RNA recognition motif, RNP-1 is a putative

RNA Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and deoxyribonucleic acid ( DNA) are nucleic acids. Along with lipids, proteins, and carbohydra ...

-binding domain of about 90 amino acids that are known to bind single-stranded RNAs. It was found in many

eukaryotic Eukaryotes () are organisms whose cells have a nucleus. All animals, plants, fungi, and many unicellular organisms, are Eukaryotes. They belong to the group of organisms Eukaryota or Eukarya, which is one of the three domains of life. Bact ...

proteins. The largest group of single strand

RNA-binding protein RNA-binding proteins (often abbreviated as RBPs) are proteins that bind to the double or single stranded RNA in cells and participate in forming ribonucleoprotein complexes. RBPs contain various structural motifs, such as RNA recognition moti ...

is the eukaryotic RNA recognition motif (RRM) family that contains an eight amino acid RNP-1 consensus sequence. RRM proteins have a variety of RNA binding preferences and functions, and include heterogeneous nuclear ribonucleoproteins ( hnRNPs), proteins implicated in regulation of alternative splicing (SR, U2AF2, Sxl), protein components of small nuclear ribonucleoproteins (U1 and U2

snRNP snRNPs (pronounced "snurps"), or small nuclear ribonucleoproteins, are RNA-protein complexes that combine with unmodified pre-mRNA and various other proteins to form a spliceosome, a large RNA-protein molecular complex upon which splicing of pr ...

s), and proteins that regulate RNA stability and translation ( PABP, La, Hu). The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor appears to have two RRM-like domains with specialised features for protein recognition. The motif also appears in a few single stranded DNA binding proteins. The typical RRM consists of four anti-parallel beta-strands and two alpha-helices arranged in a beta-alpha-beta-beta-alpha-beta fold with side chains that stack with RNA bases. A third helix is present during RNA binding in some cases. The RRM is reviewed in a number of publications.

Human proteins containing this domain

A2BP1; ACF; BOLL;

BRUNOL4 CUGBP Elav-like family member 4 (CELF4) also known as bruno-like protein 4 (BRUNOL4) is a protein that in humans is encoded by the CELF4 gene. Function Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif ( ...

; BRUNOL5; BRUNOL6;

CCBL2 The Cape Cod Baseball League (CCBL or Cape League) is a collegiate summer baseball wooden bat league located on Cape Cod in the U.S. state of Massachusetts. One of the nation's premier collegiate summer leagues, the league boasts over one thousan ...

; CGI-96; CIRBP; CNOT4; CPEB2; CPEB3; CPEB4; CPSF7; CSTF2; CSTF2T; CUGBP1; CUGBP2; D10S102;

DAZ1 Deleted in azoospermia 1, also known as DAZ1, is a protein which in humans is encoded by the ''DAZ1'' gene. Function This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its e ...

;

DAZ2 Deleted in azoospermia protein 2 is a protein that in humans is encoded by the ''DAZ2'' gene. This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted t ...

;

DAZ3 Deleted in azoospermia protein 3 is a protein that in humans is encoded by the ''DAZ3'' gene. This gene is a member of the DAZ protein family, DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression ...

; DAZ4;

DAZAP1 DAZ-associated protein 1 is a protein that in humans is encoded by the ''DAZAP1'' gene. Function In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infert ...

;

DAZL Deleted in azoospermia-like is a protein that in humans is encoded by the ''DAZL'' gene. Function The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of ...

; DNAJC17; DND1; EIF3S4; EIF3S9; EIF4B; EIF4H; ELAVL1;

ELAVL2 ELAV-like protein 2 is a protein that in humans is encoded by the ''ELAVL2'' gene. References Further reading

* * * * * * * * {{gene-9-stub ...

; ELAVL3;

ELAVL4 HuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ''ELAVL4'' gene. The HuD/ELAVL4 protein is an RNA-binding protein. HuD contains three RRM protein domains In molecular biology, a protein domain is a ...

; ENOX1;

ENOX2 ENOX2 is a gene located on the long arm of the X chromosome in humans. The gene encodes the protein Ecto-NOX disulfide-thiol exchanger 2, a member of the NOX family of NADPH oxidases. Ecto-NOX disulfide-thiol exchanger 2 is a growth-related cell ...

; EWSR1; FUS; FUSIP1; G3BP; G3BP1; G3BP2; GRSF1; HNRNPL; HNRPA0;

HNRPA1 Heterogeneous nuclear ribonucleoprotein A1 is a protein that in humans is encoded by the ''HNRNPA1'' gene. Mutations in hnRNP A1 are causative of amyotrophic lateral sclerosis and the syndrome multisystem proteinopathy. Function This ge ...

