Sten Grillner (born 14 June 1941,

Stockholm Stockholm () is the Capital city, capital and List of urban areas in Sweden by population, largest city of Sweden as well as the List of urban areas in the Nordic countries, largest urban area in Scandinavia. Approximately 980,000 people liv ...

) is a Swedish neurophysiologist and distinguished professor at the

Karolinska Institute The Karolinska Institute (KI; sv, Karolinska Institutet; sometimes known as the (Royal) Caroline Institute in English) is a research-led medical university in Solna within the Stockholm urban area of Sweden. The Karolinska Institute is consist ...

's Nobel Institute for Neurophysiology in

where he is the director of that institute. He is considered one of the world's foremost experts in the cellular bases of motor behaviour. His research is focused on understanding the

cellular Cellular may refer to: *Cellular automaton, a model in discrete mathematics * Cell biology, the evaluation of cells work and more * ''Cellular'' (film), a 2004 movie *Cellular frequencies, assigned to networks operating in cellular RF bands *Cell ...

bases of

motor An engine or motor is a machine designed to convert one or more forms of energy into mechanical energy. Available energy sources include potential energy (e.g. energy of the Earth's gravitational field as exploited in hydroelectric power gen ...

behaviour; in particular, he has shown how neuronal circuits in the

spine Spine or spinal may refer to: Science Biology * Vertebral column, also known as the backbone * Dendritic spine, a small membranous protrusion from a neuron's dendrite * Thorns, spines, and prickles, needle-like structures in plants * Spine (zoolog ...

help control rhythmic movements, such as those needed for

locomotion Locomotion means the act or ability of something to transport or move itself from place to place. Locomotion may refer to: Motion * Motion (physics) * Robot locomotion, of man-made devices By environment * Aquatic locomotion * Flight * Locomo ...

. He is the current secretary general of the

International Brain Research Organization The International Brain Research Organization (IBRO) is the global federation of neuroscience organizations that aims to promote and support neuroscience around the world through training, teaching, collaborative research, advocacy and outreach. M ...

(IBRO) and president of the

Federation of European Neuroscience Societies The Federation of European Neuroscience Societies (FENS) is a European federation of scientific societies for basic scientists and physicians whose research is focused on the brain and nervous system (i.e., neuroscience). History The federation w ...

(FENS). For his work, in 2008 he was awarded the $1 million Kavli Prize for deciphering the basic mechanisms which govern the development and functioning of the networks of cells in the brain and spinal cord. This prize distinguish the recipient from the Nobel prizes in basic medical sciences. Notable neuroscientists like

Eric Kandel Eric Richard Kandel (; born Erich Richard Kandel, November 7, 1929) is an Austrian-born American medical doctor who specialized in psychiatry, a neuroscientist and a professor of biochemistry and biophysics at the College of Physicians and Surge ...

, 2000

Nobel laureate The Nobel Prizes ( sv, Nobelpriset, no, Nobelprisen) are awarded annually by the Royal Swedish Academy of Sciences, the Swedish Academy, the Karolinska Institutet, and the Norwegian Nobel Committee to individuals and organizations who make out ...

s in physiology or medicine named Grillner's work on the workings of complex neurocircuitry extremely important and this progress in understanding motor systems, the cognitive role in motor systems, is a brilliant advance and has revolutionized our understanding of how the nervous system is wired. Prof. Grillner studied at the medical faculty in

Gothenburg, Sweden Gothenburg (; abbreviated Gbg; sv, Göteborg ) is the second-largest city in Sweden, fifth-largest in the Nordic countries, and capital of the Västra Götaland County. It is situated by the Kattegat, on the west coast of Sweden, and has a ...

, and received his Doctor of Medicine (MD); PhD in neurophysiology in 1969. He has been a Professor and Director of the Nobel Institute for Neurophysiology at the Karolinska Institute since 1987. He is a member of the

Academia Europaea The Academia Europaea is a pan-European Academy of Humanities, Letters, Law, and Sciences. The Academia was founded in 1988 as a functioning Europe-wide Academy that encompasses all fields of scholarly inquiry. It acts as co-ordinator of Europea ...

Royal Swedish Academy of Science The Royal Swedish Academy of Sciences ( sv, Kungliga Vetenskapsakademien) is one of the royal academies of Sweden. Founded on 2 June 1739, it is an independent, non-governmental scientific organization that takes special responsibility for prom ...

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

(US), Institute of Medicine (US) and former member, deputy chair and chairperson between 1988 and 2008 of the

Nobel Assembly at Karolinska Institutet The Nobel Assembly at the Karolinska Institute is a body at Karolinska Institute which awards the Nobel Prize in Physiology or Medicine. It is headquartered in the Nobel Forum on the grounds of the Karolinska Institute campus. Originally the Nobel ...

which awards Nobel Prize in Physiology or Medicine, and has received a number of awards including the

Bristol-Myers Squibb Award Between 1977 and 2006, the Bristol-Myers Squibb Foundation presented annual awards of US$50,000 to scientists for distinguished achievements in fields such as cancer, infectious disease, neuroscience, nutrition, and cardiovascular disease. The rec ...

in 1993 and the Reeve–Irvine award in 2002. He was the co-recipient of the 2005 SfN Ralph Gerard Prize, highest recognition conferred by

Society for Neuroscience The Society for Neuroscience (SfN) is a professional society, headquartered in Washington, DC, for basic scientists and physicians around the world whose research is focused on the study of the brain and nervous system. It is especially well kn ...

and he was a co-recipient, with

Thomas Jessell Thomas Michael Jessell (2 August 1951 – 28 April 2019) was the Claire Tow Professor of biochemistry and molecular biophysics at Columbia University in New York and a prominent developmental neuroscientist. In 2018, Columbia University announce ...

and

Pasko Rakic Pasko Rakic ( hr, Paško Rakić, ) is a Yugoslav-born American neuroscientist, who presently works in the Yale School of Medicine Department of Neuroscience in New Haven, Connecticut. His main research interest is in the development and evolutio ...

, of the inaugural

Kavli Prize The Kavli Prize was established in 2005 as a joint venture of the Norwegian Academy of Science and Letters, the Norwegian Ministry of Education and Research, and the Kavli Foundation. It honors, supports, and recognizes scientists for outstand ...

for Neuroscience in 2008.

Research

His research has focused on the extraordinary capability of the brain to control movement. Early on he demonstrated that networks within the mammalian spinal cord can produce the detailed motor pattern of locomotion involving the coordination of hundreds of different muscles. In a paper published in 1987, he and James Buchanan provided a putative network scheme of interacting interneurons in the lamprey spinal cord, a model vertebrate system. The level of detail gained in this work is unique in that it has allowed changes in behaviour to be related to changes occurring at the cellular and network level. His later work is directed towards understanding the forebrain mechanisms underlying selection of behavior, and has shown that the organization of the basal ganglia, dopamine system, habenulae and pallium is evolutionary conserved in considerable detail over more than 500 million years. He is a member of the

Norwegian Academy of Science and Letters The Norwegian Academy of Science and Letters ( no, Det Norske Videnskaps-Akademi, DNVA) is a learned society based in Oslo, Norway. Its purpose is to support the advancement of science and scholarship in Norway. History The Royal Frederick Univer ...

References

External links

Sten Grillner's homepage
{{DEFAULTSORT:Grillner, Sten Academic staff of the Karolinska Institute Swedish neuroscientists 1941 births Living people Members of the Norwegian Academy of Science and Letters Foreign associates of the National Academy of Sciences Neurophysiologists Kavli Prize laureates in Neuroscience Members of the National Academy of Medicine