RU-28306 is a tricyclic tryptamine derivative which acts as a

serotonin receptor 5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neur ...

agonist, with selectivity for 5-HT₁ and 5-HT₂ subtypes. It can be regarded either as a conformationally constrained derivative of

DMT ''N'',''N''-Dimethyltryptamine (DMT or ''N'',''N''-DMT, SPL026) is a substituted tryptamine that occurs in many plants and animals, including human beings, and which is both a derivative and a structural analog of tryptamine. It is used as a ...

, or a structurally simplified analogue of LSD, but the binding affinity of racemic RU-28306 is closer to that of DMT, though with relatively higher affinity for 5-HT₂ subtypes and lower for 5-HT₁. It has been sold as a designer drug and was first reported to the EMCDDA by a forensic laboratory in Slovenia in 2017.EMCDDA – Europol 2017 Annual Report on the implementation of Council Decision 2005/387/JHA
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References

{{Tryptamines Serotonin receptor agonists Tryptamines Phenethylamines

See also

References