Richard Henderson (born 19 July 1945) is a Scottish molecular biologist and biophysicist and pioneer in the field of

electron microscopy An electron microscope is a microscope that uses a beam of accelerated electrons as a source of illumination. As the wavelength of an electron can be up to 100,000 times shorter than that of visible light photons, electron microscopes have a hi ...

of biological molecules. Henderson shared the

Nobel Prize in Chemistry ) , image = Nobel Prize.png , alt = A golden medallion with an embossed image of a bearded man facing left in profile. To the left of the man is the text "ALFR•" then "NOBEL", and on the right, the text (smaller) "NAT•" then "M ...

in 2017 with Jacques Dubochet and

Joachim Frank Joachim Frank () (born September 12, 1940) is a German-American biophysicist at Columbia University and a Nobel laureate. He is regarded as the founder of single-particle cryo-electron microscopy (cryo-EM), for which he shared the Nobel Prize i ...

Education

Henderson was educated at Newcastleton primary school,

Hawick High School Hawick High School is a non-denominational secondary school in Hawick, in the Scottish Borders. As well as serving the town, it also takes in pupils from as far away as Newcastleton. History The first mention of educational provision in the ...

and Boroughmuir High School. He went on to study Physics at the

University of Edinburgh The University of Edinburgh ( sco, University o Edinburgh, gd, Oilthigh Dhùn Èideann; abbreviated as ''Edin.'' in post-nominals) is a public research university based in Edinburgh, Scotland. Granted a royal charter by King James VI in 1 ...

graduating with a BSc degree in Physics, 1st Class honours in 1966. He then commenced postgraduate study at

Corpus Christi College, Cambridge Corpus Christi College (full name: "The College of Corpus Christi and the Blessed Virgin Mary", often shortened to "Corpus"), is a constituent college of the University of Cambridge. From the late 14th century through to the early 19th centur ...

, and obtained his

PhD PHD or PhD may refer to: * Doctor of Philosophy (PhD), an academic qualification Entertainment * '' PhD: Phantasy Degree'', a Korean comic series * '' Piled Higher and Deeper'', a web comic * Ph.D. (band), a 1980s British group ** Ph.D. (Ph.D. al ...

degree from the

University of Cambridge , mottoeng = Literal: From here, light and sacred draughts. Non literal: From this place, we gain enlightenment and precious knowledge. , established = , other_name = The Chancellor, Masters and Schola ...

in 1969.

Career and research

Research

Henderson worked on the structure and mechanism of

chymotrypsin Chymotrypsin (, chymotrypsins A and B, alpha-chymar ophth, avazyme, chymar, chymotest, enzeon, quimar, quimotrase, alpha-chymar, alpha-chymotrypsin A, alpha-chymotrypsin) is a digestive enzyme component of pancreatic juice acting in the duod ...

for his doctorate under the supervision of David Mervyn Blow at the

MRC Laboratory of Molecular Biology The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical ...

.Dr Richard Henderson FRS FMedSci Fellow Profile

Academy of Medical Sciences The Academy of Medical Sciences is an organisation established in the UK in 1998. It is one of the four UK National Academies, the others being the British Academy, the Royal Academy of Engineering and the Royal Society. Its mission is to adv ...

His interest in

membrane protein Membrane proteins are common proteins that are part of, or interact with, biological membranes. Membrane proteins fall into several broad categories depending on their location. Integral membrane proteins are a permanent part of a cell membrane ...

s led to him working on voltage-gated

sodium channel Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's membrane. They belong to the superfamily of cation channels and can be classified according to the trigger that opens the chan ...

s as a post-doctoral researcher at

Yale University Yale University is a private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the third-oldest institution of higher education in the United States and among the most prestigious in the w ...

. Returning to the

in 1975, Henderson worked with

Nigel Unwin Peter Nigel Tripp Unwin FRS is a British scientist at the MRC Laboratory of Molecular Biology, where he was Head of the Neurobiology Division from 1992 until 2008. He is currently also Emeritus Professor of Cell Biology at the Scripps Research In ...

to study the structure of the

bacteriorhodopsin Bacteriorhodopsin is a protein used by Archaea, most notably by haloarchaea, a class of the Euryarchaeota. It acts as a proton pump; that is, it captures light energy and uses it to move protons across the membrane out of the cell. The resulting ...

. A seminal paper in ''

Nature Nature, in the broadest sense, is the physical world or universe. "Nature" can refer to the phenomena of the physical world, and also to life in general. The study of nature is a large, if not the only, part of science. Although humans are ...

