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Joachim Frank
Joachim Frank () (born September 12, 1940) is a German-American biophysicist at Columbia University and a Nobel laureate. He is regarded as the founder of single-particle cryo-electron microscopy (cryo-EM), for which he shared the Nobel Prize in Chemistry in 2017 with Jacques Dubochet and Richard Henderson. He also made significant contributions to structure and function of the ribosome from bacteria and eukaryotes. Life and career Frank was born in Siegen in the borough of Weidenau. After completing his Vordiplom (B.S.) degree in physics at the University of Freiburg (1963) and his Diplom under Walter Rollwagen's mentorship at the Ludwig Maximilian University of Munich with the thesis "Untersuchung der Sekundärelektronen-Emission von Gold am Schmelzpunkt" (Investigation of secondary electron emission of gold at its melting point) (1967), Frank obtained his Ph.D. from the Technical University of Munich for graduate studies in Walter Hoppe's lab at the Max Planck Instit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Siegen
Siegen () is a city in Germany, in the south Westphalian part of North Rhine-Westphalia North Rhine-Westphalia (german: Nordrhein-Westfalen, ; li, Noordrien-Wesfale ; nds, Noordrhien-Westfalen; ksh, Noodrhing-Wäßßfaale), commonly shortened to NRW (), is a States of Germany, state (''Land'') in Western Germany. With more tha .... It is located in the district of Siegen-Wittgenstein in the Arnsberg (region), Arnsberg region. The university town (nearly 20,000 students in the 2018–2019 winter semester) is the district seat, and is ranked as a "higher centre" in the South Westphalian urban agglomeration. In 1975, municipal reforms and amalgamations lifted Siegen's population above the 100,000 mark. Geography Location The city of Siegen lies in the basin of the upper reaches of the river Sieg (river), Sieg. From there, lateral valleys branch off in many directions. The heights of the surrounding mountains, wherever they are not actually settled, are covered in Coppic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Honorary Fellow Of The Royal Microscopical Society
The Royal Microscopical Society (RMS) is a learned society for the promotion of microscopy. It was founded in 1839 as the Microscopical Society of London making it the oldest organisation of its kind in the world. In 1866, the society gained its royal charter and took its current name. Founded as a society of amateurs, its membership consists of individuals of all skill levels in numerous related fields from throughout the world. Every year since 1841, the society has published its own scientific journal, the Journal of Microscopy, which contains peer-reviewed papers and book reviews. The society is a registered charity that is dedicated to advancing science, developing careers and supporting wider understanding of science and microscopy through its Outreach activities. Probably the society's greatest contribution is its standardised 3x1 inches microscope glass slides in 1840, which are still the most widely used size today and known as the "RMS standard". The Royal Microscopic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diplom
A ''Diplom'' (, from grc, δίπλωμα ''diploma'') is an academic degree in the German-speaking countries Germany, Austria, and Switzerland and a similarly named degree in some other European countries including Albania, Bulgaria, Belarus, Bosnia and Herzegovina, Croatia, Estonia, Finland, Poland, Russia, and Ukraine and only for engineers in France, Greece, Hungary, North Macedonia, Romania, Serbia, Slovenia, and Brazil. History The Diplom originates from the French Diplôme (''Diplôme de l'ordre impérial de la légion d'honneur'') describing a certificate devised during the Second French Empire to bestow honours upon outstanding citizens and soldiers of the imperial French army to promote them into the Legion of Honour since 1862. The Magister degree was the original graduate degree at German-speaking universities. In Germany the Diplom dates back to the pre-republican period: In October 1899 the engineering degree ''Diplom'' was announced by a ''supreme decree'' of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Weidenau
Weidenau is a suburban part (Stadtteil) of the city Siegen in Germany. Weidenau, a northern part of Siegen, shares borders with Niedersetzen in the north, Geisweid in the north-west, the central part of Siegen in the south, Birlenbach in the west, Bürbach in the south-east and Dreis-Tiefenbach, a part of the city of Netphen in the north-east. The University of Siegen The University of Siegen (german: Universität Siegen) is a public research university located in Siegen, North Rhine-Westphalia and is part of the Deutsche Forschungsgemeinschaft, a society of Germany's leading research universities. The Univers ... is located in Weidenau. History Weidenau, formerly belonging to the Amt Weidenau till 1966 and afterwards to the city of Hüttental is a part of Siegen since 1. January 1975. Population At the end of 2010 Weidenau had a population of 15.064 inhabitants. Development of Population:Otto Schaefer: ''Der Kreis Siegen'', Siegen 1968 References {{Auth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ribosome
Ribosomes ( ) are macromolecular machines, found within all cells, that perform biological protein synthesis (mRNA translation). Ribosomes link amino acids together in the order specified by the codons of messenger RNA (mRNA) molecules to form polypeptide chains. Ribosomes consist of two major components: the small and large ribosomal subunits. Each subunit consists of one or more ribosomal RNA (rRNA) molecules and many ribosomal proteins (RPs or r-proteins). The ribosomes and associated molecules are also known as the ''translational apparatus''. Overview The sequence of DNA that encodes the sequence of the amino acids in a protein is transcribed into a messenger RNA chain. Ribosomes bind to messenger RNAs and use their sequences for determining the correct sequence of amino acids to generate a given protein. Amino acids are selected and carried to the ribosome by transfer RNA (tRNA) molecules, which enter the ribosome and bind to the messenger RNA chain via an anti-c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Richard Henderson (biologist)