; HNRPA2B1; HNRPA3; HNRPAB;

HNRPC Heterogeneous nuclear ribonucleoproteins C1/C2 is a protein that in humans is encoded by the ''HNRNPC'' gene. It is abnormally expressed in fetuses of both in vitro fertilization, IVF and intracytoplasmic sperm injection, ICSI, which may contribu ...

; HNRPCL1; HNRPD; HNRPDL;

HNRPF Heterogeneous nuclear ribonucleoprotein F is a protein that in humans is encoded by the ''HNRNPF'' gene. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding ...

; HNRPH1; HNRPH2; HNRPH3; HNRPL; HNRPLL; HNRPM; HNRPR; HRNBP1; HSU53209; HTATSF1; IGF2BP1; IGF2BP2; IGF2BP3; LARP7;

MKI67IP MKI67 FHA domain-interacting nucleolar phosphoprotein is a protein that in humans is encoded by the ''MKI67IP'' gene. MKI67 FHA domain-interacting nucleolar phosphoprotein contains an RNA recognition motif (RRM) near to the N-terminus and a F ...

;

MSI1 RNA-binding protein Musashi homolog 1 also known as Musashi-1 is a protein that in humans is encoded by the ''MSI1'' gene. Function This gene encodes a protein containing two conserved tandem RNA recognition motifs and functions as an RNA b ...

;

MSI2 Musashi-2, also known as Musashi RNA binding protein 2, is a protein that in humans is encoded by the ''MSI2'' gene. Like its homologue musashi-1 (''MSI1''), it is an RNA-binding protein involved in stemness. Expression There are two homolog ...

; MSSP-2; MTHFSD;

MYEF2 Myelin expression factor 2 is a protein that in humans is encoded by the MYEF2 gene. References Further reading

{{gene-15-stub ...

; NCBP2; NCL; NOL8; NONO;

P14 P14, P-14 or P.14 may refer to: * P14 (tax), a British tax form * Aviatik P.14, a German reconnaissance biplane * Holbrook Municipal Airport, in Navajo County, Arizona, United States * LSWR P14 class, a British steam locomotive * P-14 radar, a Sovi ...

; PABPC1; PABPC1L;

PABPC3 Polyadenylate-binding protein 3 is a protein that in humans is encoded by the ''PABPC3'' gene. PABPC3 is a member of a larger family of poly(A)-binding proteins in the human genome. References Further reading * * * * * * External ...

;

PABPC4 Polyadenylate-binding protein 4 (PABPC4) is a protein that in humans is encoded by the ''PABPC4'' gene. Function Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP ...

;

PABPC5 Poly(A) binding protein cytoplasmic 5 is a protein that in humans is encoded by the PABPC5 gene. Function This gene encodes a poly(A)-binding protein that binds to the polyA tail found at the 3' end of most eukaryotic mRNAs. It is though ...

;

PABPN1 Polyadenylate-binding protein 2 (PABP-2) also known as polyadenylate-binding nuclear protein 1 (PABPN1) is a protein that in humans is encoded by the ''PABPN1'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word ...

;

POLDIP3 Polymerase delta-interacting protein 3 is an enzyme that in humans is encoded by the ''POLDIP3'' gene. This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and r ...

; PPARGC1; PPARGC1A; PPARGC1B; PPIE; PPIL4; PPRC1; PSPC1; PTBP1; PTBP2; PUF60; RALY;

RALYL RNA-binding Raly-like protein is a protein that in humans is encoded by the ''RALYL'' gene. References Further reading

* * * * * * {{gene-8-stub ...

;

RAVER1 Ribonucleoprotein, PTB-binding 1 (also known as RAVER1), is a human gene. References Further reading

* * * * * * {{gene-19-stub ...

;

RAVER2 Raver or ravers may refer to: Places * Raver, Maharashtra, a city in India * Raver (Vidhan Sabha constituency) * Raver (Lok Sabha constituency) People * Kim Raver (born 1969), American actress * Lorna Raver (born 1943), American actress Com ...

;

RBM10 RNA-binding motif 10 is a protein that is encoded by the RBM10 gene. This gene maps on the X chromosome at Xp11.23 in humans. RBM10 is a regulator of alternative splicing. Alternative splicing is a process associated with gene expression to produ ...

;

RBM11 Splicing regulator RBM11 is a protein that is encoded by the ''RBM11'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' ...

;

RBM12 RNA-binding protein 12 is a protein that in humans is encoded by the ''RBM12'' gene. This gene encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-rich regions. This gene and the gene for c ...

;

RBM12B RNA-binding motif protein, Y chromosome, family 1 member A1/C is a protein that in humans is encoded by the ''RBMY1A1'' gene. This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine ...

