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Christopher G. Tate
Christopher G. Tate FRS (born 5 May 1964) is an English membrane protein biochemist and molecular biologist who works at the Medical Research Council Laboratory of Molecular Biology in Cambridge, UK. Tate is known for his contributions to the understanding of G protein-coupled receptors. Education Tate was awarded the degree of BSC (Hons) in biochemistry by the University of Bristol in 1985. He was then awarded a PhD in 1989 by the University of Bristol for his work on integral membrane proteins in the red blood cell, under the supervision of Michael J. A. Tanner. Career and research Tate worked as a postdoctoral researcher (1989–1992) at the Department of Biochemistry, Cambridge, on bacterial sugar transporters in the group of Peter J. F. Henderson. After obtaining a research fellowship at Girton College, Cambridge, he then moved in 1992 to the Medical Research Council Laboratory of Molecular Biology to work with Richard Henderson, initially on the serotonin tran ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Laboratory Of Molecular Biology
The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical research laboratory at the forefront of scientific discovery, dedicated to improving the understanding of key biological processes at atomic, molecular and cellular levels using multidisciplinary methods, with a focus on using this knowledge to address key issues in human health. A new replacement building constructed close by to the original site on the Cambridge Biomedical Campus was opened by Her Majesty the Queen in May 2013. The road outside the new building is named Francis Crick Avenue after the 1962 joint Nobel Prize winner and LMB alumnus, who co-discovered the helical structure of DNA in 1953. History Origins: 1947-61 Max Perutz, following undergraduate training in organic chemistry, left Austria in 1936 and came to the Universi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurotensin Receptor
Neurotensin receptors are transmembrane receptors that bind the neurotransmitter A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse. The cell receiving the signal, any main body part or target cell, may be another neuron, but could also be a gland or muscle cell. Neuro ... neurotensin. Two of the receptors encoded by the and genes contain seven transmembrane helices and are G protein coupled. Numerous crystal structures have been reported for the neurotensin receptor 1 (NTS1). The third receptor has a single transmembrane domain and is encoded by the gene. Ligands Agonists ;Peptide * Beta-lactotensin (NTS2) * JMV-449 * Neurotensin * Neuromedin N (NTS1 selective) * PD-149,163 (NTS1 selective, reduced amide bond 8-13 fragment of neurotensin) ;Non-peptide * NTS1 full agonist SRI-9829 * Partial agonists derived from SR-48692 Antagonists * Levocabastine (NTS2 selective, also H1 histamine antagonist) * S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
21st-century English Scientists
The 1st century was the century spanning AD 1 ( I) through AD 100 ( C) according to the Julian calendar. It is often written as the or to distinguish it from the 1st century BC (or BCE) which preceded it. The 1st century is considered part of the Classical era, epoch, or historical period. The 1st century also saw the appearance of Christianity. During this period, Europe, North Africa and the Near East fell under increasing domination by the Roman Empire, which continued expanding, most notably conquering Britain under the emperor Claudius (AD 43). The reforms introduced by Augustus during his long reign stabilized the empire after the turmoil of the previous century's civil wars. Later in the century the Julio-Claudian dynasty, which had been founded by Augustus, came to an end with the suicide of Nero in AD 68. There followed the famous Year of Four Emperors, a brief period of civil war and instability, which was finally brought to an end by Vespasian, ninth Roman emperor, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alumni Of The University Of Bristol
This is a list of University of Bristol people, including a brief description of their notability. This list includes not just former students but persons who are or have been associated with the university, including former academics, Chancellors, and recipients of honorary degrees. Staff and academics Chancellors and Vice-Chancellors Alumni Government and politics United Kingdom International The Law * Alexander Cameron, English Barrister *Sir Richard Field, English High Court Judge, Academic of University of British Columbia, University of Hong Kong, McGill University * Louisa Ghevaert, British family law lawyer *Brenda Hale, Baroness Hale of Richmond, English judge and first woman to be appointed as the President of the Supreme Court of the United Kingdom, Chancellor of University (2004-2016) * Sir Stephen Laws, British lawyer and civil servant who served as the First Parliamentary Counsel (2006-2012) *Victoria Sharp, English Lady Justice of Appeal and Vice-Presid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
English Biochemists
