just above room temperature. Mercury occurs in deposits throughout the world mostly as cinnabar (mercuric sulfide). The red pigment vermilion is obtained by Mill (grinding), grinding natural cinnabar or synthetic mercuric sulfide. Mercury is used in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erich Hoffmann
Erich Hoffmann (25 April 1868 – 8 May 1959) was a German dermatologist who was a native of Witzmitz, Pomerania. He studied medicine at the Berlin Military Academy, and was later a professor at the Universities of Halle and Bonn. Hoffmann is remembered for his research performed with zoologist Fritz Schaudinn (1871-1906) at the Charité Clinic in Berlin. In 1905 Schaudinn and Hoffmann discovered the bacterium that was responsible for syphilis, a spiral-shaped spirochete called ''Treponema pallidum''. The organism was removed from a papula in the vulva of a patient with secondary syphilis. The two doctors documented their findings in a treatise called ''Vorläufiger Bericht über das Vorkommen von Spirochaeten in syphilitischen Krankheitsprodukten und bei Papillome''.Fritz Richard Schaudinn, Erich Hoffmann: Vorläufiger Bericht über das Vorkommen von Spirochaeten in syphilitischen Krankheitsprodukten und bei Papillomen. Arbeiten aus dem kaiserlichen Gesundheitsamtes (Berlin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fritz Schaudinn
Fritz Richard Schaudinn (19 September 1871 – 22 June 1906) was a German zoologist. Born in Röseningken, East Prussia, he co-discovered, with Erich Hoffmann in 1905, the causative agent of syphilis, ''Spirochaeta pallida'' (also known as ''Treponema pallidum''). The work was carried out at the Berlin Charité. Among Schaudinn's other contributions to medicine include his work in the field of amoebic dysentery and sleeping sickness, his confirmation of the work of Sir Ronald Ross and Giovanni Battista Grassi (1854–1925) in the field of malaria research. He also demonstrated that human hookworm infection is contracted through the skin of the feet. He made noted contributions to zoology and was one of the developers of protozoology as an experimental science. Schaudinn was a graduate in zoology of the Friedrich Wilhelm University in Berlin. Since 2002 an annual medical prize has been awarded in his name. In 1898 with zoologist Fritz Römer (1866–1909), he participated on a s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Treponema Pallidum
''Treponema pallidum'', formerly known as ''Spirochaeta pallida'', is a spirochaete bacterium with various subspecies that cause the diseases syphilis, bejel (also known as endemic syphilis), and yaws. It is transmitted only among humans. It is a helically coiled microorganism usually 6–15 μm long and 0.1–0.2 μm wide. ''T. pallidum'''s lack of either a tricarboxylic acid cycle or oxidative phosphorylation results in minimal metabolic activity. The treponemes have a cytoplasmic and an outer membrane. Using light microscopy, treponemes are visible only by using dark field illumination. ''Treponema pallidum'' consists of three subspecies, ''T. p. pallidum, T. p. endemicum,'' and ''T. p. pertenue,'' each of which has a distinct associated disease. Subspecies Three subspecies of ''T. pallidum'' are known: * ''Treponema pallidum pallidum'', which causes syphilis * ''T. p. endemicum'', which causes bejel or endemic syphilis * ''T. p. pertenue'', which causes yaws The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spirochaete
A spirochaete () or spirochete is a member of the phylum Spirochaetota (), (synonym Spirochaetes) which contains distinctive diderm (double-membrane) gram-negative bacteria, most of which have long, helically coiled (corkscrew-shaped or spiraled, hence the name) cells. Spirochaetes are chemoheterotrophic in nature, with lengths between 3 and 500 μm and diameters around 0.09 to at least 3 μm. Spirochaetes are distinguished from other bacterial phyla by the location of their flagella, called endoflagella which are sometimes called ''axial filaments''. Endoflagella are anchored at each end (pole) of the bacterium within the periplasmic space (between the inner and outer membranes) where they project backwards to extend the length of the cell. These cause a twisting motion which allows the spirochaete to move about. When reproducing, a spirochaete will undergo asexual transverse binary fission. Most spirochaetes are free-living and anaerobic, but there are numero ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frankfurt
Frankfurt, officially Frankfurt am Main (; Hessian: , "Frank ford on the Main"), is the most populous city in the German state of Hesse. Its 791,000 inhabitants as of 2022 make it the fifth-most populous city in Germany. Located on its namesake Main River, it forms a continuous conurbation with the neighboring city of Offenbach am Main and its urban area has a population of over 2.3 million. The city is the heart of the larger Rhine-Main metropolitan region, which has a population of more than 5.6 million and is Germany's second-largest metropolitan region after the Rhine-Ruhr region. Frankfurt's central business district, the Bankenviertel, lies about northwest of the geographic center of the EU at Gadheim, Lower Franconia. Like France and Franconia, the city is named after the Franks. Frankfurt is the largest city in the Rhine Franconian dialect area. Frankfurt was a city state, the Free City of Frankfurt, for nearly five centuries, and was one of the most import ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hata Sahachiro
{{disambiguation, geo ...
Hata may refer to: Places *Hata, Nagano, a former town in Nagano Prefecture, Japan *Hata District, Kōchi, a district in Kōchi Prefecture, Japan *Hata, India, a town and municipal council in Uttar Pradesh, India *Hata (Assembly constituency), a constituency of the Uttar Pradesh Legislative Assembly *Hata, a former village that is now the site of Ahta Indian Reserve No. 3 *Hata, Purvi Singhbhum, a village in Jharkhand, India Other uses *Hata (surname), a Japanese surname *Hata clan, a former immigrant clan to Japan See also *Hata Station (other), multiple railway stations in Japan *Hatamoto A was a high ranking samurai in the direct service of the Tokugawa shogunate of feudal Japan. While all three of the shogunates in Japanese history had official retainers, in the two preceding ones, they were referred to as ''gokenin.'' However ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Portrait Of Paul Ehrlich And Sahachiro Hata Wellcome M0013258
A portrait is a painting, photograph, sculpture, or other artistic representation of a person, in which the face and its expressions are predominant. The intent is to display the likeness, personality, and even the mood of the person. For this reason, in photography a portrait is generally not a snapshot, but a composed image of a person in a still position. A portrait often shows a person looking directly at the painter or photographer, in order to most successfully engage the subject with the viewer. History Prehistorical portraiture Plastered human skulls were reconstructed human skulls that were made in the ancient Levant between 9000 and 6000 BC in the Pre-Pottery Neolithic B period. They represent some of the oldest forms of art in the Middle East and demonstrate that the prehistoric population took great care in burying their ancestors below their homes. The skulls denote some of the earliest sculptural examples of portraiture in the history of art. Historical portraitur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
_Trypanosoma_equiperdum.jpg "Click for more on -> Trypanosomatida")