; RBM14;

RBM15 Putative RNA-binding protein 15 is a protein that in humans is encoded by the ''RBM15'' gene. It is an RNA-binding protein RNA-binding proteins (often abbreviated as RBPs) are proteins that bind to the double or single stranded RNA in cells a ...

; RBM15B; RBM16;

RBM17 Splicing factor 45 is a protein that in humans is encoded by the ''RBM17'' gene. References Further reading

* * * * * * * * * * {{gene-10-stub ...

; RBM18; RBM19;

RBM22 Pre-mRNA-splicing factor RBM22 is a protein that in humans is encoded by the ''RBM22'' gene. References Further reading

* * * * * * * * * * {{gene-5-stub ...

;

RBM23 Probable RNA-binding protein 23 is a protein that in humans is encoded by the ''RBM23'' gene. Function This gene encodes a member of the U2AF-like family of RNA binding proteins. This protein interacts with some steroid nuclear receptors, l ...

; RBM24;

RBM25 RNA-binding protein 25 is a protein that in humans is encoded by the ''RBM25'' gene. References Further reading

* * * * * * * {{gene-14-stub ...

;

RBM26 RNA-binding protein 26 is a protein that in humans is encoded by the ''RBM26'' gene. References Further reading

* * * * * * {{gene-13-stub ...

;

RBM27 RBM is a three-letter acronym. It refers to: * 89.1 Radio Blue Mountains, Radio station in Katoomba, New South Wales *The Roll Back Malaria (RBM) Partnership, the global framework to implement coordinated action against malaria. * Restricted Boltzm ...

; RBM28;

RBM3 Putative RNA-binding protein 3 is a protein that in humans is encoded by the ''RBM3'' gene. Function This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expres ...

;

RBM32B Putative RNA-binding protein 3 is a protein that in humans is encoded by the ''RBM3'' gene. Function This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expres ...

;

RBM33 RNA-binding protein 33 is a protein that in humans is encoded by the ''RBM33'' gene. References Further reading

* * * * * * * * * * {{gene-7-stub ...

;

RBM34 RNA-binding protein 34 is a protein that in humans is encoded by the ''RBM34'' gene. References Further reading

* * * {{gene-1-stub ...

; RBM35A; RBM35B; RBM38;

RBM39 RNA-binding protein 39 is a protein that in humans is encoded by the ''RBM39'' gene. Function The protein encoded by this gene is an RNA binding protein and possible splicing factor. The encoded protein is found in the nucleus, where it coloca ...

;

RBM4 RNA-binding protein 4 is a protein that in humans is encoded by the ''RBM4'' gene. RBM4 is a protein categorized as an RNA recognition motif (RRM). RRM proteins represent a substantial and functionally varied category of RNA-binding proteins, pa ...

; RBM41;

RBM42 RNA-binding protein 4 is a protein that in humans is encoded by the ''RBM4'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or '' ...

; RBM44; RBM45; RBM46;

RBM47 RNA binding motif protein 47 is a protein in humans that is encoded by the RBM47 gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ...

; RBM4B;

RBM5 RNA-binding protein 5 is a protein that in humans is encoded by the ''RBM5'' gene. References Further reading * * * * * * * * * * * * * * * * External links

* * {{gene-3-stub ...

;

RBM7 RNA-binding motif protein 7 is a protein that in humans is encoded by the ''RBM7'' gene. Interactions RBM7 has been shown to interact with SF3B2 and SFRS3 Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by t ...

; RBM8A; RBM9; RBMS1;

RBMS2 RBMS may refer to: * Rare Books and Manuscripts Section *River Bend Middle School Loudoun County Public Schools (LCPS) is a branch of the Loudoun County, Virginia, United States government, and administers public schools in the county. LCPS's h ...

;

RBMS3 RNA-binding motif, single-stranded-interacting protein 3 is a protein that in humans is encoded by the ''RBMS3'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of hered ...

; RBMX;

RBMX2 Heterogeneous nuclear ribonucleoprotein G is a protein that in humans is encoded by the ''RBMX'' gene. Function This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chrom ...

; RBMXL2;

RBMY1A1 RNA-binding motif protein, Y chromosome, family 1 member A1/C is a protein that in humans is encoded by the ''RBMY1A1'' gene. This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, ...

; RBMY1B; RBMY1E; RBMY1F; RBMY2FP; RBPMS;

RBPMS2 RNA-binding protein with multiple splicing is a protein that in humans is encoded by the ''RBPMS'' gene. Function This gene encodes a member of the RRM family of RNA-binding proteins. The RRM domain is between 80-100 amino acids in length an ...

; RDBP; RNPC3; RNPC4; RNPS1; ROD1; SAFB; SAFB2; SART3; SETD1A; SF3B14;

SF3B4 Splicing factor 3B subunit 4 is a protein that in humans is encoded by the ''SF3B4'' gene. Function This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA imme ...

