Robert B. Mellor
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Robert B. Mellor (born in Yorkshire, UK) is a British scientist probably best known for his 1989 "unified vacuole theory", although also made significant contributions to environmental technology and to our understanding of the workings of the tech entrepreneurship ecosystem.


Unified vacuole theory

The theory states that in plant endosymbioses, the micro-symbiont and the macro-symbiont generally share their lytic vacuolar compartments. This stems from Mellor's earlier 1988 symbiosome (or "symbiosome is a lysosome") theory, which states that the organelle that microsymbionts inhabit partially takes over the lysosomal functions in these plant cells. These plant cells are analogous to the role of protein bodies in seeds, in particular that the
rhizobia Rhizobia are diazotrophic bacteria that fix nitrogen after becoming established inside the root nodules of legumes (Fabaceae). To express genes for nitrogen fixation, rhizobia require a plant host; they cannot independently fix nitrogen. In gene ...
l symbiosome is an organ-specific form of lysosome or vacuole in
legume A legume () is a plant in the family Fabaceae (or Leguminosae), or the fruit or seed of such a plant. When used as a dry grain, the seed is also called a pulse. Legumes are grown agriculturally, primarily for human consumption, for livestock f ...
root nodule Root nodules are found on the roots of plants, primarily legumes, that form a symbiosis with nitrogen-fixing bacteria. Under nitrogen-limiting conditions, capable plants form a symbiotic relationship with a host-specific strain of bacteria known a ...
s.


The Marburg and Basel Years (plant biology)

Mellor was interested in how plants distinguish between symbiotic and pathogenic infections. In 1984, he set about measuring defence responses including Phytoalexin and Chitinase in nodules infected with different
rhizobia Rhizobia are diazotrophic bacteria that fix nitrogen after becoming established inside the root nodules of legumes (Fabaceae). To express genes for nitrogen fixation, rhizobia require a plant host; they cannot independently fix nitrogen. In gene ...
l mutants. Gradually, he observed that in Rhizobia, the nod genes are responsible for producing different nod factors (lipo-chitin molecules). Among many other effects he also observed that they can provoke plant defence responses, so that it is essential that these genes be switched off after infection, or symbiosis could not take place. This model won general acclaim, and the paper with David Collinge was later reprinted (Mellor and Collinge, 1995) as that year’s number one most important publication in the area of Plant Sciences. In other works, Mellor has claimed that in
legume A legume () is a plant in the family Fabaceae (or Leguminosae), or the fruit or seed of such a plant. When used as a dry grain, the seed is also called a pulse. Legumes are grown agriculturally, primarily for human consumption, for livestock f ...
s the
root nodule Root nodules are found on the roots of plants, primarily legumes, that form a symbiosis with nitrogen-fixing bacteria. Under nitrogen-limiting conditions, capable plants form a symbiotic relationship with a host-specific strain of bacteria known a ...
cytoplasm may be under water stress and the plant may combat this by using the bacterial/fungal (in the case of vesicular arbuscular mycorrhiza) disaccharide sugar trehalose. The concept has been repeatedly confirmed, and this effect explains why nodulated plants have a higher drought tolerance than non-nodulated plants.


The Göttingen Years (environmental nanotech)

Mellor was also interested in
applied science Applied science is the use of the scientific method and knowledge obtained via conclusions from the method to attain practical goals. It includes a broad range of disciplines such as engineering and medicine. Applied science is often contrasted ...
, and after leaving the University of Basel he became director of research and development at a German chemical company. There he led the group that invented and patented a system to power immobilized oxido-reductase enzymes and artificial co-factors using electrical power from a domestic socket. Twenty-five years later, the authors Eltarahony et al. stated in their round-up review paper that "... Mellor et al. 992pioneered the concept of current promotion, electrode bioreactor and denitrification control, this concept,
s now S, or s, is the nineteenth letter in the Latin alphabet, used in the modern English alphabet, the alphabets of other western European languages and others worldwide. Its name in English is ''ess'' (pronounced ), plural ''esses''. History ...
widely used to treat different types of wastewater, such as toxic and refractory organic wastewater as well as wastewater containing heavy metal ions" helping to provide clean water for millions of people globally.