English usually refers to: * English language * English people English may also refer to: Peoples, culture, and language * ''English'', an adjective for something of, from, or related to England ** English national identity, an identity and common culture ** English language in England, a variant of the English language spoken in England * English languages (other) * English studies, the study of English language and literature * ''English'', an Amish term for non-Amish, regardless of ethnicity Individuals * English (surname), a list of notable people with the surname ''English'' * People with the given name ** English McConnell (1882–1928), Irish footballer ** English Fisher (1928–2011), American boxing coach ** English Gardner (b. 1992), American track and field sprinter Places United States * English, Indiana, a town * English, Kentucky, an unincorporated community * English, Brazoria County, Texas, an unincorporated communi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Related categories * :Year of birth missing (living people) / :Year of birth unknown * :Date of birth missing (living people) / :Date of birth unknown * :Place of birth missing (living people) / :Place of birth unknown * :Year of death missing / :Year of death unknown * :Date of death missing / :Date of death unknown * :Place of death missing / :Place of death unknown * :Missing middle or first names See also * :Dead people * :Template:L, which generates this category or death years, and birth year and sort keys. : {{DEFAULTSORT:Living people 21st-century people People by status ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1964 Births
Events January * January 1 – The Federation of Rhodesia and Nyasaland is dissolved. * January 5 - In the first meeting between leaders of the Roman Catholic and Orthodox churches since the fifteenth century, Pope Paul VI and Patriarch Athenagoras I of Constantinople meet in Jerusalem. * January 6 – A British firm, the Leyland Motor Corp., announces the sale of 450 buses to the Cuban government, challenging the United States blockade of Cuba. * January 9 – ''Martyrs' Day'': Armed clashes between United States troops and Panamanian civilians in the Panama Canal Zone precipitate a major international crisis, resulting in the deaths of 21 Panamanians and 4 U.S. soldiers. * January 11 – United States Surgeon General Luther Terry reports that smoking may be hazardous to one's health (the first such statement from the U.S. government). * January 12 ** Zanzibar Revolution: The predominantly Arab government of Zanzibar is overthrown by African nationalist rebels; a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adenosine A2A Receptor
The adenosine A2A receptor, also known as ADORA2A, is an adenosine receptor, and also denotes the human gene encoding it. Structure This protein is a member of the G protein-coupled receptor (GPCR) family which possess seven transmembrane alpha helices, as well as an extracellular N-terminus and an intracellular C-terminus. Furthermore, located in the intracellular side close to the membrane is a small alpha helix, often referred to as helix 8 (H8). The crystallographic structure of the adenosine A2A receptor reveals a ligand binding pocket distinct from that of other structurally determined GPCRs (i.e., the beta-2 adrenergic receptor and rhodopsin).; Below this primary ( orthosteric) binding pocket lies a secondary ( allosteric) binding pocket. The crystal-structure of A2A bound to the antagonist ZM241385 (PDB code: 4EIY) showed that a sodium-ion can be found in this location of the protein, thus giving it the name 'sodium-ion binding pocket'. Heteromers The actions of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Bristol
, mottoeng = earningpromotes one's innate power (from Horace, ''Ode 4.4'') , established = 1595 – Merchant Venturers School1876 – University College, Bristol1909 – received royal charter , type = Public red brick research university , endowment = £91.3 million (2021) , budget = £752.0 million (2020–21) , chancellor = Paul Nurse , vice_chancellor = Professor Evelyn Welch , head_label = Visitor , head = Rt Hon. Penny Mordaunt MP , academic_staff = 3,385 (2020) , students = () , undergrad = () , postgrad = () , city = Bristol , country = England , coor = , campus = Urban , free_label = Students' Union , free = University of Bristol Union , colours = ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Beta-1 Adrenergic Receptor
The beta-1 adrenergic receptor (β1 adrenoceptor), also known as ADRB1, is a beta-adrenergic receptor, and also denotes the human gene encoding it. It is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein and is expressed predominantly in cardiac tissue. Receptor Actions Actions of the β1 receptor include: The receptor is also present in the cerebral cortex. Agonists Isoprenaline has higher affinity for β1 than adrenaline, which, in turn, binds with higher affinity than noradrenaline at physiologic concentrations. Selective agonists to the beta-1 receptor are: *Denopamine *Dobutamine (in cardiogenic shock) *Xamoterol (cardiac stimulant) Antagonists ''(Beta blockers)'' β1-selective antagonists include: *Acebutolol (in hypertension, angina pectoris and arrhythmias) *Atenolol (in hypertension, coronary heart disease, arrhythmias and myocardial infarction) * Betaxolol (in hypertension and glaucoma) *Bisoprolol (in hypertension, coronary heart disea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