'' by Henderson and Unwin (1975) established a low resolution structural model for bacteriorhodopsin showing the protein to consist of seven transmembrane helices. This paper was important for a number of reasons, not the least of which was that it showed that membrane proteins had well defined structures and that transmembrane alpha-helices could occur. After 1975 Henderson continued to work on the structure of

without Unwin. In 1990 Henderson published an atomic model of

by electron crystallography in the ''

Journal of Molecular Biology The ''Journal of Molecular Biology'' is a biweekly peer-reviewed scientific journal covering all aspects of molecular biology. It was established in 1959 and is published by Elsevier. The editor-in-chief is Peter Wright ( The Scripps Research In ...

''. This model was the second ever atomic model of a membrane protein. The techniques Henderson developed for electron crystallography are still in use. Together with Chris Tate, Henderson helped develop conformational thermostabilisation: a method that allows any protein to be made more stable while still holding a chosen conformation of interest. This method has been critical in crystallising and solving the structures of several

G protein–coupled receptor G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related p ...

s (GPCRs). With help from the charity LifeArc, Henderson and Tate founded the

MRC MRC may refer to Government * Medical Research Council (United Kingdom) * Medical Reserve Corps, a US network of volunteer organizations * Municipalité régionale de comté (regional county municipality), Quebec, Canada * Military Revolutionar ...

start-up company, Heptares Therapeutics Ltd (HTL) in 2007. HTL continues to develop new drugs targeting medically important GPCRs linked to a wide range of human diseases. In the last few years, Henderson has returned to hands-on research focusing on single particle electron microscopy. Having been an early proponent of the idea that single particle electron microscopy is capable of determining atomic resolution models for proteins, explained in a 1995 paper in Quarterly Reviews of Biophysics. Henderson aims to be able to routinely obtain atomic structures without crystals. He has made seminal contributions to many of the approaches used in single particle electron microscopy, including pioneering the development of direct electron detectors that recently allowed single particle cryo-electron microscopy to achieve its goals.

Post-docs and PhD students

Although Henderson has typically worked independently, he has trained a number of scientists who have gone on to independent research careers. These scientists include: * David Agard, since 1983 at

UCSF The University of California, San Francisco (UCSF) is a public land-grant research university in San Francisco, California. It is part of the University of California system and is dedicated entirely to health science and life science. It con ...

* Per Bullough, since 1994 at the

University of Sheffield , mottoeng = To discover the causes of things , established = – University of SheffieldPredecessor institutions: – Sheffield Medical School – Firth College – Sheffield Technical School – University College of Sheffield , type = Pu ...

* Nikolaus Grigorieff, since 2013 at HHMI Janelia Research Campus * Reinhard Grisshammer, since 2017 at the

National Cancer Institute The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. T ...

* Edmund Kunji, since 2000 at

MRC Mitochondrial Biology Unit The MRC Mitochondrial Biology Unit (formerly the MRC Dunn Human Nutrition Unit) is a department of the School of Clinical Medicine at the University of Cambridge, funded through a strategic partnership between the Medical Research Council and th ...

* Peter Rosenthal, since 2015 at the

Francis Crick Institute The Francis Crick Institute (formerly the UK Centre for Medical Research and Innovation) is a biomedical research centre in London, which was established in 2010 and opened in 2016. The institute is a partnership between Cancer Research UK, Impe ...

* John Rubinstein, since 2006 at The Hospital for Sick Children, Toronto * Gebhard Schertler, since 2010 at ETH

Paul Scherrer Institute The Paul Scherrer Institute (PSI) is a multi-disciplinary research institute for natural and engineering sciences in Switzerland. It is located in the Canton of Aargau in the municipalities Villigen and Würenlingen on either side of the River ...

* Christopher Tate, since 1992 at MRC

Laboratory of Molecular Biology The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical r ...

* Vinzenz Unger, since 2010 at

Northwestern University Northwestern University is a private research university in Evanston, Illinois. Founded in 1851, Northwestern is the oldest chartered university in Illinois and is ranked among the most prestigious academic institutions in the world. Charte ...

Other positions

Henderson has worked at the Medical Research Council

(MRC LMB) in

Cambridge Cambridge ( ) is a university city and the county town in Cambridgeshire, England. It is located on the River Cam approximately north of London. As of the 2021 United Kingdom census, the population of Cambridge was 145,700. Cambridge bec ...

since 1973, and was its director between 1996 and 2006. He was also a visiting professor at the Miller Institute of the

University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant un ...

in Spring 1993. He is currently a mentor for the

Mentoring Scheme. Outside academia, he lists his interests as hill walking in Scotland, kayaking and drinking good wine.

Awards and honours

* 1978 Awarded the William Bate Hardy Prize * 1983 Elected a

Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural knowledge, including mathemati ...

