''S''-Adenosylmethioninamine is a
substrate that is required for the biosynthesis of
polyamines
A polyamine is an organic compound having more than two amino groups. Alkyl polyamines occur naturally, but some are synthetic. Alkylpolyamines are colorless, Hygroscopy, hygroscopic, and water soluble. Near neutral pH, they exist as the ammonium d ...
including
spermidine
Spermidine is a polyamine compound () found in ribosomes and living tissues and having various metabolic functions within organisms. It was originally isolated from semen.
Function
Spermidine is an aliphatic polyamine. Spermidine synthase (SP ...
,
spermine
Spermine is a polyamine involved in cellular metabolism that is found in all eukaryotic cells. The precursor for synthesis of spermine is the amino acid ornithine. It is an essential growth factor in some bacteria as well. It is found as a p ...
, and
thermospermine.
It is produced by
decarboxylation of
''S''-adenosyl methionine.
See also
*
Adenosylmethionine decarboxylase
*
Spermidine synthase
Spermidine synthase is an enzyme () that catalyzes the transfer of the propylamine group from ''S''-adenosylmethioninamine to putrescine in the biosynthesis of spermidine. The systematic name is S-adenosyl 3-(methylthio)propylamine:putrescine 3-a ...
*
Spermine synthase
Spermine synthase (, ''spermidine aminopropyltransferase'', ''spermine synthetase'') is an enzyme that converts spermidine into spermine. This enzyme catalyses the following chemical reaction
: S-adenosylmethioninamine + spermidine \rightlefthar ...
*
Thermospermine synthase (ACAULIS5)
References
Nucleosides
Purines
Organosulfur compounds
Cations
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