Richard Henderson (born 19 July 1945) is a Scottish molecular biologist and biophysicist and pioneer in the field of electron microscopy of biological molecules. Henderson shared the Nobel Prize in Chemistry in 2017 with Jacques Dubochet and Joachim Frank. Education Henderson was educated at Newcastleton primary school, Hawick High School and Boroughmuir High School. He went on to study Physics at the University of Edinburgh graduating with a BSc degree in Physics, 1st Class honours in 1966. He then commenced postgraduate study at Corpus Christi College, Cambridge, and obtained his PhD degree from the University of Cambridge in 1969. Career and research Research Henderson worked on the structure and mechanism of chymotrypsin for his doctorate under the supervision of David Mervyn Blow at the MRC Laboratory of Molecular Biology. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jacques Dubochet
Jacques Dubochet (born 8 June 1942) is a retired Swiss biophysicist. He is a former researcher at the European Molecular Biology Laboratory in Heidelberg, Germany, and an honorary professor of biophysics at the University of Lausanne in Switzerland. In 2017, he received the Nobel Prize in Chemistry together with Joachim Frank and Richard Henderson "for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution". He received the Royal Photographic Society Progress Medal, alongside his colleagues Professor Joachim Frank and Dr Richard Henderson, in 2018 for 'an important advance in the scientific or technological development of photography or imaging in the widest sense'. Career Dubochet started to study physics at the ''École polytechnique de l' Université de Lausanne'' (now École polytechnique fédérale de Lausanne) in 1962 and obtained his degree in physical engineering in 1967. He obtained a Certificate of Molecular B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Columbia University
Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhattan, Columbia is the oldest institution of higher education in New York and the fifth-oldest institution of higher learning in the United States. It is one of nine colonial colleges founded prior to the Declaration of Independence. It is a member of the Ivy League. Columbia is ranked among the top universities in the world. Columbia was established by royal charter under George II of Great Britain. It was renamed Columbia College in 1784 following the American Revolution, and in 1787 was placed under a private board of trustees headed by former students Alexander Hamilton and John Jay. In 1896, the campus was moved to its current location in Morningside Heights and renamed Columbia University. Columbia scientists and scholars have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biophysics
Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations. Biophysical research shares significant overlap with biochemistry, molecular biology, physical chemistry, physiology, nanotechnology, bioengineering, computational biology, biomechanics, developmental biology and systems biology. The term ''biophysics'' was originally introduced by Karl Pearson in 1892.Roland Glaser. Biophysics: An Introduction'. Springer; 23 April 2012. . The term ''biophysics'' is also regularly used in academia to indicate the study of the physical quantities (e.g. electric current, temperature, stress, entropy) in biological systems. Other biological sciences also perform research on the biophysical properties of living organisms including molecular biology, cell biology, chemical biology, and biochemistry. Overview ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Columbia University College Of Physicians And Surgeons
Columbia University Vagelos College of Physicians and Surgeons (VP&S) is the graduate medical school of Columbia University, located at the Columbia University Irving Medical Center in the Washington Heights neighborhood of Manhattan. Founded in 1767 by Samuel Bard as the medical department of King's College (now Columbia University), VP&S was the first medical school in the Thirteen Colonies to award the Doctor of Medicine (MD) degree. Beginning in 1993, VP&S was also the first U.S. medical school to hold a white coat ceremony. According to '' U.S. News & World Report'', VP&S is one of the most selective medical schools in the United States based on average MCAT score, GPA, and acceptance rate. In 2018, 7,537 people applied and 1,007 were interviewed for 140 seats in its entering MD class. The median undergraduate GPA and average MCAT score for successful applicants in 2014 were 3.82 and 36, respectively. Columbia is third for research among American medical schools by ''U.S. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University At Albany
The State University of New York at Albany, commonly referred to as the University at Albany, UAlbany or SUNY Albany, is a public research university with campuses in Albany, Rensselaer, and Guilderland, New York. Founded in 1844, it is one of the four "university centers" of the State University of New York (SUNY) system. The university enrolls 16,648 students in nine schools and colleges, which offer 50 undergraduate majors and 125 graduate degree programs. The university's academic choices include new and emerging fields in public policy, homeland security, globalization, documentary studies, biotechnology, and informatics. Through the UAlbany and SUNY-wide exchange programs, students have more than 600 study-abroad programs to choose from, as well as government and business internship opportunities in New York's capital and surrounding region. It is classified among "R1: Doctoral Universities – Very high research activity". The research enterprise totaled expenditure ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cryo-electron Microscopy
Cryogenic electron microscopy (cryo-EM) is a cryomicroscopy technique applied on samples cooled to cryogenic temperatures. For biological specimens, the structure is preserved by embedding in an environment of vitreous ice. An aqueous sample solution is applied to a grid-mesh and plunge-frozen in liquid ethane or a mixture of liquid ethane and propane. While development of the technique began in the 1970s, recent advances in detector technology and software algorithms have allowed for the determination of biomolecular structures at near-atomic resolution. This has attracted wide attention to the approach as an alternative to X-ray crystallography or NMR spectroscopy for macromolecular structure determination without the need for crystallization. In 2017, the Nobel Prize in Chemistry was awarded to Jacques Dubochet, Joachim Frank, and Richard Henderson "for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution." ''Nature M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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