Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform is an

enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...

that (in humans) is encoded by the ''PPP2CA''

gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

Function

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.

Interactions

PPP2CA has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...

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Bcl-2 Bcl-2 (B-cell lymphoma 2), encoded in humans by the ''BCL2'' gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis. ...

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Bestrophin 1 Bestrophin-1 (Best1) is a protein that, in humans, is encoded by the ''BEST1'' gene (RPD ID - 5T5N/4RDQ). The bestrophin family of proteins comprises four evolutionary related genes (BEST1, BEST2, BEST3, and BEST4) that code for integral membrane ...

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CCNG2 Cyclin-G2 is a protein that in humans is encoded by the ''CCNG2'' gene. Function The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cy ...

, * CTTNBP2NL, * CTTNBP2, *

Cyclin-dependent kinase 2 Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the ''CDK2'' gene. The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein ...

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Cyclin-dependent kinase 6 Cell division protein kinase 6 (CDK6) is an enzyme encoded by the ''CDK6'' gene. It is regulated by cyclins, more specifically by Cyclin D proteins and Cyclin-dependent kinase inhibitor proteins. The protein encoded by this gene is a member of t ...

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FAM40A Protein FAM40A is a protein that is located on chromosome 1 in humans and is encoded by the ''FAM40A'' gene. Characteristics and secondary structure FAM40A has an isoelectric point of 5.92 and a molecular weight of 95,575 daltons. It is predict ...

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IGBP1 Immunoglobulin-binding protein 1 is a protein that in humans is encoded by the ''IGBP1'' gene. Function The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific ...

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MOBKL3 Mps one binder kinase activator-like 3 is an enzyme that in humans is encoded by the ''MOBKL3'' gene. Function This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expres ...

, * PPP2R1A, * PPP2R1B, *

PPP2R2A Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform is an enzyme regulator that in humans is encoded by the ''PPP2R2A'' gene. Function The product of this gene belongs to the phosphatase 2 regulatory subunit B fam ...

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PPP2R3B Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta is an enzyme that in humans is encoded by the ''PPP2R3B'' gene. Function Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases a ...

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PPP2R5A Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform is an enzyme that in humans is encoded by the ''PPP2R5A'' gene. Function The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protei ...

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PPP2R5B Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform is an enzyme that in humans is encoded by the ''PPP2R5B'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Me ...

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PPP2R5C Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform is an enzyme that in humans is encoded by the ''PPP2R5C'' gene. Function The product of this gene belongs to the Protein phosphatase 2A regulatory subunit B family. ...

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PPP2R5D Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform is an enzyme that in humans is encoded by the ''PPP2R5D'' gene. Mutations in ''PPP2R5D'' cause Jordan's Syndrome. Function The product of this gene belongs to the ph ...

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PPP2R5E Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform is an enzyme that in humans is encoded by the ''PPP2R5E'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the ...

, * STRN3, * STRN, and *

TLX1 T-cell leukemia homeobox protein 1 is a protein that in humans is encoded by the ''TLX1'' gene, which was initially named ''HOX11''. Interactions TLX1 has been shown to interact with PPP1CC, PPP2CB Serine/threonine-protein phosphatase 2A c ...

Function

Interactions

See also

References

Further reading