; SFPQ;

SFRS1 Serine/arginine-rich splicing factor 1 (SRSF1) also known as alternative splicing factor 1 (ASF1), pre-mRNA-splicing factor SF2 (SF2) or ASF1/SF2 is a protein that in humans is encoded by the ''SRSF1'' gene. ASF/SF2 is an essential sequence spec ...

;

SFRS10 Transformer-2 protein homolog beta, also known as TRA2B previously known as splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) (SFRS10), is a protein that in humans is encoded by the ''TRA2B'' gene. Interactions TRA2B has ...

;

SFRS11 Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the ''SFRS11'' gene. This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. ...

;

SFRS12 Splicing factor, arginine/serine-rich 12 is a protein that in humans is encoded by the ''SFRS12'' gene. SFRS12 belongs to the superfamily of serine/arginine-rich (SR) splicing factors. It modulates splice site selection by regulating the acti ...

; SFRS15;

SFRS2 Splicing factor, arginine/serine-rich 2 is a protein that in humans is encoded by the ''SFRS2'' gene. MDS-associated splicing factor SRSF2 affects the expression of Class III and Class IV isoforms and perturbs granulopoiesis and SRSF2 P95H promo ...

;

SFRS2B The Scottish Fire and Rescue Service (SFRS; gd, Seirbheis Smàlaidh agus Teasairginn na h-Alba) is the national fire and rescue service of Scotland. It was formed by the merger of eight regional fire services in the country on 1 April 2013. ...

; SFRS3; SFRS4;

SFRS5 Splicing factor, arginine/serine-rich 5 is a protein that in humans is encoded by the ''SFRS5'' gene. References Further reading

* * * * * * * * * * * * * * * * * {{gene-14-stub ...

; SFRS6;

SFRS7 Serine/arginine-rich splicing factor 7 (SRSF7) also known as splicing factor, arginine/serine-rich 7 (SFRS7) or splicing factor 9G8 is a protein that in humans is encoded by the ''SRSF7'' gene. Function The protein encoded by this gene is a ...

; SFRS9;

SLIRP Slirp (sometimes capitalized SLiRP) is a software program that emulates a PPP, SLIP, or CSLIP connection to the Internet using a text-based shell account. Its original purpose became largely obsolete as dedicated dial-up PPP connections and b ...

; SLTM;

SNRP70 snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein that in humans is encoded by the ''SNRNP70'' gene. snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core comp ...

;

SNRPA U1 small nuclear ribonucleoprotein A is a protein that in humans is encoded by the ''SNRPA'' gene. Interactions Small nuclear ribonucleoprotein polypeptide A has been shown to interact Advocates for Informed Choice, dba interACT or int ...

;

SNRPB2 U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the ''SNRPB2'' gene. The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The en ...

; SPEN; SR140; SRRP35;

SSB SSB may refer to: Organizations * Scandinavian School of Brussels * Social Security Board (disambiguation) * , the Society of Saint Bridget * Society of the Sisters of Bethany, an Anglican order of sisters * Society of Systematic Biologists * , ...

; SYNCRIP; TAF15; TARDBP;

THOC4 Aly/REF export factor, also known as THO complex subunit 4 is a protein that in humans is encoded by the ''ALYREF'' gene. The ALYREF gene encodes Aly/REF export factor (ALY; THO complex subunit 4, Tho4; RNA and export factor binding protein 1, ...

;

TIA1 TIA1 or Tia1 cytotoxic granule-associated rna binding protein is a 3'UTR mRNA binding protein that can bind the 5'TOP sequence of 5'TOP mRNAs. It is associated with programmed cell death (apoptosis) and regulates alternative splicing of the gen ...

;

TIAL1 Nucleolysin TIAR is a protein that in humans is encoded by the ''TIAL1'' gene. The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elem ...

; TNRC4; TNRC6C; TRA2A; TRSPAP1; TUT1; U1SNRNPBP; U2AF1; U2AF2;

UHMK1 U2AF homology motif (UHM) kinase 1, also known as UHMK1, is a protein which in humans is encoded by the ''UHMK1'' gene. Function UHMK1 is a kinase enzyme which phosphorylates the protein stathmin and has an RNA recognition motif of unknown funct ...

; ZCRB1;

ZNF638 Zinc finger protein 638 is a protein that in humans is encoded by the ''ZNF638'' gene. The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: ...

;

ZRSR1 U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 is a protein that in humans is encoded by the ''ZRSR1'' gene. References Further reading * * * * * * {{protein-stub Proteins ...

;

ZRSR2 U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 is a protein that in humans is encoded by the ''ZRSR2'' gene. This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxi ...

;

References

External links

* {{InterPro content, IPR000504 Protein domains