The London Years (computing and maths)

In early 2000, Mellor joined and helped
start-up A startup or start-up is a company or project undertaken by an entrepreneur to seek, develop, and validate a scalable business model. While entrepreneurship refers to all new businesses, including self-employment and businesses that never intend t ...
IT the University of Copenhagen, alongside Mads Tofte and others. In 2005 he became Director of Enterprise at Kingston University, London, (and quadrupling enterprise income) in Computing, Information Systems and Mathematics while teaching the mathematical modelling of business processes and knowledge management at MSc level. Mellor, influenced by
Stiglitz Joseph Eugene Stiglitz (; born February 9, 1943) is an American New Keynesian economist, a public policy analyst, and a full professor at Columbia University. He is a recipient of the Nobel Memorial Prize in Economic Sciences (2001) and the Joh ...
, realized that econometric methods can be used to quantify the value of knowledge management. His breakthrough computer modelling resulted in a complete explanation of the developmental lifecycle of SMEs ( small and medium-sized enterprises), firstly in his 2011 book and then later expanded upon in his 2018 publication, "Big Data Modelling the Knowledge Economy". He runs a Masters programme around IT Consultancy, as well as a select "
Big Data Though used sometimes loosely partly because of a lack of formal definition, the interpretation that seems to best describe Big data is the one associated with large body of information that we could not comprehend when used only in smaller am ...
" research group engaged with modelling organizations, especially Science Parks, in the context of regional development. Most recently, working together with Matthias Georg Will, an econometric computer model was developed which explains why, in modern business environments, flat organizations can only exist if employees are able to competently evaluate incoming innovations and their judgement is accepted by their managers, a situation typified by the successful tech firms.


Works

R. B. Mellor PhD DSc, is the author of over 100 scientific publications in journals, as well as eleven books, several of which have been translated into other languages. His impact factor (h-Index) is 26, putting him well into the top decile (10%) of all researchers worldwide and in the top 20 researchers in computer modelling. He is an active consultant with over twelve years of industrial experience, and he lectures at postgraduate level on subjects like ‘information systems and econometrics’, ‘mathematical knowledge management’, ‘strategic innovation’, and ‘tech entrepreneurship’. He has received many international prizes for his work and ideas, and in 2020, he became a member of the advisor pool to the UK Government Office for Science on post-COVID-19 needs.


Personal life

Keen on outdoor activities, R. B. Mellor has cycled across most of Europe; in the 1970's with his friend
John Jowett John D. Jowett is an English Shakespeare scholar and editor. He is the Professor of Shakespeare Studies at the University of Birmingham and Deputy Director of the Shakespeare Institute. Born in Lancashire, England, Jowett took his BA and MA at ...
he traversed Scotland on foot and also in 1980 co-wrote "The Pennine Way Pub Guide" (with John Jowett and Paul Wilson). He has climbed most of the central Pyrenees and in the 80's and 90's was occasional guide ('bergführer') for the Alpine Association (Alpenverein) in the Dolomites and Austrian Eastern Alps. Always interested in music, he added support to the Danish Soca music band Tropicats on their 1995 CD "Lets go Bananas". He holds an enhanced certificate for working with children and the vulnerable, and can often be found holding careers talks etc. in local schools and colleges.


Articles

* * * * * * * *


Books

*1996: ''The Nodulation of Legumes''. DSR forlag. OCLC 1124029713. *''2001: ASP: Learning by Example.'' Franklin Beedle. . *''2002: DHTML: Learning by Example.'' Franklin Beedle. . *''2003: XML: Learning by Example''. Franklin Beedle. . *''2008: Entrepreneurship for Everyone.'' Sage. . *''2011: Knowledge Management and Information Systems.'' Palgrave Macmillan. . *''2019: Management for Scientists.'
Emerald Publishing Limited


References


External links

* {{DEFAULTSORT:Mellor, Robert B. English biologists Living people Year of birth missing (living people)