(FRS) * 1984 Awarded the Sir Hans Krebs Medal by the

Federation of European Biochemical Societies The Federation of the European Biochemical Societies, frequently abbreviated FEBS, is an international scientific society promoting activities in biochemistry, molecular biology and related research areas in Europe and neighbouring regions. It was ...

* 1998 Elected a Foreign Associate of the US

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nat ...

* 1981 Awarded the Ernst-Ruska Prize for Electron Microscopy * 1991 Awarded the Lewis S. Rosenstiel Award * 1993 Awarded the Louis-Jeantet Prize for Medicine * 1998 Elected as a founder Fellow of the

(FMedSci) * 1999 Awarded the

Gregori Aminoff prize The Gregori Aminoff Prize is an international prize awarded since 1979 by the Royal Swedish Academy of Sciences in the field of crystallography, rewarding "a documented, individual contribution in the field of crystallography, including areas conce ...

(together with

) * 2003 Honorary Fellow of the

* 2003 Honorary Member of the

British Biophysical Society The British Biophysical Society is a scientific society that exists to encourage and disseminate developments in the application of physical and chemical concepts to biological systems. It was founded in 1960 following a report from a Working Par ...

* 2005 Awarded Distinguished Scientist Award and Fellow, Microscopy Society of America * 2008 Honorary

Doctor of Science Doctor of Science ( la, links=no, Scientiae Doctor), usually abbreviated Sc.D., D.Sc., S.D., or D.S., is an academic research degree awarded in a number of countries throughout the world. In some countries, "Doctor of Science" is the degree used f ...

degree from the

* 2016 Awarded the

Copley Medal The Copley Medal is an award given by the Royal Society, for "outstanding achievements in research in any branch of science". It alternates between the physical sciences or mathematics and the biological sciences. Given every year, the medal is t ...

of the Royal Society * 2016 Awarded the Alexander Hollaender Award in Biophysics * 2017 Awarded the Wiley Prize * 2017 Honorary Fellow of the

Royal Society of Chemistry The Royal Society of Chemistry (RSC) is a learned society (professional association) in the United Kingdom with the goal of "advancing the chemical sciences". It was formed in 1980 from the amalgamation of the Chemical Society, the Royal Inst ...

(HonFRSC) * 2017 Awarded the

together with Jacques Dubochet and

''"for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution"'' * 2018 Appointed Member of the Order of the Companions of Honour (CH) in the

Queen's Birthday Honours The Birthday Honours, in some Commonwealth realms, mark the King's Official Birthday, reigning British monarch's official birthday by granting various individuals appointment into Order (honour), national or Dynastic order of knighthood, dynastic ...

for services to electron microscopy of biological molecules * 2018 Awarded the Royal Medal of the

Royal Society of Edinburgh The Royal Society of Edinburgh is Scotland's national academy of science and letters. It is a registered charity that operates on a wholly independent and non-partisan basis and provides public benefit throughout Scotland. It was established i ...

* 2019 Honorary

degree from the

University of Leeds , mottoeng = And knowledge will be increased , established = 1831 – Leeds School of Medicine1874 – Yorkshire College of Science1884 - Yorkshire College1887 – affiliated to the federal Victoria University1904 – University of Leeds , ...

Interviews

He was interviewed by

Jim Al-Khalili Jameel Sadik "Jim" Al-Khalili ( ar, جميل صادق الخليلي; born 20 September 1962) is an Iraqi-British theoretical physicist, author and broadcaster. He is professor of theoretical physics and chair in the public engagement in scie ...

for ''

The Life Scientific ''The Life Scientific'' is a BBC Radio 4 science programme, presented by Professor Jim Al-Khalili , in which each episode is dedicated to the biography and work of one living scientist. The programme consists of an interview between Al-Khalili ...

'', first broadcast on

BBC Radio 4 BBC Radio 4 is a British national radio station owned and operated by the BBC that replaced the BBC Home Service in 1967. It broadcasts a wide variety of spoken-word programmes, including news, drama, comedy, science and history from the BBC's ...

in February 2018.

References

External links

* including the Nobel Lecture on 8 December 2017 ''From Electron Crystallography to Single Particle cryoEM''
Richard Henderson
on The Scientists' Channel {{DEFAULTSORT:Henderson, Richard 1945 births Alumni of Corpus Christi College, Cambridge Alumni of the University of Edinburgh British molecular biologists Recipients of the Copley Medal Fellows of Corpus Christi College, Cambridge Fellows of Darwin College, Cambridge Fellows of the Royal Society Living people Members of the Order of the Companions of Honour Foreign associates of the National Academy of Sciences Microscopists People educated at Hawick High School People educated at Boroughmuir High School Scientists from Edinburgh Nobel laureates in Chemistry Scottish biochemists Scottish biologists Scottish Nobel laureates